(±)-Aegeline (BioDeep_00000017726)

   

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


2-PROPENAMIDE, N-(2-HYDROXY-2-(4-METHOXYPHENYL)ETHYL)-3-PHENYL-, (E)-(+/-)-

化学式: C18H19NO3 (297.1365)
中文名称: 印枳碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 83.33%

分子结构信息

SMILES: COC1=CC=C(C=C1)C(CNC(=O)C=CC2=CC=CC=C2)O
InChI: InChI=1S/C18H19NO3/c1-22-16-10-8-15(9-11-16)17(20)13-19-18(21)12-7-14-5-3-2-4-6-14/h2-12,17,20H,13H2,1H3,(H,19,21)/b12-7+

描述信息

(±)-Aegeline is found in fruits. (±)-Aegeline is an alkaloid from the leaves of Aegle marmelos (bael).
Alkaloid from the leaves of Aegle marmelos (bael). (±)-Aegeline is found in fruits.
Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity[1].
Aegeline, a main alkaloid, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Aegeline restores growth of yeast cells suppressed by either αsyn or Bax. Antioxidant activity[1].

同义名列表

24 个代谢物同义名

2-PROPENAMIDE, N-(2-HYDROXY-2-(4-METHOXYPHENYL)ETHYL)-3-PHENYL-, (E)-(+/-)-; 2-Propenamide, N-(2-hydroxy-2-(4-methoxyphenyl)ethyl)-3-phenyl-, (E)-; (2E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenylprop-2-enimidate; (2E)-N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenylprop-2-enamide; N-(2-Hydroxy-2(4-methoxyphenyl)ethyl)-3-phenyl-2-propenamide, (E)-; (E)-N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenylprop-2-enamide; N-[2-hydroxy-2(4-methoxyphenyl) ethyl]-3-phenyl-2-propenamide; N-(2-hydroxy-2(4-methoxyphenyl)ethyl)-3-phenyl-2-propenamide; (E)-N-[2-Hydroxy-2-(4-methoxyphenyl)ethyl]cinnamamide; N-(2-Hydroxy-2-(4-methoxyphenyl)ethyl)cinnamamide; N-Cinnamoyl-?-Hydroxy-4-methoxyphenyl-aethylamin; EGELINE [USP-RS]; UNII-60T59LN3SG; (+/-)-Aegeline; (+-)-Aegeline; MEGxp0_001339; (±)-Aegeline; ACon1_000768; (+-)-Egeline; 60T59LN3SG; Aegeline; Aegelin; EGELINE; MFCD00048045



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Min Tian, Shenzhi Zhou, Wei Li, Jiaru Li, Lan Yang, Ying Peng, Jiang Zheng. Metabolic activation of aegeline mediated by CYP2C19. Xenobiotica; the fate of foreign compounds in biological systems. 2021 Nov; 51(11):1217-1228. doi: 10.1080/00498254.2021.1913666. [PMID: 33892609]
  • Vamshi K Manda, Mona H Haron, Tahir M Mir, Bharathi Avula, Mohammad K Ashfaq, Saqlain Haider, Amar G Chittiboyina, Ikhlas A Khan, Shabana I Khan. Pharmacokinetics and Tissue Distribution of Aegeline after Oral Administration in Mice. Planta medica. 2019 Apr; 85(6):491-495. doi: 10.1055/a-0851-6879. [PMID: 30754052]
  • Asma Derf, Ankita Sharma, Sandip B Bharate, Bhabatosh Chaudhuri. Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing α-synuclein and Bax toxicity in yeast. Bioorganic & medicinal chemistry letters. 2019 02; 29(3):454-460. doi: 10.1016/j.bmcl.2018.12.028. [PMID: 30579794]
  • Abhilasha Singh, Ashok Kumar Srinivasan, Lakshmi Narasimhan Chakrapani, Periandavan Kalaiselvi. LOX-1, the Common Therapeutic Target in Hypercholesterolemia: A New Perspective of Antiatherosclerotic Action of Aegeline. Oxidative medicine and cellular longevity. 2019; 2019(?):8285730. doi: 10.1155/2019/8285730. [PMID: 31885819]
  • Sujith Rajan, Sabbu Satish, Kripa Shankar, Sukanya Pandeti, Salil Varshney, Ankita Srivastava, Durgesh Kumar, Abhishek Gupta, Sanchita Gupta, Rakhi Choudhary, Vishal M Balaramnavar, Tadigoppula Narender, Anil N Gaikwad. Aegeline inspired synthesis of novel β3-AR agonist improves insulin sensitivity in vitro and in vivo models of insulin resistance. Metabolism: clinical and experimental. 2018 08; 85(?):1-13. doi: 10.1016/j.metabol.2018.03.001. [PMID: 29524448]
  • Sabbu Satish, Ankita Srivastava, Pragya Yadav, Salil Varshney, Rakhi Choudhary, Vishal M Balaramnavar, Tadigoppula Narender, Anil Nilkanth Gaikwad. Aegeline inspired synthesis of novel amino alcohol and thiazolidinedione hybrids with antiadipogenic activity in 3T3-L1 cells. European journal of medicinal chemistry. 2018 Jan; 143(?):780-791. doi: 10.1016/j.ejmech.2017.11.041. [PMID: 29220798]
  • Lauren A Heidemann, Victor J Navarro, Jawad Ahmad, Paul H Hayashi, Andrew Stolz, David E Kleiner, Robert J Fontana. Severe Acute Hepatocellular Injury Attributed to OxyELITE Pro: A Case Series. Digestive diseases and sciences. 2016 09; 61(9):2741-8. doi: 10.1007/s10620-016-4181-7. [PMID: 27142670]
  • Bharathi Avula, Amar G Chittiboyina, Yan-Hong Wang, Satyanarayanaraju Sagi, Vijayasankar Raman, Mei Wang, Ikhlas A Khan. Simultaneous Determination of Aegeline and Six Coumarins from Different Parts of the Plant Aegle marmelos Using UHPLC-PDA-MS and Chiral Separation of Aegeline Enantiomers Using HPLC-ToF-MS. Planta medica. 2016 Apr; 82(6):580-8. doi: 10.1055/s-0042-103160. [PMID: 27054911]
  • Vamshi K Manda, Bharathi Avula, Amar G Chittiboyina, Ikhlas A Khan, Larry A Walker, Shabana I Khan. Inhibition of CYP3A4 and CYP1A2 by Aegle marmelos and its constituents. Xenobiotica; the fate of foreign compounds in biological systems. 2016; 46(2):117-25. doi: 10.3109/00498254.2015.1053006. [PMID: 26247834]
  • Aniket Karmase, Sneha Jagtap, Kamlesh K Bhutani. Anti adipogenic activity of Aegle marmelos Correa. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2013 Nov; 20(14):1267-71. doi: 10.1016/j.phymed.2013.07.011. [PMID: 23972792]