Cyclocreatine (BioDeep_00000177805)
human metabolite blood metabolite
代谢物信息卡片
化学式: C5H9N3O2 (143.0695)
中文名称: 2-亚氨基-1-咪唑烷乙酸
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: C1CN(C(=N1)N)CC(=O)O
InChI: InChI=1S/C5H9N3O2/c6-5-7-1-2-8(5)3-4(9)10/h1-3H2,(H2,6,7)(H,9,10)
描述信息
D000970 - Antineoplastic Agents
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Jeffrey J Wallery, Vijay Pralhad Kale, Joseph Novak, Seth Gibbs, Minh-Ha T Do, John C McKew, Pramod S Terse. Evaluation of chronic toxicity of cyclocreatine in beagle dogs after oral gavage administration for up to 23 weeks.
Toxicology and applied pharmacology.
2021 11; 430(?):115680. doi:
10.1016/j.taap.2021.115680. [PMID: 34411581] - Minh-Ha Thi Do, Joy Cavagnaro, Mark Butt, Pramod S Terse, John C McKew. Use of an animal model of disease for toxicology enables identification of a juvenile no observed adverse effect level for cyclocreatine in creatine transporter deficiency.
Regulatory toxicology and pharmacology : RTP.
2021 Jul; 123(?):104939. doi:
10.1016/j.yrtph.2021.104939. [PMID: 33961952] - Vijay Pralhad Kale, Jeffery Wallery, Joseph Novak, Seth Gibbs, Mohammed Bourdi, Minh-Ha T Do, John C McKew, Pramod S Terse. Evaluation of chronic toxicity of cyclocreatine, a creatine analog, in Sprague Dawley rat after oral gavage administration for up to 26 weeks.
Regulatory toxicology and pharmacology : RTP.
2020 Nov; 117(?):104750. doi:
10.1016/j.yrtph.2020.104750. [PMID: 32745584] - Francesco Cacciante, Mariangela Gennaro, Giulia Sagona, Raffaele Mazziotti, Leonardo Lupori, Elisa Cerri, Elena Putignano, Mark Butt, Minh-Ha T Do, John C McKew, Maria Grazia Alessandrì, Roberta Battini, Giovanni Cioni, Tommaso Pizzorusso, Laura Baroncelli. Cyclocreatine treatment ameliorates the cognitive, autistic and epileptic phenotype in a mouse model of Creatine Transporter Deficiency.
Scientific reports.
2020 10; 10(1):18361. doi:
10.1038/s41598-020-75436-4. [PMID: 33110151] - Kirill Gorshkov, Amy Q Wang, Wei Sun, Ethan Fisher, Marta Frigeni, Marc Singleton, Natasha Thorne, Bradley Class, Wenwei Huang, Nicola Longo, Minh-Ha T Do, Elizabeth A Ottinger, Xin Xu, Wei Zheng. Phosphocyclocreatine is the dominant form of cyclocreatine in control and creatine transporter deficiency patient fibroblasts.
Pharmacology research & perspectives.
2019 12; 7(6):e00525. doi:
10.1002/prp2.525. [PMID: 31859463] - Hu Wang, Fanny Cheung, Anna C Stoll, Patricia Rockwell, Maria E Figueiredo-Pereira. Mitochondrial and calcium perturbations in rat CNS neurons induce calpain-cleavage of Parkin: Phosphatase inhibition stabilizes pSer65Parkin reducing its calpain-cleavage.
Biochimica et biophysica acta. Molecular basis of disease.
2019 06; 1865(6):1436-1450. doi:
10.1016/j.bbadis.2019.02.016. [PMID: 30796971] - Amy Q Wang, Emma Hughes, Wenwei Huang, Edward H Kerns, Xin Xu. Quantification of cyclocreatine in mouse and rat plasma using hydrophilic-interaction ultra-performance liquid chromatography-tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2017 Oct; 145(?):629-633. doi:
10.1016/j.jpba.2017.07.049. [PMID: 28800523] - G Ara, L M Gravelin, R Kaddurah-Daouk, B A Teicher. Antitumor activity of creatine analogs produced by alterations in pancreatic hormones and glucose metabolism.
In vivo (Athens, Greece).
1998 Mar; 12(2):223-31. doi:
. [PMID: 9627806] - Y S Schiffenbauer, C Tempel, R Abramovitch, G Meir, M Neeman. Cyclocreatine accumulation leads to cellular swelling in C6 glioma multicellular spheroids: diffusion and one-dimensional chemical shift nuclear magnetic resonance microscopy.
Cancer research.
1995 Jan; 55(1):153-8. doi:
". [PMID: 7805026] - S A Elgebaly, M E Allam, S Houser, F Hashmi, F Forouhar, D Miano. Cyclocreatine inhibits neutrophil accumulation in the myocardium of a canine model of coronary artery occlusion and reperfusion.
The Journal of pharmacology and experimental therapeutics.
1993 Sep; 266(3):1670-7. doi:
NULL. [PMID: 8371165] - H Pösö, E Karvonen, H Suomalainen, L C Andersson. A human neuroblastoma cell line with an altered ornithine decarboxylase.
The Journal of biological chemistry.
1984 Oct; 259(20):12307-10. doi:
10.1016/s0021-9258(18)90742-8. [PMID: 6436232]
