N-[1-Hydroxy-3-(morpholin-4-yl)-1-phenylpropan-2-yl]hexadecanamide (BioDeep_00000177220)

   

human metabolite blood metabolite


代谢物信息卡片


DL-Threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol hydrochloride

化学式: C29H50N2O3 (474.382123)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 99.09%

分子结构信息

SMILES: CCCCCCCCCCCCCCCC(=O)NC(CN1CCOCC1)C(C2=CC=CC=C2)O
InChI: InChI=1S/C29H50N2O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-17-20-28(32)30-27(25-31-21-23-34-24-22-31)29(33)26-18-15-14-16-19-26/h14-16,18-19,27,29,33H,2-13,17,20-25H2,1H3,(H,30,32)

描述信息

同义名列表

7 个代谢物同义名

DL-Threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol hydrochloride; N-[1-Hydroxy-3-(morpholin-4-yl)-1-phenylpropan-2-yl]hexadecanamide; N-[1-Hydroxy-3-(morpholin-4-yl)-1-phenylpropan-2-yl]palmitamide; 1-Phenyl-2-hexadecanoylamino-3-morpholino-1-propanol; 1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol; PPMP-1; 1-PPMP



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • G E Atilla-Gokcumen, A V Bedigian, S Sasse, U S Eggert. Inhibition of glycosphingolipid biosynthesis induces cytokinesis failure. Journal of the American Chemical Society. 2011 Jul; 133(26):10010-3. doi: 10.1021/ja202804b. [PMID: 21668028]
  • Grégory Seumois, Marianne Fillet, Laurent Gillet, Céline Faccinetto, Christophe Desmet, Cédric François, Benjamin Dewals, Cécile Oury, Alain Vanderplasschen, Pierre Lekeux, Fabrice Bureau. De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosis. Journal of leukocyte biology. 2007 Jun; 81(6):1477-86. doi: 10.1189/jlb.0806529. [PMID: 17329567]
  • Sherimay Ablan, Satinder S Rawat, Mathias Viard, Ji Ming Wang, Anu Puri, Robert Blumenthal. The role of cholesterol and sphingolipids in chemokine receptor function and HIV-1 envelope glycoprotein-mediated fusion. Virology journal. 2006 Dec; 3(?):104. doi: 10.1186/1743-422x-3-104. [PMID: 17187670]
  • Xiaqin Wu, Youngleem Kim, Bee-Chun Sun, Jeff D Moore, Walter A Shaw, Barry J Maurer. Liquid chromatography method for quantifying D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (D-threo-PPMP) in mouse plasma and liver. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 Jun; 837(1-2):44-8. doi: 10.1016/j.jchromb.2006.03.060. [PMID: 16716770]
  • Satinder Singh Rawat, Mathias Viard, Stephen A Gallo, Robert Blumenthal, Anu Puri. Sphingolipids, cholesterol, and HIV-1: a paradigm in viral fusion. Glycoconjugate journal. 2006 May; 23(3-4):189-97. doi: 10.1007/s10719-006-7924-4. [PMID: 16691502]
  • Hiroshi Sakamoto, Koichi Okamoto, Masahiro Aoki, Hideyuki Kato, Asao Katsume, Atsunori Ohta, Takuo Tsukuda, Nobuo Shimma, Yuko Aoki, Mikio Arisawa, Michinori Kohara, Masayuki Sudoh. Host sphingolipid biosynthesis as a target for hepatitis C virus therapy. Nature chemical biology. 2005 Nov; 1(6):333-7. doi: 10.1038/nchembio742. [PMID: 16408072]
  • Alicia S Couto, Carolina Caffaro, M Laura Uhrig, Emilia Kimura, Valnice J Peres, Emilio F Merino, Alejandro M Katzin, Masae Nishioka, Hiroshi Nonami, Rosa Erra-Balsells. Glycosphingolipids in Plasmodium falciparum. Presence of an active glucosylceramide synthase. European journal of biochemistry. 2004 Jun; 271(11):2204-14. doi: 10.1111/j.1432-1033.2004.04150.x. [PMID: 15153110]
  • Tilla S Worgall, Rebecca A Juliano, Toru Seo, Richard J Deckelbaum. Ceramide synthesis correlates with the posttranscriptional regulation of the sterol-regulatory element-binding protein. Arteriosclerosis, thrombosis, and vascular biology. 2004 May; 24(5):943-8. doi: 10.1161/01.atv.0000125703.20434.4d. [PMID: 15132973]
  • Anu Puri, Satinder S Rawat, Han-Ming Joseph Lin, Catherine M Finnegan, Judy Mikovits, Francis W Ruscetti, Robert Blumenthal. An inhibitor of glycosphingolipid metabolism blocks HIV-1 infection of primary T-cells. AIDS (London, England). 2004 Apr; 18(6):849-58. doi: 10.1097/00002030-200404090-00002. [PMID: 15060432]
  • Subroto Chatterjee, Judith A Berliner, Ganesamoorthy G Subbanagounder, Anil K Bhunia, Steve Koh. Identification of a biologically active component in minimally oxidized low density lipoprotein (MM-LDL) responsible for aortic smooth muscle cell proliferation. Glycoconjugate journal. 2004; 20(5):331-8. doi: 10.1023/b:glyc.0000033629.54962.68. [PMID: 15229397]
  • Lawrence W Leung, Ruben G Contreras, Catalina Flores-Maldonado, Marcelino Cereijido, Enrique Rodriguez-Boulan. Inhibitors of glycosphingolipid biosynthesis reduce transepithelial electrical resistance in MDCK I and FRT cells. American journal of physiology. Cell physiology. 2003 Apr; 284(4):C1021-30. doi: 10.1152/ajpcell.00149.2002. [PMID: 12490435]
  • R J Grigsby, R T Dobrowsky. Inhibition of ceramide production reverses TNF-induced insulin resistance. Biochemical and biophysical research communications. 2001 Oct; 287(5):1121-4. doi: 10.1006/bbrc.2001.5694. [PMID: 11587538]
  • M Basu, M Girzadas, S Dastgheib, J Baker, F Rossi, N S Radin, S Basu. Ceramide glycanase from rat mammary tissues: inhibition by PPMP(D-/L-) and its probable role in signal transduction. Indian journal of biochemistry & biophysics. 1997 Feb; 34(1-2):142-9. doi: NULL. [PMID: 9343942]
  • E I de Chaves, M Bussière, D E Vance, R B Campenot, J E Vance. Elevation of ceramide within distal neurites inhibits neurite growth in cultured rat sympathetic neurons. The Journal of biological chemistry. 1997 Jan; 272(5):3028-35. doi: 10.1074/jbc.272.5.3028. [PMID: 9006952]
  • G N Sando, E J Howard, K C Madison. Induction of ceramide glucosyltransferase activity in cultured human keratinocytes. Correlation with culture differentiation. The Journal of biological chemistry. 1996 Sep; 271(36):22044-51. doi: 10.1074/jbc.271.36.22044. [PMID: 8703011]
  • S A Lauer, N Ghori, K Haldar. Sphingolipid synthesis as a target for chemotherapy against malaria parasites. Proceedings of the National Academy of Sciences of the United States of America. 1995 Sep; 92(20):9181-5. doi: 10.1073/pnas.92.20.9181. [PMID: 7568097]