A6 Peptide (BioDeep_00000175509)
human metabolite blood metabolite
代谢物信息卡片
化学式: C39H62N10O15 (910.4396)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: CC(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CO)C(=O)NC(CO)C(=O)N1CCCC1C(=O)N1CCCC1C(=O)NC(CCC(O)=O)C(=O)NC(CCC(O)=O)C(N)=O
InChI: InChI=1S/C39H62N10O15/c1-21(52)42-24(7-2-3-15-40)37(62)47-16-4-8-27(47)36(61)45-25(19-50)34(59)46-26(20-51)38(63)49-18-6-10-29(49)39(64)48-17-5-9-28(48)35(60)44-23(12-14-31(55)56)33(58)43-22(32(41)57)11-13-30(53)54/h22-29,50-51H,2-20,40H2,1H3,(H2,41,57)(H,42,52)(H,43,58)(H,44,60)(H,45,61)(H,46,59)(H,53,54)(H,55,56)
描述信息
同义名列表
7 个代谢物同义名
4-({[1-(1-{2-[(2-{[(1-{6-amino-2-[(1-hydroxyethylidene)amino]hexanoyl}pyrrolidin-2-yl)(hydroxy)methylidene]amino}-1,3-dihydroxypropylidene)amino]-3-hydroxypropanoyl}pyrrolidine-2-carbonyl)pyrrolidin-2-yl](hydroxy)methylidene}amino)-4-{[3-carboxy-1-(C-hydroxycarbonimidoyl)propyl]-C-hydroxycarbonimidoyl}butanoate; 4-{2-[(1-{1-[2-(2-{[1-(6-amino-2-acetamidohexanoyl)pyrrolidin-2-yl]formamido}-3-hydroxypropanamido)-3-hydroxypropanoyl]pyrrolidine-2-carbonyl}pyrrolidin-2-yl)formamido]-4-carboxybutanamido}-4-carbamoylbutanoic acid; Acetyl-lysyl-prolyl-seryl-seryl-prolyl-prolyl-glutamyl-glutamic acid amide; Urokinase plasminogen activator (136-143), human; Ac-lys-pro-ser-ser-pro-pro-glu-glu-NH2; Ac-kpssppee-NH2; A6 Peptide
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Ran Cui, Huimin Bai, Guangming Cao, Zhenyu Zhang. The Role of Lysophosphatidic Acid Receptors in Ovarian Cancer: A Minireview.
Critical reviews in eukaryotic gene expression.
2020; 30(3):265-272. doi:
10.1615/critreveukaryotgeneexpr.2020031091. [PMID: 32749113] - Miriam Cantero, Héctor Rojas, Eduardo Anglés-Cano, Rita Marchi. Fibrin γ/γ' influences the secretion of fibrinolytic components and clot structure.
BMC molecular and cell biology.
2019 11; 20(1):47. doi:
10.1186/s12860-019-0233-0. [PMID: 31675913] - Sharad A Ghamande, Michael H Silverman, Warner Huh, Kian Behbakht, Greg Ball, Luceli Cuasay, Sidse O Würtz, Nils Brunner, Michael A Gold. A phase 2, randomized, double-blind, placebo-controlled trial of clinical activity and safety of subcutaneous A6 in women with asymptomatic CA125 progression after first-line chemotherapy of epithelial ovarian cancer.
Gynecologic oncology.
2008 Oct; 111(1):89-94. doi:
10.1016/j.ygyno.2008.06.028. [PMID: 18760451] - Anna Berkenblit, Ursula A Matulonis, Joan F Kroener, Bruce J Dezube, Gil N Lam, Luceli C Cuasay, Nils Brünner, Terence R Jones, Michael H Silverman, Michael A Gold. A6, a urokinase plasminogen activator (uPA)-derived peptide in patients with advanced gynecologic cancer: a phase I trial.
Gynecologic oncology.
2005 Oct; 99(1):50-7. doi:
10.1016/j.ygyno.2005.05.023. [PMID: 16023182] - A R van Troostenburg, D Lee, T R Jones, J A Dyck-Jones, M H Silverman, G N Lam, S J Warrington. Safety, tolerability and pharmacokinetics of subcutaneous A6, an 8-amino acid peptide with anti-angiogenic properties, in healthy men.
International journal of clinical pharmacology and therapeutics.
2004 May; 42(5):253-9. doi:
10.5414/cpp42253. [PMID: 15176647]
