Desmethylofloxacin (BioDeep_00000178112)
human metabolite blood metabolite
Metabolite Card
Formula: C17H18FN3O4 (347.1281)
Chinese Names:
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Molecular Structure
SMILES: CN1CCN(CC1)C1=C(F)C=C2C(=O)C(=CN3CCOC1=C23)C(O)=O
InChI: InChI=1S/C17H18FN3O4/c1-19-2-4-20(5-3-19)14-12(18)8-10-13-16(14)25-7-6-21(13)9-11(15(10)22)17(23)24/h8-9H,2-7H2,1H3,(H,23,24)
Description
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
Synonyms
Cross Reference
Classification Terms
Related Pathways
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Biological Process
0 related biological process reactions.
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1 organism taxonomy source information
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
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Literature Reference
- C Horstkötter, G Blaschke. Stereoselective determination of ofloxacin and its metabolites in human urine by capillary electrophoresis using laser-induced fluorescence detection.
Journal of chromatography. B, Biomedical sciences and applications.
2001 Apr; 754(1):169-78. doi:
10.1016/s0378-4347(00)00595-8. [PMID: 11318412] - R J Körner, C M McMullin, K A Bowker, L O White, D S Reeves, A P MacGowan. The serum concentrations of desmethyl ofloxacin and ofloxacin N-oxide in seriously ill patients and their possible contributions to the antibacterial activity of ofloxacin.
The Journal of antimicrobial chemotherapy.
1994 Aug; 34(2):300-3. doi:
10.1093/jac/34.2.300. [PMID: 7814297] - O Okazaki, T Kurata, H Hakusui, H Tachizawa. Species-related stereoselective disposition of ofloxacin in the rat, dog and monkey.
Xenobiotica; the fate of foreign compounds in biological systems.
1992 Apr; 22(4):439-50. doi:
10.3109/00498259209046656. [PMID: 1523865] - S Flor. Pharmacokinetics of ofloxacin. An overview.
The American journal of medicine.
1989 Dec; 87(6C):24S-30S. doi:
NULL. [PMID: 2603892] - L O White, A P MacGowan, I G Mackay, D S Reeves. The pharmacokinetics of ofloxacin, desmethyl ofloxacin and ofloxacin N-oxide in haemodialysis patients with end-stage renal failure.
The Journal of antimicrobial chemotherapy.
1988 Sep; 22 Suppl C(?):65-72. doi:
10.1093/jac/22.supplement_c.65. [PMID: 3182464] - L O White, A P MacGowan, A M Lovering, D S Reeves, I G Mackay. A preliminary report on the pharmacokinetics of ofloxacin, desmethyl ofloxacin and ofloxacin N-oxide in patients with chronic renal failure.
Drugs.
1987; 34 Suppl 1(?):56-61. doi:
10.2165/00003495-198700341-00013. [PMID: 3481329]
