6-Acryloyl-2-dimethylaminonaphthalene (BioDeep_00000175714)
human metabolite blood metabolite
代谢物信息卡片
1-[6-(dimethylamino)naphthalen-2-yl]prop-2-en-1-one
化学式: C15H15NO (225.115358)
中文名称: 6-丙烯酰-2-二甲氨基萘
谱图信息:
最多检出来源 Homo sapiens(blood) 98.74%
分子结构信息
SMILES: CN(C)C1=CC2=C(C=C1)C=C(C=C2)C(=O)C=C
InChI: InChI=1S/C15H15NO/c1-4-15(17)13-6-5-12-10-14(16(2)3)8-7-11(12)9-13/h4-10H,1H2,2-3H3
描述信息
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents
D004396 - Coloring Agents > D005456 - Fluorescent Dyes
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xuan Luo, Yunfei Zhao, Yang Cai, Jun Chen, Lulu Zhao, Tianlan Lan, Yaxi Chen, Xiong Z Ruan. Dual-monomer solvatochromic probe system (DSPS) for effectively differentiating lipid raft cholesterol and active membrane cholesterol in the inner-leaflet plasma membrane.
Journal of materials chemistry. B.
2024 Mar; 12(10):2547-2558. doi:
10.1039/d3tb02857g. [PMID: 38358131] - Diana Acosta, Tapojyoti Das, David Eliezer. Probing IDP Interactions with Membranes by Fluorescence Spectroscopy.
Methods in molecular biology (Clifton, N.J.).
2020; 2141(?):555-567. doi:
10.1007/978-1-0716-0524-0_28. [PMID: 32696377] - Andrew H Huber, Alan M Kleinfeld. Unbound free fatty acid profiles in human plasma and the unexpected absence of unbound palmitoleate.
Journal of lipid research.
2017 03; 58(3):578-585. doi:
10.1194/jlr.m074260. [PMID: 28082409] - W Cho, Y Yoon, S-L Liu, K Baek, R Sheng. Fluorescence-Based In Situ Quantitative Imaging for Cellular Lipids.
Methods in enzymology.
2017; 583(?):19-33. doi:
10.1016/bs.mie.2016.09.005. [PMID: 28063491] - Saikat Biswas, Pramit Kumar Chowdhury. Correlated and Anticorrelated Domain Movement of Human Serum Albumin: A Peek into the Complexity of the Crowded Milieu.
The journal of physical chemistry. B.
2016 06; 120(22):4897-911. doi:
10.1021/acs.jpcb.6b01671. [PMID: 27163260] - Saikat Biswas, Pramit K Chowdhury. Unusual domain movement in a multidomain protein in the presence of macromolecular crowders.
Physical chemistry chemical physics : PCCP.
2015 Aug; 17(30):19820-33. doi:
10.1039/c5cp02674a. [PMID: 26156390] - Chiharu Mizuguchi, Mami Hata, Padmaja Dhanasekaran, Margaret Nickel, Keiichiro Okuhira, Michael C Phillips, Sissel Lund-Katz, Hiroyuki Saito. Fluorescence study of domain structure and lipid interaction of human apolipoproteins E3 and E4.
Biochimica et biophysica acta.
2014 Dec; 1841(12):1716-24. doi:
10.1016/j.bbalip.2014.09.019. [PMID: 25281910] - Chiharu Mizuguchi, Mami Hata, Padmaja Dhanasekaran, Margaret Nickel, Michael C Phillips, Sissel Lund-Katz, Hiroyuki Saito. Fluorescence analysis of the lipid binding-induced conformational change of apolipoprotein E4.
Biochemistry.
2012 Jul; 51(28):5580-8. doi:
10.1021/bi300672s. [PMID: 22730894] - Andrew H Huber, Baolong Zhu, Thomas Kwan, J Patrick Kampf, Thomas Hegyi, Alan M Kleinfeld. Fluorescence sensor for the quantification of unbound bilirubin concentrations.
Clinical chemistry.
2012 May; 58(5):869-76. doi:
10.1373/clinchem.2011.176412. [PMID: 22395024] - Youngdae Yoon, Park J Lee, Svetlana Kurilova, Wonhwa Cho. In situ quantitative imaging of cellular lipids using molecular sensors.
Nature chemistry.
2011 Oct; 3(11):868-74. doi:
10.1038/nchem.1163. [PMID: 22024883] - Kwanghee Koh Park, Joon Woo Park, Andrew D Hamilton. Novel 7-(dimethylamino)fluorene-based fluorescent probes and their binding to human serum albumin.
Organic & biomolecular chemistry.
2009 Oct; 7(20):4225-32. doi:
10.1039/b911605b. [PMID: 19795061] - Eun Jung Choi, Jessica Mao, Stephen L Mayo. Computational design and biochemical characterization of maize nonspecific lipid transfer protein variants for biosensor applications.
Protein science : a publication of the Protein Society.
2007 Apr; 16(4):582-8. doi:
10.1110/ps.062607007. [PMID: 17384226] - Angela Valeva, Iwan Walev, Fatima Boukhallouk, Trudy M Wassenaar, Natalia Heinz, Julia Hedderich, Sina Lautwein, Moritz Möcking, Silvia Weis, Alexander Zitzer, Sucharit Bhakdi. Identification of the membrane penetrating domain of Vibrio cholerae cytolysin as a beta-barrel structure.
Molecular microbiology.
2005 Jul; 57(1):124-31. doi:
10.1111/j.1365-2958.2005.04684.x. [PMID: 15948954] - J K Amisha Kamal, Liang Zhao, Ahmed H Zewail. Ultrafast hydration dynamics in protein unfolding: human serum albumin.
Proceedings of the National Academy of Sciences of the United States of America.
2004 Sep; 101(37):13411-6. doi:
10.1073/pnas.0405724101. [PMID: 15353599] - José González-Jiménez, Manuel Cortijo. Resonance energy transfer between tryptophan-214 in human serum albumin and acrylodan, prodan, and promen.
The protein journal.
2004 Jul; 23(5):351-5. doi:
10.1023/b:jopc.0000032655.26249.ba. [PMID: 15328891] - Olga V Oskolkova, Albin Hermetter. Fluorescent inhibitors reveal solvent-dependent micropolarity in the lipid binding sites of lipases.
Biochimica et biophysica acta.
2002 May; 1597(1):60-6. doi:
10.1016/s0167-4838(02)00277-7. [PMID: 12009403] - Andrea K Behling Agree, M Alejandra Tricerri, Kirsten Arnvig McGuire, Shao-min Tian, Ana Jonas. Folding and stability of the C-terminal half of apolipoprotein A-I examined with a Cys-specific fluorescence probe.
Biochimica et biophysica acta.
2002 Feb; 1594(2):286-96. doi:
10.1016/s0167-4838(01)00317-x. [PMID: 11904224] - Bo Pei, Zhi Ping Liu, Jian Wen Chen. Ganglioside GM(1) biphasically regulates the activity of protein kinase C by the effects on the structure of the lipid bilayer.
Chemistry and physics of lipids.
2002 Feb; 114(2):131-8. doi:
10.1016/s0009-3084(01)00193-1. [PMID: 11934394] - José González-Jiménez, Manuel Cortijo. Urea-induced denaturation of human serum albumin labeled with acrylodan.
Journal of protein chemistry.
2002 Feb; 21(2):75-9. doi:
10.1023/a:1014508610017. [PMID: 11934277] - M A Tricerri, A K Behling Agree, S A Sanchez, A Jonas. Characterization of apolipoprotein A-I structure using a cysteine-specific fluorescence probe.
Biochemistry.
2000 Nov; 39(47):14682-91. doi:
10.1021/bi0014251. [PMID: 11087425] - B Promdonkoy, D J Ellar. Membrane pore architecture of a cytolytic toxin from Bacillus thuringiensis.
The Biochemical journal.
2000 Aug; 350 Pt 1(?):275-82. doi:
10.1042/bj3500275. [PMID: 10926854] - V I Emel'ianenko, Ia K Reshetniak, O A Andreev, E A Burshteĭn. [Analysis of log-normal components of fluorescence spectra of prodan and acrylodan bound to proteins].
Biofizika.
2000 Mar; 45(2):207-19. doi:
NULL. [PMID: 10776530] - D Murray, A Arbuzova, G Hangyás-Mihályné, A Gambhir, N Ben-Tal, B Honig, S McLaughlin. Electrostatic properties of membranes containing acidic lipids and adsorbed basic peptides: theory and experiment.
Biophysical journal.
1999 Dec; 77(6):3176-88. doi:
10.1016/s0006-3495(99)77148-1. [PMID: 10585939] - F Moreno, M Cortijo, J González-Jiménez. Interaction of acrylodan with human serum albumin. A fluorescence spectroscopic study.
Photochemistry and photobiology.
1999 Nov; 70(5):695-700. doi:
10.1111/j.1751-1097.1999.tb08272.x. [PMID: 10568165] - G Anderluh, A Barlic, Z Podlesek, P Macek, J Pungercar, F Gubensek, M L Zecchini, M D Serra, G Menestrina. Cysteine-scanning mutagenesis of an eukaryotic pore-forming toxin from sea anemone: topology in lipid membranes.
European journal of biochemistry.
1999 Jul; 263(1):128-36. doi:
10.1046/j.1432-1327.1999.00477.x. [PMID: 10429196] - K Flora, J D Brennan, G A Baker, M A Doody, F V Bright. Unfolding of acrylodan-labeled human serum albumin probed by steady-state and time-resolved fluorescence methods.
Biophysical journal.
1998 Aug; 75(2):1084-96. doi:
10.1016/s0006-3495(98)77598-8. [PMID: 9675210] - S Engelbrecht, E Giakas, O Marx, H Lill. Fluorescence resonance energy transfer mapping of subunit delta in spinach chloroplast F1 ATPase.
European journal of biochemistry.
1998 Mar; 252(2):277-83. doi:
10.1046/j.1432-1327.1998.2520277.x. [PMID: 9523699] - M Palmer, I Vulicevic, P Saweljew, A Valeva, M Kehoe, S Bhakdi. Streptolysin O: a proposed model of allosteric interaction between a pore-forming protein and its target lipid bilayer.
Biochemistry.
1998 Feb; 37(8):2378-83. doi:
10.1021/bi9720890. [PMID: 9485385] - A Valeva, M Palmer, S Bhakdi. Staphylococcal alpha-toxin: formation of the heptameric pore is partially cooperative and proceeds through multiple intermediate stages.
Biochemistry.
1997 Oct; 36(43):13298-304. doi:
10.1021/bi971075r. [PMID: 9341221] - E Kurian, F G Prendergast, J R Small. Photoacoustic analysis of proteins: volumetric signals and fluorescence quantum yields.
Biophysical journal.
1997 Jul; 73(1):466-76. doi:
10.1016/s0006-3495(97)78085-8. [PMID: 9199809] - A Valeva, J Pongs, S Bhakdi, M Palmer. Staphylococcal alpha-toxin: the role of the N-terminus in formation of the heptameric pore -- a fluorescence study.
Biochimica et biophysica acta.
1997 Apr; 1325(2):281-6. doi:
10.1016/s0005-2736(96)00266-0. [PMID: 9168153] - R Narazaki, T Maruyama, M Otagiri. Probing the cysteine 34 residue in human serum albumin using fluorescence techniques.
Biochimica et biophysica acta.
1997 Apr; 1338(2):275-81. doi:
10.1016/s0167-4838(96)00221-x. [PMID: 9128146] - R Narazaki, T Maruyama, M Otagiri. Effect of N-B transition on the microenvironment surrounding 34Cys in human serum albumin.
Biological & pharmaceutical bulletin.
1997 Apr; 20(4):452-4. doi:
10.1248/bpb.20.452. [PMID: 9145230] - M Palmer, P Saweljew, I Vulicevic, A Valeva, M Kehoe, S Bhakdi. Membrane-penetrating domain of streptolysin O identified by cysteine scanning mutagenesis.
The Journal of biological chemistry.
1996 Oct; 271(43):26664-7. doi:
10.1074/jbc.271.43.26664. [PMID: 8900142] - C M Ingersoll, J D Jordan, F V Bright. Accessibility of the fluorescent reporter group in native, silica-adsorbed, and covalently attached acrylodan-labeled serum albumins.
Analytical chemistry.
1996 Sep; 68(18):3194-8. doi:
10.1021/ac960315q. [PMID: 8797379] - J S Lundgren, M P Heitz, F V Bright. Dynamics of acrylodan-labeled bovine and human serum albumin sequestered within aerosol-OT reverse micelles.
Analytical chemistry.
1995 Oct; 67(20):3775-81. doi:
10.1021/ac00116a025. [PMID: 8644923] - J D Jordan, R A Dunbar, F V Bright. Dynamics of acrylodan-labeled bovine and human serum albumin entrapped in a sol-gel-derived biogel.
Analytical chemistry.
1995 Jul; 67(14):2436-43. doi:
10.1021/ac00110a019. [PMID: 8686877] - A Valeva, M Palmer, K Hilgert, M Kehoe, S Bhakdi. Correct oligomerization is a prerequisite for insertion of the central molecular domain of staphylococcal alpha-toxin into the lipid bilayer.
Biochimica et biophysica acta.
1995 Jun; 1236(2):213-8. doi:
10.1016/0005-2736(95)00060-g. [PMID: 7794960] - R Wang, S Sun, E J Bekos, F V Bright. Dynamics surrounding Cys-34 in native, chemically denatured, and silica-adsorbed bovine serum albumin.
Analytical chemistry.
1995 Jan; 67(1):149-59. doi:
10.1021/ac00097a024. [PMID: 7864387] - Y Huang, J Tong, Z Liu, F Yang. Further study on the magnesium-mediated change in physical state of phospholipid modulates mitochondrial F0-F1-ATPase activity.
Magnesium research.
1993 Dec; 6(4):321-7. doi:
". [PMID: 8155482] - M P Mims, C B Sturgis, J T Sparrow, J D Morrisett. Acrylodan can label amino as well as sulfhydryl groups: results with low-density lipoprotein, lipoprotein[a], and lipid-free proteins.
Biochemistry.
1993 Sep; 32(35):9215-20. doi:
10.1021/bi00086a029. [PMID: 8369288] - S W Reid, E K Koepf, L D Burtnick. Fluorescent responses of acrylodan-labeled plasma gelsolin.
Archives of biochemistry and biophysics.
1993 Apr; 302(1):31-6. doi:
10.1006/abbi.1993.1176. [PMID: 8385903]
