5-O-[2-(4-Benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate (BioDeep_00000176475)
human metabolite blood metabolite
代谢物信息卡片
5-O-[2-(4-Benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylic acid
化学式: C35H38N4O6 (610.2791208000001)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 99.17%
分子结构信息
SMILES: CC1=NC(=C(C(C1C(=O)OC)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OCCN3CCN(CC3)C(C4=CC=CC=C4)C5=CC=CC=C5)C
InChI: InChI=1S/C35H38N4O6/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27/h4-16,23,30,32-33H,17-22H2,1-3H3
描述信息
同义名列表
4 个代谢物同义名
5-O-[2-(4-Benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylic acid; 3-{2-[4-(diphenylmethyl)piperazin-1-yl]ethyl} 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-4,5-dihydropyridine-3,5-dicarboxylate; 5-{2-[4-(diphenylmethyl)piperazin-1-yl]ethyl} 3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate; 5-O-[2-(4-Benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylate
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yoshihiro Uesawa, Takahiro Takeuchi, Kiminori Mohri. Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions.
Current pharmaceutical biotechnology.
2012 Jul; 13(9):1705-17. doi:
10.2174/138920112800958878. [PMID: 22039822] - P Vejakama, A Thakkinstian, D Lertrattananon, A Ingsathit, C Ngarmukos, J Attia. Reno-protective effects of renin-angiotensin system blockade in type 2 diabetic patients: a systematic review and network meta-analysis.
Diabetologia.
2012 Mar; 55(3):566-78. doi:
10.1007/s00125-011-2398-8. [PMID: 22189484] - María Paz Ocaranza, Jorge E Jalil. Protective Role of the ACE2/Ang-(1-9) Axis in Cardiovascular Remodeling.
International journal of hypertension.
2012; 2012(?):594361. doi:
10.1155/2012/594361. [PMID: 22315665] - Piero Ruggenenti, Giuseppe Lauria, Ilian Petrov Iliev, Anna Fassi, Aneliya Parvanova Ilieva, Stefano Rota, Carlos Chiurchiu, Drazenka Pongrac Barlovic, Angelo Sghirlanzoni, Raffaella Lombardi, Paola Penza, Guido Cavaletti, Maria Luisa Piatti, Barbara Frigeni, Marco Filipponi, Nadia Rubis, Greta Noris, Nicola Motterlini, Bogdan Ene-Iordache, Flavio Gaspari, Annalisa Perna, Jelka Zaletel, Antonio Bossi, Alessandro Roberto Dodesini, Roberto Trevisan, Giuseppe Remuzzi. Effects of manidipine and delapril in hypertensive patients with type 2 diabetes mellitus: the delapril and manidipine for nephroprotection in diabetes (DEMAND) randomized clinical trial.
Hypertension (Dallas, Tex. : 1979).
2011 Nov; 58(5):776-83. doi:
10.1161/hypertensionaha.111.174474. [PMID: 21931073] - Alessandro Inno, Michele Basso, Fabio M Vecchio, Valentina A Marsico, Eleonora Cerchiaro, Ettore D'Argento, Cinzia Bagalà, Carlo Barone. Anastrozole-related acute hepatitis with autoimmune features: a case report.
BMC gastroenterology.
2011 Mar; 11(?):32. doi:
10.1186/1471-230x-11-32. [PMID: 21453541] - Nieves Martell-Claros, Juan Jose de la Cruz. Manidipine for hypertension not controlled by dual therapy in patients with diabetes mellitus: a non-comparative, open-label study.
Clinical drug investigation.
2011; 31(6):427-34. doi:
10.2165/11587400-000000000-00000. [PMID: 21528940] - Francisco J Martinez-Martin, Alicia Macias-Batista, Cristina Comi-Diaz, Herminia Rodriguez-Rosas, Paula Soriano-Perera, Pablo Pedrianes-Martin. Effects of manidipine and its combination with an ACE inhibitor on insulin sensitivity and metabolic, inflammatory and prothrombotic markers in hypertensive patients with metabolic syndrome: the MARCADOR study.
Clinical drug investigation.
2011; 31(3):201-12. doi:
10.2165/11587590-000000000-00000. [PMID: 21155616] - M C Viñolo López, P C Gutiérrez Rivas, A Liébana Cañada, J M Gil Cunquero, E Merino García. Clinical case: Peritoneal dialysis patient with cloudy peritoneal fluid following administration of calcium antagonists.
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.
2011; 31(5):624. doi:
10.3265/nefrologia.pre2011.jun.10968. [PMID: 21959742] - J Zaletel, D Pongrac Barlovic, J Prezelj. Adiponectin-leptin ratio: a useful estimate of insulin resistance in patients with Type 2 diabetes.
Journal of endocrinological investigation.
2010 Sep; 33(8):514-8. doi:
10.1007/bf03346639. [PMID: 20142631] - Tatsuya Kondo, Rieko Goto, Kazuhiro Sonoda, Takeomi Yasuda, Kaoru Ono, Yuki Takaki, Riichiro Yatsuda, Nobuhiro Miyamura, Eiichi Araki. Plasma renin activity and aldosterone concentration are not altered by the novel calcium channel antagonist, azelnidipine, in hypertensive patients.
Internal medicine (Tokyo, Japan).
2010; 49(7):637-43. doi:
10.2169/internalmedicine.49.2749. [PMID: 20371952] - Francisco Javier Martínez Martín. Manidipine in hypertensive patients with metabolic syndrome: the MARIMBA study.
Expert review of cardiovascular therapy.
2009 Jul; 7(7):863-9. doi:
10.1586/erc.09.53. [PMID: 19589122] - Adebowale Adeyemo, Norman Gerry, Guanjie Chen, Alan Herbert, Ayo Doumatey, Hanxia Huang, Jie Zhou, Kerrie Lashley, Yuanxiu Chen, Michael Christman, Charles Rotimi. A genome-wide association study of hypertension and blood pressure in African Americans.
PLoS genetics.
2009 Jul; 5(7):e1000564. doi:
10.1371/journal.pgen.1000564. [PMID: 19609347] - Osvaldo Kohlmann, Alejandro Roca-Cusachs, Stéphane Laurent, Roland E Schmieder, René R Wenzel, Roberto Fogari. Fixed-dose manidipine/delapril versus losartan/hydrochlorothiazide in hypertensive patients with type 2 diabetes and microalbuminuria.
Advances in therapy.
2009 Mar; 26(3):313-24. doi:
10.1007/s12325-009-0015-8. [PMID: 19330493] - Luca Cavalieri, Giovanni Cremonesi. Metabolic effects of manidipine.
American journal of cardiovascular drugs : drugs, devices, and other interventions.
2009; 9(3):163-76. doi:
10.1007/bf03256573. [PMID: 19463022] - Giuseppe Rossoni, Barbara Manfredi, Maurizio Civelli, Ferruccio Berti, Roberta Razzetti. Combined simvastatin-manidipine protect against ischemia-reperfusion injury in isolated hearts from normocholesterolemic rats.
European journal of pharmacology.
2008 Jun; 587(1-3):224-30. doi:
10.1016/j.ejphar.2008.03.026. [PMID: 18442813] - Yoshihiro Uesawa, Kiminori Mohri. Relationship between lipophilicities of 1,4-dihydropyridine derivatives and pharmacokinetic interaction strengths with grapefruit juice.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2008 Jan; 128(1):117-22. doi:
10.1248/yakushi.128.117. [PMID: 18176062] - Roberto Fogari, Giuseppe Derosa, Annalisa Zoppi, Pierangelo Lazzari, Luca Corradi, Paola Preti, Amedeo Mugellini. Effect of delapril/manidipine vs olmesartan/ hydrochlorothiazide combination on insulin sensitivity and fibrinogen in obese hypertensive patients.
Internal medicine (Tokyo, Japan).
2008; 47(5):361-6. doi:
10.2169/internalmedicine.47.0449. [PMID: 18310964] - Roberto Fogari, Giuseppe Derosa, Annalisa Zoppi, Andrea Rinaldi, Paola Preti, Pierangelo Lazzari, Amedeo Mugellini. Effects of manidipine/delapril versus olmesartan/hydrochlorothiazide combination therapy in elderly hypertensive patients with type 2 diabetes mellitus.
Hypertension research : official journal of the Japanese Society of Hypertension.
2008 Jan; 31(1):43-50. doi:
10.1291/hypres.31.43. [PMID: 18360017] - Nicolás Roberto Robles. Calcium antagonists and renal failure progression.
Renal failure.
2008; 30(3):247-55. doi:
10.1080/08860220701856946. [PMID: 18350443] - Roberto Fogari, Luca Corradi, Annalisa Zoppi, Pierangelo Lazzari, Amedeo Mugellini, Paola Preti, Andrea Rinaldi. Addition of manidipine improves the antiproteinuric effect of candesartan in hypertensive patients with type II diabetes and microalbuminuria.
American journal of hypertension.
2007 Oct; 20(10):1092-6. doi:
10.1016/j.amjhyper.2007.05.012. [PMID: 17903693] - Jing Jing, Weichao Ren, Xijing Chen, Hui He, Wei Zhou, Xuping Zhu, Ya Sun, Guangji Wang. Determination and pharmacokinetics of manidipine in human plasma by HPLC/ESIMS.
Biomedical chromatography : BMC.
2007 Aug; 21(8):836-40. doi:
10.1002/bmc.827. [PMID: 17428020] - Tsukasa Uno, Tadashi Ohkubo, Shigeru Motomura, Kazunobu Sugawara. Effect of grapefruit juice on the disposition of manidipine enantiomers in healthy subjects.
British journal of clinical pharmacology.
2006 May; 61(5):533-7. doi:
10.1111/j.1365-2125.2006.02583.x. [PMID: 16669846] - Sylvain Richard. Vascular effects of calcium channel antagonists: new evidence.
Drugs.
2005; 65 Suppl 2(?):1-10. doi:
10.2165/00003495-200565002-00002. [PMID: 16398057] - René R Wenzel. Renal protection in hypertensive patients: selection of antihypertensive therapy.
Drugs.
2005; 65 Suppl 2(?):29-39. doi:
10.2165/00003495-200565002-00005. [PMID: 16398060] - Alex Roca-Cusachs, Filippos Triposkiadis. Antihypertensive effect of manidipine.
Drugs.
2005; 65 Suppl 2(?):11-9. doi:
10.2165/00003495-200565002-00003. [PMID: 16398058] - A Mugellini, P Preti, A Zoppi, L Corradi, E Fogari, G Derosa, R Fogari. Effect of delapril-manidipine combination vs irbesartan-hydrochlorothiazide combination on fibrinolytic function in hypertensive patients with type II diabetes mellitus.
Journal of human hypertension.
2004 Oct; 18(10):687-91. doi:
10.1038/sj.jhh.1001726. [PMID: 15071488] - Hiroshi Yamanari, Kazufumi Nakamura, Mikio Kakishita, Tohru Ohe. Effects of cyclooxygenase inhibition on endothelial function in hypertensive patients treated with angiotensin-converting enzyme inhibitors.
Clinical cardiology.
2004 Sep; 27(9):523-7. doi:
10.1002/clc.4960270911. [PMID: 15471166] - Hajime Ueshiba, Yukitaka Miyachi. Effects of the long-acting calcium channel blockers, amlodipine, manidipine and cilnidipine on steroid hormones and insulin resistance in hypertensive obese patients.
Internal medicine (Tokyo, Japan).
2004 Jul; 43(7):561-5. doi:
10.2169/internalmedicine.43.561. [PMID: 15335180] - Lucia Del Vecchio, Marco Pozzi, Antonio Salvetti, Giuseppe Maschio, Maurizio Fusaroli, Carlo Rovati, Francesco Antonucci, Carmelo Cascone, Flavio Scanferla, Vincenzo Panichi, Alessandra Sturani, Francesco Locatelli. Efficacy and tolerability of manidipine in the treatment of hypertension in patients with non-diabetic chronic kidney disease without glomerular disease. Prospective, randomized, double-blind study of parallel groups in comparison with enalapril.
Journal of nephrology.
2004 Mar; 17(2):261-9. doi:
NULL. [PMID: 15293527] - Guido Bellinghieri, Giampiero Mazzaglia, Vincenzo Savica, Domenico Santoro. Effects of manidipine and nifedipine on blood pressure and renal function in patients with chronic renal failure: a multicenter randomized controlled trial.
Renal failure.
2003 Sep; 25(5):681-9. doi:
10.1081/jdi-120024284. [PMID: 14575277] - Koichi Hayashi, Yuri Ozawa, Keiji Fujiwara, Shu Wakino, Hiroo Kumagai, Takao Saruta. Role of actions of calcium antagonists on efferent arterioles--with special references to glomerular hypertension.
American journal of nephrology.
2003 Jul; 23(4):229-44. doi:
10.1159/000072054. [PMID: 12840599] - Armel Stockis, Steven De Bruyn, Christophe Gengler, Fabienne Goethals, Simone Lens, Gianluigi Poli, Daniela Acerbi. Pharmacokinetics and tolerability of a new manidipine and delapril fixed oral combination in young and elderly subjects.
Arzneimittel-Forschung.
2003; 53(8):554-61. doi:
10.1055/s-0031-1297149. [PMID: 13677245] - Armel Stockis, Christophe Gengler, Fabienne Goethals, Bernard Jeanbaptiste, Simone Lens, Gianluigi Poli, Daniela Acerbi. Single oral dose pharmacokinetic interaction study of manidipine and delapril in healthy volunteers.
Arzneimittel-Forschung.
2003; 53(9):627-34. doi:
10.1055/s-0031-1297159. [PMID: 14558436] - Shuji Hirano, Takuroh Imamura, Hisamitsu Onitsuka, Takeshi Matsuo, Kazuo Kitamura, Yasushi Koiwaya, Tanenao Eto. Rapid increase in cardiac adrenomedullin gene expression caused by acute pressure overload: effect of the renin-angiotensin system on gene expression.
Circulation journal : official journal of the Japanese Circulation Society.
2002 Apr; 66(4):397-402. doi:
10.1253/circj.66.397. [PMID: 11954957] - Maurizio Sabbatini, Amedeo Leonardi, Rodolfo Testa, Daniele Tomassoni, Lucia Vitaioli, Francesco Amenta. Effects of dihydropyridine-type Ca2+ antagonists on the renal arterial tree in spontaneously hypertensive rats.
Journal of cardiovascular pharmacology.
2002 Jan; 39(1):39-48. doi:
10.1097/00005344-200201000-00005. [PMID: 11743226] - O Kohlmann, A B Ribeiro. [Manidipine in the treatment of stage I and II essential hypertension patients with overweight or android obesity. A Brazilian multicentre study of efficacy, tolerability and metabolic effects].
Arquivos brasileiros de cardiologia.
2001 Nov; 77(5):463-70. doi:
NULL. [PMID: 11733819] - A Ohtahara, I Hisatome, Y Yamamoto, M Furuse, K Sonoyama, Y Furuse, T Hamada, M Katoh, M Watanabe, T Kinugawa, K Ogino, O Igawa, T Shimomura, F Murakami, T Yamamoto, C Shigemasa. The release of the substrate for xanthine oxidase in hypertensive patients was suppressed by angiotensin converting enzyme inhibitors and alpha1-blockers.
Journal of hypertension.
2001 Mar; 19(3 Pt 2):575-82. doi:
10.1097/00004872-200103001-00009. [PMID: 11327632] - C Deerochanawong, P Kornthong, S Phongwiratchai, S Serirat. Effects on urinary albumin excretion and renal function changes by delapril and manidipine in normotensive type 2 diabetic patients with microalbuminuria.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2001 Feb; 84(2):234-41. doi:
NULL. [PMID: 11336083] - S M Cheer, K McClellan. Manidipine: a review of its use in hypertension.
Drugs.
2001; 61(12):1777-99. doi:
10.2165/00003495-200161120-00010. [PMID: 11693466]