Aminoguanidine (BioDeep_00000175986)
human metabolite blood metabolite
代谢物信息卡片
Hydrazinecarboximidamide(9CI)
化学式: CH6N4 (74.0592436)
中文名称: 氨基胍媒染剂
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(=NN)(N)N
InChI: InChI=1S/CH6N4/c2-1(3)5-4/h4H2,(H4,2,3,5)
描述信息
C471 - Enzyme Inhibitor > C29574 - Nitric Oxide Synthase Inhibitor
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:40618
- PubChem: 2146
- HMDB: HMDB0248318
- DrugBank: DB05383
- ChEMBL: CHEMBL225304
- Wikipedia: Pimagedine
- chemspider: 2061
- CAS: 79-17-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Md Yousof Ali, Se Eun Park, Su Hui Seong, Gerald W Zamponi, Hyun Ah Jung, Jae Sue Choi. Ursonic acid from Artemisia montana exerts anti-diabetic effects through anti-glycating properties, and by inhibiting PTP1B and activating the PI3K/Akt signaling pathway in insulin-resistant C2C12 cells.
Chemico-biological interactions.
2023 May; 376(?):110452. doi:
10.1016/j.cbi.2023.110452. [PMID: 36933777] - Ashwani Kumar Sharma, Anmoldeep Kaur, Tajpreet Kaur, Sarabjit Kaur, Devendra Pathak, Amrit Pal Singh. Ameliorative role of inducible nitric oxide synthase inhibitors against sodium arsenite-induced renal and hepatic dysfunction in rats.
Drug and chemical toxicology.
2022 Sep; 45(5):2255-2261. doi:
10.1080/01480545.2021.1926109. [PMID: 34006163] - Gemma Regan, Philip Mullen, Mary Moloney, Karl De Ruyck, Terence Fodey, Sarah E Millar, Steven Crooks, Anna Gadaj, Chris Elliott, Martin Danaher. Verification of Bound Aminoguanidine as the Marker Residue for the Banned Antibiotic, Nitrovin, in Pig Tissues.
Journal of agricultural and food chemistry.
2022 Jun; 70(23):7248-7257. doi:
10.1021/acs.jafc.2c00843. [PMID: 35666992] - Alexander Dontsov, Marina Yakovleva, Natalia Trofimova, Natalia Sakina, Alexander Gulin, Arseny Aybush, Fedor Gostev, Alexander Vasin, Tatiana Feldman, Mikhail Ostrovsky. Water-Soluble Products of Photooxidative Destruction of the Bisretinoid A2E Cause Proteins Modification in the Dark.
International journal of molecular sciences.
2022 Jan; 23(3):. doi:
10.3390/ijms23031534. [PMID: 35163454] - Binish Arif, Zarina Arif, Jamal Ahmad, Kahkashan Perveen, Najat A Bukhari, Jalaluddin M Ashraf, Moinuddin, Khursheed Alam. Attenuation of hyperglycemia and amadori products by aminoguanidine in alloxan-diabetic rabbits occurs via enhancement in antioxidant defenses and control of stress.
PloS one.
2022; 17(1):e0262233. doi:
10.1371/journal.pone.0262233. [PMID: 34986201] - Mariko Takenokuchi, Kinuyo Matsumoto, Yuko Nitta, Rumi Takasugi, Yukari Inoue, Michi Iwai, Keiichi Kadoyama, Kazutoshi Yoshida, Hiromi Takano-Ohmuro, Taizo Taniguchi. In Vitro and In Vivo Antiglycation Effects of Connarus ruber Extract.
Planta medica.
2021 Dec; ?(?):. doi:
10.1055/a-1690-3528. [PMID: 34861700] - Dan Tang, Wei Xiao, Wen-Ting Gu, Zhi-Tong Zhang, Shu-Hong Xu, Zhi-Quan Chen, You-Hua Xu, Lu-Yong Zhang, Shu-Mei Wang, Hong Nie. Pterostilbene prevents methylglyoxal-induced cytotoxicity in endothelial cells by regulating glyoxalase, oxidative stress and apoptosis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Jul; 153(?):112244. doi:
10.1016/j.fct.2021.112244. [PMID: 33930484] - Hiviny de Ataides Raquel, Carla Fabiana Souza Guazelli, Waldiceu A Verri, Lisete C Michelini, Marli Cardoso Martins-Pinge. Swimming training reduces iNOS expression, augments the antioxidant defense and reduces sympathetic responsiveness in the rostral ventrolateral medulla of normotensive male rats.
Brain research bulletin.
2021 05; 170(?):225-233. doi:
10.1016/j.brainresbull.2021.02.023. [PMID: 33631270] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Jun Gu Kim, Jin Woo Lee, Thi Phuong Linh Le, Jae Sang Han, Yong Beom Cho, Haeun Kwon, Dongho Lee, Mi Kyeong Lee, Bang Yeon Hwang. Sesquiterpenoids from Chrysanthemum indicum with Inhibitory Effects on NO Production.
Journal of natural products.
2021 03; 84(3):562-569. doi:
10.1021/acs.jnatprod.0c01121. [PMID: 33667099] - Renren Bai, Chuansheng Yao, Zhichao Zhong, Jiamin Ge, Ziqiang Bai, Xiangyang Ye, Tian Xie, Yuanyuan Xie. Discovery of natural anti-inflammatory alkaloids: Potential leads for the drug discovery for the treatment of inflammation.
European journal of medicinal chemistry.
2021 Mar; 213(?):113165. doi:
10.1016/j.ejmech.2021.113165. [PMID: 33454546] - Nehal A Afifi, A Ramadan, Emad Y Erian, Ahmed A Sedik, Mohamed M Amin, Azza Hassan, Dalia O Saleh. Synergistic effect of aminoguanidine and l-carnosine against thioacetamide-induced hepatic encephalopathy in rats: behavioral, biochemical, and ultrastructural evidence.
Canadian journal of physiology and pharmacology.
2021 Mar; 99(3):332-347. doi:
10.1139/cjpp-2020-0212. [PMID: 32721224] - Daniel Prantner, Shreeram Nallar, Katharina Richard, David Spiegel, Kim D Collins, Stefanie N Vogel. Classically activated mouse macrophages produce methylglyoxal that induces a TLR4- and RAGE-independent proinflammatory response.
Journal of leukocyte biology.
2021 03; 109(3):605-619. doi:
10.1002/jlb.3a0520-745rr. [PMID: 32678947] - Jun Gu Kim, Jin Woo Lee, Thi Phuong Linh Le, Jae Sang Han, Haeun Kwon, Dongho Lee, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang. Diterpenoids and Diacetylenes from the Roots of Aralia cordata with Inhibitory Effects on Nitric Oxide Production.
Journal of natural products.
2021 02; 84(2):230-238. doi:
10.1021/acs.jnatprod.0c00842. [PMID: 33476145] - Dan Di Zhang, Yan Gang Wang, Chun Yan Liu, Ze Hou Wang, Yue Fen Wang. Aminoguanidine ameliorates ovariectomy-induced neuronal deficits in rats by inhibiting AGE-mediated Aβ production.
Acta neurobiologiae experimentalis.
2021; 81(1):10-20. doi:
10.21307/ane-2021-002. [PMID: 33949165] - Farimah Beheshti, Mahmoud Hosseini, Milad Hashemzehi, Mohammad Reza Hadipanah, Maryam Mahmoudabady. The Cardioprotective Effects of Aminoguanidine on Lipopolysaccharide Induced Inflammation in Rats.
Cardiovascular toxicology.
2020 10; 20(5):474-481. doi:
10.1007/s12012-020-09570-w. [PMID: 32232724] - Mahmoud Hosseini, Farimah Beheshti, Akbar Anaeigoudari. Improving Effect of Aminoguanidine on Lipopolysaccharide-Caused Kidney Dysfunction in Rats.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
2020 Sep; 31(5):1025-1033. doi:
10.4103/1319-2442.301167. [PMID: 33229765] - O Yaremchuk, Yu Soroka, M Kulitska, I Kuzmak, V Chernyashova, M Namoradze, D Delibashvili, K Posokhova. [NEUROPROTECTIVE EFFECT OF AMINOGUANIDINE IN EXPERIMENTAL OBSTETRIC ANTIPHOSPHOLIPID SYNDROME].
Georgian medical news.
2020 Apr; ?(301):159-165. doi:
NULL. [PMID: 32535582] - Larissa de Freitas, Marilia Valli, Alessandra C Dametto, Paula C Pennacchi, Adriano D Andricopulo, Silvya S Maria-Engler, Vanderlan S Bolzani. Advanced Glycation End Product Inhibition by Alkaloids from Ocotea paranapiacabensis for the Prevention of Skin Aging.
Journal of natural products.
2020 03; 83(3):649-656. doi:
10.1021/acs.jnatprod.9b01083. [PMID: 32134650] - Sonja Ilić, Nenad Stojiljković, Dusan Sokolović, Ivan Jovanović, Nikola Stojanović. Morphometric analysis of structural renal alterations and beneficial effects of aminoguanidine in acute kidney injury induced by cisplatin in rats.
Canadian journal of physiology and pharmacology.
2020 Feb; 98(2):117-123. doi:
10.1139/cjpp-2019-0252. [PMID: 31995714] - Achara Raksat, Piyaporn Phukhatmuen, Jianxiong Yang, Wisanu Maneerat, Rawiwan Charoensup, Raymond J Andersen, Yan A Wang, Stephen G Pyne, Surat Laphookhieo. Phloroglucinol Benzophenones and Xanthones from the Leaves of Garcinia cowa and Their Nitric Oxide Production and α-Glucosidase Inhibitory Activities.
Journal of natural products.
2020 01; 83(1):164-168. doi:
10.1021/acs.jnatprod.9b00849. [PMID: 31860303] - Konstantin Savateev, Victor Fedotov, Ilya Butorin, Oleg Eltsov, Pavel Slepukhin, Evgeny Ulomsky, Vladimir Rusinov, Roman Litvinov, Denis Babkov, Elisaveta Khokhlacheva, Pyotr Radaev, Pavel Vassiliev, Alexandr Spasov. Nitrothiadiazolo[3,2-a]pyrimidines as promising antiglycating agents.
European journal of medicinal chemistry.
2020 Jan; 185(?):111808. doi:
10.1016/j.ejmech.2019.111808. [PMID: 31683103] - Tayra Ferreira Oliveira Lima, Mariana Campos Costa, Ingrid Delbone Figueiredo, Maiara Destro Inácio, Maria Rita Rodrigues, Renata Pires Assis, Amanda Martins Baviera, Iguatemy Lourenço Brunetti. Curcumin, Alone or in Combination with Aminoguanidine, Increases Antioxidant Defenses and Glycation Product Detoxification in Streptozotocin-Diabetic Rats: A Therapeutic Strategy to Mitigate Glycoxidative Stress.
Oxidative medicine and cellular longevity.
2020; 2020(?):1036360. doi:
10.1155/2020/1036360. [PMID: 32566072] - Qinghao Jin, Jin Woo Lee, Jun Gu Kim, Dongho Lee, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang. Lignans from Saururus chinensis with Inhibitory Effects on Nitric Oxide Production.
Journal of natural products.
2019 11; 82(11):3002-3009. doi:
10.1021/acs.jnatprod.9b00520. [PMID: 31642320] - Denis A Babkov, Olga N Zhukowskaya, Alexander V Borisov, Valentina A Babkova, Elena V Sokolova, Anastasia A Brigadirova, Roman A Litvinov, Alexandra A Kolodina, Anatolii S Morkovnik, Vadim S Sochnev, Gennady S Borodkin, Alexander A Spasov. Towards multi-target antidiabetic agents: Discovery of biphenyl-benzimidazole conjugates as AMPK activators.
Bioorganic & medicinal chemistry letters.
2019 09; 29(17):2443-2447. doi:
10.1016/j.bmcl.2019.07.035. [PMID: 31358465] - Laxman N Bavkar, Rahul S Patil, Sheetalnath B Rooge, Megha L Nalawade, Akalpita U Arvindekar. Acceleration of protein glycation by oxidative stress and comparative role of antioxidant and protein glycation inhibitor.
Molecular and cellular biochemistry.
2019 Sep; 459(1-2):61-71. doi:
10.1007/s11010-019-03550-7. [PMID: 31102033] - Rebecca J Abraham, Sam Abraham, Andrew J Stevens, Stephen W Page, Adam McCluskey, Darren J Trott, Ryan M O'Handley. Aminoguanidines: New leads for treatment of Giardia duodenalis infection.
International journal for parasitology. Drugs and drug resistance.
2019 08; 10(?):38-44. doi:
10.1016/j.ijpddr.2019.04.003. [PMID: 31015151] - Mohammad Khabbaz Shirazi, Asaad Azarnezhad, Mohammad Foad Abazari, Mansour Poorebrahim, Pegah Ghoraeian, Nima Sanadgol, Hanieh Bokharaie, Sahar Heydari, Amin Abbasi, Sahra Kabiri, Maryam Nouri Aleagha, Seyed Ehsan Enderami, Amir Savar Dashtaki, Hassan Askari. The role of nitric oxide signaling in renoprotective effects of hydrogen sulfide against chronic kidney disease in rats: Involvement of oxidative stress, autophagy and apoptosis.
Journal of cellular physiology.
2019 07; 234(7):11411-11423. doi:
10.1002/jcp.27797. [PMID: 30478901] - Chaosheng Li, Zhenhua Wang, Xiaoli Li, Jun Chen. Effects of semicarbazide-sensitive amine oxidase inhibitors on morphology of aorta and kidney in diabetic rats.
BMC endocrine disorders.
2019 Jun; 19(1):59. doi:
10.1186/s12902-019-0392-1. [PMID: 31182088] - Saeideh Saadat, Farimah Beheshti, Vahid Reza Askari, Mahmoud Hosseini, Nema Mohamadian Roshan, Mohammad Hossein Boskabady. Aminoguanidine affects systemic and lung inflammation induced by lipopolysaccharide in rats.
Respiratory research.
2019 May; 20(1):96. doi:
10.1186/s12931-019-1054-6. [PMID: 31113409] - Mingxia Song, Shiben Wang, Zengtao Wang, Zhiyang Fu, Shengchao Zhou, Huabin Cheng, Zhuo Liang, Xianqing Deng. Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety.
European journal of medicinal chemistry.
2019 Mar; 166(?):108-118. doi:
10.1016/j.ejmech.2019.01.038. [PMID: 30685534] - Mohamad Fawzi Mahomoodally, Arzu Atalay, Marie Carene Nancy Picot, Onur Bender, Evrim Celebi, Adriano Mollica, Gokhan Zengin. Chemical, biological and molecular modelling analyses to probe into the pharmacological potential of Antidesma madagascariense Lam.: A multifunctional agent for developing novel therapeutic formulations.
Journal of pharmaceutical and biomedical analysis.
2018 Nov; 161(?):425-435. doi:
10.1016/j.jpba.2018.09.002. [PMID: 30216791] - Barbara Tóth, Judit Hohmann, Andrea Vasas. Phenanthrenes: A Promising Group of Plant Secondary Metabolites.
Journal of natural products.
2018 03; 81(3):661-678. doi:
10.1021/acs.jnatprod.7b00619. [PMID: 29280630] - Chao Chen, Xiao-Jing Yun, Li-Ze Liu, Hong Guo, Lian-Feng Liu, Xiao-Ling Chen. Exogenous nitric oxide enhances the prophylactic effect of aminoguanidine, a preferred iNOS inhibitor, on bleomycin-induced fibrosis in the lung: Implications for the direct roles of the NO molecule in vivo.
Nitric oxide : biology and chemistry.
2017 Nov; 70(?):31-41. doi:
10.1016/j.niox.2017.07.005. [PMID: 28757441] - Yuanjian Song, Fang Zhang, Changjiang Ying, Kiran Ashok Kumar, Xiaoyan Zhou. Inhibition of NF-κB activity by aminoguanidine alleviates neuroinflammation induced by hyperglycemia.
Metabolic brain disease.
2017 10; 32(5):1627-1637. doi:
10.1007/s11011-017-0013-5. [PMID: 28634786] - Parimal Chowdhury. Aminoguanidine (AG) Induces Induced both Pro- and Antioxidant Effect in AR42J Cells, a Rat Pancreatic Tumor Cell Line.
Annals of clinical and laboratory science.
2017 Sep; 47(5):572-580. doi:
". [PMID: 29066484] - Karina Gutiérrez-García, Adriana Neira-González, Rosa Martha Pérez-Gutiérrez, Giovana Granados-Ramírez, Ramon Zarraga, Kazimierz Wrobel, Francisco Barona-Gómez, Luis B Flores-Cotera. Phylogenomics of 2,4-Diacetylphloroglucinol-Producing Pseudomonas and Novel Antiglycation Endophytes from Piper auritum.
Journal of natural products.
2017 07; 80(7):1955-1963. doi:
10.1021/acs.jnatprod.6b00823. [PMID: 28704049] - Marika Svrckova, Martina Zatloukalova, Petra Dvorakova, Dominika Coufalova, David Novak, Lenka Hernychova, Jan Vacek. Na+/K+-ATPase interaction with methylglyoxal as reactive metabolic side product.
Free radical biology & medicine.
2017 07; 108(?):146-154. doi:
10.1016/j.freeradbiomed.2017.03.024. [PMID: 28342847] - Madhav M Joglekar, Laxman N Bavkar, Srinivas Sistla, Akalpita U Arvindekar. Effective inhibition of protein glycation by combinatorial usage of limonene and aminoguanidine through differential and synergistic mechanisms.
International journal of biological macromolecules.
2017 Jun; 99(?):563-569. doi:
10.1016/j.ijbiomac.2017.02.104. [PMID: 28274869] - Xiao Yan Zhou, Fang Zhang, Chang Jiang Ying, Jing Chen, Ling Chen, Jing Dong, Yue Shi, Mang Tang, Xiao Tong Hu, Zhi Hua Pan, Na Na Xu, Kui Yang Zheng, Ren Xian Tang, Yuan Jian Song. Inhibition of iNOS alleviates cognitive deficits and depression in diabetic mice through downregulating the NO/sGC/cGMP/PKG signal pathway.
Behavioural brain research.
2017 03; 322(Pt A):70-82. doi:
10.1016/j.bbr.2016.12.046. [PMID: 28077315] - Susmita Sil, Tusharkanti Ghosh, Rupsa Ghosh, Pritha Gupta. Nitric oxide synthase inhibitor, aminoguanidine reduces intracerebroventricular colchicine induced neurodegeneration, memory impairments and changes of systemic immune responses in rats.
Journal of neuroimmunology.
2017 02; 303(?):51-61. doi:
10.1016/j.jneuroim.2016.12.007. [PMID: 28065581] - Ik-Soo Lee, Yu Jin Kim, Seung-Hyun Jung, Joo-Hwan Kim, Jin Sook Kim. Flavonoids from Litsea japonica Inhibit AGEs Formation and Rat Lense Aldose Reductase In Vitro and Vessel Dilation in Zebrafish.
Planta medica.
2017 Feb; 83(3-04):318-325. doi:
10.1055/s-0042-116324. [PMID: 27690380] - Natalia Veronez da Cunha, Fernanda Novi Cortegoso Lopes, Carolina Panis, Rubens Cecchini, Phileno Pinge-Filho, Marli Cardoso Martins-Pinge. iNOS inhibition improves autonomic dysfunction and oxidative status in hypertensive obese rats.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2017; 39(1):50-57. doi:
10.1080/10641963.2016.1210628. [PMID: 28055264] - Qinghao Jin, Jin Woo Lee, Hari Jang, Ji Eun Choi, Hyung Sik Kim, Dongho Lee, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang. Dimeric sesquiterpene and thiophenes from the roots of Echinops latifolius.
Bioorganic & medicinal chemistry letters.
2016 12; 26(24):5995-5998. doi:
10.1016/j.bmcl.2016.10.017. [PMID: 27865705] - Qing Liu, Yang Hee Jo, Seon Beom Kim, Qinghao Jin, Bang Yeon Hwang, Mi Kyeong Lee. Sesquiterpenes from the roots of Lindera strychnifolia with inhibitory effects on nitric oxide production in RAW 264.7 cells.
Bioorganic & medicinal chemistry letters.
2016 10; 26(20):4950-4954. doi:
10.1016/j.bmcl.2016.09.012. [PMID: 27634197] - Fernando Almeida-Souza, Celeste da Silva Freitas de Souza, Noemi Nosomi Taniwaki, João José Mendes Silva, Renata Mondêgo de Oliveira, Ana Lúcia Abreu-Silva, Kátia da Silva Calabrese. Morinda citrifolia Linn. fruit (Noni) juice induces an increase in NO production and death of Leishmania amazonensis amastigotes in peritoneal macrophages from BALB/c.
Nitric oxide : biology and chemistry.
2016 08; 58(?):51-8. doi:
10.1016/j.niox.2016.06.004. [PMID: 27328771] - K Ekici, O Temelli, H Parlakpinar, E Samdanci, A Polat, A Beytur, K Tanbek, C Ekici, I H Dursun. Beneficial effects of aminoguanidine on radiotherapy-induced kidney and testis injury.
Andrologia.
2016 Aug; 48(6):683-92. doi:
10.1111/and.12500. [PMID: 26610736] - V N Perfilova, T A Popova, I I Prokofiev, A V Borisov, G I Zaypullaev, E A Muzyko, M V Kustova, I N Tuyrenkov. [CHANGES OF THE OXIDATIVE STATUS, MITOCHONDRIAL FUNCTION, BLOOD PRESSURE AND INDICATORS OF HEMOSTASIS IN STRESSED ANIMALS AND IN THE CONDITIONS OF NO-SYNTHASE BLOCKADE].
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova.
2016 Jul; 102(7):833-46. doi:
NULL. [PMID: 30193051] - Jong-Seok Kim, Sang-Ho Cha, Woo Sik Kim, Seung Jung Han, Seung Bin Cha, Hong Min Kim, Kee Woong Kwon, So Jeong Kim, Hong-Hee Choi, Jienny Lee, Sang-Nae Cho, Won-Jung Koh, Yeong-Min Park, Sung Jae Shin. A Novel Therapeutic Approach Using Mesenchymal Stem Cells to Protect Against Mycobacterium abscessus.
Stem cells (Dayton, Ohio).
2016 07; 34(7):1957-70. doi:
10.1002/stem.2353. [PMID: 26946350] - Shweta Bhat, Mashanipalya G Jagadeeshaprasad, Yugendra R Patil, Mahemud L Shaikh, Bhaskaran S Regin, Viswanathan Mohan, Ashok P Giri, Muthuswamy Balasubramanyam, Ramanamurthy Boppana, Mahesh J Kulkarni. Proteomic Insight Reveals Elevated Levels of Albumin in Circulating Immune Complexes in Diabetic Plasma.
Molecular & cellular proteomics : MCP.
2016 06; 15(6):2011-20. doi:
10.1074/mcp.m116.058008. [PMID: 27056913] - Hang Ma, Weixi Liu, Leslie Frost, Louis J Kirschenbaum, Joel A Dain, Navindra P Seeram. Glucitol-core containing gallotannins inhibit the formation of advanced glycation end-products mediated by their antioxidant potential.
Food & function.
2016 May; 7(5):2213-22. doi:
10.1039/c6fo00169f. [PMID: 27101975] - Hossein Fatemikia, Farzaneh Ketabchi, Zynab Karimi, Seyed Mostafa Shid Moosavi. Distant effects of unilateral renal ischemia/reperfusion on contralateral kidney but not lung in rats: the roles of ROS and iNOS.
Canadian journal of physiology and pharmacology.
2016 May; 94(5):477-87. doi:
10.1139/cjpp-2015-0285. [PMID: 26854976] - Cláudia de Souza Ferreira, Paula Commune Pennacchi, Tomaz Henrique Araújo, Noemi Nosomi Taniwaki, Fernanda Borges de Araújo Paula, Stella Maris da Silveira Duarte, Maria Rita Rodrigues. Aminoguanidine treatment increased NOX2 response in diabetic rats: Improved phagocytosis and killing of Candida albicans by neutrophils.
European journal of pharmacology.
2016 Feb; 772(?):83-91. doi:
10.1016/j.ejphar.2015.12.044. [PMID: 26724393] - Jin Woo Lee, Chul Lee, Qinghao Jin, Hari Jang, Dongho Lee, Ha-Jin Lee, Jong Won Shin, Sang Bae Han, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang. Diterpenoids from the Roots of Euphorbia fischeriana with Inhibitory Effects on Nitric Oxide Production.
Journal of natural products.
2016 Jan; 79(1):126-31. doi:
10.1021/acs.jnatprod.5b00789. [PMID: 26702644] - Priyanka Singh, Ramesha H Jayaramaiah, Sachin B Agawane, Garikapati Vannuruswamy, Arvind M Korwar, Atul Anand, Vitthal S Dhaygude, Mahemud L Shaikh, Rakesh S Joshi, Ramanamurthy Boppana, Mahesh J Kulkarni, Hirekodathakallu V Thulasiram, Ashok P Giri. Potential Dual Role of Eugenol in Inhibiting Advanced Glycation End Products in Diabetes: Proteomic and Mechanistic Insights.
Scientific reports.
2016 Jan; 6(?):18798. doi:
10.1038/srep18798. [PMID: 26739611] - Heba M Hafez, Mohamed A Ibrahim, Salwa A Ibrahim, Entesar F Amin, Wafaey Goma, Aly M Abdelrahman. Potential protective effect of etanercept and aminoguanidine in methotrexate-induced hepatotoxicity and nephrotoxicity in rats.
European journal of pharmacology.
2015 Dec; 768(?):1-12. doi:
10.1016/j.ejphar.2015.08.047. [PMID: 26332135] - Hamed Shafaroodi, Mahsa Hassanipour, Zahra Mousavi, Nastaran Rahimi, Ahmad Reza Dehpour. The Effects of Sub-Chronic Treatment with Pioglitazone on the Septic Mice Mortality in the Model of Cecal Ligation and Puncture: Involvement of Nitric Oxide Pathway.
Acta medica Iranica.
2015 Oct; 53(10):608-16. doi:
NULL. [PMID: 26615372] - Suna Sabuncuoglu, Ayse Eken, Ahmet Aydin, Hilal Ozgunes, Hilmi Orhan. Cofactor metals and antioxidant enzymes in cisplatin-treated rats: effect of antioxidant intervention.
Drug and chemical toxicology.
2015 Oct; 38(4):375-82. doi:
10.3109/01480545.2014.974107. [PMID: 25346999] - Eung Tae Yeon, Jin Woo Lee, Chul Lee, Qinghao Jin, Hari Jang, Dongho Lee, Jong Seog Ahn, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang. neo-Clerodane Diterpenoids from Scutellaria barbata and Their Inhibitory Effects on LPS-Induced Nitric Oxide Production.
Journal of natural products.
2015 Sep; 78(9):2292-6. doi:
10.1021/acs.jnatprod.5b00126. [PMID: 26331882] - Jaeyoung Kwon, Sunita Basnet, Jin Woo Lee, Eun-Kyoung Seo, Nanzad Tsevegsuren, Bang Yeon Hwang, Dongho Lee. Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages.
Bioorganic & medicinal chemistry letters.
2015 Aug; 25(16):3314-8. doi:
10.1016/j.bmcl.2015.05.062. [PMID: 26073007] - Md Maroof Alam, Irshad Ahmad, Imrana Naseem. Inhibitory effect of quercetin in the formation of advance glycation end products of human serum albumin: An in vitro and molecular interaction study.
International journal of biological macromolecules.
2015 Aug; 79(?):336-43. doi:
10.1016/j.ijbiomac.2015.05.004. [PMID: 25982953] - Kuo-Tong Huang, Cheng-Tien Wu, Kuo-How Huang, Wei-Chou Lin, Chang-Mu Chen, Siao-Syun Guan, Chih-Kang Chiang, Shing-Hwa Liu. Titanium nanoparticle inhalation induces renal fibrosis in mice via an oxidative stress upregulated transforming growth factor-β pathway.
Chemical research in toxicology.
2015 Mar; 28(3):354-64. doi:
10.1021/tx500287f. [PMID: 25406100] - Marika Havlikova, Martina Zatloukalova, Jitka Ulrichova, Petr Dobes, Jan Vacek. Electrocatalytic assay for monitoring methylglyoxal-mediated protein glycation.
Analytical chemistry.
2015 Feb; 87(3):1757-63. doi:
10.1021/ac503705d. [PMID: 25539570] - Songyan Wang, Bing Li, Chunguang Li, Wenpeng Cui, Lining Miao. Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy.
Journal of diabetes research.
2015; 2015(?):962383. doi:
10.1155/2015/962383. [PMID: 26421309] - Ana C A X De-Oliveira, Kátia S Poça, Paulo R R Totino, Francisco J R Paumgartten. Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.
PloS one.
2015; 10(1):e0117842. doi:
10.1371/journal.pone.0117842. [PMID: 25635819] - Jalaluddin M Ashraf, Uzma Shahab, Shams Tabrez, Eun Ju Lee, Inho Choi, Saheem Ahmad. Quercetin as a finer substitute to aminoguanidine in the inhibition of glycation products.
International journal of biological macromolecules.
2015; 77(?):188-92. doi:
10.1016/j.ijbiomac.2015.03.021. [PMID: 25799884] - Giovane S Galdino, Carlos H Xavier, Renato Almeida, Grazielle Silva, Marcos A Fontes, Gustavo Menezes, Igor D Duarte, Andrea C Perez. The Nitric oxide/CGMP/KATP pathway mediates systemic and central antinociception induced by resistance exercise in rats.
The International journal of neuroscience.
2015; 125(10):765-73. doi:
10.3109/00207454.2014.970256. [PMID: 25271801] - Eunsoo Jung, Junghyun Kim, Sung Ho Kim, Sanghwa Kim, Myung-Haing Cho. Gemigliptin, a novel dipeptidyl peptidase-4 inhibitor, exhibits potent anti-glycation properties in vitro and in vivo.
European journal of pharmacology.
2014 Dec; 744(?):98-102. doi:
10.1016/j.ejphar.2014.10.008. [PMID: 25448307] - Mohsen Alipour, Alipour Mohsen, Farhad Gadiri-Soufi, Gadiri Soufi Farhad, Mohammad-Reza Jafari, Jafari Mohammad-Reza. Effect of aminoguanidine on sciatic functional index, oxidative stress, and rate of apoptosis in an experimental rat model of ischemia-reperfusion injury.
Canadian journal of physiology and pharmacology.
2014 Dec; 92(12):1013-9. doi:
10.1139/cjpp-2014-0315. [PMID: 25391296] - Bingjie Xie, Fankai Lin, Lei Peng, Kaleem Ullah, Hanyan Wu, Hong Qing, Yulin Deng. Methylglyoxal increases dopamine level and leads to oxidative stress in SH-SY5Y cells.
Acta biochimica et biophysica Sinica.
2014 Nov; 46(11):950-6. doi:
10.1093/abbs/gmu094. [PMID: 25274329] - Neeraj Gilhotra, Dinesh Dhingra. Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice.
Pharmacological reports : PR.
2014 Oct; 66(5):885-91. doi:
10.1016/j.pharep.2014.05.008. [PMID: 25149996] - Elahe Sattarinezhad, Hamed Shafaroodi, Kiandokht Sheikhnouri, Zahra Mousavi, Leila Moezi. The effects of coenzyme Q10 on seizures in mice: the involvement of nitric oxide.
Epilepsy & behavior : E&B.
2014 Aug; 37(?):36-42. doi:
10.1016/j.yebeh.2014.05.024. [PMID: 24972157] - Atul Upadhyay, Emmy Tuenter, Rizwan Ahmad, Adnan Amin, Vasiliki Exarchou, Sandra Apers, Nina Hermans, Luc Pieters. Kavalactones, a novel class of protein glycation and lipid peroxidation inhibitors.
Planta medica.
2014 Aug; 80(12):1001-8. doi:
10.1055/s-0034-1382949. [PMID: 25098935] - Jin Woo Lee, Chul Lee, Qinghao Jin, Eung Tae Yeon, Dongho Lee, Soo-Young Kim, Sang Bae Han, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang. Pyranocoumarins from Glehnia littoralis inhibit the LPS-induced NO production in macrophage RAW 264.7 cells.
Bioorganic & medicinal chemistry letters.
2014 Jun; 24(12):2717-9. doi:
10.1016/j.bmcl.2014.04.046. [PMID: 24813739] - Runqiang Yang, Yongqi Yin, Liping Guo, Yongbin Han, Zhenxin Gu. Sequence analysis of diamine oxidase gene from fava bean and its expression related to γ-aminobutyric acid accumulation in seeds germinating under hypoxia-NaCl stress.
Journal of the science of food and agriculture.
2014 Jun; 94(8):1585-91. doi:
10.1002/jsfa.6461. [PMID: 24170570] - V S Tomaz, R C Cordeiro, A M N Costa, D F de Lucena, H V Nobre Júnior, F C F de Sousa, S M M Vasconcelos, M L Vale, J Quevedo, D Macêdo. Antidepressant-like effect of nitric oxide synthase inhibitors and sildenafil against lipopolysaccharide-induced depressive-like behavior in mice.
Neuroscience.
2014 May; 268(?):236-46. doi:
10.1016/j.neuroscience.2014.03.025. [PMID: 24662848] - Julie L Heinecke, Lisa A Ridnour, Robert Y S Cheng, Christopher H Switzer, Michael M Lizardo, Chand Khanna, Sharon A Glynn, S Perwez Hussain, Howard A Young, Stefan Ambs, David A Wink. Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression.
Proceedings of the National Academy of Sciences of the United States of America.
2014 Apr; 111(17):6323-8. doi:
10.1073/pnas.1401799111. [PMID: 24733928] - L Duran, A Guzel, H U Akdemir, F Demir, C Karadeniz, H Alacam, A Gacar, N Murat, S Ozdemir, T Guvenc. Cardioprotective effect of aminoguanidine in combination with steroid therapy after blunt chest trauma.
Bratislavske lekarske listy.
2014; 115(9):538-43. doi:
10.4149/bll_2014_104. [PMID: 25318911] - Bilquees Bano, Sanaullah Abbasi, Jalaluddin A J Khan, Shafqat Hussain, Saima Rasheed, Shahnaz Perveen, Khalid Mohammed Khan, M Iqbal Choudhary. Antiglycation activity of quinoline derivatives- a new therapeutic class for the management of type 2 diabetes complications.
Medicinal chemistry (Shariqah (United Arab Emirates)).
2014; 11(1):60-8. doi:
10.2174/1573406410666140526151254. [PMID: 24875825] - Bhupesh Sharma, P M Sharma. Arsenic toxicity induced endothelial dysfunction and dementia: pharmacological interdiction by histone deacetylase and inducible nitric oxide synthase inhibitors.
Toxicology and applied pharmacology.
2013 Nov; 273(1):180-8. doi:
10.1016/j.taap.2013.07.017. [PMID: 23921152] - S Mostafa Moosavi, Zohreh Bagheri, Izadpanah Gheitasi, Jamshid Roozbeh. Pre- or post-treatment with aminoguanidine attenuates a renal distal acidification defect induced by acute ureteral obstruction in rats.
Canadian journal of physiology and pharmacology.
2013 Nov; 91(11):920-8. doi:
10.1139/cjpp-2013-0059. [PMID: 24117259] - Ik-Soo Lee, Song Yi Yu, Seung-Hyun Jung, Yu-Ri Lee, Yun Mi Lee, Joo-Hwan Kim, Hang Sun, Jin Sook Kim. Proanthocyanidins from Spenceria ramalana and their effects on AGE formation in vitro and hyaloid-retinal vessel dilation in larval zebrafish in vivo.
Journal of natural products.
2013 Oct; 76(10):1881-8. doi:
10.1021/np400442b. [PMID: 24131240] - M K Radika, P Viswanathan, C V Anuradha. Nitric oxide mediates the insulin sensitizing effects of β-sitosterol in high fat diet-fed rats.
Nitric oxide : biology and chemistry.
2013 Aug; 32(?):43-53. doi:
10.1016/j.niox.2013.04.007. [PMID: 23624268] - Chul Lee, Jin Woo Lee, Qinghao Jin, Dae Sik Jang, Sung-Joon Lee, Dongho Lee, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang. Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages.
Bioorganic & medicinal chemistry letters.
2013 Jul; 23(14):4263-6. doi:
10.1016/j.bmcl.2013.04.032. [PMID: 23743282] - Ni Zheng, Xing Lin, Qingwei Wen, Kintoko, Shijun Zhang, Jianchun Huang, Xiaohui Xu, Renbin Huang. Effect of 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from Averrhoa carambola L. (Oxalidaceae) roots, on advanced glycation end-product-mediated renal injury in type 2 diabetic KKAy mice.
Toxicology letters.
2013 May; 219(1):77-84. doi:
10.1016/j.toxlet.2013.03.001. [PMID: 23500658] - Tarcisio Vieira de Brito, Rafael da Silva Prudêncio, Adriano Bezerra Sales, Francisco das Chagas Vieira, Starley Jone Nogueira Candeira, Álvaro Xavier Franco, Karoline Sabóia Aragão, Ronaldo de Albuquerque Ribeiro, Marcellus Henrique Loiola Ponte de Souza, Luciano de Sousa Chaves, Ana Lúcia Ponte Freitas, Jand-Venes Rolim Medeiros, André Luiz dos Reis Barbosa. Anti-inflammatory effect of a sulphated polysaccharide fraction extracted from the red algae Hypnea musciformis via the suppression of neutrophil migration by the nitric oxide signalling pathway.
The Journal of pharmacy and pharmacology.
2013 May; 65(5):724-33. doi:
10.1111/jphp.12024. [PMID: 23600390] - Caronda J Moore, Chun Hong Shao, Ryoji Nagai, Shelby Kutty, Jaipaul Singh, Keshore R Bidasee. Malondialdehyde and 4-hydroxynonenal adducts are not formed on cardiac ryanodine receptor (RyR2) and sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA2) in diabetes.
Molecular and cellular biochemistry.
2013 Apr; 376(1-2):121-35. doi:
10.1007/s11010-013-1558-1. [PMID: 23354458] - Manju Gurung, Birendra Babu Adhikari, Shintaro Morisada, Hidetaka Kawakita, Keisuke Ohto, Katsutoshi Inoue, Shafiq Alam. N-aminoguanidine modified persimmon tannin: a new sustainable material for selective adsorption, preconcentration and recovery of precious metals from acidic chloride solution.
Bioresource technology.
2013 Feb; 129(?):108-17. doi:
10.1016/j.biortech.2012.11.012. [PMID: 23238341] - Anjandeep Kaur, Baldev Singh, Amteshwar Singh Jaggi. Synthesis and evaluation of novel 2,3,5-triaryl-4H,2,3,3a,5,6,6a-hexahydropyrrolo[3,4-d]isoxazole-4,6-diones for advanced glycation end product formation inhibitory activity.
Bioorganic & medicinal chemistry letters.
2013 Feb; 23(3):797-801. doi:
10.1016/j.bmcl.2012.11.080. [PMID: 23290454] - Bhupesh Sharma, Nirmal Singh. Pharmacological inhibition of inducible nitric oxide synthase (iNOS) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, convalesce behavior and biochemistry of hypertension induced vascular dementia in rats.
Pharmacology, biochemistry, and behavior.
2013 Feb; 103(4):821-30. doi:
10.1016/j.pbb.2012.11.011. [PMID: 23201648] - Chien-Fu Huang, Chien-Ning Hsu, Shao-Ju Chien, Ying-Jui Lin, Li-Tung Huang, You-Lin Tain. Aminoguanidine attenuates hypertension, whereas 7-nitroindazole exacerbates kidney damage in spontaneously hypertensive rats: the role of nitric oxide.
European journal of pharmacology.
2013 Jan; 699(1-3):233-40. doi:
10.1016/j.ejphar.2012.11.034. [PMID: 23201071] - Ching-Chia Wang, Te-I Weng, En-Ting Wu, Mei-Hwan Wu, Rong-Sen Yang, Shing-Hwa Liu. Involvement of interleukin-6-regulated nitric oxide synthase in hemorrhagic cystitis and impaired bladder contractions in young rats induced by acrolein, a urinary metabolite of cyclophosphamide.
Toxicological sciences : an official journal of the Society of Toxicology.
2013 Jan; 131(1):302-10. doi:
10.1093/toxsci/kfs270. [PMID: 22961095] - Yu-Si Cheng, Xiao-Dong Cong, De-Zai Dai, Yun Zhang, Yin Dai. Argirein alleviates corpus cavernosum dysfunction by suppressing pro-inflammatory factors p66Shc and ER stress chaperone Bip in diabetic rats.
The Journal of pharmacy and pharmacology.
2013 Jan; 65(1):94-101. doi:
10.1111/j.2042-7158.2012.01565.x. [PMID: 23215692] - Deidiane E Ribeiro, Viviane M Maiolini, Roseli Soncini, José Antunes-Rodrigues, Lucila L K Elias, Fabiana C Vilela, Alexandre Giusti-Paiva. Inhibition of nitric oxide synthase accentuates endotoxin-induced sickness behavior in mice.
Pharmacology, biochemistry, and behavior.
2013 Jan; 103(3):535-40. doi:
10.1016/j.pbb.2012.09.022. [PMID: 23046850] - Lina Nordquist, Per Liss, Angelica Fasching, Peter Hansell, Fredrik Palm. Hypoxia in the diabetic kidney is independent of advanced glycation end-products.
Advances in experimental medicine and biology.
2013; 765(?):185-193. doi:
10.1007/978-1-4614-4989-8_26. [PMID: 22879032] - A Babicová, Z Havlínová, M Hroch, M Rezáčová, J Pejchal, J Vávrová, J Chládek. In vivo study of radioprotective effect of NO-synthase inhibitors and acetyl-L-carnitine.
Physiological research.
2013; 62(6):701-10. doi:
10.33549/physiolres.932541. [PMID: 23869893] - Ji-Hun Park, Tae-Saeng Choi. Polycystic ovary syndrome (PCOS)-like phenotypes in the d-galactose-induced aging mouse model.
Biochemical and biophysical research communications.
2012 Nov; 427(4):701-4. doi:
10.1016/j.bbrc.2012.09.099. [PMID: 23022527] - Mariana Seija, Cecilia Baccino, Nicolás Nin, Carolina Sánchez-Rodríguez, Rosario Granados, Antonio Ferruelo, Leticia Martínez-Caro, Jesús Ruíz-Cabello, Marta de Paula, Oscar Noboa, Andrés Esteban, José Angel Lorente. Role of peroxynitrite in sepsis-induced acute kidney injury in an experimental model of sepsis in rats.
Shock (Augusta, Ga.).
2012 Oct; 38(4):403-10. doi:
10.1097/shk.0b013e31826660f2. [PMID: 22777123] - Sushma Ror Maratha, N Mahadevan. Memory enhancing activity of naringin in unstressed and stressed mice: possible cholinergic and nitriergic modulation.
Neurochemical research.
2012 Oct; 37(10):2206-12. doi:
10.1007/s11064-012-0844-8. [PMID: 22821418]