Apixaban (BioDeep_00000176140)

   

human metabolite blood metabolite


代谢物信息卡片


1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide

化学式: C25H25N5O4 (459.190645)
中文名称: 阿哌沙班
谱图信息: 最多检出来源 Homo sapiens(blood) 96%

分子结构信息

SMILES: COC1=CC=C(C=C1)N1N=C(C(N)=O)C2=C1C(=O)N(CC2)C1=CC=C(C=C1)N1CCCCC1=O
InChI: InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32)

描述信息

B - Blood and blood forming organs > B01 - Antithrombotic agents > B01A - Antithrombotic agents > B01AF - Direct factor xa inhibitors
C78275 - Agent Affecting Blood or Body Fluid > C263 - Anticoagulant Agent > C173067 - Direct Factor Xa Inhibitor
C78275 - Agent Affecting Blood or Body Fluid > C263 - Anticoagulant Agent > C180619 - Direct Oral Anticoagulant
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015842 - Serine Proteinase Inhibitors
D006401 - Hematologic Agents > D000925 - Anticoagulants > D000991 - Antithrombins
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

7 个代谢物同义名

1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide; BMS-562247-01; BMS 562247-01; Apixabanum; BMS-562247; Apixaban; Eliquis



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Safaa E Ramadan, Sanaa A El-Gizawy, Mohamed A Osman, Mona F Arafa. Application of Design of Experiment in the Optimization of Apixaban-Loaded Solid Lipid Nanoparticles: In Vitro and In Vivo Evaluation. AAPS PharmSciTech. 2023 Aug; 24(6):167. doi: 10.1208/s12249-023-02628-2. [PMID: 37552329]
  • Lucas Van Hoof, Isabelle Truyers, Hadewych Van Hauwermeiren, Bram Nachtergaele, Tom Langenaeken, Marc Jacquemin, Filip Rega, Peter Verhamme, Bart Meuris. Apixaban in a porcine model of mechanical valve thrombosis in pulmonary position-a pilot study. Interactive cardiovascular and thoracic surgery. 2022 Jul; 35(2):. doi: 10.1093/icvts/ivac070. [PMID: 35253872]
  • Cecilia Becattini, Rupert Bauersachs, Giorgio Maraziti, Laurent Bertoletti, Alexander Cohen, Jean M Connors, Dario Manfellotto, Antonio Sanchez, Benjamin Brenner, Giancarlo Agnelli. Renal function and clinical outcome of patients with cancer-associated venous thromboembolism randomized to receive apixaban or dalteparin. Results from the Caravaggio trial. Haematologica. 2022 07; 107(7):1567-1576. doi: 10.3324/haematol.2021.279072. [PMID: 34382385]
  • Holly Mansell, Ahmed Shoker, Jane Alcorn, Mark E Fenton, Julian S Tam, William Semchuk, Babar Bashir, Walter K Kraft, Shenzhen Yao, James D Douketis. Pharmacokinetics of apixaban and tacrolimus or cyclosporine in kidney and lung transplant recipients. Clinical and translational science. 2022 Jul; 15(7):1687-1697. doi: 10.1111/cts.13284. [PMID: 35439353]
  • Ozkan Ates, Ibrahim Yilmaz, Numan Karaarslan, Emel Ersoz, Fatma Bahar Hacioglu Kasim, Mustafa Dogan, Hanefi Ozbek. Coexistence of SARS-CoV-2 and cerebrovascular diseases: does COVID-19 positivity trigger cerebrovascular pathologies?. Journal of infection in developing countries. 2022 Jun; 16(6):981-992. doi: 10.3855/jidc.15800. [PMID: 35797292]
  • Min Zhuo, Julie M Paik, Theodore N Tsacogianis, Rishi J Desai. Use of Anticoagulants and Dosing Appropriateness of Apixaban for New-Onset Atrial Fibrillation Among Hemodialysis Patients. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2022 06; 79(6):909-912. doi: 10.1053/j.ajkd.2021.08.014. [PMID: 34571068]
  • William Towers, Steffany N Nguyen, Melanie C Ruegger, Eric Salazar, Kevin R Donahue. Apixaban and Rivaroxaban Anti-Xa Level Monitoring Versus Standard Monitoring in Hospitalized Patients With Acute Kidney Injury. The Annals of pharmacotherapy. 2022 06; 56(6):656-663. doi: 10.1177/10600280211046087. [PMID: 34541895]
  • Geno J Merli, Walter K Kraft, Luis H Eraso, Taki Galanis, Lynda J Thomson, Geoffrey O Ouma, Eugene Viscusi, Jerald Z Gong, Edwin Lam. Apixaban Discontinuation for Invasive Or major Surgical procedures (ADIOS): A prospective cohort study. Vascular medicine (London, England). 2022 06; 27(3):269-276. doi: 10.1177/1358863x211047270. [PMID: 34809507]
  • Pancras C Wong, Earl Crain. Calibration and validation of the rabbit model of electrolytic-mediated arterial thrombosis against the standard-of-care anticoagulant apixaban. Pharmacology research & perspectives. 2022 06; 10(3):e00963. doi: 10.1002/prp2.963. [PMID: 35680619]
  • Alexander T Cohen, Janvi Sah, Amol D Dhamane, Theodore Lee, Lisa Rosenblatt, Patrick Hlavacek, Birol Emir, Rachel Delinger, Huseyin Yuce, Xuemei Luo. Effectiveness and Safety of Apixaban versus Warfarin in Venous Thromboembolism Patients with Chronic Kidney Disease. Thrombosis and haemostasis. 2022 Jun; 122(6):926-938. doi: 10.1055/s-0041-1740254. [PMID: 34963185]
  • Muhammad Imran Ahmad Qureshi, Bilal Azam, Muhammad Aamir Waheed, Afsheen Imran. Venous sinus thrombosis after the first dose of Pfizer BioNTech vaccine. BMJ case reports. 2022 May; 15(5):. doi: 10.1136/bcr-2021-247493. [PMID: 35606039]
  • Haithuy Pham, Whitney Gibson Medford, Spencer Horst, Melissa Levesque, David Ragoonanan, Christine Price, Harold Colbassani, Keaton Piper, Keith Chastain. Andexanet alfa versus four-factor prothrombin complex concentrate for the reversal of apixaban- or rivaroxaban-associated intracranial hemorrhages. The American journal of emergency medicine. 2022 05; 55(?):38-44. doi: 10.1016/j.ajem.2022.02.029. [PMID: 35272069]
  • Brittany Elgersma, Sara Zochert. Utilization of apixaban anti-Xa levels in transition from apixaban to warfarin in a patient with chronic renal dysfunction. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 2022 04; 79(9):e104-e109. doi: 10.1093/ajhp/zxab469. [PMID: 34864841]
  • Jonathan P Piccini, Valeria Caso, Stuart J Connolly, Keith A A Fox, Jonas Oldgren, W Schuyler Jones, Diana A Gorog, Václav Durdil, Thomas Viethen, Christoph Neumann, Hardi Mundl, Manesh R Patel. Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study. Lancet (London, England). 2022 04; 399(10333):1383-1390. doi: 10.1016/s0140-6736(22)00456-1. [PMID: 35385695]
  • Michael E Farkouh, Gregg W Stone, Anuradha Lala, Emilia Bagiella, Pedro R Moreno, Girish N Nadkarni, Ori Ben-Yehuda, Juan F Granada, Ovidiu Dressler, Elizabeth O Tinuoye, Carlos Granada, Jessica Bustamante, Carlos Peyra, Lucas C Godoy, Igor F Palacios, Valentin Fuster. Anticoagulation in Patients With COVID-19: JACC Review Topic of the Week. Journal of the American College of Cardiology. 2022 03; 79(9):917-928. doi: 10.1016/j.jacc.2021.12.023. [PMID: 35241226]
  • Thom Kok, Hans de Boer, Bart Witteman, Marcel Hovens, Matthijs van Luin, Houshang Monajemi. Anti-Xa Levels in Morbidly Obese Patients Using Apixaban or Rivaroxaban, Before and After Bariatric Surgery. Obesity surgery. 2022 03; 32(3):607-614. doi: 10.1007/s11695-021-05814-y. [PMID: 34822108]
  • Tzu-Fei Wang, Ranjeeta Mallick, Marc Carrier, Philip S Wells. Safety and efficacy of apixaban thromboprophylaxis in ambulatory cancer patients according to renal function: A subgroup analysis of the AVERT trial. Thrombosis research. 2022 03; 211(?):85-87. doi: 10.1016/j.thromres.2022.01.022. [PMID: 35124234]
  • Christian Pfrepper, Lisa-Charlott Behrendt, Hagen Bönigk, Thomas Siegemund, Michael Metze, Dirk Franke, Sirak Petros, Annelie Siegemund. Influence of direct oral anticoagulants on thrombin generation on Ceveron TGA. International journal of laboratory hematology. 2022 Feb; 44(1):193-201. doi: 10.1111/ijlh.13721. [PMID: 34585540]
  • Henrik von Horn, Agnes Rasmusson, Lisbeth Söderblom, Rickard E Malmström, Jovan Antovic. Using a low-molecular weight heparin-calibrated anti-factor Xa assay to assess the concentration of apixaban and rivaroxaban. International journal of laboratory hematology. 2022 Feb; 44(1):163-167. doi: 10.1111/ijlh.13692. [PMID: 34523813]
  • Xiaoan Li, Tiantian Guo, Qian Feng, Tiantian Bai, Lei Wu, Yubo Liu, Xu Zheng, Jianzhong Jia, Jin Pei, Shaoping Wu, Yiming Song, Yongmin Zhang. Progress of thrombus formation and research on the structure-activity relationship for antithrombotic drugs. European journal of medicinal chemistry. 2022 Jan; 228(?):114035. doi: 10.1016/j.ejmech.2021.114035. [PMID: 34902735]
  • Katarzyna Papaj, Patrycja Spychalska, Patryk Kapica, André Fischer, Jakub Nowak, Maria Bzówka, Manuel Sellner, Markus A Lill, Martin Smieško, Artur Góra. Evaluation of Xa inhibitors as potential inhibitors of the SARS-CoV-2 Mpro protease. PloS one. 2022; 17(1):e0262482. doi: 10.1371/journal.pone.0262482. [PMID: 35015795]
  • Shin-Yi Lin, Ching-Hua Kuo, Tao-Min Huang, Yu-Fong Peng, Chih-Fen Huang, Sung-Chun Tang, Jiann-Shing Jeng. Impact of different renal function equations on direct oral anticoagulant concentrations. Scientific reports. 2021 12; 11(1):23833. doi: 10.1038/s41598-021-03318-4. [PMID: 34903821]
  • Mansour A Alkhunaizi, Basim Ali. Left Ventricular Assist Device Pump Thrombosis in a Patient Treated with Apixaban. The American journal of case reports. 2021 Dec; 22(?):e934787. doi: 10.12659/ajcr.934787. [PMID: 34880201]
  • Emmanouela Kampouraki, Peter Avery, Tina Biss, Hilary Wynne, Farhad Kamali. Assessment of exposure to direct oral anticoagulants in elderly hospitalised patients. British journal of haematology. 2021 12; 195(5):790-801. doi: 10.1111/bjh.17899. [PMID: 34658009]
  • Andrea Rubboli, Claudio Fresco, Maurizio Paciaroni, Bianca Rocca, Domenico Pecora, Iolanda Enea, Claudio Cuccia, Giuseppe Patti. How lower doses of direct oral anticoagulants are interpreted in clinical practice: a national survey of the Italian Atherosclerosis, Thrombosis and Vascular Biology (ATVB) Study Group. Journal of cardiovascular medicine (Hagerstown, Md.). 2021 Dec; 22(11):924-928. doi: 10.2459/jcm.0000000000001204. [PMID: 33927142]
  • Hakeam A Hakeam, Mohammed Alkhani, Zyad Alyahya, Ziyad Alawaji, Sandra Ofori. Direct Acting Oral Anticoagulants Following Gastrointestinal Tract Surgery. Journal of cardiovascular pharmacology. 2021 12; 78(6):867-874. doi: 10.1097/fjc.0000000000001142. [PMID: 34882113]
  • Charles E Frost, Van Ly, Samira M Garonzik. Apixaban Pharmacokinetics and Pharmacodynamics in Subjects with Mild or Moderate Hepatic Impairment. Drugs in R&D. 2021 Dec; 21(4):375-384. doi: 10.1007/s40268-021-00359-y. [PMID: 34363188]
  • David M Salerno, Megan E Thornberg, Nicholas W Lange, Jessica Hedvat, Hilary Robbins, Robert S Brown, Douglas L Jennings, Jenna Scheffert. Less bleeding associated with apixaban versus other direct acting oral anticoagulation in solid organ transplant recipients. Clinical transplantation. 2021 12; 35(12):e14396. doi: 10.1111/ctr.14396. [PMID: 34165845]
  • Kazuki Takasaki, Takazumi Tsunenari, Kazuma Mori, Satsuki Aochi. COVID-19 with essential thrombocythemia treated with apixaban for antithrombotic prophylaxis. BMJ case reports. 2021 Nov; 14(11):. doi: 10.1136/bcr-2021-246700. [PMID: 34848425]
  • Chen Gurevitz, Ela Giladi, Alon Barsheshet, Robert Klempfner, Ilan Goldenberg, Ran Kornowski, Avishay Elis. Comparison of Low and Full Dose Apixaban Versus Warfarin in Patients With Atrial Fibrillation and Renal Dysfunction (from a National Registry). The American journal of cardiology. 2021 11; 159(?):87-93. doi: 10.1016/j.amjcard.2021.08.022. [PMID: 34503821]
  • Jean M Connors, Maria M Brooks, Frank C Sciurba, Jerry A Krishnan, Joseph R Bledsoe, Andrei Kindzelski, Amanda L Baucom, Bridget-Anne Kirwan, Heather Eng, Deborah Martin, Elaine Zaharris, Brendan Everett, Lauren Castro, Nancy L Shapiro, Janet Y Lin, Peter C Hou, Carl J Pepine, Eileen Handberg, Daniel O Haight, Jason W Wilson, Sarah Majercik, Zhuxuan Fu, Yongqi Zhong, Vidya Venugopal, Scott Beach, Steve Wisniewski, Paul M Ridker. Effect of Antithrombotic Therapy on Clinical Outcomes in Outpatients With Clinically Stable Symptomatic COVID-19: The ACTIV-4B Randomized Clinical Trial. JAMA. 2021 11; 326(17):1703-1712. doi: 10.1001/jama.2021.17272. [PMID: 34633405]
  • Xinhua Hu, Yichao Xu, Jinliang Chen, Yuting Shen, Dandan Yang, Yin Hu, Bo Jiang, Honggang Lou, Zourong Ruan. A validated UPLC-MS/MS method for the determination of CX3002 in human plasma and its application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Oct; 1183(?):122954. doi: 10.1016/j.jchromb.2021.122954. [PMID: 34628186]
  • Ziv Harel, Eric McArthur, Nivethika Jeyakumar, Manish M Sood, Amit X Garg, Samuel A Silver, Paul Dorian, Daniel Blum, William Beaubien-Souligny, Andrew T Yan, Sunil V Badve, Brendan Smyth, Min Jun, Racquel Jandoc, Abhijat Kitchlu, Ron Wald. The Risk of Acute Kidney Injury with Oral Anticoagulants in Elderly Adults with Atrial Fibrillation. Clinical journal of the American Society of Nephrology : CJASN. 2021 10; 16(10):1470-1479. doi: 10.2215/cjn.05920421. [PMID: 34407990]
  • Hefziba Green, Ruth Rahamimov, Galia Spectre, Benaya Rozen-Zvi, Shmuel Fuchs, Shiri Avni, Ran Nissan. Apixaban Level and Its Influence on Immunosuppression and Graft Outcome in Kidney Transplant Recipients With Atrial Fibrillation. Therapeutic drug monitoring. 2021 10; 43(5):637-644. doi: 10.1097/ftd.0000000000000858. [PMID: 33337589]
  • Katharina Thuile, Katia Giacomuzzi, Erika Jani, Peter Marschang, Thomas Mueller. Evaluation of the in vitro stability of direct oral anticoagulants in blood samples under different storage conditions. Scandinavian journal of clinical and laboratory investigation. 2021 Oct; 81(6):461-468. doi: 10.1080/00365513.2021.1946844. [PMID: 34278897]
  • Khurshid Shaikh, Ashish Mungantiwar, Supriya Halde, Nancy Pandita. A liquid chromatography-tandem mass spectrometry method for the determination of apixaban in human plasma and its application to pharmacokinetics studies in the Indian population. Analytical methods : advancing methods and applications. 2021 09; 13(33):3693-3704. doi: 10.1039/d1ay00837d. [PMID: 34333583]
  • Hafez M Abdullah, Waqas Ullah, Munnam Sohail Jafar, Martin van Zyl, Rehan Saeed, Mahboob Alam, M Chadi Alraies, David L Fischman. Safety and Efficacy of Apixaban, Rivaroxaban, and Warfarin in End-Stage Renal Disease With Atrial Fibrillation: A Systematic Review and Meta-Analysis. Cardiovascular revascularization medicine : including molecular interventions. 2021 09; 30(?):26-32. doi: 10.1016/j.carrev.2020.09.041. [PMID: 34420589]
  • Gabrielle E Wallace, Victoria F McKaba, Jennifer M Reinhart, Zhong Li, Scott Austin, Ryan C Fries. Pharmacokinetics and pharmacodynamics of intravenous and oral apixaban in horses. Journal of veterinary pharmacology and therapeutics. 2021 Sep; 44(5):724-732. doi: 10.1111/jvp.12979. [PMID: 34046920]
  • Charles Frost, Samira Garonzik, Andrew Shenker, Yu Chen Barrett, Frank LaCreta. Apixaban Single-Dose Pharmacokinetics, Bioavailability, Renal Clearance, and Pharmacodynamics Following Intravenous and Oral Administration. Clinical pharmacology in drug development. 2021 09; 10(9):974-984. doi: 10.1002/cpdd.990. [PMID: 34342172]
  • Aileen C Scheibner, Crystal Franco-Martinez, Elisabeth Kincaide, Reed Hall, Christina Long. The Impact of Rivaroxaban and Apixaban on Tacrolimus Trough Levels. Progress in transplantation (Aliso Viejo, Calif.). 2021 09; 31(3):236-241. doi: 10.1177/15269248211024601. [PMID: 34155947]
  • James B Wetmore, Heng Yan, Charles A Herzog, Eric Weinhandl, Jorge L Reyes, Nicholas S Roetker. CKD Progression in Medicare Beneficiaries With Nonvalvular Atrial Fibrillation Treated With Apixaban Versus Warfarin. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2021 08; 78(2):180-189. doi: 10.1053/j.ajkd.2020.12.004. [PMID: 33421454]
  • Geoffrey Foulon-Pinto, Georges Jourdi, Julien Perrin, Johan Abdoul, Guillaume Paris, Isabelle Gouin-Thibault, Emmanuel Curis, Thomas Lecompte, Virginie Siguret. Study of thrombin generation with St Genesia to evaluate xaban pharmacodynamics: Analytical performances over 18 months. International journal of laboratory hematology. 2021 Aug; 43(4):821-830. doi: 10.1111/ijlh.13443. [PMID: 33369212]
  • Manon Launay, Anne-Laure Demartin, Sophie Perinel Ragey, Patrick Mismetti, Elisabeth Botelho-Nevers, Xavier Delavenne. Severe Inflammation, Acute Kidney Injury, and Drug-Drug Interaction: Triple Penalty for Prolonged Elimination of Apixaban in Patients With Coronavirus Disease 2019: A Grand Round. Therapeutic drug monitoring. 2021 08; 43(4):455-458. doi: 10.1097/ftd.0000000000000899. [PMID: 33908408]
  • Matthieu Bourdin, Delphine Perrotin, Olivier Mathieu, Tristan Herve, François Depasse, Genmin Lu, Pamela B Conley, Geneviève Contant. Measuring residual anti-Xa activity of direct factor Xa inhibitors after reversal with andexanet alfa. International journal of laboratory hematology. 2021 Aug; 43(4):795-801. doi: 10.1111/ijlh.13591. [PMID: 34092030]
  • Nathaniel M Hawkins, Lee Er, Roopinder K Sandhu, Padma Kaul, Finlay A McAlister, Adeera Levin, Jason G Andrade. Validity of different dose reduction criteria for apixaban. American heart journal. 2021 08; 238(?):12-15. doi: 10.1016/j.ahj.2021.03.004. [PMID: 33762178]
  • Thoyaja Koritala, David W Johnson. Internal Jugular Vein Thrombus in Coronavirus Disease (COVID-19). AJR. American journal of roentgenology. 2021 07; 217(1):257. doi: 10.2214/ajr.21.25559. [PMID: 33566679]
  • Ingrid Škorňová, Matej Samoš, Tomáš Bolek, Alena Kamenišťáková, Lucia Stančiaková, Peter Galajda, Ján Staško, Peter Kubisz, Marián Mokáň. Direct Oral Anticoagulants Plasma Levels in Patients with Atrial Fibrillation at the Time of Bleeding: A Pilot Prospective Study. Journal of cardiovascular pharmacology. 2021 07; 78(1):e122-e127. doi: 10.1097/fjc.0000000000001038. [PMID: 34173805]
  • Akira Sezai, Makoto Taoka, Shunji Osaka, Yoshiki Kitazumi, Keito Suzuki, Keita Kamata, Masashi Tanaka. A Comparative Prospective Observational Study on the Use of Direct Oral Anticoagulants after Cardiac Surgery for the Management of Atrial Fibrillation. Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia. 2021 Jun; 27(3):191-199. doi: 10.5761/atcs.oa.20-00213. [PMID: 33208579]
  • Donglu Zhang, Cong Wei, Cornelis E C A Hop, Matthew R Wright, Ming Hu, Yurong Lai, S Cyrus Khojasteh, W Griff Humphreys. Intestinal Excretion, Intestinal Recirculation, and Renal Tubule Reabsorption Are Underappreciated Mechanisms That Drive the Distribution and Pharmacokinetic Behavior of Small Molecule Drugs. Journal of medicinal chemistry. 2021 06; 64(11):7045-7059. doi: 10.1021/acs.jmedchem.0c01720. [PMID: 34010555]
  • Sergi Torramade-Moix, Marta Palomo, Manel Vera, Didac Jerez, Ana Belen Moreno-Castaño, M Urooj Zafar, Jordi Rovira, Fritz Diekmann, Joan Carles Garcia-Pagan, Gines Escolar, Aleix Cases, Maribel Diaz-Ricart. Apixaban Downregulates Endothelial Inflammatory and Prothrombotic Phenotype in an In Vitro Model of Endothelial Dysfunction in Uremia. Cardiovascular drugs and therapy. 2021 06; 35(3):521-532. doi: 10.1007/s10557-020-07010-z. [PMID: 32651897]
  • Avishay Elis, Robert Klempfner, Chen Gurevitz, Ela Gilady, Ilan Goldenberg. Apixaban in Patients with Atrial Fibrillation and Severe Renal Dysfunction: Findings from a National Registry. The Israel Medical Association journal : IMAJ. 2021 Jun; 23(6):353-358. doi: NULL. [PMID: 34155848]
  • William Scharpf, Constance Katsafanas, Kintin Ng. COVID-19-Associated Ischemic Stroke in a Patient on Therapeutic Anticoagulation. The neurologist. 2021 May; 26(3):108-111. doi: 10.1097/nrl.0000000000000319. [PMID: 33942794]
  • Ahmed A El-Shenawy, Reda A Mahmoud, Essam A Mahmoud, Mohamed S Mohamed. Intranasal In Situ Gel of Apixaban-Loaded Nanoethosomes: Preparation, Optimization, and In Vivo Evaluation. AAPS PharmSciTech. 2021 May; 22(4):147. doi: 10.1208/s12249-021-02020-y. [PMID: 33948767]
  • Filip Ionescu, Christopher Cooper, Ioana Petrescu, Julie George, Saima Mansuri. Safety of apixaban compared to warfarin in hemodialysis patients: Do antiplatelets make a difference?. European journal of haematology. 2021 May; 106(5):689-696. doi: 10.1111/ejh.13599. [PMID: 33569825]
  • Zachary S Robinson, Nicole G Harper. Apixaban Levels Detected in a Patient 10 Days From Last Known Dose While Experiencing Acute on Chronic Kidney Disease. The Annals of pharmacotherapy. 2021 05; 55(5):687-688. doi: 10.1177/1060028020962794. [PMID: 32988217]
  • Chen Chen, Yalin Cao, Ying Zheng, Yugang Dong, Jianyong Ma, Wengen Zhu, Chen Liu. Effect of Rivaroxaban or Apixaban in Atrial Fibrillation Patients with Stage 4-5 Chronic Kidney Disease or on Dialysis. Cardiovascular drugs and therapy. 2021 04; 35(2):273-281. doi: 10.1007/s10557-021-07144-8. [PMID: 33538928]
  • Giuseppe Carli, Ilaria Nichele, Marco Ruggeri, Salvatore Barra, Alberto Tosetto. Deep vein thrombosis (DVT) occurring shortly after the second dose of mRNA SARS-CoV-2 vaccine. Internal and emergency medicine. 2021 04; 16(3):803-804. doi: 10.1007/s11739-021-02685-0. [PMID: 33687691]
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