AcF-(OPdChaWR);AcF-(OPdChaWR);AcF-(OP(D-Cha)WR) (BioDeep_00000175690)
human metabolite blood metabolite
代谢物信息卡片
化学式: C47H65N11O7 (895.5068180000001)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 66.67%
分子结构信息
SMILES: CC(=O)NC(CC1=CC=CC=C1)C(=O)NC1CCCNC(=O)C(CCCN=C(N)N)NC(=O)C(CC2=CNC3=CC=CC=C23)NC(=O)C(CC2CCCCC2)NC(=O)C2CCCN2C1=O
InChI: InChI=1S/C47H65N11O7/c1-29(59)53-37(25-30-13-4-2-5-14-30)42(61)55-36-20-11-22-50-41(60)35(19-10-23-51-47(48)49)54-44(63)39(27-32-28-52-34-18-9-8-17-33(32)34)56-43(62)38(26-31-15-6-3-7-16-31)57-45(64)40-21-12-24-58(40)46(36)65/h2,4-5,8-9,13-14,17-18,28,31,35-40,52H,3,6-7,10-12,15-16,19-27H2,1H3,(H,50,60)(H,53,59)(H,54,63)(H,55,61)(H,56,62)(H,57,64)(H4,48,49,51)
描述信息
同义名列表
8 个代谢物同义名
N-[3-(cyclohexylmethyl)-9-{3-[(diaminomethylidene)amino]propyl}-6-(1H-indol-3-ylmethyl)-1,4,7,10,16-pentaoxo-tetradecahydro-2H-pyrrolo[1,2-a]1,4,7,10,13-pentaazacyclooctadecan-15-yl]-2-acetamido-3-phenylpropanamide; N-[3-(cyclohexylmethyl)-9-{3-[(diaminomethylidene)amino]propyl}-6-[(1H-indol-3-yl)methyl]-1,4,7,10,16-pentaoxo-icosahydropyrrolo[1,2-a]1,4,7,10,13-pentaazacyclooctadecan-15-yl]-2-acetamido-3-phenylpropanamide; AcF-(OPdChaWR);AcF-(OPdChaWR);AcF-(OP(D-Cha)WR); AcPhe(ornithine-pro-cyclohexylamine-TRP-arg); AcF-(OP(D-cha)WR); AcF-(opdchawr); PMX53 CPD; PMX-53
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Andra C Dumitru, R N V Krishna Deepak, Heng Liu, Melanie Koehler, Cheng Zhang, Hao Fan, David Alsteens. Submolecular probing of the complement C5a receptor-ligand binding reveals a cooperative two-site binding mechanism.
Communications biology.
2020 12; 3(1):786. doi:
10.1038/s42003-020-01518-8. [PMID: 33339958] - E W Skjeflo, D Christiansen, A Landsem, J Stenvik, T M Woodruff, T Espevik, E W Nielsen, T E Mollnes. Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14.
Molecular immunology.
2019 08; 112(?):131-139. doi:
10.1016/j.molimm.2019.03.014. [PMID: 31102985] - Vinod Kumar, John D Lee, Richard J Clark, Trent M Woodruff. Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice.
Scientific reports.
2018 05; 8(1):8101. doi:
10.1038/s41598-018-26387-4. [PMID: 29802264] - Jing Zhang, Trent M Woodruff, Richard J Clark, Darren J Martin, Rodney F Minchin. Release of bioactive peptides from polyurethane films in vitro and in vivo: Effect of polymer composition.
Acta biomaterialia.
2016 09; 41(?):264-72. doi:
10.1016/j.actbio.2016.05.034. [PMID: 27245428] - Naheed Choudhry, Ke Li, Ting Zhang, Kun-Yi Wu, Yun Song, Conrad A Farrar, Na Wang, Cheng-Fei Liu, Qi Peng, Weiju Wu, Steven H Sacks, Wuding Zhou. The complement factor 5a receptor 1 has a pathogenic role in chronic inflammation and renal fibrosis in a murine model of chronic pyelonephritis.
Kidney international.
2016 09; 90(3):540-54. doi:
10.1016/j.kint.2016.04.023. [PMID: 27370410] - Guipeng An, Bo Li, Xiaoman Liu, Mingxiang Zhang, Fei Gao, Yuxia Zhao, Fengshuang An, Yun Zhang, Cheng Zhang. Overexpression of complement component C5a accelerates the development of atherosclerosis in ApoE-knockout mice.
Oncotarget.
2016 Aug; 7(35):56060-56070. doi:
10.18632/oncotarget.11180. [PMID: 27517153] - Supriya D Mahajan, Vincent M Tutino, Yonas Redae, Hui Meng, Adnan Siddiqui, Trent M Woodruff, James N Jarvis, Teresa Hennon, Stanley Schwartz, Richard J Quigg, Jessy J Alexander. C5a induces caspase-dependent apoptosis in brain vascular endothelial cells in experimental lupus.
Immunology.
2016 08; 148(4):407-19. doi:
10.1111/imm.12619. [PMID: 27213693] - Edimara S Reis, Hui Chen, Georgia Sfyroera, Peter N Monk, Jörg Köhl, Daniel Ricklin, John D Lambris. C5a receptor-dependent cell activation by physiological concentrations of desarginated C5a: insights from a novel label-free cellular assay.
Journal of immunology (Baltimore, Md. : 1950).
2012 Nov; 189(10):4797-805. doi:
10.4049/jimmunol.1200834. [PMID: 23041570] - Helga D Manthey, Anita C Thomas, Ian A Shiels, Alma Zernecke, Trent M Woodruff, Barbara Rolfe, Stephen M Taylor. Complement C5a inhibition reduces atherosclerosis in ApoE-/- mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2011 Jul; 25(7):2447-55. doi:
10.1096/fj.10-174284. [PMID: 21490292] - Michael Morgan, Andrew C Bulmer, Trent M Woodruff, Lavinia M Proctor, Hua M Williams, Shelli Z Stocks, Sandra Pollitt, Stephen M Taylor, Ian A Shiels. Pharmacokinetics of a C5a receptor antagonist in the rat after different sites of enteral administration.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2008 Apr; 33(4-5):390-8. doi:
10.1016/j.ejps.2008.01.009. [PMID: 18337070] - C E Vergunst, D M Gerlag, H Dinant, L Schulz, M Vinkenoog, T J M Smeets, M E Sanders, K A Reedquist, P P Tak. Blocking the receptor for C5a in patients with rheumatoid arthritis does not reduce synovial inflammation.
Rheumatology (Oxford, England).
2007 Dec; 46(12):1773-8. doi:
10.1093/rheumatology/kem222. [PMID: 17965442] - Thiruma V Arumugam, Trent M Woodruff, Shelli Z Stocks, Lavinia M Proctor, Sandra Pollitt, Ian A Shiels, Robert C Reid, David P Fairlie, Stephen M Taylor. Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats.
Journal of hepatology.
2004 Jun; 40(6):934-41. doi:
10.1016/j.jhep.2004.02.017. [PMID: 15158333] - Trent M Woodruff, Thiruma V Arumugam, Ian A Shiels, Robert C Reid, David P Fairlie, Stephen M Taylor. Protective effects of a potent C5a receptor antagonist on experimental acute limb ischemia-reperfusion in rats.
The Journal of surgical research.
2004 Jan; 116(1):81-90. doi:
10.1016/j.jss.2003.04.001. [PMID: 14732352] - Trent M Woodruff, Thiruma V Arumugam, Ian A Shiels, Robert C Reid, David P Fairlie, Stephen M Taylor. A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease.
Journal of immunology (Baltimore, Md. : 1950).
2003 Nov; 171(10):5514-20. doi:
10.4049/jimmunol.171.10.5514. [PMID: 14607958] - Thiruma V Arumugam, Ian A Shiels, Anna J Strachan, Giovani Abbenante, David P Fairlie, Stephen M Taylor. A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats.
Kidney international.
2003 Jan; 63(1):134-42. doi:
10.1046/j.1523-1755.2003.00737.x. [PMID: 12472776] - Trent M Woodruff, Anna J Strachan, Nathan Dryburgh, Ian A Shiels, Robert C Reid, David P Fairlie, Stephen M Taylor. Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat.
Arthritis and rheumatism.
2002 Sep; 46(9):2476-85. doi:
10.1002/art.10449. [PMID: 12355496] - Thiruma V Arumugam, Ian A Shiels, Trent M Woodruff, Robert C Reid, David P Fairlie, Stephen M Taylor. Protective effect of a new C5a receptor antagonist against ischemia-reperfusion injury in the rat small intestine.
The Journal of surgical research.
2002 Apr; 103(2):260-7. doi:
10.1006/jsre.2002.6369. [PMID: 11922743] - A J Strachan, I A Shiels, R C Reid, D P Fairlie, S M Taylor. Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist.
British journal of pharmacology.
2001 Dec; 134(8):1778-86. doi:
10.1038/sj.bjp.0704417. [PMID: 11739255] - R H Reznek, J G Salway, P K Thomas. Plasma-myoinositol concentrations in uraemic neuropathy.
Lancet (London, England).
1977 Mar; 1(8013):675-6. doi:
10.1016/s0140-6736(77)92116-x. [PMID: 66475]