Pinusolide (BioDeep_00000017559)

 

Secondary id: BioDeep_00000404037

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


1-Naphthalenecarboxylic acid, 5-[2-(2,5-dihydro-2-oxo-3-furanyl)ethyl]decahydro-1,4a-dimethyl-6-methylene-, methyl ester, [1S-(1,4a,5,8a)]-; Labda-8(20),13-diene-16,19-dioic acid, 15-hydroxy-, -lactone, methyl ester

化学式: C21H30O4 (346.214398)
中文名称: 红松内酯
谱图信息: 最多检出来源 Viridiplantae(plant) 7.53%

分子结构信息

SMILES: C=C1CCC2C(C)(C(=O)OC)CCCC2(C)C1CCC1=CCOC1=O
InChI: InChI=1S/C21H30O4/c1-14-6-9-17-20(2,11-5-12-21(17,3)19(23)24-4)16(14)8-7-15-10-13-25-18(15)22/h10,16-17H,1,5-9,11-13H2,2-4H3/t16-,17+,20+,21-/m0/s1

描述信息

Pinusolide is a diterpene lactone. It has a role as a metabolite.
Pinusolide is a natural product found in Agathis macrophylla, Platycladus orientalis, and other organisms with data available.
Pinusolide is found in fruits. Pinusolide is a constituent of the oleorosin of Pinus koraiensis (Korean pine)
A natural product found in Biota orientalis.

同义名列表

13 个代谢物同义名

1-Naphthalenecarboxylic acid, 5-[2-(2,5-dihydro-2-oxo-3-furanyl)ethyl]decahydro-1,4a-dimethyl-6-methylene-, methyl ester, [1S-(1,4a,5,8a)]-; Labda-8(20),13-diene-16,19-dioic acid, 15-hydroxy-, -lactone, methyl ester; 1-Naphthalenecarboxylic acid, 5-[2-(2,5-dihydro-2-oxo-3-furanyl)ethyl]decahydro-1,4a-dimethyl-6-methylene-, methyl ester, [1S-(1alpha,4aalpha,5alpha,8abeta)]-; 1-Naphthalenecarboxylic acid, 5-(2-(2,5-dihydro-2-oxo-3-furanyl)ethyl)decahydro-1,4a-dimethyl-6-methylene-, methyl ester, (1S-(1alpha,4aalpha,5alpha,8abeta))-; 1-Naphthalenecarboxylic acid, 5-[2-(2,5-dihydro-2-oxo-3-furanyl)ethyl]decahydro-1,4a-dimethyl-6-methylene-, methyl ester, (1S,4aR,5S,8aR)-; 1-Naphthalenecarboxylicacid,5-[2-(2,5-dihydro-2-oxo-3-furanyl)ethyl]decahydro-1,4a-dimethyl-6-methylene-,methyl ester, (1S,4aR,5S,8aR)-; methyl (1S,4aR,5S,8aR)-1,4a-dimethyl-6-methylidene-5-[2-(5-oxo-2H-furan-4-yl)ethyl]-3,4,5,7,8,8a-hexahydro-2H-naphthalene-1-carboxylate; methyl (1S,4aR,5S,8aR)-1,4a-dimethyl-6-methylidene-5-[2-(2-oxo-2,5-dihydrofuran-3-yl)ethyl]-decahydronaphthalene-1-carboxylate; Methyl (1S,4aR,5S,8aR)-5-[2-(2,5-dihydro-2-oxo-3-furanyl)ethyl]decahydro-1,4a-dimethyl-6-methylene-1-naphthalenecarboxylate; methyl (1S,4aR,5S,8aR)-1,4a-dimethyl-6-methylidene-5-[2-(2-oxo-5H-furan-3-yl)ethyl]-hexahydro-2H-naphthalene-1-carboxylate; Methyl 1,4a-dimethyl-6-methylidene-5-[2-(2-oxo-2,5-dihydrofuran-3-yl)ethyl]decahydronaphthalene-1-carboxylate; 6HV7MVZ4Y7; Pinusolide; MCULE-7252099279



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

33 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Seung-Lark Hwang, Yong-Tae Jeong, Ju Hye Yang, Xian Li, Yue Lu, Jong Keun Son, Hyeun Wook Chang. Pinusolide improves high glucose-induced insulin resistance via activation of AMP-activated protein kinase. Biochemical and biophysical research communications. 2013 Aug; 437(3):374-9. doi: 10.1016/j.bbrc.2013.06.084. [PMID: 23831466]
  • Ye Jin, Hyun Ok Yang, Jong Keun Son, Hyeun Wook Chang. Pinusolide isolated from Biota orientalis inhibits 5-lipoxygenase dependent leukotriene C4 generation by blocking c-Jun N-terminal kinase pathway in mast cells. Biological & pharmaceutical bulletin. 2012; 35(8):1374-8. doi: 10.1248/bpb.b12-00271. [PMID: 22863941]
  • K A Koo, M K Lee, S H Kim, E J Jeong, S Y Kim, T H Oh, Y C Kim. Pinusolide and 15-methoxypinusolidic acid attenuate the neurotoxic effect of staurosporine in primary cultures of rat cortical cells. British journal of pharmacology. 2007 Jan; 150(1):65-71. doi: 10.1038/sj.bjp.0706944. [PMID: 17143305]
  • Javad Asili, Maja Lambert, Hanne L Ziegler, Dan Staerk, Majid Sairafianpour, Matthias Witt, Gholamreza Asghari, Ismaiel S Ibrahimi, Jerzy W Jaroszewski. Labdanes and isopimaranes from Platycladus orientalis and their effects on erythrocyte membrane and on Plasmodium falciparum growth in the erythrocyte host cells. Journal of natural products. 2004 Apr; 67(4):631-7. doi: 10.1021/np034033e. [PMID: 15104493]
  • Kyung Ah Koo, Sang Hyun Sung, Young Choong Kim. A new neuroprotective pinusolide derivative from the leaves of Biota orientalis. Chemical & pharmaceutical bulletin. 2002 Jun; 50(6):834-6. doi: 10.1248/cpb.50.834. [PMID: 12045342]
  • K A Kim, T C Moon, S W Lee, K C Chung, B H Han, H W Chang. Pinusolide from the leaves of Biota orientalis as potent platelet activating factor antagonist. Planta medica. 1999 Feb; 65(1):39-42. doi: 10.1055/s-1999-13959. [PMID: 10083843]