DC-Chol (BioDeep_00000177982)
human metabolite blood metabolite
代谢物信息卡片
[10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] N-[2-(dimethylamino)ethyl]carbamate
化学式: C32H56N2O2 (500.4341556)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 90%
分子结构信息
SMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)NCCN(C)C)C)C
InChI: InChI=1S/C32H56N2O2/c1-22(2)9-8-10-23(3)27-13-14-28-26-12-11-24-21-25(36-30(35)33-19-20-34(6)7)15-17-31(24,4)29(26)16-18-32(27,28)5/h11,22-23,25-29H,8-10,12-21H2,1-7H3,(H,33,35)
描述信息
同义名列表
8 个代谢物同义名
[10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] N-[2-(dimethylamino)ethyl]carbamate; 1-{[2,15-dimethyl-14-(6-methylheptan-2-yl)tetracyclo[8.7.0.0,.0,]heptadec-7-en-5-yl]oxy}-N-[2-(dimethylamino)ethyl]methanimidate; 2,15-dimethyl-14-(6-methylheptan-2-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-7-en-5-yl N-[2-(dimethylamino)ethyl]carbamate; 3beta-(N-(N,n-dimethylaminoethane)carbamoyl)cholesterol; 3-(N-(N,n-dimethylaminoethane)carbamoyl)cholesterol; DC-Chol; DAC 30; DAC-30
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Rui Tada, Shoko Muto, Tomoko Iwata, Akira Hidaka, Hiroshi Kiyono, Jun Kunisawa, Yukihiko Aramaki. Attachment of class B CpG ODN onto DOTAP/DC-chol liposome in nasal vaccine formulations augments antigen-specific immune responses in mice.
BMC research notes.
2017 Jan; 10(1):68. doi:
10.1186/s13104-017-2380-8. [PMID: 28126014] - Jia Ju, Meng-Lei Huan, Ning Wan, Yi-Lin Hou, Xi-Xi Ma, Yi-Yang Jia, Chen Li, Si-Yuan Zhou, Bang-Le Zhang. Cholesterol derived cationic lipids as potential non-viral gene delivery vectors and their serum compatibility.
Bioorganic & medicinal chemistry letters.
2016 05; 26(10):2401-2407. doi:
10.1016/j.bmcl.2016.04.007. [PMID: 27072908] - Simona Motta, Valeria Rondelli, Laura Cantu, Elena Del Favero, Massimo Aureli, Daniela Pozzi, Giulio Caracciolo, Paola Brocca. What the cell surface does not see: The gene vector under the protein corona.
Colloids and surfaces. B, Biointerfaces.
2016 May; 141(?):170-178. doi:
10.1016/j.colsurfb.2016.01.045. [PMID: 26852100] - Pavlína Novotná, František Králík, Marie Urbanová. Chiral recognition of bilirubin and biliverdin in liposomes and micelles.
Biophysical chemistry.
2015 Oct; 205(?):41-50. doi:
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PloS one.
2015; 10(10):e0139785. doi:
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2015; 26(4):264-76. doi:
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2013 Jan; 101(?):6-13. doi:
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Proteomics.
2011 Aug; 11(16):3349-58. doi:
10.1002/pmic.201000803. [PMID: 21751361] - Anna Laura Capriotti, Giulio Caracciolo, Giuseppe Caruso, Chiara Cavaliere, Daniela Pozzi, Roberto Samperi, Aldo Laganà. Analysis of plasma protein adsorption onto DC-Chol-DOPE cationic liposomes by HPLC-CHIP coupled to a Q-TOF mass spectrometer.
Analytical and bioanalytical chemistry.
2010 Dec; 398(7-8):2895-903. doi:
10.1007/s00216-010-4104-y. [PMID: 20859620] - Emmanuel A Ho, Euan Ramsay, Mihaela Ginj, Malathi Anantha, Isaiah Bregman, Jonathan Sy, Janet Woo, Maryam Osooly-Talesh, Donald T Yapp, Marcel B Bally. Characterization of cationic liposome formulations designed to exhibit extended plasma residence times and tumor vasculature targeting properties.
Journal of pharmaceutical sciences.
2010 Jun; 99(6):2839-53. doi:
10.1002/jps.22043. [PMID: 20091826] - Yang Zhang, Huimei Li, Jing Sun, Jie Gao, Wei Liu, Bohua Li, Yajun Guo, Jianming Chen. DC-Chol/DOPE cationic liposomes: a comparative study of the influence factors on plasmid pDNA and siRNA gene delivery.
International journal of pharmaceutics.
2010 May; 390(2):198-207. doi:
10.1016/j.ijpharm.2010.01.035. [PMID: 20116418] - Giulio Caracciolo, Luciano Callipo, Sofia Candeloro De Sanctis, Chiara Cavaliere, Daniela Pozzi, Aldo Laganà. Surface adsorption of protein corona controls the cell internalization mechanism of DC-Chol-DOPE/DNA lipoplexes in serum.
Biochimica et biophysica acta.
2010 Mar; 1798(3):536-43. doi:
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Methods in molecular biology (Clifton, N.J.).
2010; 605(?):393-403. doi:
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Vaccine.
2008 May; 26(21):2657-66. doi:
10.1016/j.vaccine.2007.11.002. [PMID: 18068876] - Naoki Sakaguchi, Chie Kojima, Atsushi Harada, Kazunori Koiwai, Kazuhiro Shimizu, Nobuhiko Emi, Kenji Kono. Generation of highly potent nonviral gene vectors by complexation of lipoplexes and transferrin-bearing fusogenic polymer-modified liposomes in aqueous glucose solution.
Biomaterials.
2008 Mar; 29(9):1262-72. doi:
10.1016/j.biomaterials.2007.11.016. [PMID: 18076985] - Claudio Esposito, Johanna Generosi, Giuseppe Mossa, Andrea Masotti, Agostina Congiu Castellano. The analysis of serum effects on structure, size and toxicity of DDAB-DOPE and DC-Chol-DOPE lipoplexes contributes to explain their different transfection efficiency.
Colloids and surfaces. B, Biointerfaces.
2006 Dec; 53(2):187-92. doi:
10.1016/j.colsurfb.2006.09.011. [PMID: 17049213] - Karin Kiefer, Jule Clement, Patrick Garidel, Regine Peschka-Süss. Transfection efficiency and cytotoxicity of nonviral gene transfer reagents in human smooth muscle and endothelial cells.
Pharmaceutical research.
2004 Jun; 21(6):1009-17. doi:
10.1023/b:pham.0000029291.62615.ec. [PMID: 15212167] - Hai-liang Chen, Wen-quan Liang, Jun-bin Shao, Zhi Chen. [Preparation of cationic liposomes and its role in enhancing cellular uptake of antisense oligonucleotides].
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2004 Jan; 39(1):72-6. doi:
NULL. [PMID: 15127587] - Michael Keller, Michael R Jorgensen, Eric Perouzel, Andrew D Miller. Thermodynamic aspects and biological profile of CDAN/DOPE and DC-Chol/DOPE lipoplexes.
Biochemistry.
2003 May; 42(20):6067-77. doi:
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Gene therapy.
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Gene therapy.
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1997 Apr; 247(1):34-44. doi:
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