Apomine (BioDeep_00000176150)

   

human metabolite blood metabolite


代谢物信息卡片


bis(propan-2-yl) {1-[bis(propan-2-yloxy)phosphoryl]-2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethyl}phosphonate

化学式: C28H52O7P2 (562.3188102)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 4.55%

分子结构信息

SMILES: CC(C)OP(=O)(C(CC1=CC(=C(C(=C1)C(C)(C)C)O)C(C)(C)C)P(=O)(OC(C)C)OC(C)C)OC(C)C
InChI: InChI=1S/C28H52O7P2/c1-18(2)32-36(30,33-19(3)4)25(37(31,34-20(5)6)35-21(7)8)17-22-15-23(27(9,10)11)26(29)24(16-22)28(12,13)14/h15-16,18-21,25,29H,17H2,1-14H3

描述信息

C78281 - Agent Affecting Musculoskeletal System > C67439 - Bone Resorption Inhibitor
D050071 - Bone Density Conservation Agents > D004164 - Diphosphonates

同义名列表

4 个代谢物同义名

bis(propan-2-yl) {1-[bis(propan-2-yloxy)phosphoryl]-2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethyl}phosphonate; diisopropyl 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-1-(diisopropoxyphosphoryl)ethylphosphonate; Tetraisopropyl 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-ethyl-1,1-bisphosphonate; Apomine



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yosuke Toyota, Hiromasa Yoshioka, Ikuya Sagimori, Yuichi Hashimoto, Kenji Ohgane. Bisphosphonate esters interact with HMG-CoA reductase membrane domain to induce its degradation. Bioorganic & medicinal chemistry. 2020 07; 28(14):115576. doi: 10.1016/j.bmc.2020.115576. [PMID: 32616181]
  • Claire M Edwards, Gabrielle Mueller, Anke J Roelofs, Andrew Chantry, Mark Perry, R Graham G Russell, Ben Van Camp, Yves Guyon-Gellin, Eric J Niesor, Craig L Bentzen, Karin Vanderkerken, Peter I Croucher. Apomine, an inhibitor of HMG-CoA-reductase, promotes apoptosis of myeloma cells in vitro and is associated with a modulation of myeloma in vivo. International journal of cancer. 2007 Apr; 120(8):1657-63. doi: 10.1002/ijc.22478. [PMID: 17230522]
  • Alan Pourpak, Robert T Dorr, Ross O Meyers, Marianne B Powell, Steven P Stratton. Cytotoxic activity of Apomine is due to a novel membrane-mediated cytolytic mechanism independent of apoptosis in the A375 human melanoma cell line. Investigational new drugs. 2007 Apr; 25(2):107-14. doi: 10.1007/s10637-006-9015-6. [PMID: 17024575]
  • Peter L Bonate, Simon Floret, Craig Bentzen. Population pharmacokinetics of APOMINE: a meta-analysis in cancer patients and healthy males. British journal of clinical pharmacology. 2004 Aug; 58(2):142-55. doi: 10.1111/j.1365-2125.2004.02111.x. [PMID: 15255796]
  • Joseph Roitelman, Danièle Masson, Rachel Avner, Corinne Ammon-Zufferey, Anne Perez, Yves Guyon-Gellin, Craig L Bentzen, Eric J Niesor. Apomine, a novel hypocholesterolemic agent, accelerates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and stimulates low density lipoprotein receptor activity. The Journal of biological chemistry. 2004 Feb; 279(8):6465-73. doi: 10.1074/jbc.m308094200. [PMID: 14627708]
  • D S Alberts, A V Hallum, M Stratton-Custis, D J Garcia, M Gleason-Guzman, S E Salmon, P Santabarbara, E J Niesor, S Floret, C L Bentzen. Phase I pharmacokinetic trial and correlative in vitro phase II tumor kinetic study of Apomine (SR-45023A), a novel oral biphosphonate anticancer drug. Clinical cancer research : an official journal of the American Association for Cancer Research. 2001 May; 7(5):1246-50. doi: NULL. [PMID: 11350890]
  • B Jackson, A N Gee, Y Guyon-Gellin, E Niesor, C L Bentzen, W D Kerns, K E Suckling. Hypocholesterolaemic and antiatherosclerotic effects of tetra-iso-propyl 2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethyl-1,1-diphosphonate (SR-9223i). Arzneimittel-Forschung. 2000 Apr; 50(4):380-6. doi: 10.1055/s-0031-1300217. [PMID: 10800637]
  • G Wilcox, M A Beaven. A sensitive and specific tritium release assay for dopamine-beta-hydroxylase (DbetaH) in serum. Analytical biochemistry. 1976 Oct; 75(2):484-97. doi: 10.1016/0003-2697(76)90104-4. [PMID: 10754]