3-[2-[[2-[[2-Acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoylamino]-4-oxobutanoic acid (BioDeep_00000175546)

   

human metabolite blood metabolite


代谢物信息卡片


3-[(1-Hydroxy-2-{[1-hydroxy-2-({1-hydroxy-2-[(1-hydroxyethylidene)amino]-3-(4-hydroxyphenyl)propylidene}amino)-3-methylbutylidene]amino}propylidene)amino]-4-oxobutanoate

化学式: C23H32N4O8 (492.22200319999996)
中文名称: Caspase-1抑制剂I
谱图信息: 最多检出来源 Homo sapiens(blood) 66.67%

分子结构信息

SMILES: CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)O)C=O)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)C
InChI: InChI=1S/C23H32N4O8/c1-12(2)20(23(35)24-13(3)21(33)26-16(11-28)10-19(31)32)27-22(34)18(25-14(4)29)9-15-5-7-17(30)8-6-15/h5-8,11-13,16,18,20,30H,9-10H2,1-4H3,(H,24,35)(H,25,29)(H,26,33)(H,27,34)(H,31,32)

描述信息

D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015853 - Cysteine Proteinase Inhibitors
Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a caspase-1 inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ[1][2][3].

同义名列表

12 个代谢物同义名

3-[(1-Hydroxy-2-{[1-hydroxy-2-({1-hydroxy-2-[(1-hydroxyethylidene)amino]-3-(4-hydroxyphenyl)propylidene}amino)-3-methylbutylidene]amino}propylidene)amino]-4-oxobutanoate; 3-[2-[[2-[[2-Acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoylamino]-4-oxobutanoic acid; 3-[2-[[2-[[2-Acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoylamino]-4-oxobutanoate; 3-(2-{2-[2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido}propanamido)-4-oxobutanoic acid; N-Acetyltyrosyl-valyl-alanyl-aspartyl aldehyde; Ac-Tyr-Val-Ala-Asp-aldehyde (pseudo acid); Acetyl-tyrosyl-valyl-alanyl-aspartinal; Acetyl-tyr-val-ala-asp-cho; Ac-tyr-val-ala-asp-cho; YCAD-cho; L-709049; Ac-YVAD-CHO



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Koki Kariya, Tijen Demiral, Takayuki Sasaki, Yoshiyuki Tsuchiya, Ismail Turkan, Toshio Sano, Seiichiro Hasezawa, Yoko Yamamoto. A novel mechanism of aluminum-induced cell death involving vacuolar processing enzyme and vacuolar collapse in tobacco cell line BY-2. Journal of inorganic biochemistry. 2013 Nov; 128(?):196-201. doi: 10.1016/j.jinorgbio.2013.07.001. [PMID: 23891542]
  • Kim A Boost, Sandra Hoegl, Christian Hofstetter, Michael Flondor, Klaus Stegewerth, Ilka Platacis, Josef Pfeilschifter, Heiko Muhl, Bernhard Zwissler. Targeting caspase-1 by inhalation-therapy: effects of Ac-YVAD-CHO on IL-1 beta, IL-18 and downstream proinflammatory parameters as detected in rat endotoxaemia. Intensive care medicine. 2007 May; 33(5):863-871. doi: 10.1007/s00134-007-0588-0. [PMID: 17384935]
  • A Shanker, S M Singh, A Sodhi. Ascitic growth of a spontaneous transplantable T cell lymphoma induces thymic involution. 2. Induction of apoptosis in thymocytes. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2000 Nov; 21(6):315-27. doi: 10.1159/000030137. [PMID: 11006572]
  • M E Nuttall, D P Nadeau, P W Fisher, F Wang, P M Keller, W E DeWolf, M B Goldring, A M Badger, D Lee, M A Levy, M Gowen, M W Lark. Inhibition of caspase-3-like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2000 May; 18(3):356-63. doi: 10.1002/jor.1100180306. [PMID: 10937621]
  • Mao-Sen Sun, Shinzaburo Hattori, Shuji Kubo, Hisataka Awata, Ichiro Matsuda, Fumio Endo. A mouse model of renal tubular injury of tyrosinemia type 1: development of de Toni Fanconi syndrome and apoptosis of renal tubular cells in Fah/Hpd double mutant mice. Journal of the American Society of Nephrology : JASN. 2000 Feb; 11(2):291-300. doi: 10.1681/asn.v112291. [PMID: 10665936]
  • T Ohigashi, M Ueno, S Nonaka, T Nakanoma, Y Furukawa, N Deguchi, M Murai. Tyrosine kinase inhibitors reduce bcl-2 expression and induce apoptosis in androgen-dependent cells. American journal of physiology. Cell physiology. 2000 Jan; 278(1):C66-72. doi: 10.1152/ajpcell.2000.278.1.c66. [PMID: 10644513]
  • M Bryckaert, X Guillonneau, C Hecquet, Y Courtois, F Mascarelli. Both FGF1 and bcl-x synthesis are necessary for the reduction of apoptosis in retinal pigmented epithelial cells by FGF2: role of the extracellular signal-regulated kinase 2. Oncogene. 1999 Dec; 18(52):7584-93. doi: 10.1038/sj.onc.1203200. [PMID: 10602518]
  • P J Kingham, M L Cuzner, J M Pocock. Apoptotic pathways mobilized in microglia and neurones as a consequence of chromogranin A-induced microglial activation. Journal of neurochemistry. 1999 Aug; 73(2):538-47. doi: 10.1046/j.1471-4159.1999.0730538.x. [PMID: 10428049]
  • M L Leski, S L Valentine, J T Coyle. L-type voltage-gated calcium channels modulate kainic acid neurotoxicity in cerebellar granule cells. Brain research. 1999 May; 828(1-2):27-40. doi: 10.1016/s0006-8993(99)01270-6. [PMID: 10320722]
  • N Canu, L Dus, C Barbato, M T Ciotti, C Brancolini, A M Rinaldi, M Novak, A Cattaneo, A Bradbury, P Calissano. Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1998 Sep; 18(18):7061-74. doi: 10.1523/jneurosci.18-18-07061.1998. [PMID: 9736630]
  • R Haviv, L Lindenboim, H Li, J Yuan, R Stein. Need for caspases in apoptosis of trophic factor-deprived PC12 cells. Journal of neuroscience research. 1997 Oct; 50(1):69-80. doi: 10.1002/(sici)1097-4547(19971001)50:1<69::aid-jnr8>3.0.co;2-j. [PMID: 9379495]
  • G P Kaushal, N Ueda, S V Shah. Role of caspases (ICE/CED 3 proteases) in DNA damage and cell death in response to a mitochondrial inhibitor, antimycin A. Kidney international. 1997 Aug; 52(2):438-45. doi: 10.1038/ki.1997.350. [PMID: 9263999]
  • I I Singer, S Scott, J Chin, E K Bayne, G Limjuco, J Weidner, D K Miller, K Chapman, M J Kostura. The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy. The Journal of experimental medicine. 1995 Nov; 182(5):1447-59. doi: 10.1084/jem.182.5.1447. [PMID: 7595215]
  • D S Fletcher, L Agarwal, K T Chapman, J Chin, L A Egger, G Limjuco, S Luell, D E MacIntyre, E P Peterson, N A Thornberry. A synthetic inhibitor of interleukin-1 beta converting enzyme prevents endotoxin-induced interleukin-1 beta production in vitro and in vivo. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 1995 Mar; 15(3):243-8. doi: 10.1089/jir.1995.15.243. [PMID: 7584670]