Denzimol (BioDeep_00000178067)

   

human metabolite blood metabolite


代谢物信息卡片


N-(beta-(4-(beta-Phenylethyl)phenyl)-beta-hydroxyethyl)imidazole

化学式: C19H20N2O (292.157555)
中文名称: 登齐醇
谱图信息: 最多检出来源 Homo sapiens(blood) 66.67%

分子结构信息

SMILES: C1=CC=C(C=C1)CCC2=CC=C(C=C2)C(CN3C=CN=C3)O
InChI: InChI=1S/C19H20N2O/c22-19(14-21-13-12-20-15-21)18-10-8-17(9-11-18)7-6-16-4-2-1-3-5-16/h1-5,8-13,15,19,22H,6-7,14H2

描述信息

C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants

同义名列表

5 个代谢物同义名

N-(beta-(4-(beta-Phenylethyl)phenyl)-beta-hydroxyethyl)imidazole; 2-(1H-imidazol-1-yl)-1-[4-(2-phenylethyl)phenyl]ethan-1-ol; 2-imidazol-1-yl-1-[4-(2-phenylethyl)phenyl]ethanol; PHEP-heiz; Denzimol



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • P N Patsalos, M S Alavijeh, W Brownhill, P T Lascelles. Effect of denzimol on carbamazepine and carbamazepine-10,11-epoxide concentrations in serum, liver, spleen and different brain regions of the rat: an inhibitory metabolic interaction. Naunyn-Schmiedeberg's archives of pharmacology. 1988 Jan; 337(1):111-4. doi: 10.1007/bf00169486. [PMID: 3368010]
  • S Caccia, L Conforti, I Conti. Effect of the anticonvulsant denzimol on the disposition of diazepam in the rat. The Journal of pharmacy and pharmacology. 1986 Jun; 38(6):469-72. doi: 10.1111/j.2042-7158.1986.tb04613.x. [PMID: 2873226]
  • D Bertin, A Cova, C Reschiotto, A Tajana. Determination of denzimol, a new anticonvulsant agent, and its main metabolite in biological material by gas chromatography and high-performance liquid chromatography. Journal of chromatography. 1986 May; 378(1):147-54. doi: 10.1016/s0378-4347(00)80707-0. [PMID: 3733967]
  • G A Abbiati, D Bertin, M Ibba, G Graziani, R Testa. Relationship between plasma and brain concentrations of Denzimol and its anticonvulsant and neurotoxic effects in the rat. Archives internationales de pharmacodynamie et de therapie. 1986 Mar; 280(1):117-28. doi: NULL. [PMID: 3718074]
  • G A Abbiati, G Restelli, G Graziani, R Testa. [HPLC method for the determination of plasma and tissue levels of denzimol hydrochloride]. Bollettino chimico farmaceutico. 1985 Apr; 124(4):178-85. doi: NULL. [PMID: 4041249]
  • P N Patsalos, S D Shorvon, A A Elyas, G Smith. The interaction of denzimol (a new anticonvulsant) with carbamazepine and phenytoin. Journal of neurology, neurosurgery, and psychiatry. 1985 Apr; 48(4):374-7. doi: 10.1136/jnnp.48.4.374. [PMID: 3923158]
  • A Dal Pozzo, M Acquasaliente, A Tajana. Comparative binding studies of anticonvulsant drugs to bovine serum albumin. Il Farmaco; edizione scientifica. 1983 Aug; 38(8):609-18. doi: NULL. [PMID: 6617856]
  • G Graziani, E Barbadoro, R Testa. Denzimol, a new anticonvulsant drug. III. Toxicological evaluation. Arzneimittel-Forschung. 1983; 33(8):1168-73. doi: NULL. [PMID: 6685495]