Bifemelane (BioDeep_00000176676)

   

human metabolite blood metabolite


代谢物信息卡片


[4-(2-benzylphenoxy)butyl](methyl)amine

化学式: C18H23NO (269.178)
中文名称: 二苯美伦
谱图信息: 最多检出来源 Homo sapiens(blood) 11.72%

分子结构信息

SMILES: CNCCCCOC1=CC=CC=C1CC1=CC=CC=C1
InChI: InChI=1S/C18H23NO/c1-19-13-7-8-14-20-18-12-6-5-11-17(18)15-16-9-3-2-4-10-16/h2-6,9-12,19H,7-8,13-15H2,1H3

描述信息

D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants
C78272 - Agent Affecting Nervous System

同义名列表

7 个代谢物同义名

[4-(2-benzylphenoxy)butyl](methyl)amine; 4-(2-Benzylphenoxy)-N-methylbutylamine; 2-(4-Methylaminobutoxy)diphenylmethane; Bifemelane hydrochloride; Bifemelane HCL; Bifemelane; Celeport



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • I Miyazaki, E Iwata-Ichikawa, M Asanuma, M Iida, N Ogawa. Bifemelane hydrochloride protects against cytotoxicity of hydrogen peroxide on cultured rat neuroblastoma cell line. Neurochemical research. 1999 Jul; 24(7):857-60. doi: 10.1023/a:1020953913490. [PMID: 10403625]
  • M Yasui, K Ota, A Oshima. Effects of bifemelane hydrochloride on atherosclerosis in aged rats fed low-calcium diets. The Journal of international medical research. 1996 Nov; 24(6):454-65. doi: 10.1177/030006059602400602. [PMID: 8959529]
  • M Minami, H Arai, T Takahashi, M Kimura, I Noguchi, T Suzuki, R Inoue. A preliminary study on plasma concentrations of bifemelane, indeloxazine and propentofylline in aged patients with organic brain disorders. Progress in neuro-psychopharmacology & biological psychiatry. 1995 Jan; 19(1):59-64. doi: 10.1016/0278-5846(94)00104-p. [PMID: 7708932]
  • S Koide, H Onishi, H Hashimoto, T Kai, M Katayama, S Yamagami. Effects of bifemelane hydrochloride on plasma neuropeptide Y, 3-methoxy-4-hydroxyphenylethylene glycol and 5-hydroxy-indole acetic acid concentrations in patients with cerebral infarction. Drugs under experimental and clinical research. 1995; 21(5):175-80. doi: . [PMID: 8846747]
  • D N Dill, B Eilbacher. Gas chromatographic-mass spectrometric method for the determination of bifemelane in human plasma at therapeutic doses. Journal of chromatography. 1993 Mar; 613(1):150-7. doi: 10.1016/0378-4347(93)80209-m. [PMID: 8458893]
  • M Yasui, I Yano, T Tsuda, K Ota. [Effects of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (bifemelane) on deposition of calcium and magnesium in the central nervous system tissues of rats maintained on low-calcium diets]. No to shinkei = Brain and nerve. 1991 Dec; 43(12):1133-7. doi: NULL. [PMID: 1799520]
  • M Yasui, T Tsuda, K Ota. Effects of bifemelane on calcium and magnesium deposition in the central nervous system tissues of rats maintained on low-calcium diets. The Journal of international medical research. 1991 Nov; 19(6):471-8. doi: 10.1177/030006059101900607. [PMID: 1845351]
  • T Sugiyama, H Matuda, N Ohnishi, H Kiwamoto, A Esa, Y C Park, T Kurita, A Uchida, S Kunikata. [Effect of the cerebro-metabolism activator (bifemelane hydrochloride) on urinary incontinence and pollakisuria associated with cerebrovascular dementia]. Hinyokika kiyo. Acta urologica Japonica. 1991 Mar; 37(3):249-54. doi: NULL. [PMID: 2069105]
  • T Mitsuma, Y Hirooka, K Yuasa, T Nogimori. Bifemelane hydrochloride reduces plasma beta-endorphin-like immunoreactivity levels in rats. Experimental and clinical endocrinology. 1990 Aug; 95(3):301-5. doi: 10.1055/s-0029-1210969. [PMID: 2245819]
  • T Nagai, T Egashira, Y Yamanaka. Suppressive effect of bifemelane on lipid peroxidation in rat liver. The Journal of toxicological sciences. 1990 Feb; 15(1):47-60. doi: 10.2131/jts.15.47. [PMID: 2159522]
  • T Nagai, T Egashira, Y Yamanaka. Effect of bifemelane hydrochloride on an injury of the liver caused by ischemia-reperfusion in rats. Japanese journal of pharmacology. 1990 Feb; 52(2):383-5. doi: 10.1254/jjp.52.383. [PMID: 2313943]
  • M Suno, A Nagaoka. [Effect of idebenone and various nootropic drugs on lipid peroxidation in rat brain homogenate in the presence of succinate]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1988 May; 91(5):295-9. doi: 10.1254/fpj.91.295. [PMID: 3410376]
  • Y Tamao, H Hara, K Umezu, J Ito, A Doi, A Sudo, T Hirata, K Mineo, A Tobe. [Effects of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (MCI-2016, bifemelane hydrochloride) on coagulation, fibrinolysis, hemolysis, hemorheological properties and platelet aggregation]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1986 Feb; 87(2):161-7. doi: 10.1254/fpj.87.161. [PMID: 3699629]
  • A Narimatsu, K Nakao, H Ikoma, M Egawa, Y Kitada, S Yamazaki, K Umezu, M Miyake, E Nishimura, N Hashimoto. [General pharmacological action of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (MCI-2016, bifemelane hydrochloride). Influence on respiratory and cardiovascular systems, renal function, autonomic nervous system, isolated smooth muscle and digestive organs]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1986 Feb; 87(2):223-51. doi: 10.1254/fpj.87.223. [PMID: 3754532]