alpha-Artemether (BioDeep_00000175897)
Main id: BioDeep_00000017350
human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs
代谢物信息卡片
10-methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecane
化学式: C16H26O5 (298.1780146)
中文名称: 蒿甲醚
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)OC)C
InChI: InChI=1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D009676 - Noxae > D016877 - Oxidants > D010545 - Peroxides
Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria.
Artemether is an anti-malarial compound that targets drug-resistant strains of falciparum malaria.
同义名列表
17 个代谢物同义名
10-methoxy-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecane; artemether, (3R-(3alpha,5abeta,6beta,8abeta,9alpha,10alpha,12beta,12aR*))-isomer; artemether, (3R-(3alpha,5abeta,6alpha,8abeta,9alpha,10beta,12beta,12aR*))-isomer; artemether, (3R-(3alpha,5abeta,6beta,8aalpha,9alpha,10beta,12beta,12aR*))-isomer; O Methyldihydroartemisinine; O-methyldihydroartemisinine; alpha Artemether; alpha-Artemether; beta-arthemeter; beta Arthemeter; Α-artemether; a-Artemether; Artemether; artenam; Dihydroqinghaosu methyl ether; Dihydroartemisinin methyl ether; SM224
数据库引用编号
8 个数据库交叉引用编号
- PubChem: 500199
- HMDB: HMDB0248189
- ChEMBL: CHEMBL3190493
- MeSH: Artemether
- chemspider: 437594
- CAS: 80581-45-9
- CAS: 71963-77-4
- medchemexpress: HY-N0402
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ellen K G Mhango, Benjamin R Sveinbjornsson, Bergthora S Snorradottir, Sveinbjorn Gizurarson. Incompatibility of antimalarial drugs: challenges in formulating combination products for malaria.
Drug delivery.
2024 Dec; 31(1):2299594. doi:
10.1080/10717544.2023.2299594. [PMID: 38180033] - Denis Ponomarev, Maria Lvova, Viatcheslav Mordvinov, Irina Chidunchi, Alexander Dushkin, Damira Avgustinovich. Anti-Opisthorchis felineus effects of artemisinin derivatives: An in vitro study.
Acta tropica.
2024 Jun; 254(?):107196. doi:
10.1016/j.actatropica.2024.107196. [PMID: 38521124] - Pamela Weathers, Melissa Towler, Bushra Hafeez Kiani, David Dolivo, Tanja Dominko. Differential Anti-Fibrotic and Remodeling Responses of Human Dermal Fibroblasts to Artemisia sp., Artemisinin, and Its Derivatives.
Molecules (Basel, Switzerland).
2024 May; 29(9):. doi:
10.3390/molecules29092107. [PMID: 38731597] - Paul N Newton, Lesley A Chesson, Mayfong Mayxay, Arjen Dondorp, Patricia Tabernero, John D Howa, Thure E Cerling. Forensic investigation of falsified antimalarials using isotope ratio mass spectrometry: a pilot investigation.
Scientific reports.
2024 02; 14(1):3995. doi:
10.1038/s41598-024-54168-9. [PMID: 38369604] - Yongyi Liang, Shaojun Qiu, Youwen Zou, Lianxiang Luo. Targeting ferroptosis with natural products in liver injury: new insights from molecular mechanisms to targeted therapies.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jan; 122(?):155134. doi:
10.1016/j.phymed.2023.155134. [PMID: 37863001] - Yan-Hang Wang, Xin Chen, Yi-Zhen Bai, Peng Gao, Zhuo Yang, Qiang Guo, Ying-Yuan Lu, Jiao Zheng, Dan Liu, Jun Yang, Peng-Fei Tu, Ke-Wu Zeng. Palmitoylation of PKCδ by ZDHHC5 in hypothalamic microglia presents as a therapeutic target for fatty liver disease.
Theranostics.
2024; 14(3):988-1009. doi:
10.7150/thno.89602. [PMID: 38250049] - Wenci Weng, Xuewen Yu, Yifan Dong, Taifen Wang, Mumin Shao, Huili Sun, Pengxun Han. Artemether ameliorates adriamycin induced cardiac atrophy in mice.
Molecular medicine reports.
2023 Aug; 28(2):. doi:
10.3892/mmr.2023.13040. [PMID: 37387406] - Xin-Na Gao, Jing-Jie Kang, Peng Sun, Yi-Fan Zhao, Dong Zhang, Lan Yang, Yue Ma, Hui-Min Gao. [Microbial transformation of artemisinin and its derivatives].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Jun; 48(11):2876-2895. doi:
10.19540/j.cnki.cjcmm.20230327.301. [PMID: 37381950] - Li Chen, Shuang Yu, Shubing Hong, Xia Lin, Xiaonan Zhu, Xiaopei Cao, Yanbing Li, Haipeng Xiao. Therapeutic role of Artemether in the prevention of hepatic steatosis through miR-34a-5p/PPARα pathway.
Drug development research.
2023 04; 84(2):156-171. doi:
10.1002/ddr.22020. [PMID: 36541217] - Ikponmwosa Owen Evbuomwan, Omokolade Oluwaseyi Alejolowo, Tobiloba Christiana Elebiyo, Charles Obiora Nwonuma, Oluwafemi Adeleke Ojo, Evelyn Uwa Edosomwan, Joy Ifeyinwa Chikwendu, Nwanneka Victoria Elosiuba, Justina Chimezie Akulue, Festus Ayorinde Dogunro, Damilare Emmanuel Rotimi, Omorefosa Osarenkhoe Osemwegie, Adebola Busola Ojo, Olusegun George Ademowo, Oluyomi Stephen Adeyemi, Olarewaju Michael Oluba. In silico modeling revealed phytomolecules derived from Cymbopogon citratus (DC.) leaf extract as promising candidates for malaria therapy.
Journal of biomolecular structure & dynamics.
2023 Mar; ?(?):1-18. doi:
10.1080/07391102.2023.2192799. [PMID: 36974933] - Isaac A Adedara, Solomon E Owumi. Neurobehavioral and biochemical responses to artemisinin-based drug and aflatoxin B1 co-exposure in rats.
Mycotoxin research.
2023 Jan; ?(?):. doi:
10.1007/s12550-023-00474-6. [PMID: 36701108] - Dancan M Wakoli, Bartholomew N Ondigo, Douglas O Ochora, Joseph G Amwoma, Winnie Okore, Edwin W Mwakio, Gladys Chemwor, Jackeline Juma, Raphael Okoth, Charles Okudo, Redemptah Yeda, Benjamin H Opot, Agnes C Cheruiyot, Dennis Juma, Amanda Roth, Benhards R Ogutu, Daniel Boudreaux, Ben Andagalu, Hoseah M Akala. Impact of parasite genomic dynamics on the sensitivity of Plasmodium falciparum isolates to piperaquine and other antimalarial drugs.
BMC medicine.
2022 11; 20(1):448. doi:
10.1186/s12916-022-02652-2. [PMID: 36397090] - Joyce Hernandez Maldonado, Oliver Grundmann. Drug-Drug Interactions of Artemisinin-Based Combination Therapies in Malaria Treatment: A Narrative Review of the Literature.
Journal of clinical pharmacology.
2022 10; 62(10):1197-1205. doi:
10.1002/jcph.2073. [PMID: 35543380] - Jader Pires, Suéllen Alves Costa, Karoline Paiva da Silva, Aline Gomes Batista da Conceição, Érica de Melo Reis, Adilson Paulo Sinhorin, Carmen Lucia Bassi Branco, Letícia Cruz, Stela Regina Ferrarini, Cláudia Marlise Balbinotti Andrade. Artemether-loaded polymeric lipid-core nanocapsules reduce cell viability and alter the antioxidant status of U-87 MG cells.
Pharmaceutical development and technology.
2022 Oct; 27(8):892-903. doi:
10.1080/10837450.2022.2128819. [PMID: 36168940] - Golbarg Esfahani, Olaf Häusler, Karsten Mäder. Controlled release starch-lipid implant for the therapy of severe malaria.
International journal of pharmaceutics.
2022 Jun; 622(?):121879. doi:
10.1016/j.ijpharm.2022.121879. [PMID: 35649475] - Sri Riyati Sugiarto, Balbir Singh, Madhu Page-Sharp, Wendy A Davis, Sam Salman, King Ching Hii, Timothy M E Davis. The pharmacokinetic properties of artemether and lumefantrine in Malaysian patients with Plasmodium knowlesi malaria.
British journal of clinical pharmacology.
2022 02; 88(2):691-701. doi:
10.1111/bcp.15001. [PMID: 34296469] - M Farouk Chughlay, Karen I Barnes, Myriam El Gaaloul, Nada Abla, Jörg J Möhrle, Paul Griffin, Paul van Giersbergen, Stephanie E Reuter, Hayley B Schultz, Anita Kress, Peter Tapley, Rebecca A Webster, Timothy Wells, James S McCarthy, Bridget E Barber, Louise Marquart, Michelle J Boyle, Christian R Engwerda, Stephan Chalon. Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Coadministered Ruxolitinib and Artemether-Lumefantrine in Healthy Adults.
Antimicrobial agents and chemotherapy.
2022 01; 66(1):e0158421. doi:
10.1128/aac.01584-21. [PMID: 34694880] - Guangli Rong, Wenci Weng, Jingting Huang, Yijun Chen, Xuewen Yu, Rui Yuan, Xiufen Gu, Xia Wu, Yuchun Cai, Pengxun Han, Mumin Shao, Huili Sun, Na Ge. Artemether Alleviates Diabetic Kidney Disease by Modulating Amino Acid Metabolism.
BioMed research international.
2022; 2022(?):7339611. doi:
10.1155/2022/7339611. [PMID: 35601149] - Carolyne M Kifude, Ashleigh Roberds, Janet Oyieko, Stephen Ocholla, Solomon Otieno, John N Waitumbi, Jack Hutter, Hunter Smith, Nathanial K Copeland, Shirley Luckhart, V Ann Stewart. Initiation of anti-retroviral/Trimethoprim-Sulfamethoxazole therapy in a longitudinal cohort of HIV-1 positive individuals in Western Kenya rapidly decreases asymptomatic malarial parasitemia.
Frontiers in cellular and infection microbiology.
2022; 12(?):1025944. doi:
10.3389/fcimb.2022.1025944. [PMID: 36506016] - Ashleigh Roberds, Carolyne Kifude, Janet Oyieko, Stephen Ocholla, James Mutunga, David Oullo, Charles Waga, Zhaozhang Li, Shirley Luckhart, V Ann Stewart. Longitudinal impact of asymptomatic malaria/HIV-1 co-infection on Plasmodium falciparum gametocyte transcript expression and transmission to Anopheles mosquitoes.
Frontiers in cellular and infection microbiology.
2022; 12(?):934641. doi:
10.3389/fcimb.2022.934641. [PMID: 36189366] - Ogechi Chinelo Ekoh, Uchechukwu Okoro, David Ugwu, Rafat Ali, Sunday Okafor, Daniel Ugwuja, Solomon Attah. Novel Dipeptides Bearing Sulfonamide as Antimalarial and Antitrypanosomal Agents: Synthesis and Molecular Docking.
Medicinal chemistry (Shariqah (United Arab Emirates)).
2022; 18(3):394-405. doi:
10.2174/1573406417666210604101201. [PMID: 34097595] - Fazli Khuda, Zafar Iqbal, Ayub Khan, Zakiullah, Samiullah, Muhammad Umar Khayam Sahibzada, Mahboob Alam, Ameer Khusro. Effect of fresh pomegranate juice on the pharmacokinetic profile of artemether: An open-label, randomized, 2- period crossover study in healthy human volunteers.
Journal of pharmaceutical and biomedical analysis.
2021 Sep; 203(?):114179. doi:
10.1016/j.jpba.2021.114179. [PMID: 34082142] - Xuerong Dong, Xiang Zhang, Manyuan Wang, Liwei Gu, Jing Li, Muxin Gong. Heparin-decorated nanostructured lipid carriers of artemether-protoporphyrin IX-transferrin combination for therapy of malaria.
International journal of pharmaceutics.
2021 Aug; 605(?):120813. doi:
10.1016/j.ijpharm.2021.120813. [PMID: 34144137] - Petra O Nnamani, Agatha A Ugwu, Ogechukwu H Nnadi, Franklin C Kenechukwu, Kenneth C Ofokansi, Anthony A Attama, Claus-Michael Lehr. Formulation and evaluation of transdermal nanogel for delivery of artemether.
Drug delivery and translational research.
2021 08; 11(4):1655-1674. doi:
10.1007/s13346-021-00951-4. [PMID: 33742415] - Daniel J Watson, Lizahn Laing, Liezl Gibhard, Ho Ning Wong, Richard K Haynes, Lubbe Wiesner. Toward New Transmission-Blocking Combination Therapies: Pharmacokinetics of 10-Amino-Artemisinins and 11-Aza-Artemisinin and Comparison with Dihydroartemisinin and Artemether.
Antimicrobial agents and chemotherapy.
2021 07; 65(8):e0099021. doi:
10.1128/aac.00990-21. [PMID: 34097488] - Saba Gul, Flavia L Ribeiro-Gomes, Aline S Moreira, Guilherme S Sanches, Fabiana G Conceição, Cláudio Tadeu Daniel-Ribeiro, Hans C Ackerman, Leonardo J M Carvalho. Whole blood transfusion improves vascular integrity and increases survival in artemether-treated experimental cerebral malaria.
Scientific reports.
2021 06; 11(1):12077. doi:
10.1038/s41598-021-91499-3. [PMID: 34103601] - Aida N Kawuma, Stephen I Walimbwa, Goonaseelan Colin Pillai, Saye Khoo, Mohammed Lamorde, Roeland E Wasmann, Paolo Denti. Dolutegravir pharmacokinetics during co-administration with either artemether/lumefantrine or artesunate/amodiaquine.
The Journal of antimicrobial chemotherapy.
2021 04; 76(5):1269-1272. doi:
10.1093/jac/dkab022. [PMID: 33550391] - Ruili Wang, Guangyu Shi, Liqing Chai, Rongrong Wang, Guoshun Zhang, Guolian Ren, Shuqiu Zhang. Choline and PEG dually modified artemether nano delivery system targeting intra-erythrocytic Plasmodium and its pharmacodynamics in vivo.
Drug development and industrial pharmacy.
2021 Mar; 47(3):454-464. doi:
10.1080/03639045.2021.1892737. [PMID: 33646854] - Elisa Gomes Lanna, Raoni Pais Siqueira, Marina Guimarães Carvalho Machado, Aline de Souza, Izabel Cristina Trindade, Renata Tupinambá Branquinho, Vanessa Carla Furtado Mosqueira. Lipid-based nanocarriers co-loaded with artemether and triglycerides of docosahexaenoic acid: Effects on human breast cancer cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Feb; 134(?):111114. doi:
10.1016/j.biopha.2020.111114. [PMID: 33352447] - Pengxun Han, Yuchun Cai, Yao Wang, Wenci Weng, Yinghui Chen, Menghua Wang, Hongyue Zhan, Xuewen Yu, Taifen Wang, Mumin Shao, Huili Sun. Artemether ameliorates kidney injury by restoring redox imbalance and improving mitochondrial function in Adriamycin nephropathy in mice.
Scientific reports.
2021 01; 11(1):1266. doi:
10.1038/s41598-020-80298-x. [PMID: 33446820] - Yunjia Hu, Meiqin Liu, Hongbo Qin, Haofeng Lin, Xiaoping An, Zhengli Shi, Lihua Song, Xinglou Yang, Huahao Fan, Yigang Tong. Artemether, Artesunate, Arteannuin B, Echinatin, Licochalcone B and Andrographolide Effectively Inhibit SARS-CoV-2 and Related Viruses In Vitro.
Frontiers in cellular and infection microbiology.
2021; 11(?):680127. doi:
10.3389/fcimb.2021.680127. [PMID: 34527599] - Xiuying Li, Luanxia Shi, Yandong Li, Qinqing Li, Xiujun Duan, Yingli Wang, Qingshan Li. The enhanced treatment efficacy of invasive brain glioma by dual-targeted artemether plus paclitaxel micelles.
Artificial cells, nanomedicine, and biotechnology.
2020 Dec; 48(1):983-996. doi:
10.1080/21691401.2020.1773489. [PMID: 32524852] - Adebanjo J Adegbola, Julius O Soyinka, Oluseye O Bolaji. Effect of CYP3A5*3 genotypes on lumefantrine plasma concentrations among malaria-HIV-infected women.
Pharmacogenomics.
2020 12; 21(18):1289-1297. doi:
10.2217/pgs-2020-0081. [PMID: 33243092] - Yujia Li, Chun Jin, Min Shen, Zhenyi Wang, Shanzhong Tan, Anping Chen, Shijun Wang, Jiangjuan Shao, Feng Zhang, Zili Zhang, Shizhong Zheng. Iron regulatory protein 2 is required for artemether -mediated anti-hepatic fibrosis through ferroptosis pathway.
Free radical biology & medicine.
2020 11; 160(?):845-859. doi:
10.1016/j.freeradbiomed.2020.09.008. [PMID: 32947011] - Christi A Wilkins, Lissinda H du Plessis, Joe M Viljoen. Characterization of solid lipid dispersions prepared by hot fusion containing a double-fixed dose combination of artemether and lumefantrine.
Drug development and industrial pharmacy.
2020 Aug; 46(8):1289-1297. doi:
10.1080/03639045.2020.1788065. [PMID: 32594776] - Hiren Khatri, Nimitt Chokshi, Shruti Rawal, Bhoomika M Patel, Murali Badanthadka, Mayur M Patel. Fabrication and in vivo evaluation of ligand appended paclitaxel and artemether loaded lipid nanoparticulate systems for the treatment of NSCLC: A nanoparticle assisted combination oncotherapy.
International journal of pharmaceutics.
2020 Jun; 583(?):119386. doi:
10.1016/j.ijpharm.2020.119386. [PMID: 32376440] - Asiye Akbarian, Masoumeh Ebtekar, Nafiseh Pakravan, Zuhair Mohammad Hassan. Folate receptor alpha targeted delivery of artemether to breast cancer cells with folate-decorated human serum albumin nanoparticles.
International journal of biological macromolecules.
2020 Jun; 152(?):90-101. doi:
10.1016/j.ijbiomac.2020.02.106. [PMID: 32057865] - Sa'ad T Abdullahi, Julius O Soyinka, Adeniyi Olagunju, Rahman A Bolarinwa, Olusola J Olarewaju, Moji T Bakare-Odunola, Markus Winterberg, Joel Tarning, Andrew Owen, Saye Khoo. Differential Impact of Nevirapine on Artemether-Lumefantrine Pharmacokinetics in Individuals Stratified by CYP2B6 c.516G>T Genotypes.
Antimicrobial agents and chemotherapy.
2020 02; 64(3):. doi:
10.1128/aac.00947-19. [PMID: 31871092] - Marie A Onyamboko, Richard M Hoglund, Sue J Lee, Charlie Kabedi, Daddy Kayembe, Benjamin B Badjanga, Gareth D H Turner, Nikky V Jackson, Joel Tarning, Rose McGready, Francois Nosten, Nicholas J White, Nicholas P J Day, Caterina Fanello. A Randomized Controlled Trial of Three- versus Five-Day Artemether-Lumefantrine Regimens for Treatment of Uncomplicated Plasmodium falciparum Malaria in Pregnancy in Africa.
Antimicrobial agents and chemotherapy.
2020 02; 64(3):. doi:
10.1128/aac.01140-19. [PMID: 31818818] - Xiaolin Bai, Ruixia Pei, Wen Lei, Meiyun Zhao, Jialin Zhang, Lu Tian, Junke Shang. Antidiabetic Effect of Artemether in Db/Db Mice Involves Regulation of AMPK and PI3K/Akt Pathways.
Frontiers in endocrinology.
2020; 11(?):568864. doi:
10.3389/fendo.2020.568864. [PMID: 33101203] - Arun Kumar, Tapan Behl, Toshi Uniyal, Swati Chadha. Synthesis of Nanostructured Lipid Carriers Loaded Chitosan/ Carbopol Hybrid Nanocomposite Gel for Oral Delivery of Artemether and Curcumin.
Pharmaceutical nanotechnology.
2020; 8(5):418-432. doi:
10.2174/2211738508666200907110444. [PMID: 32895049] - Plínio Cerqueira Dos Santos Cardoso, Carlos Alberto Machado da Rocha, Tatiane Cristina Mota, Marcelo de Oliveira Bahia, Regianne Maciel Dos Santos Correa, Lorena Monteiro Gomes, Diego Di Felipe Avila Alcântara, Taíssa Maíra Thomaz Araújo, Leopoldo Silva de Moraes, Rommel Burbano. In vitro assessment of cytotoxic, genotoxic and mutagenic effects of antimalarial drugs artemisinin and artemether in human lymphocytes.
Drug and chemical toxicology.
2019 Nov; 42(6):608-614. doi:
10.1080/01480545.2018.1455207. [PMID: 29681192] - Jian Chen, Xiaofei Huang, Cheng Tao, Ting Xiao, Xinping Li, Qiang Zeng, Min Ma, Zhengzhi Wu. Artemether Attenuates the Progression of Non-small Cell Lung Cancer by Inducing Apoptosis, Cell Cycle Arrest and Promoting Cellular Senescence.
Biological & pharmaceutical bulletin.
2019 Oct; 42(10):1720-1725. doi:
10.1248/bpb.b19-00391. [PMID: 31378747] - Kashif Shakeel, Sheikh Raisuddin, Sadath Ali, Syed Sarim Imam, Md Akhlaquer Rahman, Gaurav Kumar Jain, Farhan Jalees Ahmad. Development and in vitro/in vivo evaluation of artemether and lumefantrine co-loaded nanoliposomes for parenteral delivery.
Journal of liposome research.
2019 Mar; 29(1):35-43. doi:
10.1080/08982104.2017.1410173. [PMID: 29179636] - Naglaa Fathy Abd El-Aal, Eman Hassan Abdelbary. Paeoniflorin in experimental BALB/c mansoniasis: A novel anti-angiogenic therapy.
Experimental parasitology.
2019 Feb; 197(?):85-92. doi:
10.1016/j.exppara.2018.11.002. [PMID: 30414842] - Stephen I Walimbwa, Mohammed Lamorde, Catriona Waitt, Julian Kaboggoza, Laura Else, Pauline Byakika-Kibwika, Alieu Amara, Joshua Gini, Markus Winterberg, Justin Chiong, Joel Tarning, Saye H Khoo. Drug Interactions between Dolutegravir and Artemether-Lumefantrine or Artesunate-Amodiaquine.
Antimicrobial agents and chemotherapy.
2019 02; 63(2):. doi:
10.1128/aac.01310-18. [PMID: 30420479] - Tianming Dai, Weifan Jiang, Zizheng Guo, Yanxiang Xie, Renke Dai. Comparison of in vitro/in vivo blood distribution and pharmacokinetics of artemisinin, artemether and dihydroartemisinin in rats.
Journal of pharmaceutical and biomedical analysis.
2019 Jan; 162(?):140-148. doi:
10.1016/j.jpba.2018.09.024. [PMID: 30240987] - Sören Frahm, Anisuzzaman Anisuzzaman, Ulrich Fabien Prodjinotho, Nermina Vejzagić, Admar Verschoor, Clarissa Prazeres da Costa. A novel cell-free method to culture Schistosoma mansoni from cercariae to juvenile worm stages for in vitro drug testing.
PLoS neglected tropical diseases.
2019 01; 13(1):e0006590. doi:
10.1371/journal.pntd.0006590. [PMID: 30689639] - Ling Wang, Zili Zhang, Mengmeng Li, Feixia Wang, Yan Jia, Feng Zhang, Jiangjuan Shao, Anping Chen, Shizhong Zheng. P53-dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation.
IUBMB life.
2019 01; 71(1):45-56. doi:
10.1002/iub.1895. [PMID: 30321484] - Shuai Li, Xia Zhao, Philip Lazarovici, Wenhua Zheng. Artemether Activation of AMPK/GSK3β(ser9)/Nrf2 Signaling Confers Neuroprotection towards β-Amyloid-Induced Neurotoxicity in 3xTg Alzheimer's Mouse Model.
Oxidative medicine and cellular longevity.
2019; 2019(?):1862437. doi:
10.1155/2019/1862437. [PMID: 31871541] - Jesmin Lohy Das, Stephen Rulisa, Peter J de Vries, Petra F Mens, Nadine Kaligirwa, Steven Agaba, Joel Tarning, Mats O Karlsson, Thomas P C Dorlo. Population Pharmacokinetics of Artemether, Dihydroartemisinin, and Lumefantrine in Rwandese Pregnant Women Treated for Uncomplicated Plasmodium falciparum Malaria.
Antimicrobial agents and chemotherapy.
2018 10; 62(10):. doi:
10.1128/aac.00518-18. [PMID: 30061282] - Yinxian Yang, Hailing Gao, Shuang Zhou, Xiao Kuang, Zhenjie Wang, Hongzhuo Liu, Jin Sun. Optimization and evaluation of lipid emulsions for intravenous co-delivery of artemether and lumefantrine in severe malaria treatment.
Drug delivery and translational research.
2018 10; 8(5):1171-1179. doi:
10.1007/s13346-018-0537-1. [PMID: 29748832] - Janine Naß, Thomas Efferth. The activity of Artemisia spp. and their constituents against Trypanosomiasis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 Aug; 47(?):184-191. doi:
10.1016/j.phymed.2018.06.002. [PMID: 30166103] - Yinxian Yang, Hailing Gao, Shanshan Hou, Ruijuan Su, Hongzhuo Liu, Jin Sun. A sensitive, high-throughput, and ecofriendly method for the determination of lumefantrine, artemether, and its active metabolite dihydroartemisinin by supercritical fluid chromatography and tandem mass spectrometry.
Journal of separation science.
2018 Jun; 41(12):2688-2696. doi:
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Journal of pharmaceutical and biomedical analysis.
2018 May; 154(?):263-277. doi:
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Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2018 Mar; 24(3):216-219. doi:
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Journal of microencapsulation.
2018 Mar; 35(2):121-136. doi:
10.1080/02652048.2018.1441915. [PMID: 29448884] - Liu Tian, Jingjing Liu, Qingwen Jia, Yong Ying, Zhenlei Yang, Guihua Huang. Preparation and Evaluation of Artemether Liposomes for Enhanced Anti-Tumor Therapy.
AAPS PharmSciTech.
2018 Feb; 19(2):512-521. doi:
10.1208/s12249-017-0896-9. [PMID: 29038986] - Yu Guo, Wei Fu, Yakai Xin, Jinlei Bai, Huifang Peng, Liujun Fu, Jie Liu, Liping Li, Yujin Ma, Hongwei Jiang. Antidiabetic and Antiobesity Effects of Artemether in db/db Mice.
BioMed research international.
2018; 2018(?):8639523. doi:
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Acta parasitologica.
2017 Dec; 62(4):708-716. doi:
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Drug development and industrial pharmacy.
2017 Mar; 43(3):372-378. doi:
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European journal of medicinal chemistry.
2017 Feb; 127(?):740-747. doi:
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PloS one.
2017; 12(1):e0169307. doi:
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PloS one.
2017; 12(10):e0186589. doi:
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Birth defects research. Part B, Developmental and reproductive toxicology.
2016 Dec; 107(6):243-257. doi:
10.1002/bdrb.21189. [PMID: 28032463] - Chandra Bhushan Tripathi, Sarwar Beg, Ripandeep Kaur, Geeta Shukla, Shantanu Bandopadhyay, Bhupinder Singh. Systematic development of optimized SNEDDS of artemether with improved biopharmaceutical and antimalarial potential.
Drug delivery.
2016 Nov; 23(9):3209-3223. doi:
10.3109/10717544.2016.1162876. [PMID: 27022886] - Uchechukwu P Okorji, Ravikanth Velagapudi, Abdelmeneim El-Bakoush, Bernd L Fiebich, Olumayokun A Olajide. Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia Through Nrf2-Dependent Mechanisms.
Molecular neurobiology.
2016 11; 53(9):6426-6443. doi:
10.1007/s12035-015-9543-1. [PMID: 26607631] - Chinazom Agbo, Chukwuebuka Umeyor, Franklin Kenechukwu, John Ogbonna, Salome Chime, Charles Lovelyn, Obumneme Agubata, Kenneth Ofokansi, Anthony Attama. Formulation design, in vitro characterizations and anti-malarial investigations of artemether and lumefantrine-entrapped solid lipid microparticles.
Drug development and industrial pharmacy.
2016 Oct; 42(10):1708-21. doi:
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International journal of pharmaceutics.
2016 Sep; 511(1):473-487. doi:
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Parasitology.
2016 09; 143(11):1421-32. doi:
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Journal of photochemistry and photobiology. B, Biology.
2016 Sep; 162(?):14-23. doi:
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International journal of pharmaceutics.
2016 Jul; 508(1-2):1-9. doi:
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International journal of toxicology.
2016 07; 35(4):420-8. doi:
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The pharmacogenomics journal.
2016 Feb; 16(1):88-95. doi:
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Drug delivery.
2016; 23(1):123-9. doi:
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BMC medicine.
2015 Sep; 13(?):227. doi:
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Antimicrobial agents and chemotherapy.
2015 Aug; 59(8):4366-74. doi:
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Veterinary parasitology.
2015 Jul; 211(3-4):182-94. doi:
10.1016/j.vetpar.2015.05.027. [PMID: 26093822] - Murat Yalçın, Erol Sevim, Arzu Duran. [Treated with Artemether-Lumefantrine Five Evaluation of P. Falciparum Malaria Cases in Terms of Hyponatremia and Thrombocytopenia].
Turkiye parazitolojii dergisi.
2015 Jun; 39(2):155-8. doi:
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Journal of separation science.
2015 May; 38(9):1521-8. doi:
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International journal of pharmaceutics.
2015 Jan; 478(1):202-222. doi:
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Drug delivery.
2015; 22(7):940-54. doi:
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PloS one.
2015; 10(10):e0140266. doi:
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Antimicrobial agents and chemotherapy.
2015; 59(6):3208-15. doi:
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Antimicrobial agents and chemotherapy.
2015; 59(6):3197-207. doi:
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International journal of pharmaceutics.
2014 Dec; 477(1-2):208-17. doi:
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Parasitology research.
2014 Dec; 113(12):4415-22. doi:
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Antimicrobial agents and chemotherapy.
2014 Oct; 58(10):5658-65. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Aug; 965(?):45-53. doi:
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The Journal of parasitology.
2014 Aug; 100(4):516-21. doi:
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Biomaterials.
2014 Jul; 35(21):5591-604. doi:
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Journal of vector borne diseases.
2014 Jun; 51(2):147-8. doi:
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Toxicology and applied pharmacology.
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The American journal of tropical medicine and hygiene.
2013 Dec; 89(6):1122-8. doi:
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International journal of pharmaceutics.
2013 Oct; 455(1-2):229-34. doi:
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Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.
2013 Oct; 18(40):. doi:
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International journal of pharmaceutics.
2013 Aug; 452(1-2):321-32. doi:
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HIV medicine.
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