Clinofibrate (BioDeep_00000177556)

 

Secondary id: BioDeep_00000015445

human metabolite blood metabolite


代谢物信息卡片


2-(4-{1-[4-(1-carboxy-1-methylpropoxy)phenyl]cyclohexyl}phenoxy)-2-methylbutanoic acid

化学式: C28H36O6 (468.2512)
中文名称: 克利贝特
谱图信息: 最多检出来源 Homo sapiens(not specific) 22.22%

分子结构信息

SMILES: CCC(C)(C(=O)O)OC1=CC=C(C=C1)C2(CCCCC2)C3=CC=C(C=C3)OC(C)(CC)C(=O)O
InChI: InChI=1S/C28H36O6/c1-5-26(3,24(29)30)33-22-14-10-20(11-15-22)28(18-8-7-9-19-28)21-12-16-23(17-13-21)34-27(4,6-2)25(31)32/h10-17H,5-9,18-19H2,1-4H3,(H,29,30)(H,31,32)



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Yohtaro Sato, Nobuaki Arai, Hidemi Yasuda, Yasushi Mizoguchi. Clinofibrate improved canine lipid metabolism in some but not all breeds. The Journal of veterinary medical science. 2018 Jun; 80(6):945-949. doi: 10.1292/jvms.17-0703. [PMID: 29576583]
  • Jian-Kang Li, Chentao Lu, Jing Yang, Fan Li, Jie Ge, Song Wei, Li Xueqing, Likun Ding, Wen Ai-Dong. Development of a LC-MS/MS method for the estimation of clinofibrate in human urine. Die Pharmazie. 2015 Apr; 70(4):219-24. doi: NULL. [PMID: 26012250]
  • Jian-kang Li, Li-kun Ding, Xue-qin Li, Min-chun Chen, Lei Wang, Jing Yang, Ying Song, Wei Song, Yan-yan Jia, Ai-dong Wen. Effect of food on the single-dose pharmacokinetics and tolerability of clinofibrate tablets in Chinese healthy volunteers. International journal of clinical pharmacology and therapeutics. 2013 Aug; 51(8):672-7. doi: 10.5414/cp201855. [PMID: 23849436]
  • Li Jian-Kang, Song Ying, Wang Lei, Chen Minchun, Song Wei, Li Xueqing, Sun Xiao-Li, Li Guangqing, Jia Yan-Yan, Wen Ai-Dong. High-performance liquid chromatographic method for determination of clinofibrate and its application to a pharmacokinetic study in healthy volunteers. Journal of pharmaceutical and biomedical analysis. 2013 Mar; 76(?):152-6. doi: 10.1016/j.jpba.2012.12.008. [PMID: 23319135]
  • Yutaka Shiina, Yasuhiko Homma, Toshiaki Oguma, Yuichi Fusegawa, Hideki Ozawa, Shunnosuke Handa, Teruhisa Tanabe. A case of familial hypercholesterolemia; secession from LDL-apheresis by the drug treatment with potent statin and resin. The Tokai journal of experimental and clinical medicine. 2005 Sep; 30(3):149-55. doi: NULL. [PMID: 16285605]
  • Itsuko Sato, Mari Hyakuta, Fujio Hayashi, Masahiko Mukai, Shinichi Kondo, Eiichi Maeda, Shuniti Kumagai. [Usefulness of examination of the cholesterol versus triglyceride ratio for lipoprotein fractions in a patient with marked hyper-triglyceridemia]. Rinsho byori. The Japanese journal of clinical pathology. 2002 Oct; 50(10):987-91. doi: NULL. [PMID: 12451680]
  • Y Nishizawa, T Shoji, T Tabata, T Inoue, H Morii. Effects of lipid-lowering drugs on intermediate-density lipoprotein in uremic patients. Kidney international. Supplement. 1999 Jul; 71(?):S134-6. doi: 10.1046/j.1523-1755.1999.07133.x. [PMID: 10412757]
  • M Okazaki, H Zhang, K Ichino, M Amamiya, S Nakayama, K Oguchi. Effects of clinofibrate on plasma fibrinogen level in high fructose diet-induced hyperlipidemic rats. In vivo (Athens, Greece). 1994 Nov; 8(6):1057-61. doi: NULL. [PMID: 7772737]
  • S Imasaka, S Nakayama, K Oguchi. [Changes of lipids and lipoproteins in cholesterol free-high fructose diet-fed rats and the effects of clinofibrate]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1994 Feb; 103(2):67-78. doi: 10.1254/fpj.103.67. [PMID: 8112691]
  • Y Nishizawa, T Shoji, H Nishitani, M Yamakawa, T Konishi, K Kawasaki, H Morii. Hypertriglyceridemia and lowered apolipoprotein C-II/C-III ratio in uremia: effect of a fibric acid, clinofibrate. Kidney international. 1993 Dec; 44(6):1352-9. doi: 10.1038/ki.1993.388. [PMID: 8301936]
  • H Maruno, T Shimizu, K Kawai, K Hirohata. The response of osteocytes to a lipid clearing agent in steroid-treated rabbits. The Journal of bone and joint surgery. British volume. 1991 Nov; 73(6):911-5. doi: 10.1302/0301-620x.73b6.1955435. [PMID: 1955435]
  • T Horio, M Kohno, K Murakawa, K Yasunari, K Yokokawa, M Ueda, T Takeda. Increased plasma immunoreactive endothelin-1 concentration in hypercholesterolemic rats. Atherosclerosis. 1991 Aug; 89(2-3):239-46. doi: 10.1016/0021-9150(91)90065-b. [PMID: 1793451]
  • S Okada, Y Miyai, K Ichiki, K Sato, Y Masaki, T Higuchi, Y Ogino, Z Ota. Clinofibrate therapy raises high-density lipoprotein levels and lowers atherogenic index in diabetes mellitus patients. The Journal of international medical research. 1989 Nov; 17(6):521-5. doi: 10.1177/030006058901700604. [PMID: 2628128]
  • T Watanabe, M Mitsukawa, S Horie, T Suga, K Seki. Effects of some hypolipidemic agents on biochemical values and hepatic peroxisomal enzymes in rats: comparison of probucol, CGA, KCD-232, MLM-160, AL-369 and clinofibrate with clofibrate. Journal of pharmacobio-dynamics. 1987 Mar; 10(3):142-7. doi: 10.1248/bpb1978.10.142. [PMID: 3625448]
  • K Shirai, Y Ishikawa, T Nishide, N Sasaki, S Murano, N Matsuoka, Y Saito, S Yoshida. Effect of clinofibrate on lipid metabolism of aorta in atherosclerotic rats. Artery. 1983; 12(3):145-55. doi: . [PMID: 6680996]
  • N Takeuchi, H Kukita, G Kajiyama, M Fujiyama, K Ishikawa, H Miki, T Mishima, K Murata, T Asano. Effect of clinofibrate, a new hypolipidemic agent, on biliary and serum lipids in patients with hyperlipidemia. Atherosclerosis. 1982 Apr; 42(2-3):129-39. doi: 10.1016/0021-9150(82)90145-9. [PMID: 7073798]