Benzodiazepine (BioDeep_00000176548)
human metabolite blood metabolite
代谢物信息卡片
Benzodiazepine compounds
化学式: C9H8N2 (144.0687448)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 98.11%
分子结构信息
SMILES: C1=CC=C2C(=C1)C=CC=NN2
InChI: InChI=1S/C9H8N2/c1-2-6-9-8(4-1)5-3-7-10-11-9/h1-7,11H
描述信息
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- PubChem: 134664
- HMDB: HMDB0249012
- DrugBank: DB12537
- ChEMBL: CHEMBL4297264
- Wikipedia: Benzodiazepine
- MeSH: Benzodiazepines
- CAS: 12794-10-4
- CAS: 264-60-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tong Zhu, Hongxia Zhao, Yufan Chao, Songyan Gao, Xin Dong, Zuowei Wang. Olanzapine-induced weight gain and lipid dysfunction in mice between different gender.
Biomedical chromatography : BMC.
2024 Jun; 38(6):e5864. doi:
10.1002/bmc.5864. [PMID: 38551083] - Lidan Huang, Hong Liu, Xue Zou, Jiawang Ding, Song Tao. Adverse Drug Events Observed with the Newly Approved Remimazolam in Comparison to Propofol for General Anesthesia in Patients Undergoing Surgery: A Meta-analysis.
Advances in therapy.
2024 May; 41(5):1896-1910. doi:
10.1007/s12325-024-02820-1. [PMID: 38480661] - Jinfang Song, Wenqiang Yu, Shuangquan Chen, Jiamin Huang, Chujun Zhou, Hua Liang. Remimazolam attenuates inflammation and kidney fibrosis following folic acid injury.
European journal of pharmacology.
2024 Mar; 966(?):176342. doi:
10.1016/j.ejphar.2024.176342. [PMID: 38290569] - Ling Zhou, Yang Jianying. Letter to the article by Yunoki et al.
Journal of anesthesia.
2024 Feb; 38(1):148. doi:
10.1007/s00540-023-03280-7. [PMID: 37930421] - Yating Guo, Jiamin Lin, Tingting Wu, Tingting Zhou, Yan Mu. Risk factors for delirium among hospitalized adults with COVID-19: A systematic review and meta-analysis of cohort studies.
International journal of nursing studies.
2023 Dec; 148(?):104602. doi:
10.1016/j.ijnurstu.2023.104602. [PMID: 37801933] - Hesham Shamshoum, Kyle D Medak, Greg L McKie, Stewart Jeromson, Margaret K Hahn, David C Wright. Salsalate and/or metformin therapy confer beneficial metabolic effects in olanzapine treated female mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Dec; 168(?):115671. doi:
10.1016/j.biopha.2023.115671. [PMID: 37839107] - Yan Li, Lei Zhu. Effect of perioperative benzodiazepine use on intraoperative awareness and postoperative delirium. Comment on Br J Anaesth 2023; 131: 302-13.
British journal of anaesthesia.
2023 12; 131(6):e201-e202. doi:
10.1016/j.bja.2023.09.012. [PMID: 37833126] - Wenwen Ni, Xiuwen Yi, Lili Feng, Yilei Shen, Jiali Jiao, Yirong Cai, Danyun Fu, Yuan Han, Ji'e Jia, Wenxian Li. Comparison of different weight-based scalars of remimazolam tosylate for anesthesia induction in obese patients: study protocol for a prospective, controlled trial.
Trials.
2023 Nov; 24(1):719. doi:
10.1186/s13063-023-07739-6. [PMID: 37950290] - Eric J Lavonas, Peter D Akpunonu, Ann M Arens, Kavita M Babu, Dazhe Cao, Robert S Hoffman, Christopher O Hoyte, Maryann E Mazer-Amirshahi, Andrew Stolbach, Maude St-Onge, Trevonne M Thompson, George Sam Wang, Amber V Hoover, Ian R Drennan. 2023 American Heart Association Focused Update on the Management of Patients With Cardiac Arrest or Life-Threatening Toxicity Due to Poisoning: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.
Circulation.
2023 Sep; ?(?):. doi:
10.1161/cir.0000000000001161. [PMID: 37721023] - Christoph U Correll, Mikkel Højlund, Christine Graham, Mark S Todtenkopf, David McDonnell, Adam Simmons. Weight Gain and Metabolic Changes in Patients With First-Episode Psychosis or Early-Phase Schizophrenia Treated With Olanzapine: A Meta-analysis.
The international journal of neuropsychopharmacology.
2023 Jun; ?(?):. doi:
10.1093/ijnp/pyad029. [PMID: 37326421] - Yueqing Su, Chao Deng, Xuemei Liu, Jiamei Lian. Epigenetic Histone Methylation of PPARγ and CPT1A Signaling Contributes to Betahistine Preventing Olanzapine-Induced Dyslipidemia.
International journal of molecular sciences.
2023 May; 24(11):. doi:
10.3390/ijms24119143. [PMID: 37298094] - Kirill P Cheremnykh, Arkadiy O Bryzgalov, Dmitry S Baev, Sergey A Borisov, Yulia S Sotnikova, Victor A Savelyev, Tatyana G Tolstikova, Shamansur S Sagdullaev, Elvira E Shults. Synthesis, Pharmacological Evaluation, and Molecular Modeling of Lappaconitine-1,5-Benzodiazepine Hybrids.
Molecules (Basel, Switzerland).
2023 May; 28(10):. doi:
10.3390/molecules28104234. [PMID: 37241973] - Mehmet Alper Arslan, Özgür Korhan Tunçel, Birşen Bilgici, Arzu Karaustaoğlu, Taner İlker Gümrükçüoğlu. Increased levels of lipid and protein oxidation in rat prefrontal cortex after treatment by lithium, valproic acid, and olanzapine.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 Apr; ?(?):. doi:
10.1007/s00210-023-02494-6. [PMID: 37093250] - Flávia Natividade da Silva, Priscila Laiz Zimath, Thais Alves do Amaral, José Rodrigo Nascimento Martins, Alex Rafacho. Coadministration of olanzapine causes minor impacts on the diabetogenic outcomes induced by dexamethasone treatment in rats.
Life sciences.
2023 Apr; 322(?):121660. doi:
10.1016/j.lfs.2023.121660. [PMID: 37011876] - Jingda Cai, Li Li, Tiannan Shao, Mengxi Sun, Weiyan Wang, Peng Xie, Xiaoyi Wang, Ye Yang, Yujun Long, Dongyu Kang, Jingmei Xiao, Yuhan Su, Xingjie Peng, Yuyan Huang, Menghui Gao, Qiongqiong Wu, Chuhan Song, Furu Liu, Ping Shao, Jianjun Ou, Yidong Shen, Jing Huang, Renrong Wu. Relapse in patients with schizophrenia and amisulpride-induced hyperprolactinemia or olanzapine-induced metabolic disturbance after switching to other antipsychotics.
Psychiatry research.
2023 Mar; 322(?):115138. doi:
10.1016/j.psychres.2023.115138. [PMID: 36871411] - Richard Bade, Geoff Eaglesham, Katja M Shimko, Jochen Mueller. Quantification of new psychoactive substances in Australian wastewater utilising direct injection liquid chromatography coupled to tandem mass spectrometry.
Talanta.
2023 Jan; 251(?):123767. doi:
10.1016/j.talanta.2022.123767. [PMID: 35973252] - Ai Wei, Shijin Ma, Yuzhe Dou, Xiaojun Wang, Jianxiong Wu, Shuzhi Zhou, Yanfang Deng, Xinquan Liu, Dongming Li, Mengchang Yang. The safety and efficacy of remimazolam tosylate combined with propofol in upper gastrointestinal endoscopy: A multicenter, randomized clinical trial.
PloS one.
2023; 18(8):e0282930. doi:
10.1371/journal.pone.0282930. [PMID: 37535618] - Yusheng Yao, Jinsheng Guan, Linwei Liu, Bingbing Fu, Lei Chen, Xiaochun Zheng. Discharge readiness after remimazolam versus propofol for colonoscopy: A randomised, double-blind trial.
European journal of anaesthesiology.
2022 12; 39(12):911-917. doi:
10.1097/eja.0000000000001715. [PMID: 35796575] - Christoph U Correll, István Bitter, Fabian Hoti, Juha Mehtälä, Annette Wooller, Katalin Pungor, Jari Tiihonen. Factors and their weight in reducing life expectancy in schizophrenia.
Schizophrenia research.
2022 Dec; 250(?):67-75. doi:
10.1016/j.schres.2022.10.019. [PMID: 36368280] - Madhura P Dixit, Shivkumar S Sammeta, Mrunali D Dhokne, Shubhada Mangrulkar, Manoj A Upadhya, Milind J Umekar, Brijesh G Taksande, Nandkishor R Kotagale. Chronic agmatine treatment prevents olanzapine-induced obesity and metabolic dysregulation in female rats.
Brain research bulletin.
2022 12; 191(?):69-77. doi:
10.1016/j.brainresbull.2022.10.013. [PMID: 36272666] - Xiao Wang, Wenwang Rao, Xueyan Chen, Xinqiao Zhang, Zeng Wang, Xianglin Ma, Qinge Zhang. The sociodemographic characteristics and clinical features of the late-life depression patients: results from the Beijing Anding Hospital mental health big data platform.
BMC psychiatry.
2022 11; 22(1):677. doi:
10.1186/s12888-022-04339-7. [PMID: 36324116] - Anne-Sophie Winter, Christian Haverkamp, Christian Gratzke, Roman Huber, Ann-Kathrin Lederer. Valerian and postoperative sleep: a retrospective cohort analysis of gynecological, urologic, and general surgical patients.
Sleep.
2022 10; 45(10):. doi:
10.1093/sleep/zsac122. [PMID: 35640263] - Timothy A Troppoli, Panos Zanos, Polymnia Georgiou, Todd D Gould, Uwe Rudolph, Scott M Thompson. Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at α5 Subunit-Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice.
Biological psychiatry.
2022 08; 92(3):216-226. doi:
10.1016/j.biopsych.2021.11.024. [PMID: 35120711] - Reeha Sharon, Theis Lange, Mia Aakjær, Sarah Brøgger Kristiansen, Morten Baltzer Houlind, Morten Andersen. Incidence of hospital contacts with acute kidney injury after initiation of second-generation antipsychotics in older adults: a Danish population-based cohort study.
European journal of clinical pharmacology.
2022 Aug; 78(8):1341-1349. doi:
10.1007/s00228-022-03339-6. [PMID: 35639132] - Xudong Cao, Peng Wang, Haoxing Yuan, Haoran Zhang, Yan He, Kequan Fu, Qian Fang, Hongli Liu, Limin Su, Long Yin, Pei Xu, Yuyang Xie, Xiaochun Xiong, Junqi Wang, Xu Zhu, Dong Guo. Benzodiazepine Derivatives as Potent Vasopressin V2 Receptor Antagonists for the Treatment of Autosomal Dominant Kidney Disease.
Journal of medicinal chemistry.
2022 Jul; 65(13):9295-9311. doi:
10.1021/acs.jmedchem.2c00567. [PMID: 35579344] - Jan-Niklas Kleis, Cornelius Hess, Tanja Germerott, Joerg Roehrich. Sensitive Screening of New Psychoactive Substances in Serum Using Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry.
Journal of analytical toxicology.
2022 Jul; 46(6):592-599. doi:
10.1093/jat/bkab072. [PMID: 34125215] - Snežana Đorđević, Nataša Perković Vukčević, Marko Antunović, Vesna Kilibarda, Gordana Vuković Ercegović, Jasmina Jović Stošić, Slavica Vučinić. Olanzapine poisoning in patients treated at the National Poison Control Centre in Belgrade, Serbia in 2017 and 2018: a brief review of serum concentrations and clinical symptoms.
Arhiv za higijenu rada i toksikologiju.
2022 Jul; 73(2):126-130. doi:
10.2478/aiht-2022-73-3635. [PMID: 35792773] - Karissa Weidman, Elyse LaFond, Katherine L Hoffman, Parag Goyal, Christopher N Parkhurst, Heather Derry-Vick, Edward Schenck, Lindsay Lief. Post-Intensive Care Unit Syndrome in a Cohort of COVID-19 Survivors in New York City.
Annals of the American Thoracic Society.
2022 07; 19(7):1158-1168. doi:
10.1513/annalsats.202104-520oc. [PMID: 34936536] - Lia D Delaney, Mark C Bicket, Hsou Mei Hu, Megan O'Malley, Elizabeth McLaughlin, Scott A Flanders, Valerie M Vaughn, Jennifer F Waljee. Opioid and benzodiazepine prescribing after COVID-19 hospitalization.
Journal of hospital medicine.
2022 Jul; 17(7):539-544. doi:
10.1002/jhm.12842. [PMID: 35621024] - Nicholas Lintzeris, Rachel M Deacon, Victoria Hayes, Tracy Cowan, Llewellyn Mills, Laila Parvaresh, Lucy Harvey Dodds, Louisa Jansen, Raelene Dojcinovic, Man Cho Leung, Apo Demirkol, Therese Finch, Kristie Mammen. Opioid agonist treatment and patient outcomes during the COVID-19 pandemic in south east Sydney, Australia.
Drug and alcohol review.
2022 Jul; 41(5):1009-1019. doi:
10.1111/dar.13382. [PMID: 34520592] - Guillaume Drevin, Marie Briet, Severine Ferec, Chadi Abbara. Toxicity of designer benzodiazepines: A case of etizolam and cocaine intoxication.
Forensic science international.
2022 Jul; 336(?):111324. doi:
10.1016/j.forsciint.2022.111324. [PMID: 35525006] - Poorvi Shah, Kati L Stegner-Smith, Mohamad Rachid, Tabassum Hanif, Kenneth W Dodd. Front-Loaded Versus Low-Intermittent Phenobarbital Dosing for Benzodiazepine-Resistant Severe Alcohol Withdrawal Syndrome.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2022 07; 18(3):198-204. doi:
10.1007/s13181-022-00900-8. [PMID: 35668289] - Ivana Kacirova, Milan Grundmann, Hana Brozmanova. Carbamazepine and carbamazepine-epoxide concentrations in mothers, colostrum, and breastfed newborns: Comparison with concentrations determined during delivery and in the mature milk period.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Jul; 151(?):113176. doi:
10.1016/j.biopha.2022.113176. [PMID: 35623166] - Mohamed Ismail, Thomas Straubinger, Hiroyuki Uchida, Ariel Graff-Guerrero, Shinichiro Nakajima, Takefumi Suzuki, Fernando Caravaggio, Philip Gerretsen, David Mamo, Benoit H Mulsant, Bruce G Pollock, Robert Bies. MAP Bayesian modelling combining striatal dopamine receptor occupancy and plasma concentrations to optimize antipsychotic dose regimens in individual patients.
British journal of clinical pharmacology.
2022 07; 88(7):3341-3350. doi:
10.1111/bcp.15260. [PMID: 35112390] - Koushik Kasanagottu, Shoshana J Herzig. Opioids, benzodiazepines, and COVID-19: A recipe for risk.
Journal of hospital medicine.
2022 Jul; 17(7):580-581. doi:
10.1002/jhm.12889. [PMID: 35700321] - Arnim Johannes Gaebler, Michelle Finner-Prével, Sarah Lammertz, Sabrina Schaffrath, Patrick Eisner, Felix Stöhr, Erik Röcher, Lina Winkler, Peter Kaleta, Laura Lenzen, Marc Augustin, Jana Hovancakova, Lara Schwemmer, Eva Stormanns, Fatih Keskin, Frederik Hendricks, Michael Paulzen, Gerhard Gründer, Frank Schneider, Klaus Mathiak. The negative impact of vitamin D on antipsychotic drug exposure may counteract its potential benefits in schizophrenia.
British journal of clinical pharmacology.
2022 07; 88(7):3193-3200. doi:
10.1111/bcp.15223. [PMID: 35380747] - QingLiang Wu, YiTing Hu, CuiTong Wang, Wei Wei, LanLan Gui, WuShuang Zeng, Changxiao Liu, Wei Jia, Jia Miao, Ke Lan. Reevaluate In Vitro CYP3A Index Reactions of Benzodiazepines and Steroids between Humans and Dogs.
Drug metabolism and disposition: the biological fate of chemicals.
2022 06; 50(6):741-749. doi:
10.1124/dmd.122.000864. [PMID: 35351776] - Nancy Zaki, Vlasios Brakoulias. The impact of COVID-19 on benzodiazepine usage in psychiatric inpatient units.
Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists.
2022 06; 30(3):334-337. doi:
10.1177/10398562211059090. [PMID: 35144489] - Alexander Ferro Uriguen, Esther Laso Lucas, Cinzia Sannino Menicucci, Izaskun Iturrioz Arrechea, Javier Alaba Trueba, Enrique Echevarría Orella, Javier Gil Goikouria, Idoia Beobide Telleria. Psychotropic Drug Prescription in Nursing Homes During the COVID-19 Pandemic.
Drugs & aging.
2022 Jun; 39(6):467-475. doi:
10.1007/s40266-022-00948-9. [PMID: 35726042] - Meiyun Shi, Xinyue Zheng, Di Lu, Xujian Duan, Yongqi Wang, Yajun Liu, Hongyu Xue, Lei Yin. Ultrafast and high-throughput quantitative analysis of carbamazepine in human plasma by direct analysis in real time tandem mass spectrometry coupled with solid phase extraction to eliminate matrix effects.
Journal of pharmaceutical and biomedical analysis.
2022 May; 214(?):114751. doi:
10.1016/j.jpba.2022.114751. [PMID: 35398614] - Jose de Leon. Precision psychiatry: The complexity of personalizing antipsychotic dosing.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2022 05; 58(?):80-85. doi:
10.1016/j.euroneuro.2022.03.001. [PMID: 35314415] - Omid Azimaraghi, Karuna Wongtangman, Luca J Wachtendorf, Peter Santer, Sandra Rumyantsev, Curie Ahn, Michael E Kiyatkin, Bijan Teja, Todd Sarge, Balachundhar Subramaniam, Matthias Eikermann. Differential Effects of Gamma-Aminobutyric Acidergic Sedatives on Risk of Post-Extubation Delirium in the ICU: A Retrospective Cohort Study From a New England Health Care Network.
Critical care medicine.
2022 05; 50(5):e434-e444. doi:
10.1097/ccm.0000000000005425. [PMID: 34982739] - Avery E Michienzi, Heather A Borek. Emerging Agents of Substance Use/Misuse.
Emergency medicine clinics of North America.
2022 May; 40(2):265-281. doi:
10.1016/j.emc.2022.01.001. [PMID: 35461623] - Jeneva M Garland, Jason D Hull, Chantel L Bender, Lucas Marshall, Andrew C Holt. Evidence of Designer Benzodiazepine Use in Routine Healthcare Urine Drug Specimens.
Journal of addiction medicine.
2022 May; 16(3):354-356. doi:
10.1097/adm.0000000000000884. [PMID: 34172626] - Raka Jain, Siddharth Sarkar, Nizamuddin Saifi, Shayani Ghosh. Urinalysis based assessment of compliance and drug use patterns in patients prescribed tramadol: A cross-sectional study from a tertiary care centre.
Asian journal of psychiatry.
2022 May; 71(?):103080. doi:
10.1016/j.ajp.2022.103080. [PMID: 35305452] - Junbao Zhang, Xin Wang, Qing Zhang, Zicheng Wang, Shoufeng Zhu. Application effects of remimazolam and propofol on elderly patients undergoing hip replacement.
BMC anesthesiology.
2022 04; 22(1):118. doi:
10.1186/s12871-022-01641-5. [PMID: 35461223] - Jennifer Fontaine, Evelyn Chin, Jean-François Provencher, Anthony Rainone, Dana Wazzan, Carmella Roy, Soham Rej, Marie Lordkipanidze, Vincent Dagenais-Beaulé. Assessing cardiometabolic parameter monitoring in inpatients taking a second-generation antipsychotic: The CAMI-SGA study - a cross-sectional study.
BMJ open.
2022 04; 12(4):e055454. doi:
10.1136/bmjopen-2021-055454. [PMID: 35414553] - Georgios Schoretsanitis, Céline Dubath, Claire Grosu, Marianna Piras, Nermine Laaboub, Setareh Ranjbar, Nicolas Ansermot, Séverine Crettol, Frederik Vandenberghe, Franziska Gamma, Armin von Gunten, Kerstin Jessica Plessen, Erich Seifritz, Philippe Conus, Chin B Eap. Olanzapine-associated dose-dependent alterations for weight and metabolic parameters in a prospective cohort.
Basic & clinical pharmacology & toxicology.
2022 Apr; 130(4):531-541. doi:
10.1111/bcpt.13715. [PMID: 35150056] - Eleftherios Mellos, Thomas Paparrigopoulos. Substance use during the COVID-19 pandemic: What is really happening?.
Psychiatrike = Psychiatriki.
2022 Mar; 33(1):17-20. doi:
10.22365/jpsych.2022.072. [PMID: 35255473] - Noelia Caballero-Casero, Libargachew D Mihretu, Soledad Rubio. Interference-Free Method for Determination of Benzodiazepines in Urine Based on Restricted-Access Supramolecular Solvents and LC-MS-MS.
Journal of analytical toxicology.
2022 Mar; 46(3):285-294. doi:
10.1093/jat/bkab023. [PMID: 33674823] - Ye Yang, Peng Xie, Yujun Long, Jing Huang, Jingmei Xiao, Jingping Zhao, Weihua Yue, Renrong Wu. Previous exposure to antipsychotic drug treatment is an effective predictor of metabolic disturbances experienced with current antipsychotic drug treatments.
BMC psychiatry.
2022 03; 22(1):210. doi:
10.1186/s12888-022-03853-y. [PMID: 35313842] - Sophie Cousin, Jean-Yves Blay, Irene Braña Garcia, Johann S de Bono, Christophe Le Tourneau, Victor Moreno, Jose Trigo, Christine L Hann, Arun A Azad, Seock-Ah Im, Philippe A Cassier, Christopher A French, Antoine Italiano, Vicki L Keedy, Ruth Plummer, Marie-Paule Sablin, Matthew L Hemming, Geraldine Ferron-Brady, Anastasia Wyce, Ahmed Khaled, Antara Datta, Shawn W Foley, Michael T McCabe, Yuehui Wu, Thierry Horner, Brandon E Kremer, Arindam Dhar, Peter J O'Dwyer, Geoffrey I Shapiro, Sarina A Piha-Paul. Safety, pharmacokinetic, pharmacodynamic and clinical activity of molibresib for the treatment of nuclear protein in testis carcinoma and other cancers: Results of a Phase I/II open-label, dose escalation study.
International journal of cancer.
2022 03; 150(6):993-1006. doi:
10.1002/ijc.33861. [PMID: 34724226] - Danielle Harmatz, Shlomo Vinker, Talia Wagner, Tal Raveh, Eugene Merzon, Avivit Golan Cohen. The efficacy of single pharmacist medication review among type II diabetic patients who take six chronic medications or more: a case-control study.
Israel journal of health policy research.
2022 03; 11(1):15. doi:
10.1186/s13584-022-00513-0. [PMID: 35241170] - Cintia R Prokopez, Romina Farinola, Miguel Vallejos, Lorena S Lopredo, Luciano E Sfriso, Luciana C Chiapella, Claudio Arce, Ricardo M Corral, Manuel J Cuesta, Martín Alomo. Olanzapine, risperidone and quetiapine: Do these atypical antipsychotics have a protective effect for SARS-CoV-2?.
Schizophrenia research.
2022 03; 241(?):140-141. doi:
10.1016/j.schres.2022.01.035. [PMID: 35123336] - Linda Peng, David Lawrence, Ximena A Levander. Challenges of Diagnosing and Managing Designer Benzodiazepine Dependence and Withdrawal: A Case Report.
Journal of addiction medicine.
2022 Mar; 16(2):249-251. doi:
10.1097/adm.0000000000000869. [PMID: 34001772] - S Echater, M Hasnaoui, W El Bouchali, F Elghazouani. [Acute cholestatic hepatitis associated with olanzapine in a patient with bipolar disorder].
Revue medicale de Liege.
2022 Feb; 77(2):80-84. doi:
NULL. [PMID: 35143126] - Zhixia Lu, Na Zhou, Yan Li, Li Yang, Wei Hao. Up-down determination of the 90\% effective dose (ED90) of remimazolam besylate for anesthesia induction.
Annals of palliative medicine.
2022 Feb; 11(2):568-573. doi:
10.21037/apm-22-89. [PMID: 35249335] - Sunjeev Uthayakumar, Mina Tadrous, Simone N Vigod, Sophie A Kitchen, Tara Gomes. The effects of COVID-19 on the dispensing rates of antidepressants and benzodiazepines in Canada.
Depression and anxiety.
2022 02; 39(2):156-162. doi:
10.1002/da.23228. [PMID: 34843627] - Jeremy D Furtado, Giacomo Ruotolo, Stephen J Nicholls, Robert Dullea, Santos Carvajal-Gonzalez, Frank M Sacks. Pharmacological Inhibition of CETP (Cholesteryl Ester Transfer Protein) Increases HDL (High-Density Lipoprotein) That Contains ApoC3 and Other HDL Subspecies Associated With Higher Risk of Coronary Heart Disease.
Arteriosclerosis, thrombosis, and vascular biology.
2022 02; 42(2):227-237. doi:
10.1161/atvbaha.121.317181. [PMID: 34937388] - André Niebel, Fritz Pragst, Franziska Krumbiegel, Sven Hartwig. Prevalence of cathinones and other new psychoactive substances in hair of parents and children of families with known or suspected parental abuse of conventional illegal drugs.
Forensic science international.
2022 Feb; 331(?):111148. doi:
10.1016/j.forsciint.2021.111148. [PMID: 34923263] - Meirambek Ospanov, Suresh P Sulochana, Jason J Paris, John M Rimoldi, Nicole Ashpole, Larry Walker, Samir A Ross, Abbas G Shilabin, Mohamed A Ibrahim. Identification of an Orally Bioavailable, Brain-Penetrant Compound with Selectivity for the Cannabinoid Type 2 Receptor.
Molecules (Basel, Switzerland).
2022 Jan; 27(2):. doi:
10.3390/molecules27020509. [PMID: 35056824] - Anna Basińska-Szafrańska. Delayed crises following benzodiazepine withdrawal: deficient adaptive mechanisms or simple pharmacokinetics? Detoxification assisted by serum-benzodiazepine elimination tracking.
European journal of clinical pharmacology.
2022 Jan; 78(1):101-110. doi:
10.1007/s00228-021-03205-x. [PMID: 34515812] - Beatriz Oda Plasencia-García, María Isabel Rico-Rangel, Gonzalo Rodríguez-Menéndez, Ana Rubio-García, Jaime Torelló-Iserte, Benedicto Crespo-Facorro. Drug-drug Interactions between COVID-19 Treatments and Antidepressants, Mood Stabilizers/Anticonvulsants, and Benzodiazepines: Integrated Evidence from 3 Databases.
Pharmacopsychiatry.
2022 Jan; 55(1):40-47. doi:
10.1055/a-1492-3293. [PMID: 34171927] - Gia Melikishvili, Thierry Bienvenu, Nazhi Tabatadze, Tamar Gachechiladze, Ekaterine Kurua, Sopio Gverdtsiteli, Mariam Melikishvili, Olivier Dulac. Novel UBE3A pathogenic variant in a large Georgian family produces non-convulsive status epilepticus responsive to ketogenic diet.
Seizure.
2022 Jan; 94(?):70-73. doi:
10.1016/j.seizure.2021.11.012. [PMID: 34872019] - Su Ying Yeoh, Emmert Roberts, Fraser Scott, Timothy R Nicholson, Anthony S David, Jonathan P Rogers. Catatonic Episodes Related to Substance Use: A Cross-Sectional Study Using Electronic Healthcare Records.
Journal of dual diagnosis.
2022 Jan; 18(1):52-58. doi:
10.1080/15504263.2021.2016342. [PMID: 35001837] - Helen H Ha, Dani C Mata. Flualprazolam distribution in postmortem samples.
Journal of forensic sciences.
2022 Jan; 67(1):297-308. doi:
10.1111/1556-4029.14893. [PMID: 34585411] - Mark Haden, Josephine Cashman, Andrew Ketchin, Rebecca Macfarlane, Shabana Issa, Michael Eddleston, Selina Hines, Simon Hudson, Simon L Hill, Simon H L Thomas. Detection of flubromazolam in patients with suspected non-medical drug use attending emergency departments in the United Kingdom.
Clinical toxicology (Philadelphia, Pa.).
2022 Jan; 60(1):33-37. doi:
10.1080/15563650.2021.1931692. [PMID: 34080515] - K Skov, S S Johansen, K Linnet, M K K Nielsen. A review on the forensic toxicology of global drug-facilitated sexual assaults.
European review for medical and pharmacological sciences.
2022 Jan; 26(1):183-197. doi:
10.26355/eurrev_202201_27767. [PMID: 35048994] - Yoko Shimamoto, Michiyoshi Sanuki, Shigeaki Kurita, Masaya Ueki, Yoshie Kuwahara, Ayumu Matsumoto. Factors affecting prolonged time to extubation in patients given remimazolam.
PloS one.
2022; 17(5):e0268568. doi:
10.1371/journal.pone.0268568. [PMID: 35584094] - Daniel Sykora, Cynthia M Stonnington, Neeta Jain. An Agitated Patient With COVID-19 Infection and Early-onset Alzheimer Disease.
Alzheimer disease and associated disorders.
2022 Jan; 36(1):83-84. doi:
10.1097/wad.0000000000000456. [PMID: 33973880] - Yulin Zhu, Chen Li, Jingui Yu, Lingzhi Yu, Wei Shao, Shujun Shang. Interaction of remimazolam benzenesulfonate and human serum albumin: a simulated physiological study.
Luminescence : the journal of biological and chemical luminescence.
2022 Jan; 37(1):51-57. doi:
10.1002/bio.4145. [PMID: 34610201] - Rui Zhang, Esrat Jahan Rupa, Siwen Zheng, Jinnatun Nahar, Deok Chun Yang, Se Chan Kang, Yingping Wang. Panos-Fermented Extract-Mediated Nanoemulsion: Preparation, Characterization, and In Vitro Anti-Inflammatory Effects on RAW 264.7 Cells.
Molecules (Basel, Switzerland).
2021 Dec; 27(1):. doi:
10.3390/molecules27010218. [PMID: 35011448] - Brian Rossi, Francesca Freni, Claudia Vignali, Cristiana Stramesi, Giancarlo Collo, Claudia Carelli, Matteo Moretti, Dario Galatone, Luca Morini. Comparison of Two Immunoassay Screening Methods and a LC-MS/MS in Detecting Traditional and Designer Benzodiazepines in Urine.
Molecules (Basel, Switzerland).
2021 Dec; 27(1):. doi:
10.3390/molecules27010112. [PMID: 35011344] - Yuta Horikoshi, Norifumi Kuratani, Ken Tateno, Hiroshi Hoshijima, Tina Nakamura, Tsutomu Mieda, Katsushi Doi, Hiroshi Nagasaka. Anesthetic management with remimazolam for a pediatric patient with Duchenne muscular dystrophy.
Medicine.
2021 Dec; 100(49):e28209. doi:
10.1097/md.0000000000028209. [PMID: 34889305] - Constanza de Dios, Brisa S Fernandes, Kristine Whalen, Shruti Bandewar, Robert Suchting, Michael F Weaver, Sudhakar Selvaraj. Prescription fill patterns for benzodiazepine and opioid drugs during the COVID-19 pandemic in the United States.
Drug and alcohol dependence.
2021 12; 229(Pt A):109176. doi:
10.1016/j.drugalcdep.2021.109176. [PMID: 34808468] - David Frank. 'I'm pretty sure it's either food poisoning or Covid-19': Lived experience versus medical knowledge in diagnosing substance use problems.
The International journal on drug policy.
2021 12; 98(?):103348. doi:
10.1016/j.drugpo.2021.103348. [PMID: 34183237] - Lea Wagmann, Sascha K Manier, Christina Felske, Tanja M Gampfer, Matthias J Richter, Niels Eckstein, Markus R Meyer. Flubromazolam-Derived Designer Benzodiazepines: Toxicokinetics and Analytical Toxicology of Clobromazolam and Bromazolam.
Journal of analytical toxicology.
2021 Nov; 45(9):1014-1027. doi:
10.1093/jat/bkaa161. [PMID: 33048135] - Justin Jek-Kahn Koh, Madeline Malczewska, Mary M Doyle-Waters, Jessica Moe. Prevention of alcohol withdrawal seizure recurrence and treatment of other alcohol withdrawal symptoms in the emergency department: a rapid review.
BMC emergency medicine.
2021 11; 21(1):131. doi:
10.1186/s12873-021-00524-1. [PMID: 34742248] - M S Zastrozhin, A V Efimova, VYu Skryabin, V V Smirnov, A E Petukhov, E P Pankratenko, S A Pozdniakov, E V Kaverina, D A Klepikov, E A Grishina, K A Ryzhikova, I V Bure, E A Bryun, D A Sychev. Influence of Plasma Concentration of Hsa-Mir-370-3p and Cyp2d6*4 On Equilibrium Concentration of Phenazepam in Patients with Recurrent Depressive Disorder.
Psychopharmacology bulletin.
2021 11; 51(4):87-104. doi:
NULL. [PMID: 34887601] - Kaushal Shah, Dhwani Kamrai, Sushma Srinivas, Nikhila Veluri, Gaurav Chaudhari, Chintan Trivedi, Zeeshan Mansuri. Benzodiazepine Interaction With COVID-19 Drugs.
The primary care companion for CNS disorders.
2021 10; 23(6):. doi:
10.4088/pcc.21br03081. [PMID: 34710952] - Duygu Eryavuz Onmaz, Sedat Abusoglu, Bahadir Ozturk, Gulsum Abusoglu, Fatma Humeyra Yerlikaya, Ali Unlu. Determination of serum carbamazepine and its metabolite by validated tandem mass spectrometric method and the effect of carbamazepine on various hematological and biochemical parameters.
Journal of pharmaceutical and biomedical analysis.
2021 Oct; 205(?):114299. doi:
10.1016/j.jpba.2021.114299. [PMID: 34388672] - Betty S Chan, Alexander Kiss, Nathan McIntosh, Vicky Sheppeard, Andrew H Dawson. E-cigarette or vaping product use-associated lung injury in an adolescent.
The Medical journal of Australia.
2021 Oct; 215(7):313-314.e1. doi:
10.5694/mja2.51244. [PMID: 34490629] - Sadaf Arefi Milani, Mukaila A Raji, Lu Chen, Yong-Fang Kuo. Trends in the Use of Benzodiazepines, Z-Hypnotics, and Serotonergic Drugs Among US Women and Men Before and During the COVID-19 Pandemic.
JAMA network open.
2021 10; 4(10):e2131012. doi:
10.1001/jamanetworkopen.2021.31012. [PMID: 34694388] - Tianxiao Liu, Ting Lai, Jing Chen, Yizhi Lu, Fang He, Yanhua Chen, Yubo Xie. Effect of remimazolam induction on hemodynamics in patients undergoing valve replacement surgery: A randomized, double-blind, controlled trial.
Pharmacology research & perspectives.
2021 10; 9(5):e00851. doi:
10.1002/prp2.851. [PMID: 34390228] - Amand F Schmidt, Nicholas B Hunt, Maria Gordillo-Marañón, Pimphen Charoen, Fotios Drenos, Mika Kivimaki, Deborah A Lawlor, Claudia Giambartolomei, Olia Papacosta, Nishi Chaturvedi, Joshua C Bis, Christopher J O'Donnell, Goya Wannamethee, Andrew Wong, Jackie F Price, Alun D Hughes, Tom R Gaunt, Nora Franceschini, Dennis O Mook-Kanamori, Magdalena Zwierzyna, Reecha Sofat, Aroon D Hingorani, Chris Finan. Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular disease.
Nature communications.
2021 09; 12(1):5640. doi:
10.1038/s41467-021-25703-3. [PMID: 34561430] - Ulrich Baumann, Ekkehard Sturm, Florence Lacaille, Emmanuel Gonzalès, Henrik Arnell, Björn Fischler, Marianne Hørby Jørgensen, Richard J Thompson, Jan P Mattsson, Mats Ekelund, Erik Lindström, Per-Göran Gillberg, Kristina Torfgård, Paresh N Soni. Effects of odevixibat on pruritus and bile acids in children with cholestatic liver disease: Phase 2 study.
Clinics and research in hepatology and gastroenterology.
2021 09; 45(5):101751. doi:
10.1016/j.clinre.2021.101751. [PMID: 34182185] - Thomas Stöhr, Pieter J Colin, Joachim Ossig, Marija Pesic, Keith Borkett, Peter Winkle, Michel M R F Struys, Frank Schippers. Pharmacokinetic properties of remimazolam in subjects with hepatic or renal impairment.
British journal of anaesthesia.
2021 Sep; 127(3):415-423. doi:
10.1016/j.bja.2021.05.027. [PMID: 34246461] - Joana Erdmann, Bjoern Moosmann. Cross reactivity of the CEDIA and HEIA benzodiazepine kits for 29 designer benzodiazepines and tofisopam.
Drug testing and analysis.
2021 Sep; 13(9):1686-1688. doi:
10.1002/dta.3111. [PMID: 34139790] - E Martínez-Pías, D García-Azorín, J Trigo-López, B Talavera, G Valle, I Hernández, P Simón, J F Arenillas-Lara. [Effect of treatment with benzodiazepines on the hospital prognosis of Coronavirus disease 2019].
Revista de neurologia.
2021 09; 73(6):201-209. doi:
10.33588/rn.7306.2021028. [PMID: 34515333] - Hannah Lee, Seongmi Choi, Eun Jin Jang, Juhee Lee, Dalho Kim, Seokha Yoo, Seung-Young Oh, Ho Geol Ryu. Effect of Sedatives on In-hospital and Long-term Mortality of Critically Ill Patients Requiring Extended Mechanical Ventilation for ≥ 48 Hours.
Journal of Korean medical science.
2021 Aug; 36(34):e221. doi:
10.3346/jkms.2021.36.e221. [PMID: 34463064] - Li Du, Shaonan Xu, Han Wu, Tengwen Zhao, Xuesheng Wang, Manman Wang. Facile Fabrication of Diatomite-Supported ZIF-8 Composite for Solid-Phase Extraction of Benzodiazepines in Urine Samples Prior to High-Performance Liquid Chromatography.
Molecules (Basel, Switzerland).
2021 Aug; 26(17):. doi:
10.3390/molecules26175209. [PMID: 34500641] - Michael A Campitelli, Susan E Bronskill, Laura C Maclagan, Daniel A Harris, Cecilia A Cotton, Mina Tadrous, Andrea Gruneir, David B Hogan, Colleen J Maxwell. Comparison of Medication Prescribing Before and After the COVID-19 Pandemic Among Nursing Home Residents in Ontario, Canada.
JAMA network open.
2021 08; 4(8):e2118441. doi:
10.1001/jamanetworkopen.2021.18441. [PMID: 34338794] - Yin-To Liao, Yu-Hui Ku, Hong-Ming Chen, Mong-Liang Lu, Ko-Jung Chen, Yao-Hsu Yang, Jun-Cheng Weng, Vincent Chin-Hung Chen. Effect of medication on risk of traumatic brain injury in patients with bipolar disorder: A nationwide population-based cohort study.
Journal of psychopharmacology (Oxford, England).
2021 Aug; 35(8):962-970. doi:
10.1177/02698811211013582. [PMID: 33938294] - Jia Hong Liu, Nan Chen, Yan Hong Guo, Xiao Ni Guan, Jun Wang, Dong Wang, Mei Hong Xiu. Metabolomics-based understanding of the olanzapine-induced weight gain in female first-episode drug-naïve patients with schizophrenia.
Journal of psychiatric research.
2021 08; 140(?):409-415. doi:
10.1016/j.jpsychires.2021.06.001. [PMID: 34144444] - Kota Tsurumi, Shinji Takahashi, Yoshiyuki Hiramoto, Kazuhiro Nagumo, Tomonori Takazawa, Yoichiro Kamiyama. Remimazolam anaphylaxis during anesthesia induction.
Journal of anesthesia.
2021 08; 35(4):571-575. doi:
10.1007/s00540-021-02934-8. [PMID: 34050439] - Sam Topp, Emma Salisbury. Lithium use in a patient on haemodialysis with bipolar affective disorder and lithium-induced nephropathy.
BMJ case reports.
2021 Jul; 14(7):. doi:
10.1136/bcr-2021-242841. [PMID: 34330723] - A Di Trana, N La Maida. New Psychoactive Substances consumption and their monito- ring during Covid-19 pandemic.
La Clinica terapeutica.
2021 Jul; 172(4):271-272. doi:
10.7417/ct.2021.2330. [PMID: 34247209] - Edward Skicki, Madison Morgan, Catherine Brown, Eric Bradburn, Frederick Rogers. Benzodiazepines increase the likelihood of both infectious and thrombotic complications.
The journal of trauma and acute care surgery.
2021 07; 91(1):206-211. doi:
10.1097/ta.0000000000003134. [PMID: 34144564] - Claudia Carelli, Francesca Freni, Matteo Moretti, Claudia Vignali, Marco Ballardini, Luca Morini. A case report on fatal intoxication by tapentadol: Study of distribution and metabolism.
Forensic science international.
2021 Jul; 324(?):110825. doi:
10.1016/j.forsciint.2021.110825. [PMID: 34000617]