2-(p-Acetamidophenyl)-2-ethylglutarimide (BioDeep_00000175663)

   

human metabolite blood metabolite


代谢物信息卡片


N-[4-(3-ethyl-2,6-dioxopiperidin-3-yl)phenyl]acetamide

化学式: C15H18N2O3 (274.1317358)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1(CCC(=O)NC1=O)C1=CC=C(NC(C)=O)C=C1
InChI: InChI=1S/C15H18N2O3/c1-3-15(9-8-13(19)17-14(15)20)11-4-6-12(7-5-11)16-10(2)18/h4-7H,3,8-9H2,1-2H3,(H,16,18)(H,17,19,20)

描述信息

同义名列表

4 个代谢物同义名

N-[4-(3-ethyl-2,6-dioxopiperidin-3-yl)phenyl]acetamide; 2-(p-Acetamidophenyl)-2-ethylglutarimide; N-Acetylaminoglutethimide; N-AcetylAG



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • I A Alshowaier, A el-Yazigi, A Ezzat, A A el-Warith, P J Nicholls. Liquid chromatographic separation and measurement of optical isomers of aminoglutethimide and its acetyl metabolite in plasma, saliva, and urine. Therapeutic drug monitoring. 1995 Oct; 17(5):538-43. doi: 10.1097/00007691-199510000-00017. [PMID: 8585120]
  • H Y Aboul-Enein, M R Islam. Direct enantiomeric high performance liquid chromatographic separation of aminoglutethimide and its major metabolite on a series of Chiralcel OD and Chiralcel OJ columns and its application to biological fluids. Biomedical chromatography : BMC. 1991 Mar; 5(2):74-7. doi: 10.1002/bmc.1130050206. [PMID: 1868261]
  • E Strocchi, C M Camaggi, A Martoni, R Cellerino, S Miseria, P Malacarne, M Indelli, M Balli, G Bonciarelli, G Ambroso. Aminoglutethimide in advanced breast cancer: plasma levels and clinical results after low and high doses. Cancer chemotherapy and pharmacology. 1991; 27(6):451-5. doi: 10.1007/bf00685159. [PMID: 2013115]
  • C R Sirtori, E De Fabiani, D Caruso, B Malavasi, G Galli, M Galli-Kienle. Single dose pharmacokinetics of aminoglutethimide by a rapid SIM methodology. International journal of clinical pharmacology, therapy, and toxicology. 1988 Aug; 26(8):380-4. doi: NULL. [PMID: 3220611]
  • A A Miller, B E Miller, K Höffken, C G Schmidt. Clinical pharmacology of aminoglutethimide in patients with metastatic breast cancer. Cancer chemotherapy and pharmacology. 1987; 20(4):337-41. doi: 10.1007/bf00262588. [PMID: 3690808]
  • R Stuart-Harris, I Bradbrook, P Morrison, I E Smith, H J Rogers. Observations on the pharmacokinetics of low dose aminoglutethimide in patients with advanced breast cancer. British journal of cancer. 1985 Apr; 51(4):485-92. doi: 10.1038/bjc.1985.70. [PMID: 3978028]
  • A M Adam, I D Bradbrook, H J Rogers. High-performance liquid chromatographic assay for simultaneous estimation of aminoglutethimide and acetylaminoglutethimide in biological fluids. Cancer chemotherapy and pharmacology. 1985; 15(2):176-8. doi: 10.1007/bf00257533. [PMID: 4017167]
  • G Menge, J P Dubois. Determination of aminoglutethimide and N-acetylaminoglutethimide in human plasma by high-performance liquid chromatography. Journal of chromatography. 1984 Oct; 310(2):431-7. doi: 10.1016/0378-4347(84)80112-7. [PMID: 6511861]
  • M O Kamblawi, R G Stevens, P J Nicholls. High-performance liquid chromatographic assay for aminoglutethimide and its acetylated metabolite in urine. Journal of chromatography. 1984 Aug; 309(2):431-5. doi: 10.1016/0378-4347(84)80055-9. [PMID: 6480795]
  • A M Adam, H J Rogers. Gas--liquid chromatographic assay of aminoglutethimide and a high-performance liquid chromatographic assay for its acetyl metabolite in biological fluids. Journal of chromatography. 1984 Apr; 307(1):129-35. doi: 10.1016/s0378-4347(00)84079-7. [PMID: 6725479]
  • J S Schanche, P E Lønning, P M Ueland, S Kvinnsland. Determination of aminoglutethimide and N-acetylaminoglutethimide in human plasma by reversed-phase liquid chromatography. Therapeutic drug monitoring. 1984; 6(2):221-6. doi: 10.1097/00007691-198406000-00016. [PMID: 6740741]
  • R C Coombes, A B Foster, S J Harland, M Jarman, E C Nice. Polymorphically acetylated aminoglutethimide in humans. British journal of cancer. 1982 Sep; 46(3):340-5. doi: 10.1038/bjc.1982.209. [PMID: 7126424]