bemegride (BioDeep_00000176496)

   

human metabolite blood metabolite


代谢物信息卡片


4-ethyl-6-hydroxy-4-methyl-2,3,4,5-tetrahydropyridin-2-one

化学式: C8H13NO2 (155.0946238)
中文名称: 贝美格
谱图信息: 最多检出来源 Homo sapiens(blood) 2%

分子结构信息

SMILES: CCC1(C)CC(O)=NC(=O)C1
InChI: InChI=1S/C8H13NO2/c1-3-8(2)4-6(10)9-7(11)5-8/h3-5H2,1-2H3,(H,9,10,11)

描述信息

R - Respiratory system > R07 - Other respiratory system products > R07A - Other respiratory system products > R07AB - Respiratory stimulants
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants > D003292 - Convulsants
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant
D019141 - Respiratory System Agents
Bemegride (3-Ethyl-3-methylglutarimide) is a central nervous system stimulant and antidote for barbiturate poisoning[1][2].

同义名列表

8 个代谢物同义名

4-ethyl-6-hydroxy-4-methyl-2,3,4,5-tetrahydropyridin-2-one; Ethylmethylglutarimide; Methetharimide; Bemegride; Megimide; Megibal; 3-Ethyl-3-methylglutarimide; Bemegrid



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Shou-Wen Zhang, Yu-Xi Liu. Changes of serum adrenocorticotropic hormone and cortisol levels during sleep seizures. Neuroscience bulletin. 2008 Apr; 24(2):84-8. doi: 10.1007/s12264-008-0084-8. [PMID: 18369387]
  • M N Aliev, R N Rzaev, T N Mamedbeĭli, A N Aliev. [The role of lipid peroxidation in the pathogenesis of neuropathological syndromes and in experimental therapy]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 1994; 94(6):58-60. doi: ". [PMID: 7740879]
  • R Soto-Otero, E Mendez-Alvarez, G Sierra-Paredes, J Galan-Valiente, E Aguilar-Veiga, G Sierra-Marcuño. Reversed-phase high-performance liquid chromatography method for the determination of bemegride in serum and brain tissue: pharmacokinetics and brain distribution of an intraperitoneal subconvulsive dose in rats. Journal of pharmaceutical and biomedical analysis. 1991; 9(2):177-82. doi: 10.1016/0731-7085(91)80141-u. [PMID: 1873309]
  • E V Nikushkin. [Lipid peroxidation in the development of epileptic activity]. Patologicheskaia fiziologiia i eksperimental'naia terapiia. 1987 Nov; ?(6):19-24. doi: ". [PMID: 3127799]
  • E V Nikushkin, G N Kryzhanovskiĭ, I R Tupeev, M M Bordiukov, S M Iuzefova. [Blood antioxidative enzymes during epileptic activity]. Biulleten' eksperimental'noi biologii i meditsiny. 1987 Mar; 103(3):297-9. doi: ". [PMID: 3828507]
  • L N Nerobkova, T A Voronina, A N Aliev, L D Smirnov, G N Kryzhanovskiĭ. [Electrophysiological and biochemical mechanisms of the anticonvulsant action of an antioxidant of the 3-hydroxypyridine class]. Biulleten' eksperimental'noi biologii i meditsiny. 1986 Dec; 102(12):663-5. doi: ". [PMID: 3801614]
  • M M Bordiukov, G N Kryzhanovskiĭ, E V Nikushkin, E D Bogdanova, L L Prilipko. [3H-diazepam binding to brain synaptic membranes during the development of generalized epileptic activity]. Biulleten' eksperimental'noi biologii i meditsiny. 1985 Dec; 100(12):686-8. doi: ". [PMID: 3000471]
  • I R Tupeev, M M Bordiukov, G N Kryzhanovskiĭ, E V Nikushkin. [State of the antioxidant system during induction in rats of primary generalized epileptic activity]. Biulleten' eksperimental'noi biologii i meditsiny. 1985 Nov; 100(11):538-41. doi: ". [PMID: 4063495]
  • V E Braslavskiĭ, V A Shchavelev, G N Kryzhanovskiĭ, E V Nikushkin, S B Germanov. [Effect of nicotinamide on focal and generalized epileptic activity in the cerebral cortex]. Biulleten' eksperimental'noi biologii i meditsiny. 1982 Aug; 94(8):39-42. doi: ". [PMID: 6215072]
  • E V Nikushkin, V E Braslavskiĭ, G N Kryzhanovskiĭ. [Increase in the peroxidation of neuron membrane lipids, one of the pathogenetic mechanisms of epileptic activity]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952). 1981; 81(6):812-5. doi: ". [PMID: 7293577]
  • A S Jones, E James, H Bland, T Groshong. Renal failure in the newborn. Clinical pediatrics. 1979 May; 18(5):286-7, 291. doi: 10.1177/000992287901800506. [PMID: 445929]
  • O R Hommes, E J ten Berge, M J Jansen, J C Kok. Reduction of duration and severity of megimide seizures in rats on a folic acid deficient diet. Epilepsia. 1977 Dec; 18(4):425-30. doi: 10.1111/j.1528-1157.1977.tb04987.x. [PMID: 590220]
  • J Connor, T Connor, P B Marshall, A Reid, M J Turnbull. Proceedings: On the pharmacology of an extract of Avena sativa. British journal of pharmacology. 1974 Sep; 52(1):146P. doi: ". [PMID: 4451796]
  • M FRAHM, A GOTTESLEBEN, K SOEHRING. [IDENTIFICATION OF SEDATIVES IN AQUEOUS SOLUTIONS AND URINE BY THIN-LAYER CHROMATOGRAPHY]. Pharmaceutica acta Helvetiae. 1963 Nov; 38(?):785-804. doi: NULL. [PMID: 14097844]
  • T BERITIC. [ACUTE POISONING WITH HYPNOTICS AND SEDATIVES]. Lijecnicki vjesnik. 1963 Oct; 85(?):1131-9. doi: NULL. [PMID: 14097617]
  • J D GRAHAM, P J NICHOLLS. Distribution of [14C] bemegride in tissues after intravenous injection. British journal of pharmacology and chemotherapy. 1959 Mar; 14(1):35-9. doi: 10.1111/j.1476-5381.1959.tb00925.x. [PMID: 13651576]