Cariporide (BioDeep_00000177044)
human metabolite blood metabolite
代谢物信息卡片
4-Isopropyl-3-(methylsulfonyl)benzoyl-guanidine methanesulfonate
化学式: C12H17N3O3S (283.0990572)
中文名称: 卡立泊来德
谱图信息:
最多检出来源 Homo sapiens(blood) 75%
分子结构信息
SMILES: CC(C)C1=C(C=C(C=C1)C(=O)N=C(N)N)S(=O)(=O)C
InChI: InChI=1S/C12H17N3O3S/c1-7(2)9-5-4-8(11(16)15-12(13)14)6-10(9)19(3,17)18/h4-7H,1-3H3,(H4,13,14,15,16)
描述信息
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- PubChem: 151172
- HMDB: HMDB0249676
- DrugBank: DB06468
- ChEMBL: CHEMBL436559
- Wikipedia: Cariporide
- chemspider: 133240
- CAS: 159138-73-5
- CAS: 159138-80-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yanli Dong, Yiwei Gao, Alina Ilie, DuSik Kim, Annie Boucher, Bin Li, Xuejun C Zhang, John Orlowski, Yan Zhao. Structure and mechanism of the human NHE1-CHP1 complex.
Nature communications.
2021 06; 12(1):3474. doi:
10.1038/s41467-021-23496-z. [PMID: 34108458] - Marta Kantauskaitė, Anna Hucke, Moritz Reike, Sara Ahmed Eltayeb, Chuyan Xiao, Vivien Barz, Giuliano Ciarimboli. Rapid Regulation of Human Multidrug and Extrusion Transporters hMATE1 and hMATE2K.
International journal of molecular sciences.
2020 Jul; 21(14):. doi:
10.3390/ijms21145157. [PMID: 32708212] - Stefania Muzzachi, Lorenzo Guerra, Nicola Antonio Martino, Maria Favia, Giuseppe Punzi, Fabio Silvestre, Antonio Ciro Guaricci, Maria Teresa Roscino, Ciro Leonardo Pierri, Maria Elena Dell'Aquila, Valeria Casavola, Giovanni Michele Lacalandra, Elena Ciani. Effect of cariporide on ram sperm pH regulation and motility: possible role of NHE1.
Reproduction (Cambridge, England).
2018 05; 155(5):433-445. doi:
10.1530/rep-17-0456. [PMID: 29491124] - W P Li, G Y Zhao, X K Yang. [Effects of Na(+) /H(+) exchanger 1 inhibitor on intestinal injury of rats with burn sepsis and the mechanism].
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns.
2017 Jun; 33(6):349-354. doi:
10.3760/cma.j.issn.1009-2587.2017.06.013. [PMID: 28648038] - Rosa Angela Cardone, Maria Raffaella Greco, Katrine Zeeberg, Angela Zaccagnino, Mara Saccomano, Antonia Bellizzi, Philipp Bruns, Marta Menga, Christian Pilarsky, Albrecht Schwab, Frauke Alves, Holger Kalthoff, Valeria Casavola, Stephan Joel Reshkin. A novel NHE1-centered signaling cassette drives epidermal growth factor receptor-dependent pancreatic tumor metastasis and is a target for combination therapy.
Neoplasia (New York, N.Y.).
2015 Feb; 17(2):155-66. doi:
10.1016/j.neo.2014.12.003. [PMID: 25748234] - Syed M Qadri, Yang Su, Francisco S Cayabyab, Lixin Liu. Endothelial Na+/H+ exchanger NHE1 participates in redox-sensitive leukocyte recruitment triggered by methylglyoxal.
Cardiovascular diabetology.
2014 Sep; 13(?):134. doi:
10.1186/s12933-014-0134-7. [PMID: 25270604] - Sophia Koutsogiannaki, Silvia Franzellitti, Elena Fabbri, Martha Kaloyianni. Oxidative stress parameters induced by exposure to either cadmium or 17β-estradiol on Mytilus galloprovincialis hemocytes. The role of signaling molecules.
Aquatic toxicology (Amsterdam, Netherlands).
2014 Jan; 146(?):186-95. doi:
10.1016/j.aquatox.2013.11.005. [PMID: 24316436] - Xuekang Yang, Hua Bai, Weixia Cai, Jiaqi Liu, Yunchuan Wang, Yuqiao Xu, Jun Li, Qin Zhou, Juntao Han, Xiongxiang Zhu, Maolong Dong, Dahai Hu. Inhibition of Na+/H+ exchanger 1 by cariporide alleviates burn-induced multiple organ injury.
The Journal of surgical research.
2013 Dec; 185(2):797-804. doi:
10.1016/j.jss.2013.06.049. [PMID: 23910884] - Violetta Siyanov, Jay M Baltz. NHE1 is the sodium-hydrogen exchanger active in acute intracellular pH regulation in preimplantation mouse embryos.
Biology of reproduction.
2013 Jun; 88(6):157. doi:
10.1095/biolreprod.113.109033. [PMID: 23677982] - Florian Timo Ludwig, Albrecht Schwab, Christian Stock. The Na+ /H+ -exchanger (NHE1) generates pH nanodomains at focal adhesions.
Journal of cellular physiology.
2013 Jun; 228(6):1351-8. doi:
10.1002/jcp.24293. [PMID: 23184727] - Jeejabai Radhakrishnan, Julieta D Kolarova, Iyad M Ayoub, Raúl J Gazmuri. AVE4454B--a novel sodium-hydrogen exchanger isoform-1 inhibitor--compared less effective than cariporide for resuscitation from cardiac arrest.
Translational research : the journal of laboratory and clinical medicine.
2011 Feb; 157(2):71-80. doi:
10.1016/j.trsl.2010.11.004. [PMID: 21256459] - Xinzhu Lin, Meiting Li, Ronghua Zhou, Hai Yu, Leng Zhou, Qian Li, Bin Liu. [Cariporide pretreatment attenuated warm ischemia/reperfusion injury in an isolated rat lung: a study on antioxidative mechanism].
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi.
2010 Feb; 27(1):132-7. doi:
". [PMID: 20337040] - Ebbe Boedtkjer, Christian Aalkjaer. Insulin inhibits Na+/H+ exchange in vascular smooth muscle and endothelial cells in situ: involvement of H2O2 and tyrosine phosphatase SHP-2.
American journal of physiology. Heart and circulatory physiology.
2009 Feb; 296(2):H247-55. doi:
10.1152/ajpheart.00725.2008. [PMID: 19036852] - Vanda Pinto, Maria João Pinho, Ulrich Hopfer, Pedro A Jose, Patrício Soares-da-Silva. Oxidative stress and the genomic regulation of aldosterone-stimulated NHE1 activity in SHR renal proximal tubular cells.
Molecular and cellular biochemistry.
2008 Mar; 310(1-2):191-201. doi:
10.1007/s11010-007-9680-6. [PMID: 18095144] - Amélie Rebillard, Xavier Tekpli, Olivier Meurette, Odile Sergent, Gwenaëlle LeMoigne-Muller, Laurent Vernhet, Morgane Gorria, Martine Chevanne, Markus Christmann, Bernd Kaina, Laurent Counillon, Erich Gulbins, Dominique Lagadic-Gossmann, Marie-Thérèse Dimanche-Boitrel. Cisplatin-induced apoptosis involves membrane fluidification via inhibition of NHE1 in human colon cancer cells.
Cancer research.
2007 Aug; 67(16):7865-74. doi:
10.1158/0008-5472.can-07-0353. [PMID: 17699793] - Zhi Li, Tao Song, Gui-zhen Liu, Li-ying Liu. Inhibitory effects of cariporide on LPC-induced expression of ICAM-1 and adhesion of monocytes to smooth muscle cells in vitro.
Acta pharmacologica Sinica.
2006 Oct; 27(10):1326-32. doi:
10.1111/j.1745-7254.2006.00412.x. [PMID: 17007739] - Karnail S Atwal, Steven V O'Neil, Saleem Ahmad, Lidia Doweyko, Mark Kirby, Charles R Dorso, Gamini Chandrasena, Bang-Chi Chen, Rulin Zhao, Robert Zahler. Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors.
Bioorganic & medicinal chemistry letters.
2006 Sep; 16(18):4796-9. doi:
10.1016/j.bmcl.2006.06.077. [PMID: 16870436] - J F M Bechtel, W Eichler, K Toerber, B Weidtmann, M Hernandez, K F Klotz, H H Sievers, C Bartels. The Na+/H+ exchange inhibitor cariporide is washed out of the myocardium by crystalloid cardioplegia.
The Thoracic and cardiovascular surgeon.
2006 Aug; 54(5):317-23. doi:
10.1055/s-2006-923900. [PMID: 16902879] - Juliana C Fantinelli, Horacio E Cingolani, Susana M Mosca. Na+/H+ exchanger inhibition at the onset of reperfusion decreases myocardial infarct size: role of reactive oxygen species.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.
2006 Jul; 15(4):179-84. doi:
10.1016/j.carpath.2006.04.005. [PMID: 16844548] - Robert Létienne, Lydia Bel, Anne-Marie Bessac, Delphine Denais, Anne-Dominique Degryse, Gareth W John, Bruno Le Grand. Cardioprotection of cariporide evaluated by plasma myoglobin and troponin I in myocardial infarction in pigs.
Fundamental & clinical pharmacology.
2006 Apr; 20(2):105-13. doi:
10.1111/j.1472-8206.2006.00394.x. [PMID: 16573710] - U Hillebrand, M Hausberg, C Stock, V Shahin, D Nikova, C Riethmüller, K Kliche, T Ludwig, H Schillers, S W Schneider, H Oberleithner. 17beta-estradiol increases volume, apical surface and elasticity of human endothelium mediated by Na+/H+ exchange.
Cardiovascular research.
2006 Mar; 69(4):916-24. doi:
10.1016/j.cardiores.2005.11.025. [PMID: 16412402] - Kazuto Yamada, Kazuki Matsui, Shoji Ogawa, Setsuko Yamamoto, Masaya Mori, Masahumi Kitano, Naohito Ohashi. Reduction of myocardial infarct size by SM-198110, a novel Na+/H+ exchange inhibitor, in rabbits.
Naunyn-Schmiedeberg's archives of pharmacology.
2005 May; 371(5):408-19. doi:
10.1007/s00210-005-1062-6. [PMID: 15902428] - Manuel Castellá, Gerald D Buckberg, Zhongtuo Tan. Neurologic preservation by Na+-H+ exchange inhibition prior to 90 minutes of hypothermic circulatory arrest.
The Annals of thoracic surgery.
2005 Feb; 79(2):646-54; discussion 646. doi:
10.1016/j.athoracsur.2004.07.007. [PMID: 15680853] - Katrin Rungwerth, Ursula Schindler, Martin Gerl, Stefan Schäfer, Thomas Licher, Andreas E Busch, Hartmut Ruetten. Inhibition of Na+-H+ exchange by cariporide reduces inflammation and heart failure in rabbits with myocardial infarction.
British journal of pharmacology.
2004 Aug; 142(7):1147-54. doi:
10.1038/sj.bjp.0705746. [PMID: 15237093] - Oliver Jung, Udo Albus, Hans-Jochen Lang, Andreas E Busch, Wolfgang Linz. Effects of acute and chronic treatment with the sodium hydrogen exchanger 1 (NHE-1) inhibitor cariporide on myocardial infarct mass in rabbits with hypercholesterolaemia.
Basic & clinical pharmacology & toxicology.
2004 Jul; 95(1):24-30. doi:
10.1111/j.1742-7843.2004.t01-1-pto950105.x. [PMID: 15245573] - Bernhard R Winkelmann. American Heart Association scientific sessions.
Expert opinion on investigational drugs.
2004 Apr; 13(4):435-45. doi:
10.1517/13543784.13.4.435. [PMID: 15102593] - William M Yarbrough, Rupak Mukherjee, G Patricia Escobar, Joseph T Mingoia, Jeffrey A Sample, Jennifer W Hendrick, Kathryn B Dowdy, Julie E McLean, Robert E Stroud, Francis G Spinale. Direct inhibition of the sodium/hydrogen exchanger after prolonged regional ischemia improves contractility on reperfusion independent of myocardial viability.
The Journal of thoracic and cardiovascular surgery.
2003 Nov; 126(5):1489-97. doi:
10.1016/s0022-5223(03)00811-0. [PMID: 14666024] - Jonathon B Ryan, Mark Hicks, Jonathan R Cropper, Sarah R Garlick, Scott H Kesteven, Michael K Wilson, Michael P Feneley, Peter S Macdonald. Sodium-hydrogen exchanger inhibition, pharmacologic ischemic preconditioning, or both for extended cardiac allograft preservation.
Transplantation.
2003 Sep; 76(5):766-71. doi:
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European journal of medicinal chemistry.
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European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.
2003 Jun; 23(6):898-906. doi:
10.1016/s1010-7940(03)00114-3. [PMID: 12829065] - Li Chu, Reiko Takahashi, Ikuo Norota, Takuya Miyamoto, Yasuchika Takeishi, Kuniaki Ishii, Isao Kubota, Masao Endoh. Signal transduction and Ca2+ signaling in contractile regulation induced by crosstalk between endothelin-1 and norepinephrine in dog ventricular myocardium.
Circulation research.
2003 May; 92(9):1024-32. doi:
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Journal of cardiovascular pharmacology.
2003 Mar; 41(3):468-73. doi:
10.1097/00005344-200303000-00016. [PMID: 12605026] - Horacio E Cingolani, Oscar R Rebolledo, Enrique L Portiansky, Néstor G Pérez, María C Camilión de Hurtado. Regression of hypertensive myocardial fibrosis by Na(+)/H(+) exchange inhibition.
Hypertension (Dallas, Tex. : 1979).
2003 Feb; 41(2):373-7. doi:
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10.1152/ajpendo.00341.2002. [PMID: 12388133] - Willi Weber, Lutz Harnisch, Andreas Jessel. Lessons learned from a phase III population pharmacokinetic study of cariporide in coronary artery bypass graft surgery.
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2002 Jun; 71(6):457-67. doi:
10.1067/mcp.2002.124078. [PMID: 12087349] - María C Camilión de Hurtado, Enrique L Portiansky, Néstor G Pérez, Oscar R Rebolledo, Horacio E Cingolani. Regression of cardiomyocyte hypertrophy in SHR following chronic inhibition of the Na(+)/H(+) exchanger.
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2002 Mar; 53(4):862-8. doi:
10.1016/s0008-6363(01)00544-2. [PMID: 11922896] - Jiang-hua Tu, Li-ying Liu, Xiao-hong Zhang. [Protective effect of Na(+)-H+ exchanger inhibitor cariporide on the injury of vascular endothelial function induced by hypercholesterolemia].
Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University.
2002 Feb; 27(1):13-6. doi:
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American journal of physiology. Renal physiology.
2001 Oct; 281(4):F707-17. doi:
10.1152/ajprenal.2001.281.4.f707. [PMID: 11553518] - S Ahmad, L M Doweyko, S Dugar, N Grazier, K Ngu, S C Wu, K J Yost, B C Chen, J Z Gougoutas, J D DiMarco, S J Lan, B J Gavin, A Y Chen, C R Dorso, R Serafino, M Kirby, K S Atwal. Arylcyclopropanecarboxyl guanidines as novel, potent, and selective inhibitors of the sodium hydrogen exchanger isoform-1.
Journal of medicinal chemistry.
2001 Sep; 44(20):3302-10. doi:
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Gastroenterology.
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The Journal of physiology.
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Annals of the New York Academy of Sciences.
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