3-(2-Azetidinylmethoxy)-2-fluoropyridine (BioDeep_00000177364)

   

human metabolite blood metabolite


代谢物信息卡片


2-(18)F-Fluoro-3(2(S)-2-azetidinylmethoxy)pyridine

化学式: C9H11FN2O (182.0855)
中文名称:
谱图信息: 最多检出来源 Mus musculus(blood) 100%

分子结构信息

SMILES: C1CNC1COC2=C(N=CC=C2)F
InChI: InChI=1S/C9H11FN2O/c10-9-8(2-1-4-12-9)13-6-7-3-5-11-7/h1-2,4,7,11H,3,5-6H2



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Arthur L Brody, Mark A Mandelkern, Matthew R Costello, Anna L Abrams, David Scheibal, Judah Farahi, Edythe D London, Richard E Olmstead, Jed E Rose, Alexey G Mukhin. Brain nicotinic acetylcholine receptor occupancy: effect of smoking a denicotinized cigarette. The international journal of neuropsychopharmacology. 2009 Apr; 12(3):305-16. doi: 10.1017/s146114570800922x. [PMID: 18706128]
  • Brian J McParland, Matthew P Miller, Terence J Spinks, Laura M Kenny, Safiye Osman, Mandeep K Khela, Eric Aboagye, Raoul C Coombes, Ai-Min Hui, Pamela S Cohen. The biodistribution and radiation dosimetry of the Arg-Gly-Asp peptide 18F-AH111585 in healthy volunteers. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2008 Oct; 49(10):1664-7. doi: 10.2967/jnumed.108.052126. [PMID: 18794263]
  • Alexey G Mukhin, Alane S Kimes, Svetlana I Chefer, John A Matochik, Carlo S Contoreggi, Andrew G Horti, D Bruce Vaupel, Olga Pavlova, Elliot A Stein. Greater nicotinic acetylcholine receptor density in smokers than in nonsmokers: a PET study with 2-18F-FA-85380. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2008 Oct; 49(10):1628-35. doi: 10.2967/jnumed.108.050716. [PMID: 18794265]
  • Alane S Kimes, Svetlana I Chefer, John A Matochik, Carlo S Contoreggi, D Bruce Vaupel, Elliot A Stein, Alexey G Mukhin. Quantification of nicotinic acetylcholine receptors in the human brain with PET: bolus plus infusion administration of 2-[18F]F-A85380. NeuroImage. 2008 Jan; 39(2):717-27. doi: 10.1016/j.neuroimage.2007.09.015. [PMID: 17962044]
  • Dietlind Sorger, Georg A Becker, Marianne Patt, Andreas Schildan, Udo Grossmann, Reinhard Schliebs, Anita Seese, Kai Kendziorra, Magnus Kluge, Peter Brust, Alexey G Mukhin, Osama Sabri. Measurement of the alpha4beta2* nicotinic acetylcholine receptor ligand 2-[(18)F]Fluoro-A-85380 and its metabolites in human blood during PET investigation: a methodological study. Nuclear medicine and biology. 2007 Apr; 34(3):331-42. doi: 10.1016/j.nucmedbio.2006.12.008. [PMID: 17383583]
  • Dean A Shumway, Olga A Pavlova, Alexey G Mukhin. A simplified method for the measurement of nonmetabolized 2-[18F]F-A-85380 in blood plasma using solid-phase extraction. Nuclear medicine and biology. 2007 Feb; 34(2):221-8. doi: 10.1016/j.nucmedbio.2006.12.001. [PMID: 17307130]
  • Dietlind Sorger, Georg Alexander Becker, Katharina Hauber, Andreas Schildan, Marianne Patt, Gerd Birkenmeier, Andreas Otto, Philipp Meyer, Magnus Kluge, Reinhard Schliebs, Osama Sabri. Binding properties of the cerebral alpha4beta2 nicotinic acetylcholine receptor ligand 2-[18F]fluoro-A-85380 to plasma proteins. Nuclear medicine and biology. 2006 Oct; 33(7):899-906. doi: 10.1016/j.nucmedbio.2006.07.012. [PMID: 17045170]
  • F Picard, D Bruel, D Servent, W Saba, C Fruchart-Gaillard, M-A Schöllhorn-Peyronneau, D Roumenov, E Brodtkorb, S Zuberi, A Gambardella, B Steinborn, A Hufnagel, H Valette, M Bottlaender. Alteration of the in vivo nicotinic receptor density in ADNFLE patients: a PET study. Brain : a journal of neurology. 2006 Aug; 129(Pt 8):2047-60. doi: 10.1093/brain/awl156. [PMID: 16815873]
  • Arthur L Brody, Mark A Mandelkern, Edythe D London, Richard E Olmstead, Judah Farahi, David Scheibal, Jennifer Jou, Valerie Allen, Emmanuelle Tiongson, Svetlana I Chefer, Andrei O Koren, Alexey G Mukhin. Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors. Archives of general psychiatry. 2006 Aug; 63(8):907-15. doi: 10.1001/archpsyc.63.8.907. [PMID: 16894067]
  • Sascha Mitkovski, Victor L Villemagne, Kathy E Novakovic, Graeme O'Keefe, Henri Tochon-Danguy, Rachel S Mulligan, Kerryn L Dickinson, Tim Saunder, Marie-Claude Gregoire, Michel Bottlaender, Frederic Dolle, Christopher C Rowe. Simplified quantification of nicotinic receptors with 2[18F]F-A-85380 PET. Nuclear medicine and biology. 2005 Aug; 32(6):585-91. doi: 10.1016/j.nucmedbio.2005.04.013. [PMID: 16026705]
  • D Bruce Vaupel, Srihari R Tella, David L Huso, Valentine O Wagner, Alexey G Mukhin, Svetlana I Chefer, Andrew G Horti, Edythe D London, Andrei O Koren, Alane S Kimes. Pharmacological and toxicological evaluation of 2-fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-F-A-85380), a ligand for imaging cerebral nicotinic acetylcholine receptors with positron emission tomography. The Journal of pharmacology and experimental therapeutics. 2005 Jan; 312(1):355-65. doi: 10.1124/jpet.104.073999. [PMID: 15331657]
  • Alane S Kimes, Andrew G Horti, Edythe D London, Svetlana I Chefer, Carlo Contoreggi, Monique Ernst, Phyllis Friello, Andrei O Koren, Varughese Kurian, John A Matochik, Olga Pavlova, D Bruce Vaupel, Alexey G Mukhin. 2-[18F]F-A-85380: PET imaging of brain nicotinic acetylcholine receptors and whole body distribution in humans. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2003 Jul; 17(10):1331-3. doi: 10.1096/fj.02-0492fje. [PMID: 12759330]
  • Michel Bottlaender, Héric Valette, Dimitri Roumenov, Frédéric Dollé, Christine Coulon, Michèle Ottaviani, Françoise Hinnen, Marcel Ricard. Biodistribution and radiation dosimetry of 18F-fluoro-A-85380 in healthy volunteers. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2003 Apr; 44(4):596-601. doi: NULL. [PMID: 12679405]