Telaglenastat (BioDeep_00000177067)

   

human metabolite blood metabolite


代谢物信息卡片


2-(pyridin-2-yl)-N-{5-[4-(6-{2-[3-(trifluoromethoxy)phenyl]acetamido}pyridazin-3-yl)butyl]-1,3,4-thiadiazol-2-yl}acetamide

化学式: C26H24F3N7O3S (571.161335)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

分子结构信息

SMILES: C1=CC=NC(=C1)CC(=O)NC2=NN=C(S2)CCCCC3=NN=C(C=C3)NC(=O)CC4=CC(=CC=C4)OC(F)(F)F
InChI: InChI=1S/C26H24F3N7O3S/c27-26(28,29)39-20-9-5-6-17(14-20)15-22(37)31-21-12-11-18(33-34-21)7-1-2-10-24-35-36-25(40-24)32-23(38)16-19-8-3-4-13-30-19/h3-6,8-9,11-14H,1-2,7,10,15-16H2,(H,31,34,37)(H,32,36,38)

描述信息

C471 - Enzyme Inhibitor
Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inuduces autophagy and has antitumor activity[1].

同义名列表

3 个代谢物同义名

2-(pyridin-2-yl)-N-{5-[4-(6-{2-[3-(trifluoromethoxy)phenyl]acetamido}pyridazin-3-yl)butyl]-1,3,4-thiadiazol-2-yl}acetamide; Telaglenastat; CB-839



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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1 个相关的物种来源信息

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
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  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Ethan Emberley, Alison Pan, Jason Chen, Rosalyn Dang, Matt Gross, Tony Huang, Weiqun Li, Andrew MacKinnon, Devansh Singh, Natalija Sotirovska, Susanne M Steggerda, Tracy Wang, Francesco Parlati. The glutaminase inhibitor telaglenastat enhances the antitumor activity of signal transduction inhibitors everolimus and cabozantinib in models of renal cell carcinoma. PloS one. 2021; 16(11):e0259241. doi: 10.1371/journal.pone.0259241. [PMID: 34731180]
  • Bridget Duvall, Sarah C Zimmermann, Run-Duo Gao, Ajit G Thomas, Filip Kalčic, Vijayabhaskar Veeravalli, Amira Elgogary, Rana Rais, Camilo Rojas, Anne Le, Barbara S Slusher, Takashi Tsukamoto. Allosteric kidney-type glutaminase (GLS) inhibitors with a mercaptoethyl linker. Bioorganic & medicinal chemistry. 2020 10; 28(20):115698. doi: 10.1016/j.bmc.2020.115698. [PMID: 33069080]
  • Larissa Menezes Dos Reis, Douglas Adamoski, Rodolpho Ornitz Oliveira Souza, Carolline Fernanda Rodrigues Ascenção, Krishina Ratna Sousa de Oliveira, Felipe Corrêa-da-Silva, Fábio Malta de Sá Patroni, Marília Meira Dias, Sílvio Roberto Consonni, Pedro Manoel Mendes de Moraes-Vieira, Ariel Mariano Silber, Sandra Martha Gomes Dias. Dual inhibition of glutaminase and carnitine palmitoyltransferase decreases growth and migration of glutaminase inhibition-resistant triple-negative breast cancer cells. The Journal of biological chemistry. 2019 06; 294(24):9342-9357. doi: 10.1074/jbc.ra119.008180. [PMID: 31040181]
  • Ashley T Jones, Kalin Narov, Jian Yang, Julian R Sampson, Ming Hong Shen. Efficacy of Dual Inhibition of Glycolysis and Glutaminolysis for Therapy of Renal Lesions in Tsc2+/- Mice. Neoplasia (New York, N.Y.). 2019 02; 21(2):230-238. doi: 10.1016/j.neo.2018.12.003. [PMID: 30622053]
  • Zhao Chen, Di Li, Ning Xu, Jinzhang Fang, Yan Yu, Wei Hou, Haoqiang Ruan, Panpan Zhu, Renchao Ma, Shiying Lu, Danhui Cao, Rui Wu, Mowei Ni, Wei Zhang, Weike Su, Benfang Helen Ruan. Novel 1,3,4-Selenadiazole-Containing Kidney-Type Glutaminase Inhibitors Showed Improved Cellular Uptake and Antitumor Activity. Journal of medicinal chemistry. 2019 01; 62(2):589-603. doi: 10.1021/acs.jmedchem.8b01198. [PMID: 30543285]
  • Sarah C Zimmermann, Bridget Duvall, Takashi Tsukamoto. Recent Progress in the Discovery of Allosteric Inhibitors of Kidney-Type Glutaminase. Journal of medicinal chemistry. 2019 01; 62(1):46-59. doi: 10.1021/acs.jmedchem.8b00327. [PMID: 29969024]
  • Irfana Soomro, Ying Sun, Zhai Li, Lonnette Diggs, Georgia Hatzivassiliou, Ajit G Thomas, Rana Rais, Seth J Parker, Barbara S Slusher, Alec C Kimmelman, Stefan Somlo, Edward Y Skolnik. Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2018 08; 33(8):1343-1353. doi: 10.1093/ndt/gfx349. [PMID: 29420817]
  • Jing Ge, Huachun Cui, Na Xie, Sami Banerjee, Sijia Guo, Shubham Dubey, Stephen Barnes, Gang Liu. Glutaminolysis Promotes Collagen Translation and Stability via α-Ketoglutarate-mediated mTOR Activation and Proline Hydroxylation. American journal of respiratory cell and molecular biology. 2018 03; 58(3):378-390. doi: 10.1165/rcmb.2017-0238oc. [PMID: 29019707]
  • Omran Abu Aboud, Samy L Habib, Josephine Trott, Benjamin Stewart, Sitai Liang, Abhijit J Chaudhari, Julie Sutcliffe, Robert H Weiss. Glutamine Addiction in Kidney Cancer Suppresses Oxidative Stress and Can Be Exploited for Real-Time Imaging. Cancer research. 2017 12; 77(23):6746-6758. doi: 10.1158/0008-5472.can-17-0930. [PMID: 29021138]
  • Li Cheng, Can-Rong Wu, Li-Han Zhu, Hua Li, Li-Xia Chen. Physapubescin, a natural withanolide as a kidney-type glutaminase (KGA) inhibitor. Bioorganic & medicinal chemistry letters. 2017 03; 27(5):1243-1246. doi: 10.1016/j.bmcl.2017.01.057. [PMID: 28174105]
  • Polina Matre, Juliana Velez, Rodrigo Jacamo, Yuan Qi, Xiaoping Su, Tianyu Cai, Steven M Chan, Alessia Lodi, Shannon R Sweeney, Helen Ma, Richard Eric Davis, Natalia Baran, Torsten Haferlach, Xiaohua Su, Elsa Renee Flores, Doriann Gonzalez, Sergej Konoplev, Ismael Samudio, Courtney DiNardo, Ravi Majeti, Aaron D Schimmer, Weiqun Li, Taotao Wang, Stefano Tiziani, Marina Konopleva. Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes. Oncotarget. 2016 Nov; 7(48):79722-79735. doi: 10.18632/oncotarget.12944. [PMID: 27806325]
  • Amira Elgogary, Qingguo Xu, Brad Poore, Jesse Alt, Sarah C Zimmermann, Liang Zhao, Jie Fu, Baiwei Chen, Shiyu Xia, Yanfei Liu, Marc Neisser, Christopher Nguyen, Ramon Lee, Joshua K Park, Juvenal Reyes, Thomas Hartung, Camilo Rojas, Rana Rais, Takashi Tsukamoto, Gregg L Semenza, Justin Hanes, Barbara S Slusher, Anne Le. Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America. 2016 09; 113(36):E5328-36. doi: 10.1073/pnas.1611406113. [PMID: 27559084]
  • Sarah C Zimmermann, Emily F Wolf, Andrew Luu, Ajit G Thomas, Marigo Stathis, Brad Poore, Christopher Nguyen, Anne Le, Camilo Rojas, Barbara S Slusher, Takashi Tsukamoto. Allosteric Glutaminase Inhibitors Based on a 1,4-Di(5-amino-1,3,4-thiadiazol-2-yl)butane Scaffold. ACS medicinal chemistry letters. 2016 May; 7(5):520-4. doi: 10.1021/acsmedchemlett.6b00060. [PMID: 27200176]
  • Lee A McDermott, Prema Iyer, Larry Vernetti, Shawn Rimer, Jingran Sun, Melissa Boby, Tianyi Yang, Michael Fioravanti, Jason O'Neill, Liwei Wang, Dylan Drakes, William Katt, Qingqiu Huang, Richard Cerione. Design and evaluation of novel glutaminase inhibitors. Bioorganic & medicinal chemistry. 2016 Apr; 24(8):1819-39. doi: 10.1016/j.bmc.2016.03.009. [PMID: 26988803]
  • K Jacyszyn, E Kemp, T Laursen, F Rasmussen. Investigations of the excretion of gamma-glutamyl-transpeptidase into the urine. International urology and nephrology. 1975; 7(3):205-14. doi: 10.1007/bf02082676. [PMID: 1355]