2-(4-(2-Carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine (BioDeep_00000177200)

   

human metabolite blood metabolite


代谢物信息卡片


3-{4-[2-({6-amino-9-[5-(ethyl-C-hydroxycarbonimidoyl)-3,4-dihydroxyoxolan-2-yl]-2,9-dihydro-1H-purin-2-ylidene}amino)ethyl]phenyl}propanoate

化学式: C23H29N7O6 (499.2179214)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCNC(=O)C1C(C(C(O1)N2C=NC3=C(N=C(N=C32)NCCC4=CC=C(C=C4)CCC(=O)O)N)O)O
InChI: InChI=1S/C23H29N7O6/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29)

描述信息

D018377 - Neurotransmitter Agents > D058905 - Purinergic Agents > D058913 - Purinergic Agonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents

同义名列表

5 个代谢物同义名

3-{4-[2-({6-amino-9-[5-(ethyl-C-hydroxycarbonimidoyl)-3,4-dihydroxyoxolan-2-yl]-2,9-dihydro-1H-purin-2-ylidene}amino)ethyl]phenyl}propanoate; 3-{4-[2-({6-amino-9-[5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]-9H-purin-2-yl}amino)ethyl]phenyl}propanoic acid; 3-{4-[2-({6-amino-9-[5-(ethylcarbamoyl)-3,4-dihydroxyoxolan-2-yl]purin-2-yl}amino)ethyl]phenyl}propanoic acid; 3-[4-[2-[[6-Amino-9-[5-(ethylcarbamoyl)-3,4-dihydroxy-2-oxolanyl]-2-purinyl]amino]ethyl]phenyl]propanoic acid; 2-(4-(2-Carboxyethyl)phenethylamino)-5-N-ethylcarboxamidoadenosine



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Samantha L Cooper, Edward S Wragg, Patrizia Pannucci, Mark Soave, Stephen J Hill, Jeanette Woolard. Regionally selective cardiovascular responses to adenosine A2A and A2B receptor activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2022 04; 36(4):e22214. doi: 10.1096/fj.202101945r. [PMID: 35230706]
  • Zoltan Czigany, Eve Christiana Craigie, Georg Lurje, Shaowei Song, Kei Yonezawa, Yuzo Yamamoto, Thomas Minor, René Hany Tolba. Adenosine A2a Receptor Stimulation Attenuates Ischemia-Reperfusion Injury and Improves Survival in A Porcine Model of DCD Liver Transplantation. International journal of molecular sciences. 2020 Sep; 21(18):. doi: 10.3390/ijms21186747. [PMID: 32938013]
  • Zhan-Guo Gao, Kiran S Toti, Ryan Campbell, R Rama Suresh, Huijun Yang, Kenneth A Jacobson. Allosteric Antagonism of the A2A Adenosine Receptor by a Series of Bitopic Ligands. Cells. 2020 05; 9(5):. doi: 10.3390/cells9051200. [PMID: 32408534]
  • Vladimir Pedro Peralva Borges-Martins, Danielle Dias Pinto Ferreira, Arthur Cardoso Souto, Jessika Geisebel Oliveira Neto, Danniel Pereira-Figueiredo, Karin da Costa Calaza, Karen de Jesus Oliveira, Alex Christian Manhães, Ricardo Augusto de Melo Reis, Regina Célia Cussa Kubrusly. Caffeine regulates GABA transport via A1R blockade and cAMP signaling. Neurochemistry international. 2019 12; 131(?):104550. doi: 10.1016/j.neuint.2019.104550. [PMID: 31563462]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • N J Geraghty, S R Adhikary, D Watson, R Sluyter. The A2A receptor agonist CGS 21680 has beneficial and adverse effects on disease development in a humanised mouse model of graft-versus-host disease. International immunopharmacology. 2019 Jul; 72(?):479-486. doi: 10.1016/j.intimp.2019.04.037. [PMID: 31051404]
  • Xiang Kong, Yi Zuo, Yu'ang Huang, Jianjun Ge. Adenosine A2a receptor agonist CGS21680 treatment attenuates cardiopulmonary bypass‑associated inflammatory lung injury in juvenile rats. Molecular medicine reports. 2019 Jul; 20(1):117-124. doi: 10.3892/mmr.2019.10235. [PMID: 31115565]
  • Shirdi E Schmiel, Lokesh A Kalekar, Na Zhang, Thomas W Blankespoor, Londyn J Robinson, Daniel L Mueller. Adenosine 2a Receptor Signal Blockade of Murine Autoimmune Arthritis via Inhibition of Pathogenic Germinal Center-Follicular Helper T Cells. Arthritis & rheumatology (Hoboken, N.J.). 2019 05; 71(5):773-783. doi: 10.1002/art.40796. [PMID: 30516351]
  • Kristian A Haanes, Alejandro Labastida-Ramírez, Kayi Y Chan, René de Vries, Brian Shook, Paul Jackson, Jimmy Zhang, Christopher M Flores, Alexander H J Danser, Carlos M Villalón, Antoinette MaassenVanDenBrink. Characterization of the trigeminovascular actions of several adenosine A2A receptor antagonists in an in vivo rat model of migraine. The journal of headache and pain. 2018 May; 19(1):41. doi: 10.1186/s10194-018-0867-x. [PMID: 29802484]
  • Christoph Eisner, SooMi Kim, Alexandra Grill, Yan Qin, Marion Hoerl, Josephine Briggs, Hayo Castrop, Manfred Thiel, Jurgen Schnermann. Profound hypothermia after adenosine kinase inhibition in A1AR-deficient mice suggests a receptor-independent effect of intracellular adenosine. Pflugers Archiv : European journal of physiology. 2017 02; 469(2):339-347. doi: 10.1007/s00424-016-1925-3. [PMID: 27975140]
  • A Ferrante, C De Nuccio, R Pepponi, S Visentin, A Martire, A Bernardo, L Minghetti, P Popoli. Stimulation of adenosine A2A receptors reduces intracellular cholesterol accumulation and rescues mitochondrial abnormalities in human neural cell models of Niemann-Pick C1. Neuropharmacology. 2016 Apr; 103(?):155-62. doi: 10.1016/j.neuropharm.2015.11.022. [PMID: 26631535]
  • Jihong Xing, Jianhua Li. The Role Played by Adenosine in Modulating Reflex Sympathetic and Pressor Responses Evoked by Stimulation of TRPV1 in Muscle Afferents. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2016; 40(1-2):39-48. doi: 10.1159/000452523. [PMID: 27842306]
  • P Li, D Rial, P M Canas, J-H Yoo, W Li, X Zhou, Y Wang, G J P van Westen, M-P Payen, E Augusto, N Gonçalves, A R Tomé, Z Li, Z Wu, X Hou, Y Zhou, A P IJzerman, Ad PIJzerman, E S Boyden, R A Cunha, J Qu, J-F Chen. Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory. Molecular psychiatry. 2015 Nov; 20(11):1339-49. doi: 10.1038/mp.2014.182. [PMID: 25687775]
  • Giorgia Mandili, Elisa Alchera, Simone Merlin, Chiara Imarisio, Bangalore R Chandrashekar, Chiara Riganti, Alberto Bianchi, Francesco Novelli, Antonia Follenzi, Rita Carini. Mouse hepatocytes and LSEC proteome reveal novel mechanisms of ischemia/reperfusion damage and protection by A2aR stimulation. Journal of hepatology. 2015 Mar; 62(3):573-80. doi: 10.1016/j.jhep.2014.10.007. [PMID: 25315650]
  • Zeljka Minic, Donal S O'Leary, Tadeusz J Scislo. Nucleus tractus solitarii A(2a) adenosine receptors inhibit cardiopulmonary chemoreflex control of sympathetic outputs. Autonomic neuroscience : basic & clinical. 2014 Feb; 180(?):32-42. doi: 10.1016/j.autneu.2013.10.005. [PMID: 24216055]
  • Shuang-Shuang Dai, Hao Wang, Nan Yang, Jian-Hong An, Wei Li, Ya-Lei Ning, Pei-Fang Zhu, Jiang-Fan Chen, Yuan-Guo Zhou. Plasma glutamate-modulated interaction of A2AR and mGluR5 on BMDCs aggravates traumatic brain injury-induced acute lung injury. The Journal of experimental medicine. 2013 Apr; 210(4):839-51. doi: 10.1084/jem.20122196. [PMID: 23478188]
  • Fabrizio Vincenzi, Melissa Padovan, Martina Targa, Carmen Corciulo, Sarah Giacuzzo, Stefania Merighi, Stefania Gessi, Marcello Govoni, Pier Andrea Borea, Katia Varani. A(2A) adenosine receptors are differentially modulated by pharmacological treatments in rheumatoid arthritis patients and their stimulation ameliorates adjuvant-induced arthritis in rats. PloS one. 2013; 8(1):e54195. doi: 10.1371/journal.pone.0054195. [PMID: 23326596]
  • Hang Xiao, Hai-Ying Shen, Wei Liu, Ren-Ping Xiong, Ping Li, Gang Meng, Nan Yang, Xing Chen, Liang-Yi Si, Yuan-Guo Zhou. Adenosine A2A receptor: a target for regulating renal interstitial fibrosis in obstructive nephropathy. PloS one. 2013; 8(4):e60173. doi: 10.1371/journal.pone.0060173. [PMID: 23585831]
  • Chiara Imarisio, Elisa Alchera, Salvatore Sutti, Guido Valente, Francesca Boccafoschi, Emanuele Albano, Rita Carini. Adenosine A(2a) receptor stimulation prevents hepatocyte lipotoxicity and non-alcoholic steatohepatitis (NASH) in rats. Clinical science (London, England : 1979). 2012 Sep; 123(5):323-32. doi: 10.1042/cs20110504. [PMID: 22439844]
  • Fernanda C Vuaden, Luiz Eduardo B Savio, Denise B Ramos, Emerson A Casali, Maurício R Bogo, Carla D Bonan. Endotoxin-induced effects on nucleotide catabolism in mouse kidney. European journal of pharmacology. 2012 Jan; 674(2-3):422-9. doi: 10.1016/j.ejphar.2011.11.002. [PMID: 22108548]
  • Francesca Deflorian, T Santhosh Kumar, Khai Phan, Zhan-Guo Gao, Fei Xu, Huixian Wu, Vsevolod Katritch, Raymond C Stevens, Kenneth A Jacobson. Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A₂A adenosine receptor. Journal of medicinal chemistry. 2012 Jan; 55(1):538-52. doi: 10.1021/jm201461q. [PMID: 22104008]
  • Emanuela Mazzon, Emanuela Esposito, Daniela Impellizzeri, Rosanna DI Paola, Alessia Melani, Placido Bramanti, Felicita Pedata, Salvatore Cuzzocrea. CGS 21680, an agonist of the adenosine (A2A) receptor, reduces progression of murine type II collagen-induced arthritis. The Journal of rheumatology. 2011 Oct; 38(10):2119-29. doi: 10.3899/jrheum.110111. [PMID: 21765105]
  • Daniela Impellizzeri, Rosanna Di Paola, Emanuela Esposito, Emanuela Mazzon, Irene Paterniti, Alessia Melani, Placido Bramanti, Felicita Pedata, Salvatore Cuzzocrea. CGS 21680, an agonist of the adenosine (A2A) receptor, decreases acute lung inflammation. European journal of pharmacology. 2011 Oct; 668(1-2):305-16. doi: 10.1016/j.ejphar.2011.06.049. [PMID: 21756897]
  • Gabriela E Garcia, Luan D Truong, Jiang-Fan Chen, Richard J Johnson, Lili Feng. Adenosine A(2A) receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation. Kidney international. 2011 Aug; 80(4):378-88. doi: 10.1038/ki.2011.101. [PMID: 21508927]
  • David A Ferenbach, Jeremy Hughes. Adenosine A(2A) agonists as therapy for glomerulonephritis. Kidney international. 2011 Aug; 80(4):329-31. doi: 10.1038/ki.2011.167. [PMID: 21799503]
  • L Zhang, N Yang, S Wang, B Huang, F Li, H Tan, Y Liang, M Chen, Y Li, X Yu. Adenosine 2A receptor is protective against renal injury in MRL/lpr mice. Lupus. 2011 Jun; 20(7):667-77. doi: 10.1177/0961203310393262. [PMID: 21183557]
  • Mattias Carlström, Christopher S Wilcox, William J Welch. Adenosine A2A receptor activation attenuates tubuloglomerular feedback responses by stimulation of endothelial nitric oxide synthase. American journal of physiology. Renal physiology. 2011 Feb; 300(2):F457-64. doi: 10.1152/ajprenal.00567.2010. [PMID: 21106859]
  • Zhiyun Wang, Pao-Lin Che, Jian Du, Barbara Ha, Kevin J Yarema. Static magnetic field exposure reproduces cellular effects of the Parkinson's disease drug candidate ZM241385. PloS one. 2010 Nov; 5(11):e13883. doi: 10.1371/journal.pone.0013883. [PMID: 21079735]
  • Natália Assaife-Lopes, Vasco C Sousa, Daniela B Pereira, Joaquim A Ribeiro, Moses V Chao, Ana M Sebastião. Activation of adenosine A2A receptors induces TrkB translocation and increases BDNF-mediated phospho-TrkB localization in lipid rafts: implications for neuromodulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Jun; 30(25):8468-80. doi: 10.1523/jneurosci.5695-09.2010. [PMID: 20573894]
  • Vicent Casadó, Carla Ferrada, Jordi Bonaventura, Eduard Gracia, Josefa Mallol, Enric I Canela, Carmen Lluís, Antoni Cortés, Rafael Franco. Useful pharmacological parameters for G-protein-coupled receptor homodimers obtained from competition experiments. Agonist-antagonist binding modulation. Biochemical pharmacology. 2009 Dec; 78(12):1456-63. doi: 10.1016/j.bcp.2009.07.012. [PMID: 19643089]
  • Ming-Chang Chiang, Hui-Mei Chen, Hsing-Lin Lai, Hsiao-Wen Chen, Szu-Yi Chou, Chiung-Mei Chen, Fuu-Jen Tsai, Yijuang Chern. The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin-proteasome system. Human molecular genetics. 2009 Aug; 18(16):2929-42. doi: 10.1093/hmg/ddp230. [PMID: 19443488]
  • Tomoko K Ichinose, Donal S O'Leary, Tadeusz J Scislo. Activation of NTS A2a adenosine receptors differentially resets baroreflex control of renal vs. adrenal sympathetic nerve activity. American journal of physiology. Heart and circulatory physiology. 2009 Apr; 296(4):H1058-68. doi: 10.1152/ajpheart.00906.2008. [PMID: 19202001]
  • Mohammed A Nayeem, Dovenia S Ponnoth, Matthew A Boegehold, Darryl C Zeldin, John R Falck, S Jamal Mustafa. High-salt diet enhances mouse aortic relaxation through adenosine A2A receptor via CYP epoxygenases. American journal of physiology. Regulatory, integrative and comparative physiology. 2009 Mar; 296(3):R567-74. doi: 10.1152/ajpregu.90798.2008. [PMID: 19109366]
  • C Escudero, P Casanello, L Sobrevia. Human equilibrative nucleoside transporters 1 and 2 may be differentially modulated by A2B adenosine receptors in placenta microvascular endothelial cells from pre-eclampsia. Placenta. 2008 Sep; 29(9):816-25. doi: 10.1016/j.placenta.2008.06.014. [PMID: 18703227]
  • Andrei A Ivanov, Kenneth A Jacobson. Molecular modeling of a PAMAM-CGS21680 dendrimer bound to an A2A adenosine receptor homodimer. Bioorganic & medicinal chemistry letters. 2008 Aug; 18(15):4312-5. doi: 10.1016/j.bmcl.2008.06.087. [PMID: 18639453]
  • Elisa Alchera, Lorenza Tacchini, Chiara Imarisio, Caterina Dal Ponte, Cristina De Ponti, Elena Gammella, Gaetano Cairo, Emanuele Albano, Rita Carini. Adenosine-dependent activation of hypoxia-inducible factor-1 induces late preconditioning in liver cells. Hepatology (Baltimore, Md.). 2008 Jul; 48(1):230-9. doi: 10.1002/hep.22249. [PMID: 18506850]
  • Tomasz Wójcik, Michał Bereta, Agata Faron-Górecka, Marta Dziedzicka-Wasylewska, Katarzyna Kieć-Kononowicz. Flow cytometry application for studies on adenosine A2A receptors expression. Acta poloniae pharmaceutica. 2008 Jan; 65(1):65-70. doi: NULL. [PMID: 18536175]
  • Guy A Higgins, Michael E Grzelak, Annamarie J Pond, Mary E Cohen-Williams, Robert A Hodgson, Geoffrey B Varty. The effect of caffeine to increase reaction time in the rat during a test of attention is mediated through antagonism of adenosine A2A receptors. Behavioural brain research. 2007 Dec; 185(1):32-42. doi: 10.1016/j.bbr.2007.07.013. [PMID: 17707919]
  • Ruimin Gu, Jing Wang, Yunhong Zhang, Wennan Li, Ying Xu, Hongli Shan, Wen-Hui Wang, Baofeng Yang. Adenosine stimulates the basolateral 50 pS K channels in the thick ascending limb of the rat kidney. American journal of physiology. Renal physiology. 2007 Jul; 293(1):F299-305. doi: 10.1152/ajprenal.00008.2007. [PMID: 17475899]
  • Ines Kaufmann, Alwin Hoelzl, Florian Schliephake, Theresia Hummel, Alexander Chouker, Lidia Łysenko, Klaus Peter, Manfred Thiel. Effects of adenosine on functions of polymorphonuclear leukocytes from patients with septic shock. Shock (Augusta, Ga.). 2007 Jan; 27(1):25-31. doi: 10.1097/01.shk.0000238066.00074.90. [PMID: 17172976]
  • D Rüsing, C E Müller, E J Verspohl. The impact of adenosine and A(2B) receptors on glucose homoeostasis. The Journal of pharmacy and pharmacology. 2006 Dec; 58(12):1639-45. doi: 10.1211/jpp.58.12.0011. [PMID: 17331328]
  • Jianjie Wang, Virginia H Huxley. Adenosine A2A receptor modulation of juvenile female rat skeletal muscle microvessel permeability. American journal of physiology. Heart and circulatory physiology. 2006 Dec; 291(6):H3094-105. doi: 10.1152/ajpheart.00526.2006. [PMID: 16815983]
  • E Y Lai, A Patzak, A Steege, R Mrowka, R Brown, N Spielmann, P B Persson, B B Fredholm, A E G Persson. Contribution of adenosine receptors in the control of arteriolar tone and adenosine-angiotensin II interaction. Kidney international. 2006 Aug; 70(4):690-8. doi: 10.1038/sj.ki.5001650. [PMID: 16807541]
  • B Rogachev, N Y Ziv, J Mazar, S Nakav, C Chaimovitz, M Zlotnik, A Douvdevani. Adenosine is upregulated during peritonitis and is involved in downregulation of inflammation. Kidney international. 2006 Aug; 70(4):675-81. doi: 10.1038/sj.ki.5001609. [PMID: 16788688]
  • Mairéad A Carroll, Anabel B Doumad, Jing Li, Monica K Cheng, J R Falck, John C McGiff. Adenosine2A receptor vasodilation of rat preglomerular microvessels is mediated by EETs that activate the cAMP/PKA pathway. American journal of physiology. Renal physiology. 2006 Jul; 291(1):F155-61. doi: 10.1152/ajprenal.00231.2005. [PMID: 16478979]
  • Brenda Gonzalez, Francisco Paz, Leonor Florán, Jorge Aceves, David Erlij, Benjamín Florán. Adenosine A2A receptor stimulation decreases GAT-1-mediated GABA uptake in the globus pallidus of the rat. Neuropharmacology. 2006 Jul; 51(1):154-9. doi: 10.1016/j.neuropharm.2006.03.011. [PMID: 16730753]
  • Nicolas Flamand, Julie Lefebvre, Gabriel Lapointe, Serge Picard, Lise Lemieux, Sylvain G Bourgoin, Pierre Borgeat. Inhibition of platelet-activating factor biosynthesis by adenosine and histamine in human neutrophils: involvement of cPLA2alpha and reversal by lyso-PAF. Journal of leukocyte biology. 2006 May; 79(5):1043-51. doi: 10.1189/jlb.1005614. [PMID: 16501051]
  • K Celiński, B Prozorow-Król, A Korolczuk, M Słomka, E Korobowicz, W Biskup, A Madro, H Cichoz-Lach, G Czechowska. The role of adenosine A2a receptors in experimental acute pancreatitis. Advances in medical sciences. 2006; 51(?):105-10. doi: NULL. [PMID: 17357287]
  • Z Ben-Ari, O Pappo, J Sulkes, Y Cheporko, B A Vidne, E Hochhauser. Effect of adenosine A2A receptor agonist (CGS) on ischemia/reperfusion injury in isolated rat liver. Apoptosis : an international journal on programmed cell death. 2005 Oct; 10(5):955-62. doi: 10.1007/s10495-005-0440-3. [PMID: 16151631]
  • Elvira L Liclican, John C McGiff, Paulina L Pedraza, Nicholas R Ferreri, John R Falck, Mairead A Carroll. Exaggerated response to adenosine in kidneys from high salt-fed rats: role of epoxyeicosatrienoic acids. American journal of physiology. Renal physiology. 2005 Aug; 289(2):F386-92. doi: 10.1152/ajprenal.00421.2004. [PMID: 15814528]
  • Maria Torvinen, Daniel Marcellino, Meritxell Canals, Luigi F Agnati, Carmen Lluis, Rafael Franco, Kjell Fuxe. Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes. Molecular pharmacology. 2005 Feb; 67(2):400-7. doi: 10.1124/mol.104.003376. [PMID: 15539641]
  • Pier Leopoldo Capecchi, Alessandra Camurri, Gerarda Pompella, Alessia Mazzola, Massimo Maccherini, Francesco Diciolla, Pietro Enea Lazzerini, Maria P Abbracchio, Franco Laghi-Pasini. Upregulation of A2A adenosine receptor expression by TNF-alpha in PBMC of patients with CHF: a regulatory mechanism of inflammation. Journal of cardiac failure. 2005 Feb; 11(1):67-73. doi: 10.1016/j.cardfail.2004.04.005. [PMID: 15704067]
  • Xiaohong Tracey Gan, Venkatesh Rajapurohitam, James V Haist, Peter Chidiac, Michael A Cook, Morris Karmazyn. Inhibition of phenylephrine-induced cardiomyocyte hypertrophy by activation of multiple adenosine receptor subtypes. The Journal of pharmacology and experimental therapeutics. 2005 Jan; 312(1):27-34. doi: 10.1124/jpet.104.073122. [PMID: 15452191]
  • Yasunori Mori, Maiko Higuchi, Norihisa Masuyama, Yukiko Gotoh. Adenosine A2A receptor facilitates calcium-dependent protein secretion through the activation of protein kinase A and phosphatidylinositol-3 kinase in PC12 cells. Cell structure and function. 2004 Dec; 29(4):101-10. doi: 10.1247/csf.29.101. [PMID: 15665505]
  • Dimin Li, Yuan Wei, Wen-Hui Wang. Dietary K intake regulates the response of apical K channels to adenosine in the thick ascending limb. American journal of physiology. Renal physiology. 2004 Nov; 287(5):F954-9. doi: 10.1152/ajprenal.00183.2004. [PMID: 15265768]
  • Craig A Whitworth, Vickram Ramkumar, Brett Jones, Naoki Tsukasaki, Leonard P Rybak. Protection against cisplatin ototoxicity by adenosine agonists. Biochemical pharmacology. 2004 May; 67(9):1801-7. doi: 10.1016/j.bcp.2004.01.010. [PMID: 15081879]
  • Preeti Puntambekar, Jeremy Van Buren, Manish Raisinghani, Louis S Premkumar, Vickram Ramkumar. Direct interaction of adenosine with the TRPV1 channel protein. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Apr; 24(14):3663-71. doi: 10.1523/jneurosci.4773-03.2004. [PMID: 15071115]
  • Bishop F Hague, Tong Mao Zhao, Thomas J Kindt. Binding of HTLV-1 virions to T cells occurs by a temperature and calcium-dependent process and is blocked by certain type 2 adenosine receptor antagonists. Virus research. 2003 May; 93(1):31-9. doi: 10.1016/s0168-1702(03)00048-0. [PMID: 12727340]
  • Sidney R Smith, Georgetta Denhardt, Carol Terminelli. A role for histamine in cytokine modulation by the adenosine A(3) receptor agonist, 2-Cl-IB-MECA. European journal of pharmacology. 2002 Dec; 457(1):57-69. doi: 10.1016/s0014-2999(02)02645-6. [PMID: 12460644]
  • Lawrence J Macala, John P Hayslett. Basolateral and apical A1 adenosine receptors mediate sodium transport in cultured renal epithelial (A6) cells. American journal of physiology. Renal physiology. 2002 Dec; 283(6):F1216-25. doi: 10.1152/ajprenal.00085.2002. [PMID: 12388417]
  • Jason P Hannon, Bruno Tigani, Henk-Jan Schuurman, John R Fozard. Suppression of adenosine A(3) receptor-mediated hypotension and mast cell degranulation in the rat by dexamethasone. The Journal of pharmacology and experimental therapeutics. 2002 Aug; 302(2):725-30. doi: 10.1124/jpet.102.035790. [PMID: 12130737]
  • Zhan-Guo Gao, Seong Gon Kim, Kelly A Soltysiak, Neli Melman, Adriaan P IJzerman, Kenneth A Jacobson. Selective allosteric enhancement of agonist binding and function at human A3 adenosine receptors by a series of imidazoquinoline derivatives. Molecular pharmacology. 2002 Jul; 62(1):81-9. doi: 10.1124/mol.62.1.81. [PMID: 12065758]
  • Ian M Coupar, Binh L T Tran. Effects of adenosine agonists on consumptive behaviour and body temperature. The Journal of pharmacy and pharmacology. 2002 Feb; 54(2):289-94. doi: 10.1211/0022357021778330. [PMID: 11858214]
  • Constance Neely Wilson, Vinod K Batra. Lipopolysaccharide binds to and activates A(1) adenosine receptors on human pulmonary artery endothelial cells. Journal of endotoxin research. 2002; 8(4):263-71. doi: 10.1179/096805102125000470. [PMID: 12230916]
  • Akihiko Satoh, Kennichi Satoh, Atsushi Masamune, Tetsuya Yamagiwa, Tooru Shimosegawa. Activation of adenosine A2a receptor pathway reduces leukocyte infiltration but enhances edema formation in rat caerulein pancreatitis. Pancreas. 2002 Jan; 24(1):75-82. doi: 10.1097/00006676-200201000-00010. [PMID: 11741185]
  • J W Fisher, J Brookins. Adenosine A(2A) and A(2B) receptor activation of erythropoietin production. American journal of physiology. Renal physiology. 2001 Nov; 281(5):F826-32. doi: 10.1152/ajprenal.2001.281.5.f826. [PMID: 11592940]
  • I Rubinstein, R Chandilawa, S Dagar, D Hong, X P Gao. Adenosine A(1) receptors mediate plasma exudation from the oral mucosa. Journal of applied physiology (Bethesda, Md. : 1985). 2001 Aug; 91(2):552-60. doi: 10.1152/jappl.2001.91.2.552. [PMID: 11457765]
  • N K Huang, Y W Lin, C L Huang, R O Messing, Y Chern. Activation of protein kinase A and atypical protein kinase C by A(2A) adenosine receptors antagonizes apoptosis due to serum deprivation in PC12 cells. The Journal of biological chemistry. 2001 Apr; 276(17):13838-46. doi: 10.1074/jbc.m008589200. [PMID: 11278423]
  • R Tabrizchi. The influence of tumour necrosis factor-alpha on the cardiovascular system of anaesthetized rats. Naunyn-Schmiedeberg's archives of pharmacology. 2001 Mar; 363(3):307-21. doi: 10.1007/s002100000374. [PMID: 11284446]
  • B J Koos, T Maeda. Adenosine A(2A) receptors mediate cardiovascular responses to hypoxia in fetal sheep. American journal of physiology. Heart and circulatory physiology. 2001 Jan; 280(1):H83-9. doi: 10.1152/ajpheart.2001.280.1.h83. [PMID: 11123221]
  • N Harada, K Okajima, K Murakami, S Usune, C Sato, K Ohshima, T Katsuragi. Adenosine and selective A(2A) receptor agonists reduce ischemia/reperfusion injury of rat liver mainly by inhibiting leukocyte activation. The Journal of pharmacology and experimental therapeutics. 2000 Sep; 294(3):1034-42. doi: NULL. [PMID: 10945856]
  • A Satoh, T Shimosegawa, K Satoh, H Ito, Y Kohno, A Masamune, M Fujita, T Toyota. Activation of adenosine A1-receptor pathway induces edema formation in the pancreas of rats. Gastroenterology. 2000 Sep; 119(3):829-36. doi: 10.1053/gast.2000.16502. [PMID: 10982777]
  • T J Scislo, D S O'Leary. Differential role of ionotropic glutamatergic mechanisms in responses to NTS P(2x) and A(2a) receptor stimulation. American journal of physiology. Heart and circulatory physiology. 2000 Jun; 278(6):H2057-68. doi: 10.1152/ajpheart.2000.278.6.h2057. [PMID: 10843905]
  • R D Lasley, P Narayan, A Uittenbogaard, E J Smart. Activated cardiac adenosine A(1) receptors translocate out of caveolae. The Journal of biological chemistry. 2000 Feb; 275(6):4417-21. doi: 10.1074/jbc.275.6.4417. [PMID: 10660613]
  • K Miura, M Okumura, S Yamanaka, S Kim, H Iwao. Effects of activation of renal adenosine A2 receptor on renal function and renin release in dogs. Japanese journal of pharmacology. 1999 Jun; 80(2):173-6. doi: 10.1254/jjp.80.173. [PMID: 10440537]
  • H M Prior, M S Yates, D J Beech. Role of K+ channels in A2A adenosine receptor-mediated dilation of the pressurized renal arcuate artery. British journal of pharmacology. 1999 Jan; 126(2):494-500. doi: 10.1038/sj.bjp.0702310. [PMID: 10077243]
  • T J Scislo, D S O'Leary. Differential control of renal vs. adrenal sympathetic nerve activity by NTS A2a and P2x purinoceptors. The American journal of physiology. 1998 12; 275(6):H2130-9. doi: 10.1152/ajpheart.1998.275.6.h2130. [PMID: 9843813]
  • B Costa, A Lucacchini, C Martini. A2a adenosine receptors: guanine nucleotide derivative regulation in porcine striatal membranes and digitonin soluble fraction. Neurochemistry international. 1998 Aug; 33(2):121-9. doi: 10.1016/s0197-0186(98)00019-9. [PMID: 9761456]
  • T J Scislo, D S O'Leary. Activation of A2a adenosine receptors in the nucleus tractus solitarius inhibits renal but not lumbar sympathetic nerve activity. Journal of the autonomic nervous system. 1998 Feb; 68(3):145-52. doi: 10.1016/s0165-1838(97)00135-5. [PMID: 9626941]
  • R K Dubey, D G Gillespie, Z Mi, E K Jackson. Adenosine inhibits growth of human aortic smooth muscle cells via A2B receptors. Hypertension (Dallas, Tex. : 1979). 1998 Jan; 31(1 Pt 2):516-21. doi: 10.1161/01.hyp.31.1.516. [PMID: 9453355]
  • R K Dubey, D G Gillespie, Z Mi, E K Jackson. Exogenous and endogenous adenosine inhibits fetal calf serum-induced growth of rat cardiac fibroblasts: role of A2B receptors. Circulation. 1997 Oct; 96(8):2656-66. doi: 10.1161/01.cir.96.8.2656. [PMID: 9355907]
  • J Cooper, S J Hill, S P Alexander. An endogenous A2B adenosine receptor coupled to cyclic AMP generation in human embryonic kidney (HEK 293) cells. British journal of pharmacology. 1997 Oct; 122(3):546-50. doi: 10.1038/sj.bjp.0701401. [PMID: 9351513]
  • C Alberti, A Monopoli, C Casati, A Forlani, C Sala, B Nador, E Ongini, A Morganti. Mechanism and pressor relevance of the short-term cardiovascular and renin excitatory actions of the selective A2A-adenosine receptor agonists. Journal of cardiovascular pharmacology. 1997 Sep; 30(3):320-4. doi: 10.1097/00005344-199709000-00008. [PMID: 9300315]
  • C H Gleiter, M Brause, U Delabar, H Zebski, K U Eckardt. Evidence against a major role of adenosine in oxygen-dependent regulation of erythropoietin in rats. Kidney international. 1997 Aug; 52(2):338-44. doi: 10.1038/ki.1997.339. [PMID: 9263988]
  • M S Ford, S B Maggirwar, L P Rybak, C Whitworth, V Ramkumar. Expression and function of adenosine receptors in the chinchilla cochlea. Hearing research. 1997 Mar; 105(1-2):130-40. doi: 10.1016/s0378-5955(96)00204-3. [PMID: 9083810]
  • G Haskó, C Szabó, Z H Németh, V Kvetan, S M Pastores, E S Vizi. Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice. Journal of immunology (Baltimore, Md. : 1950). 1996 Nov; 157(10):4634-40. doi: NULL. [PMID: 8906843]
  • L A Price, J Strnad, M H Pausch, J R Hadcock. Pharmacological characterization of the rat A2a adenosine receptor functionally coupled to the yeast pheromone response pathway. Molecular pharmacology. 1996 Oct; 50(4):829-37. doi: NULL. [PMID: 8863827]
  • B B Fredholm, Y Zhang, I van der Ploeg. Adenosine A2A receptors mediate the inhibitory effect of adenosine on formyl-Met-Leu-Phe-stimulated respiratory burst in neutrophil leucocytes. Naunyn-Schmiedeberg's archives of pharmacology. 1996 Aug; 354(3):262-7. doi: 10.1007/bf00171056. [PMID: 8878055]
  • E P Silldorff, M S Kreisberg, T L Pallone. Adenosine modulates vasomotor tone in outer medullary descending vasa recta of the rat. The Journal of clinical investigation. 1996 Jul; 98(1):18-23. doi: 10.1172/jci118764. [PMID: 8690791]
  • J Kim, Q Jiang, M Glashofer, S Yehle, J Wess, K A Jacobson. Glutamate residues in the second extracellular loop of the human A2a adenosine receptor are required for ligand recognition. Molecular pharmacology. 1996 Apr; 49(4):683-91. doi: NULL. [PMID: 8609897]
  • K Nagashima, A Karasawa. Modulation of erythropoietin production by selective adenosine agonists and antagonists in normal and anemic rats. Life sciences. 1996; 59(9):761-71. doi: 10.1016/0024-3205(96)00362-1. [PMID: 8761029]
  • T Ohigashi, J Nakashima, S Aggarwal, J Brookins, K Agrawal, J W Fisher. Enhancement of erythropoietin production by selective adenosine A2 receptor agonists in response to hypoxia. The Journal of laboratory and clinical medicine. 1995 Sep; 126(3):299-306. doi: NULL. [PMID: 7665979]
  • J P Hannon, H J Pfannkuche, J R Fozard. A role for mast cells in adenosine A3 receptor-mediated hypotension in the rat. British journal of pharmacology. 1995 Jul; 115(6):945-52. doi: 10.1111/j.1476-5381.1995.tb15902.x. [PMID: 7582525]
  • H O Kim, X D Ji, N Melman, M E Olah, G L Stiles, K A Jacobson. Structure-activity relationships of 1,3-dialkylxanthine derivatives at rat A3 adenosine receptors. Journal of medicinal chemistry. 1994 Sep; 37(20):3373-82. doi: 10.1021/jm00046a022. [PMID: 7932565]
  • X D Ji, C Gallo-Rodriguez, K A Jacobson. A selective agonist affinity label for A3 adenosine receptors. Biochemical and biophysical research communications. 1994 Aug; 203(1):570-6. doi: 10.1006/bbrc.1994.2220. [PMID: 8074705]
  • R M Edwards, W S Spielman. Adenosine A1 receptor-mediated inhibition of vasopressin action in inner medullary collecting duct. The American journal of physiology. 1994 May; 266(5 Pt 2):F791-6. doi: 10.1152/ajprenal.1994.266.5.f791. [PMID: 8203563]
  • H H McIntosh, C Blazynski. Characterization and localization of adenosine A2 receptors in bovine rod outer segments. Journal of neurochemistry. 1994 Mar; 62(3):992-7. doi: 10.1046/j.1471-4159.1994.62030992.x. [PMID: 8113818]
  • Y Agmon, D Dinour, M Brezis. Disparate effects of adenosine A1- and A2-receptor agonists on intrarenal blood flow. The American journal of physiology. 1993 Dec; 265(6 Pt 2):F802-6. doi: 10.1152/ajprenal.1993.265.6.f802. [PMID: 8285213]
  • R L Webb, M A Sills, J P Chovan, J V Peppard, J E Francis. Development of tolerance to the antihypertensive effects of highly selective adenosine A2a agonists upon chronic administration. The Journal of pharmacology and experimental therapeutics. 1993 Oct; 267(1):287-95. doi: . [PMID: 8229754]