3,7,11,15-Tetramethyl-2,4,6,10,14-hexadecapentaenoic acid (BioDeep_00000175803)
human metabolite blood metabolite
代谢物信息卡片
3,7,11,15-tetramethylhexadeca-2,4,6,10,14-pentaenoic acid
化学式: C20H30O2 (302.2246)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)=CCCC(C)=CCCC(C)=CC=CC(C)=CC(O)=O
InChI: InChI=1S/C20H30O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h8-9,11,13-15H,6-7,10,12H2,1-5H3,(H,21,22)
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相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
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COVID-19 Disease Map(0)
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PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Xian-Yang Qin, Ting Su, Wenkui Yu, Soichi Kojima. Lipid desaturation-associated endoplasmic reticulum stress regulates MYCN gene expression in hepatocellular carcinoma cells.
Cell death & disease.
2020 01; 11(1):66. doi:
10.1038/s41419-020-2257-y. [PMID: 31988297] - Norihisa Nishimura, Kosuke Kaji, Mitsuteru Kitade, Yosuke Aihara, Shinya Sato, Kenichiro Seki, Yasuhiko Sawada, Hiroaki Takaya, Yasushi Okura, Hideto Kawaratani, Kei Moriya, Tadashi Namisaki, Akira Mitoro, Hitoshi Yoshiji. Acyclic retinoid and angiotensin-II receptor blocker exert a combined protective effect against diethylnitrosamine-induced hepatocarcinogenesis in diabetic OLETF rats.
BMC cancer.
2018 Nov; 18(1):1164. doi:
10.1186/s12885-018-5099-6. [PMID: 30477453] - Reuben Hoffmann, Kariona Grabińska, Ziqiang Guan, William C Sessa, Aaron M Neiman. Long-Chain Polyprenols Promote Spore Wall Formation in Saccharomyces cerevisiae.
Genetics.
2017 12; 207(4):1371-1386. doi:
10.1534/genetics.117.300322. [PMID: 28978675] - Xian-Yang Qin, Hideki Tatsukawa, Kiyotaka Hitomi, Yohei Shirakami, Naoto Ishibashi, Masahito Shimizu, Hisataka Moriwaki, Soichi Kojima. Metabolome Analyses Uncovered a Novel Inhibitory Effect of Acyclic Retinoid on Aberrant Lipogenesis in a Mouse Diethylnitrosamine-Induced Hepatic Tumorigenesis Model.
Cancer prevention research (Philadelphia, Pa.).
2016 Mar; 9(3):205-14. doi:
10.1158/1940-6207.capr-15-0326. [PMID: 26744170] - Haruka Kamiyama, Katsura Kakoki, Sayuri Shigematsu, Mai Izumida, Yuka Yashima, Yuetsu Tanaka, Hideki Hayashi, Toshifumi Matsuyama, Hironori Sato, Naoki Yamamoto, Tetsuro Sano, Yoshihiro Shidoji, Yoshinao Kubo. CXCR4-tropic, but not CCR5-tropic, human immunodeficiency virus infection is inhibited by the lipid raft-associated factors, acyclic retinoid analogs, and cholera toxin B subunit.
AIDS research and human retroviruses.
2013 Feb; 29(2):279-88. doi:
10.1089/aid.2012.0174. [PMID: 22845664] - Masahito Shimizu, Hiroyasu Sakai, Yohei Shirakami, Junpei Iwasa, Yoichi Yasuda, Masaya Kubota, Koji Takai, Hisashi Tsurumi, Takuji Tanaka, Hisataka Moriwaki. Acyclic retinoid inhibits diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BLKS/J- +(db)/+Lepr(db) mice.
Cancer prevention research (Philadelphia, Pa.).
2011 Jan; 4(1):128-36. doi:
10.1158/1940-6207.capr-10-0163. [PMID: 21071580] - Mitsutoshi Kimura, Makiko Watanabe, Naoto Ishibashi, Shingo Yanagida, Masahiko Ogihara. Acyclic retinoid NIK-333 accelerates liver regeneration and lowers serum transaminase activities in 70\% partially hepatectomized rats, in vivo.
European journal of pharmacology.
2010 Sep; 643(2-3):267-73. doi:
10.1016/j.ejphar.2010.06.037. [PMID: 20619257] - Maiko Mitake, Hiroko Ogawa, Kazuo Uebaba, Yoshihiro Shidoji. Increase in plasma concentrations of geranylgeranoic Acid after turmeric tablet intake by healthy volunteers.
Journal of clinical biochemistry and nutrition.
2010 May; 46(3):252-8. doi:
10.3164/jcbn.09-109. [PMID: 20490321] - Christopher W Reid, Jacek Stupak, Mark M Chen, Barbara Imperiali, Jianjun Li, Christine M Szymanski. Affinity-capture tandem mass spectrometric characterization of polyprenyl-linked oligosaccharides: tool to study protein N-glycosylation pathways.
Analytical chemistry.
2008 Jul; 80(14):5468-75. doi:
10.1021/ac800079r. [PMID: 18547063] - Takashi Tsujino, Tomoya Nagata, Fumitaka Katoh, Hiroshi Yamasaki. Inhibition of Balb/c 3T3 cell transformation by synthetic acyclic retinoid NIK-333; possible involvement of enhanced gap junctional intercellular communication.
Cancer detection and prevention.
2007; 31(4):332-8. doi:
10.1016/j.cdp.2007.06.001. [PMID: 17935907] - Run-Xuan Shao, Motoyuki Otsuka, Naoya Kato, Hiroyoshi Taniguchi, Yujin Hoshida, Masaru Moriyama, Takao Kawabe, Masao Omata. Acyclic retinoid inhibits human hepatoma cell growth by suppressing fibroblast growth factor-mediated signaling pathways.
Gastroenterology.
2005 Jan; 128(1):86-95. doi:
10.1053/j.gastro.2004.09.077. [PMID: 15633126] - M Okuno, S Kojima, H Moriwaki. Chemoprevention of hepatocellular carcinoma: concept, progress and perspectives.
Journal of gastroenterology and hepatology.
2001 Dec; 16(12):1329-35. doi:
10.1046/j.1440-1746.2001.02634.x. [PMID: 11851828] - M Okuno, T Sano, R Matsushima-Nishiwaki, S Adachi, K Akita, Y Okano, S Kojima, H Moriwaki. Apoptosis induction by acyclic retinoid: a molecular basis of 'clonal deletion' therapy for hepatocellular carcinoma.
Japanese journal of clinical oncology.
2001 Aug; 31(8):359-62. doi:
10.1093/jjco/hye078. [PMID: 11574627] - T Sakaihara, A Honda, S Tateyama, H Sagami. Subcellular fractionation of polyprenyl diphosphate synthase activities responsible for the syntheses of polyprenols and dolichols in spinach leaves.
Journal of biochemistry.
2000 Dec; 128(6):1073-8. doi:
10.1093/oxfordjournals.jbchem.a022835. [PMID: 11098151]
