Dihydrocurcumin (BioDeep_00000017543)

 

Secondary id: BioDeep_00000861507

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


4,6-Heptadien-3-one, 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-, (4Z,6E)-

化学式: C21H22O6 (370.1416312)
中文名称: 二氢姜黄素, 二氢姜黄素
谱图信息: 最多检出来源 Homo sapiens(blood) 0.83%

分子结构信息

SMILES: COC1=C(C=CC(=C1)CCC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O
InChI: InChI=1S/C21H22O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3,5-7,9-12,24-25H,4,8,13H2,1-2H3/b7-3+

描述信息

Dihydrocurcumin is a beta-diketone that is curcumin in which one of the double bonds has been reduced to a single bond. It is functionally related to a curcumin.
(1E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-1-ene-3,5-dione is a natural product found in Curcuma longa, Curcuma xanthorrhiza, and Aframomum letestuanum with data available.
Dihydrocurcumin is found in herbs and spices. Dihydrocurcumin is a constituent of Curcuma longa (turmeric)
A beta-diketone that is curcumin in which one of the double bonds has been reduced to a single bond.
Constituent of Curcuma longa (turmeric). Dihydrocurcumin is found in turmeric and herbs and spices.
Dihydrocurcumin, a major metabolites of curcumin, reduces lipid accumulation and oxidative stress. Dihydrocurcumin regulates mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increases protein expression levels of pAKT and PI3K, and reduced the levels of cellular NO and ROS via Nrf2 signaling pathways[1].
Dihydrocurcumin, a major metabolites of curcumin, reduces lipid accumulation and oxidative stress. Dihydrocurcumin regulates mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increases protein expression levels of pAKT and PI3K, and reduced the levels of cellular NO and ROS via Nrf2 signaling pathways[1].
Dihydrocurcumin, a major metabolites of curcumin, reduces lipid accumulation and oxidative stress. Dihydrocurcumin regulates mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increases protein expression levels of pAKT and PI3K, and reduced the levels of cellular NO and ROS via Nrf2 signaling pathways[1].

同义名列表

15 个代谢物同义名

4,6-Heptadien-3-one, 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-, (4Z,6E)-; 4,6-Heptadien-3-one, 5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-, (Z,E)-; (4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-4,6-dien-3-one; (1E,4Z)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4-dien-3-one; 5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-4,6-heptadien-3-one, 9CI; 5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-4,6-heptadien-3-one; (1E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-1-ene-3,5-dione; (E)-1,7-bis(4-hydroxy-3-methoxy-phenyl)hept-1-ene-3,5-dione; (e)-1,7-bis(4-hydroxy-3-methoxyphenyl)hept-1-ene-3,5-dione; 1,2-Dihydrocurcumin; Dihydrocurcumin; UNII-4YU9OA673J; letestuianin B; 4YU9OA673J; [1,7-bis(4-hydroxy-3-methoxyphenyl)-1-heptene-3,5-dione]



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Corinne Vanucci-Bacqué, Florence Bedos-Belval. Anti-inflammatory activity of naturally occuring diarylheptanoids - A review. Bioorganic & medicinal chemistry. 2021 02; 31(?):115971. doi: 10.1016/j.bmc.2020.115971. [PMID: 33422907]
  • Chatchawan Changtam, Poonpilas Hongmanee, Apichart Suksamrarn. Isoxazole analogs of curcuminoids with highly potent multidrug-resistant antimycobacterial activity. European journal of medicinal chemistry. 2010 Oct; 45(10):4446-57. doi: 10.1016/j.ejmech.2010.07.003. [PMID: 20691508]
  • Pierre Kamnaing, Apollinaire Tsopmo, Eric A Tanifum, Marguerite H K Tchuendem, Pierre Tane, Johnson F Ayafor, Olov Sterner, Donna Rattendi, Maurice M Iwu, Brian Schuster, Cyrus Bacchi. Trypanocidal diarylheptanoids from Aframomum letestuianum. Journal of natural products. 2003 Mar; 66(3):364-7. doi: 10.1021/np020362f. [PMID: 12662093]