Carazolol (BioDeep_00000176987)

   

human metabolite blood metabolite


代谢物信息卡片


1-(9H-carbazol-4-yloxy)-3-[(propan-2-yl)amino]propan-2-ol

化学式: C18H22N2O2 (298.1681192)
中文名称: 咔唑心安
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O
InChI: InChI=1S/C18H22N2O2/c1-12(2)19-10-13(21)11-22-17-9-5-8-16-18(17)14-6-3-4-7-15(14)20-16/h3-9,12-13,19-21H,10-11H2,1-2H3

描述信息

C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
Carazolol is a β1/β2 adrenoceptor antagonist of high potency used in the research of hypertension. Carazolol is also a potent, selective β3-adrenoceptor agonist[1].

同义名列表

11 个代谢物同义名

1-(9H-carbazol-4-yloxy)-3-[(propan-2-yl)amino]propan-2-ol; Carazolol, monohydrochloride; Carazolol, (+-)-isomer; Carazolol, (+)-isomer; Carazolol, (-)-isomer; (+)-CARAZOLOL; Conducton; Carazolol; Suacron; (±)-Carazolol; DL-Carazolol



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ibrahim Ramirez-Soto, Eduardo Rodriguez, Rocío Alvarez, Eugenio Quiroz, Alicia Ortega. Intracellular effect of β3-adrenoceptor agonist Carazolol on skeletal muscle, a direct interaction with SERCA. Cell calcium. 2019 05; 79(?):20-26. doi: 10.1016/j.ceca.2019.02.004. [PMID: 30776521]
  • Kevin W Kastner, Jesús A Izaguirre. Accelerated molecular dynamics simulations of the octopamine receptor using GPUs: discovery of an alternate agonist-binding position. Proteins. 2016 10; 84(10):1480-9. doi: 10.1002/prot.25091. [PMID: 27318014]
  • Stefano Costanzi, Santiago Vilar. In silico screening for agonists and blockers of the β(2) adrenergic receptor: implications of inactive and activated state structures. Journal of computational chemistry. 2012 Feb; 33(5):561-72. doi: 10.1002/jcc.22893. [PMID: 22170280]
  • Michael Leguèbe, Chuong Nguyen, Luciana Capece, Zung Hoang, Alejandro Giorgetti, Paolo Carloni. Hybrid molecular mechanics/coarse-grained simulations for structural prediction of G-protein coupled receptor/ligand complexes. PloS one. 2012; 7(10):e47332. doi: 10.1371/journal.pone.0047332. [PMID: 23094046]
  • Santiago Vilar, Giulio Ferino, Sharangdhar S Phatak, Barkin Berk, Claudio N Cavasotto, Stefano Costanzi. Docking-based virtual screening for ligands of G protein-coupled receptors: not only crystal structures but also in silico models. Journal of molecular graphics & modelling. 2011 Feb; 29(5):614-23. doi: 10.1016/j.jmgm.2010.11.005. [PMID: 21146435]
  • Daniel M Rosenbaum, Cheng Zhang, Joseph A Lyons, Ralph Holl, David Aragao, Daniel H Arlow, Søren G F Rasmussen, Hee-Jung Choi, Brian T Devree, Roger K Sunahara, Pil Seok Chae, Samuel H Gellman, Ron O Dror, David E Shaw, William I Weis, Martin Caffrey, Peter Gmeiner, Brian K Kobilka. Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature. 2011 Jan; 469(7329):236-40. doi: 10.1038/nature09665. [PMID: 21228876]
  • Gunnar Kleinau, Juliane Pratzka, Daniela Nürnberg, Annette Grüters, Dagmar Führer-Sakel, Heiko Krude, Josef Köhrle, Torsten Schöneberg, Heike Biebermann. Differential modulation of Beta-adrenergic receptor signaling by trace amine-associated receptor 1 agonists. PloS one. 2011; 6(10):e27073. doi: 10.1371/journal.pone.0027073. [PMID: 22073124]
  • Juan José Fung, Xavier Deupi, Leonardo Pardo, Xiao Jie Yao, Gisselle A Velez-Ruiz, Brian T Devree, Roger K Sunahara, Brian K Kobilka. Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model lipid bilayer. The EMBO journal. 2009 Nov; 28(21):3315-28. doi: 10.1038/emboj.2009.267. [PMID: 19763081]
  • Kamila Mitrowska, Andrzej Posyniak, Jan Zmudzki. Rapid method for the determination of tranquilizers and a beta-blocker in porcine and bovine kidney by liquid chromatography with tandem mass spectrometry. Analytica chimica acta. 2009 Apr; 637(1-2):185-92. doi: 10.1016/j.aca.2008.10.030. [PMID: 19286028]
  • Sarosh N Fatakia, Stefano Costanzi, Carson C Chow. Computing highly correlated positions using mutual information and graph theory for G protein-coupled receptors. PloS one. 2009; 4(3):e4681. doi: 10.1371/journal.pone.0004681. [PMID: 19262747]
  • Iwona Zawadzka, Lech Rodziewicz. [Determination of azaperone and carazolol residues in animals kidney using LC-MS/MS method]. Roczniki Panstwowego Zakladu Higieny. 2009; 60(1):19-23. doi: NULL. [PMID: 19579764]
  • A A M Stolker, P Rutgers, E Oosterink, J J P Lasaroms, R J B Peters, J A van Rhijn, M W F Nielen. Comprehensive screening and quantification of veterinary drugs in milk using UPLC-ToF-MS. Analytical and bioanalytical chemistry. 2008 Jul; 391(6):2309-22. doi: 10.1007/s00216-008-2168-8. [PMID: 18491081]
  • Stefano Costanzi. On the applicability of GPCR homology models to computer-aided drug discovery: a comparison between in silico and crystal structures of the beta2-adrenergic receptor. Journal of medicinal chemistry. 2008 May; 51(10):2907-14. doi: 10.1021/jm800044k. [PMID: 18442228]
  • Vesna Cerkvenik-Flajs. Determination of residues of azaperone in the kidneys by liquid chromatography with fluorescence detection. Analytica chimica acta. 2007 Mar; 586(1-2):374-82. doi: 10.1016/j.aca.2006.11.010. [PMID: 17386737]
  • Z Gajewski, R Thun, R Faundez, B Pawliński. The influence of alpha-adrenergic receptors stimulator and blockers and beta-blocker on the ovary and endocrinological activity in heifers during superovulation. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2006 Nov; 57 Suppl 8(?):173-88. doi: NULL. [PMID: 17242481]
  • E Peeters, A Neyt, F Beckers, S De Smet, A E Aubert, R Geers. Influence of supplemental magnesium, tryptophan, vitamin C, and vitamin E on stress responses of pigs to vibration. Journal of animal science. 2005 Jul; 83(7):1568-80. doi: 10.2527/2005.8371568x. [PMID: 15956466]
  • Hans H Maurer, Oliver Tenberken, Carsten Kratzsch, Armin A Weber, Frank T Peters. Screening for library-assisted identification and fully validated quantification of 22 beta-blockers in blood plasma by liquid chromatography-mass spectrometry with atmospheric pressure chemical ionization. Journal of chromatography. A. 2004 Nov; 1058(1-2):169-81. doi: . [PMID: 15595665]
  • John Cooper, Phillippe Delahaut, Terence L Fodey, Christopher T Elliott. Development of a rapid screening test for veterinary sedatives and the beta-blocker carazolol in porcine kidney by ELISA. The Analyst. 2004 Feb; 129(2):169-74. doi: 10.1039/b311709j. [PMID: 14752562]
  • F Behn, S Michels, S Läer, G Blaschke. Separation of carvedilol enantiomers in very small volumes of human plasma by capillary electrophoresis with laser-induced fluorescence. Journal of chromatography. B, Biomedical sciences and applications. 2001 May; 755(1-2):111-7. doi: 10.1016/s0378-4347(01)00045-7. [PMID: 11393694]
  • A Kaufmann, B Ryser. Multiresidue analysis of tranquilizers and the beta-blocker Carazolol in meat by liquid chromatography/tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2001; 15(18):1747-51. doi: 10.1002/rcm.393. [PMID: 11555876]
  • D Fluchard, S Kiebooms, M Dubois, P Delahaut. Determination of a method for detecting and quantifying azaperone, azaperol and carazolol in pig tissues by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications. 2000 Jul; 744(1):139-47. doi: 10.1016/s0378-4347(00)00240-1. [PMID: 10985575]
  • P Doze, A Van Waarde, P H Elsinga, N H Hendrikse, W Vaalburg. Enhanced cerebral uptake of receptor ligands by modulation of P-glycoprotein function in the blood-brain barrier. Synapse (New York, N.Y.). 2000 Apr; 36(1):66-74. doi: 10.1002/(sici)1098-2396(200004)36:1<66::aid-syn7>3.0.co;2-j. [PMID: 10700027]
  • W Arneth. [Analysis of some neuroleptics and carazolol in pork kidneys]. Zeitschrift fur Lebensmittel-Untersuchung und -Forschung. 1995 Sep; 201(3):261-5. doi: 10.1007/bf01193000. [PMID: 7483861]
  • M D Rose, G Shearer. Determination of tranquilisers and carazolol residues in animal tissue using high-performance liquid chromatography with electrochemical detection. Journal of chromatography. 1992 Oct; 624(1-2):471-7. doi: 10.1016/0021-9673(92)85696-q. [PMID: 1362965]
  • H P Lefebvre, J P Jaeg, A G Rico, P L Toutain, J P Braun. Variations of plasma creatine kinase in rabbits following repetitive blood sampling effects of pretreatment with acepromazine, carazolol and dantrolene. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies. 1992 Jul; 30(7):425-8. doi: NULL. [PMID: 1356023]
  • F Kadir, J Zuidema. High-performance liquid chromatographic method for the determination of carazolol in serum or plasma of pigs. Journal of chromatography. 1990 May; 527(2):461-6. doi: 10.1016/s0378-4347(00)82132-5. [PMID: 1974898]
  • H J Keukens, M M Aerts. Determination of residues of carazolol and a number of tranquilizers in swine kidney by high-performance liquid chromatography with ultraviolet and fluorescence detection. Journal of chromatography. 1989 Feb; 464(1):149-61. doi: 10.1016/s0021-9673(00)94231-6. [PMID: 2715246]
  • N Haagsma, E R Bathelt, J W Engelsma. Thin-layer chromatographic screening method for the tranquillizers azaperone, propiopromazine and carazolol in pig tissues. Journal of chromatography. 1988 Jan; 436(1):73-9. doi: 10.1016/s0021-9673(00)94567-9. [PMID: 2897377]
  • C Steinmann, E Perez, E Scholl. [The effect of preventative carazolol treatment on stress reactions in boars during semen collection]. Tierarztliche Praxis. Supplement. 1988; 3(?):101-6. doi: NULL. [PMID: 2897136]
  • K Bickhardt, R Fenger, A Wilms-Schulze-Kump. [Stress reactions in clinically healthy sows at the time of birth and their relationship to the CK test]. Tierarztliche Praxis. Supplement. 1988; 3(?):72-6. doi: NULL. [PMID: 2897137]
  • N Chaiyabutr, C Buranakari, T Tesaprateep, P Loypetjra. Changes in renal functions during beta-blocker carazolol administration in acute heat-stressed pigs. The British veterinary journal. 1987 Sep; 143(5):448-53. doi: 10.1016/0007-1935(87)90022-4. [PMID: 2890402]
  • M Rudolph, H Steinhart. Determination of carazolol in tissues of pigs by high-performance liquid chromatography. Journal of chromatography. 1987 Apr; 392(?):371-8. doi: 10.1016/s0021-9673(01)94280-3. [PMID: 2885333]
  • F Hartig, J Vollmar, G Bode, G Hebold, H Czerwek. Investigations on the exogenous influencing of the spontaneous tumour rate in rats. Experimental pathology. 1986; 30(3):157-64. doi: 10.1016/s0232-1513(86)80089-5. [PMID: 3792486]
  • J W Engelsma, J Simons. Simple fluorimetric screening for carazolol in swine kidneys by means of Sep-Pak cartridges. The veterinary quarterly. 1985 Jan; 7(1):73-6. doi: 10.1080/01652176.1985.9693957. [PMID: 2858140]