Ileu-anp (BioDeep_00000175424)

   

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


Bovine kunitz pancreatic trypsin inhibitor

化学式: C284H432N84O79S7 (6507.041232199999)
中文名称: 抑肽酶 来源于牛肺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC2CSSCC3C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)N4CCCC4C(=O)N5CCCC5C(=O)NC(C(=O)NC(C(=O)NCC(=O)N6CCCC6C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N3)CC(=O)O)CCC(=O)O)C)CO)CCCCN)CC7=CC=CC=C7)CC(=O)N)CC(=O)N)CCCNC(=N)N)CCCCN)C)CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CCC(=O)N)C(C)O)CC8=CC=CC=C8)C(C)C)CC9=CC=C(C=C9)O)C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCNC(=N)N)C)CCCCN)C(C)O)CC1=CC=C(C=C1)O)CCC(=O)O)CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC(=O)O)NC(=O)C1CCCN1C(=O)C(CCCNC(=N)N)N)C(=O)NCC(=O)NCC(=O)NC(C)C(=O)O)C(C)O)CCCNC(=N)N)CCSC)CC(C)C)C)CCCCN)C)CC(=O)N)CC1=CC=C(C=C1)O)CC1=CC=CC=C1)CC1=CC=C(C=C1)O)CCCNC(=N)N)C(C)CC
InChI: InChI=1S/C284H432N84O79S7/c1-21-144(9)222-271(439)337-174(68-46-105-309-282(300)301)239(407)340-187(120-160-77-85-164(374)86-78-160)251(419)341-185(116-156-55-29-24-30-56-156)250(418)342-188(121-161-79-87-165(375)88-80-161)252(420)346-191(123-208(291)378)246(414)322-149(14)230(398)326-168(62-35-39-98-285)234(402)319-146(11)227(395)314-132-215(385)324-181(113-141(3)4)247(415)354-199-137-452-453-138-200-263(431)336-179(97-112-448-20)242(410)331-176(70-48-107-311-284(304)305)244(412)363-226(154(19)372)274(442)358-197(233(401)316-129-212(382)312-130-213(383)318-151(16)278(446)447)135-449-451-139-201(355-253(421)186(117-157-57-31-25-32-58-157)344-256(424)195(127-220(393)394)350-267(435)204-72-50-109-366(204)275(443)167(289)61-43-102-306-279(294)295)265(433)339-182(114-142(5)6)248(416)338-180(93-96-218(389)390)276(444)368-111-52-74-206(368)277(445)367-110-51-73-205(367)268(436)349-189(122-162-81-89-166(376)90-82-162)259(427)362-224(152(17)370)269(437)317-133-216(386)365-108-49-71-203(365)266(434)357-202(264(432)333-169(63-36-40-99-286)235(403)320-148(13)229(397)328-175(69-47-106-310-283(302)303)243(411)360-223(145(10)22-2)272(440)361-222)140-454-450-136-198(325-214(384)131-313-211(381)128-315-232(400)183(119-159-75-83-163(373)84-76-159)351-270(438)221(143(7)8)359-258(426)190(118-158-59-33-26-34-60-158)352-273(441)225(153(18)371)364-245(413)177(335-262(199)430)91-94-207(290)377)261(429)334-172(66-44-103-307-280(296)297)236(404)321-147(12)228(396)327-170(64-37-41-100-287)237(405)330-173(67-45-104-308-281(298)299)238(406)345-192(124-209(292)379)255(423)347-193(125-210(293)380)254(422)343-184(115-155-53-27-23-28-54-155)249(417)332-171(65-38-42-101-288)240(408)353-196(134-369)260(428)323-150(15)231(399)329-178(92-95-217(387)388)241(409)348-194(126-219(391)392)257(425)356-200/h23-34,53-60,75-90,141-154,167-206,221-226,369-376H,21-22,35-52,61-74,91-140,285-289H2,1-20H3,(H2,290,377)(H2,291,378)(H2,292,379)(H2,293,380)(H,312,382)(H,313,381)(H,314,395)(H,315,400)(H,316,401)(H,317,437)(H,318,383)(H,319,402)(H,320,403)(H,321,404)(H,322,414)(H,323,428)(H,324,385)(H,325,384)(H,326,398)(H,327,396)(H,328,397)(H,329,399)(H,330,405)(H,331,410)(H,332,417)(H,333,432)(H,334,429)(H,335,430)(H,336,431)(H,337,439)(H,338,416)(H,339,433)(H,340,407)(H,341,419)(H,342,418)(H,343,422)(H,344,424)(H,345,406)(H,346,420)(H,347,423)(H,348,409)(H,349,436)(H,350,435)(H,351,438)(H,352,441)(H,353,408)(H,354,415)(H,355,421)(H,356,425)(H,357,434)(H,358,442)(H,359,426)(H,360,411)(H,361,440)(H,362,427)(H,363,412)(H,364,413)(H,387,388)(H,389,390)(H,391,392)(H,393,394)(H,446,447)(H4,294,295,306)(H4,296,297,307)(H4,298,299,308)(H4,300,301,309)(H4,302,303,310)(H4,304,305,311)

描述信息

B - Blood and blood forming organs > B02 - Antihemorrhagics > B02A - Antifibrinolytics > B02AB - Proteinase inhibitors
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015842 - Serine Proteinase Inhibitors
D006401 - Hematologic Agents > D003029 - Coagulants > D006490 - Hemostatics
Aprotinin is a bovine pancreatic trypsin inhibitor (BPTI) inhibitor which inhibits trypsin and chymotrypsin with Kis of 0.06 pM and 9 nM, respectively.
Aprotinin is a bovine pancreatic trypsin inhibitor (BPTI) inhibitor which inhibits trypsin and chymotrypsin with Kis of 0.06 pM and 9 nM, respectively.

同义名列表

24 个代谢物同义名

Bovine kunitz pancreatic trypsin inhibitor; BPTI, basic pancreatic trypsin inhibitor; Trypsin inhibitor, kunitz, pancreatic; Trypsin inhibitor, basic, pancreatic; Bovine pancreatic trypsin inhibitor; Kunitz pancreatic trypsin inhibitor; Basic pancreatic trypsin inhibitor; Inactivator, kallikrein-trypsin; Kallikrein trypsin inactivator; Kallikrein-trypsin inactivator; Aprotinin acetate salt; Kontrikal; Contrykal; Kontrykal; Antilysin; Contrical; Traskolan; Dilmintal; Trasylol; Zymofren; Ileu-anp; Iniprol; Pulmin; Aprotinin



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Rafael de Almeida Barros, Yaremis Meriño-Cabrera, José Severiche Castro, Neilier Rodrigues da Silva Junior, João Vitor Aguilar de Oliveira, Halina Schultz, Rafael Júnior de Andrade, Humberto Josué de Oliveira Ramos, Maria Goreti de Almeida Oliveira. Bovine pancreatic trypsin inhibitor and soybean Kunitz trypsin inhibitor: Differential effects on proteases and larval development of the soybean pest Anticarsia gemmatalis (Lepidoptera: Noctuidae). Pesticide biochemistry and physiology. 2022 Oct; 187(?):105188. doi: 10.1016/j.pestbp.2022.105188. [PMID: 36127063]
  • Francisco Javier Redondo-Calvo, Juan Fernando Padín, José Ramón Muñoz-Rodríguez, Leticia Serrano-Oviedo, Pilar López-Juárez, María Lourdes Porras Leal, Francisco Javier González Gasca, Marta Rodríguez Martínez, Raúl Pérez Serrano, Abraham Sánchez Cadena, Natalia Bejarano-Ramírez, Constanza Muñoz Hornero, José Ramón Barberá Farré, Inmaculada Domínguez-Quesada, María A Sepúlveda Berrocal, María Dolores Villegas Fernández-Infantes, María Isabel Manrique Romo, Ángel Parra Comino, José Manuel Pérez-Ortiz, Francisco Javier Gómez-Romero. Aprotinin treatment against SARS-CoV-2: A randomized phase III study to evaluate the safety and efficacy of a pan-protease inhibitor for moderate COVID-19. European journal of clinical investigation. 2022 Jun; 52(6):e13776. doi: 10.1111/eci.13776. [PMID: 35342931]
  • Stefan Wörner, Bernhard N Bohnert, Matthias Wörn, Mengyun Xiao, Andrea Janessa, Andreas L Birkenfeld, Kerstin Amann, Christoph Daniel, Ferruh Artunc. Renal effects of the serine protease inhibitor aprotinin in healthy conscious mice. Acta pharmacologica Sinica. 2022 Jan; 43(1):111-120. doi: 10.1038/s41401-021-00628-1. [PMID: 33758357]
  • Bernhard N Bohnert, Daniel Essigke, Andrea Janessa, Jonas C Schneider, Matthias Wörn, M Zaher Kalo, Mengyun Xiao, Lingsi Kong, Kingsley Omage, Jörg Hennenlotter, Bastian Amend, Andreas L Birkenfeld, Ferruh Artunc. Experimental nephrotic syndrome leads to proteolytic activation of the epithelial Na+ channel in the mouse kidney. American journal of physiology. Renal physiology. 2021 10; 321(4):F480-F493. doi: 10.1152/ajprenal.00199.2021. [PMID: 34423678]
  • Matthew N Creyer, Zhicheng Jin, Colman Moore, Wonjun Yim, Jiajing Zhou, Jesse V Jokerst. Modulation of Gold Nanorod Growth via the Proteolysis of Dithiol Peptides for Enzymatic Biomarker Detection. ACS applied materials & interfaces. 2021 Sep; 13(38):45236-45243. doi: 10.1021/acsami.1c11620. [PMID: 34520186]
  • Lisa Dominowski, Michael Kirsch. Synergistic Effect of β-alanine and Aprotinin on Mesenteric Ischemia. The Journal of surgical research. 2021 07; 263(?):78-88. doi: 10.1016/j.jss.2021.01.026. [PMID: 33639373]
  • Andrey A Ivashchenko, Valeria N Azarova, Alina N Egorova, Ruben N Karapetian, Dmitry V Kravchenko, Natalia V Krivonos, Vladimir G Loginov, Stanislav V Poyarkov, Elena A Merkulova, Olga S Rosinkova, Nikolay P Savchuk, Mikhail A Topr, Elena N Simakina, Elena V Yakubova, Alexandre V Ivachtchenko. Effect of Aprotinin and Avifavir® Combination Therapy for Moderate COVID-19 Patients. Viruses. 2021 06; 13(7):. doi: 10.3390/v13071253. [PMID: 34199134]
  • Eun-Jung Song, Erica Españo, Sang-Mu Shim, Jeong-Hyun Nam, Jiyeon Kim, Kiho Lee, Song-Kyu Park, Chong-Kil Lee, Jeong-Ki Kim. Inhibitory effects of aprotinin on influenza A and B viruses in vitro and in vivo. Scientific reports. 2021 05; 11(1):9427. doi: 10.1038/s41598-021-88886-1. [PMID: 33941825]
  • T Vanassche, M M Engelen, Q Van Thillo, J Wauters, J Gunst, C Wouters, C Vandenbriele, S Rex, L Liesenborghs, A Wilmer, P Meersseman, G Van den Berghe, D Dauwe, G Verbeke, M Thomeer, T Fivez, D Mesotten, D Ruttens, L Heytens, I Dapper, S Tuyls, B De Tavernier, P Verhamme. A randomized, open-label, adaptive, proof-of-concept clinical trial of modulation of host thromboinflammatory response in patients with COVID-19: the DAWn-Antico study. Trials. 2020 Dec; 21(1):1005. doi: 10.1186/s13063-020-04878-y. [PMID: 33298149]
  • Eman D Elkerdany, Suzanne M Elnassery, Fadwa M Arafa, Sahar Abdel-Fattah Zaki, Rasha F Mady. In vitro effect of a novel protease inhibitor cocktail on Toxoplasma gondii tachyzoites. Experimental parasitology. 2020 Dec; 219(?):108010. doi: 10.1016/j.exppara.2020.108010. [PMID: 33007297]
  • Seyyed Mohammad Ghahestani, Elaheh Shahab, Sara Karimi, Mohammad Hamidi Madani. Methylene blue may have a role in the treatment of COVID-19. Medical hypotheses. 2020 Nov; 144(?):110163. doi: 10.1016/j.mehy.2020.110163. [PMID: 33254484]
  • Denisa Bojkova, Marco Bechtel, Katie-May McLaughlin, Jake E McGreig, Kevin Klann, Carla Bellinghausen, Gernot Rohde, Danny Jonigk, Peter Braubach, Sandra Ciesek, Christian Münch, Mark N Wass, Martin Michaelis, Jindrich Cinatl. Aprotinin Inhibits SARS-CoV-2 Replication. Cells. 2020 10; 9(11):. doi: 10.3390/cells9112377. [PMID: 33143316]
  • Shibili Nuhmani. Injection therapies for patellar tendinopathy. The Physician and sportsmedicine. 2020 05; 48(2):125-130. doi: 10.1080/00913847.2019.1671143. [PMID: 31539489]
  • Ping Hu, Le Shang, Jincan Chen, Xuzheng Chen, Chun Chen, Wanjin Hong, Mingdong Huang, Peng Xu, Zhuo Chen. A nanometer-sized protease inhibitor for precise cancer diagnosis and treatment. Journal of materials chemistry. B. 2020 01; 8(3):504-514. doi: 10.1039/c9tb02081k. [PMID: 31840729]
  • Nadine M S Araújo, Lucas P Dias, Helen P S Costa, Daniele O B Sousa, Ilka M Vasconcelos, Glaucia A de Morais, Jose T A Oliveira. ClTI, a Kunitz trypsin inhibitor purified from Cassia leiandra Benth. seeds, exerts a candidicidal effect on Candida albicans by inducing oxidative stress and necrosis. Biochimica et biophysica acta. Biomembranes. 2019 11; 1861(11):183032. doi: 10.1016/j.bbamem.2019.183032. [PMID: 31376361]
  • M Rafiq Islam, Kelvin Ihenacho, Jae Whan Park, I Sakif Islam. Plasmid DNA nicking- a Novel Activity of Soybean Trypsin Inhibitor and Bovine Aprotinin. Scientific reports. 2019 08; 9(1):11596. doi: 10.1038/s41598-019-48068-6. [PMID: 31406183]
  • Markus Berger, João Alfredo de Moraes, Walter Orlando Beys-da-Silva, Lucélia Santi, Paula Barros Terraciano, David Driemeier, Elizabeth Obino Cirne-Lima, Eduardo Pandolfi Passos, Maria Aparecida Ribeiro Vieira, Thereza Christina Barja-Fidalgo, Jorge Almeida Guimarães. Renal and vascular effects of kallikrein inhibition in a model of Lonomia obliqua venom-induced acute kidney injury. PLoS neglected tropical diseases. 2019 02; 13(2):e0007197. doi: 10.1371/journal.pntd.0007197. [PMID: 30763408]
  • Bernhard N Bohnert, Ferruh Artunc. Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin. Journal of visualized experiments : JoVE. 2018 05; ?(135):. doi: 10.3791/57642. [PMID: 29782000]
  • Umberto Benedetto, Douglas G Altman, Stephen Gerry, Alastair Gray, Belinda Lees, Gianni D Angelini, Marcus Flather, David P Taggart. Safety of Perioperative Aprotinin Administration During Isolated Coronary Artery Bypass Graft Surgery: Insights From the ART (Arterial Revascularization Trial). Journal of the American Heart Association. 2018 03; 7(5):. doi: 10.1161/jaha.117.007570. [PMID: 29502105]
  • Pierpaolo Chivasso, Vito D Bruno, Roberto Marsico, Anilkumar Sankanahalli Annaiah, Alexander Curtis, Carlo Zebele, Gianni D Angelini, Alan J Bryan, Cha Rajakaruna. Effectiveness and Safety of Aprotinin Use in Thoracic Aortic Surgery. Journal of cardiothoracic and vascular anesthesia. 2018 02; 32(1):170-177. doi: 10.1053/j.jvca.2017.06.040. [PMID: 29217251]
  • Bernhard N Bohnert, Martina Menacher, Andrea Janessa, Matthias Wörn, Anja Schork, Sophie Daiminger, Hubert Kalbacher, Hans-Ulrich Häring, Christoph Daniel, Kerstin Amann, Florian Sure, Marko Bertog, Silke Haerteis, Christoph Korbmacher, Ferruh Artunc. Aprotinin prevents proteolytic epithelial sodium channel (ENaC) activation and volume retention in nephrotic syndrome. Kidney international. 2018 01; 93(1):159-172. doi: 10.1016/j.kint.2017.07.023. [PMID: 29042083]
  • Jaimini Cegla, Ben J Jones, James Howard, Richard Kay, Colin S Creaser, Stephen R Bloom, Tricia M Tan. The preanalytical stability of glucagon as measured by liquid chromatography tandem mass spectrometry and two commercially available immunoassays. Annals of clinical biochemistry. 2017 Mar; 54(2):293-296. doi: 10.1177/0004563216675648. [PMID: 27705885]
  • Kouhei Sasamoto, Rie Marunaka, Naomi Niisato, Hongxin Sun, Akiyuki Taruno, Giuseppe Pezzotti, Toshiro Yamamoto, Narisato Kanamura, Wenliang Zhu, Kyosuke Nishio, Toshio Inui, Douglas C Eaton, Yoshinori Marunaka. Analysis of Aprotinin, a Protease Inhibitor, Action on the Trafficking of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells Using a Mathematical Model. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017; 41(5):1865-1880. doi: 10.1159/000471934. [PMID: 28478438]
  • K Vadivel, Y Kumar, G I Ogueli, S M Ponnuraj, P Wongkongkathep, J A Loo, M S Bajaj, S P Bajaj. S2'-subsite variations between human and mouse enzymes (plasmin, factor XIa, kallikrein) elucidate inhibition differences by tissue factor pathway inhibitor -2 domain1-wild-type, Leu17Arg-mutant and aprotinin. Journal of thrombosis and haemostasis : JTH. 2016 12; 14(12):2509-2523. doi: 10.1111/jth.13538. [PMID: 27797450]
  • Hakan Turkon, Burak Toprak, Hulya Yalcin, Ayfer Colak, Nurinnisa Ozturk. The Effectiveness of Temperature Versus Aprotinin in Maintaining the Preanalytical Stability of Adrenocorticotrophin. Laboratory medicine. 2016 Nov; 47(4):279-282. doi: 10.1093/labmed/lmw027. [PMID: 27593170]
  • Derya İlem-Özdemir, Neslihan Üstündağ-Okur, Zeynep Ay Şenyiğit, Nevin Oruç, Makbule Aşıkoğlu, Ömer Özütemiz, H Yeşim Karasulu. Effect of microemulsion formulation on biodistribution of 99mTc-Aprotinin in acute pancreatitis models induced rats. Drug delivery. 2016 Oct; 23(8):3055-3062. doi: 10.3109/10717544.2016.1145306. [PMID: 26923781]
  • Ashis K Mukherjee, Sumita Dutta, Bhargab Kalita, Deepak K Jha, Pritam Deb, Stephen P Mackessy. Structural and functional characterization of complex formation between two Kunitz-type serine protease inhibitors from Russell's Viper venom. Biochimie. 2016 Sep; 128-129(?):138-47. doi: 10.1016/j.biochi.2016.08.005. [PMID: 27523780]
  • P B Olthof, F Huisman, R F van Golen, K P Cieslak, K P van Lienden, T Plug, J C M Meijers, M Heger, J Verheij, T M van Gulik. Use of an absorbable embolization material for reversible portal vein embolization in an experimental model. The British journal of surgery. 2016 Sep; 103(10):1306-15. doi: 10.1002/bjs.10208. [PMID: 27477877]
  • Anna S Kamenik, Ursula Kahler, Julian E Fuchs, Klaus R Liedl. Localization of Millisecond Dynamics: Dihedral Entropy from Accelerated MD. Journal of chemical theory and computation. 2016 Aug; 12(8):3449-55. doi: 10.1021/acs.jctc.6b00231. [PMID: 27322931]
  • Louis-Mathieu Stevens, Nicolas Noiseux, Ignacio Prieto, Jean-François Hardy. Major transfusions remain frequent despite the generalized use of tranexamic acid: an audit of 3322 patients undergoing cardiac surgery. Transfusion. 2016 07; 56(7):1857-65. doi: 10.1111/trf.13615. [PMID: 27112920]
  • Harunipriya Palaniswamy, Divya P Syamaladevi, Chakravarthi Mohan, Anna Philip, Anushya Petchiyappan, Subramonian Narayanan. Vacuolar targeting of r-proteins in sugarcane leads to higher levels of purifiable commercially equivalent recombinant proteins in cane juice. Plant biotechnology journal. 2016 Feb; 14(2):791-807. doi: 10.1111/pbi.12430. [PMID: 26183462]
  • Yan-Min Long, Xing-Chen Zhao, Allen C Clermont, Qun-Fang Zhou, Qian Liu, Edward P Feener, Bing Yan, Gui-Bin Jiang. Negatively charged silver nanoparticles cause retinal vascular permeability by activating plasma contact system and disrupting adherens junction. Nanotoxicology. 2016; 10(4):501-11. doi: 10.3109/17435390.2015.1088589. [PMID: 26399585]
  • Shiwanthi L Ranasinghe, Katja Fischer, Geoffrey N Gobert, Donald P McManus. A novel coagulation inhibitor from Schistosoma japonicum. Parasitology. 2015 Dec; 142(14):1663-72. doi: 10.1017/s0031182015001328. [PMID: 26463744]
  • M Muñoz Gómez, E Bisbe Vives, M Basora Macaya, J A García Erce, A Gómez Luque, S R Leal-Noval, M J Colomina, J Comin Colet, E Contreras Barbeta, J Cuenca Espiérrez, A Garcia de Lorenzo Y Mateos, F Gomollón García, M Izuel Ramí, M V Moral García, J B Montoro Ronsano, J A Páramo Fernández, A Pereira Saavedra, M Quintana Diaz, Á Remacha Sevilla, R Salinas Argente, C Sánchez Pérez, G Tirado Anglés, P Torrabadella de Reinoso. Forum for debate: Safety of allogeneic blood transfusion alternatives in the surgical/critically ill patient. Medicina intensiva. 2015 Dec; 39(9):552-62. doi: 10.1016/j.medin.2015.05.006. [PMID: 26183121]
  • Michelle Paul, Pritinder Kaur, Marisa Herson, Perdita Cheshire, Heather Cleland, Shiva Akbarzadeh. Use of Clotted Human Plasma and Aprotinin in Skin Tissue Engineering: A Novel Approach to Engineering Composite Skin on a Porous Scaffold. Tissue engineering. Part C, Methods. 2015 Oct; 21(10):1098-104. doi: 10.1089/ten.tec.2014.0667. [PMID: 25996837]
  • Mutsuo Yamaya, Yoshitaka Shimotai, Yukimasa Hatachi, Nadine Lusamba Kalonji, Yukiko Tando, Yasuo Kitajima, Kaori Matsuo, Hiroshi Kubo, Ryoichi Nagatomi, Seiji Hongo, Morio Homma, Hidekazu Nishimura. The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells. Pulmonary pharmacology & therapeutics. 2015 Aug; 33(?):66-74. doi: 10.1016/j.pupt.2015.07.001. [PMID: 26166259]
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