7-Octadecynoic acid (BioDeep_00000175116)
human metabolite blood metabolite
代谢物信息卡片
Tumor necrosis factor receptor superfamily, member 11b
化学式: C18H32O2 (280.2402)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 11.38%
分子结构信息
SMILES: CCCCCCCCCCC#CCCCCCC(=O)O
InChI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-10,13-17H2,1H3,(H,19,20)
描述信息
同义名列表
13 个代谢物同义名
Tumor necrosis factor receptor superfamily, member 11b; Follicular dendritic cell derived receptor 1; Receptors, tumor necrosis factor, member 11b; Follicular dendritic cell-derived receptor-1; Osteoclastogenesis inhibitory factor; Tumor necrosis factor receptor 11b; octadec-7-ynoic acid; 7-octadecynoic acid; Osteoprotegerin; 7-Octadecynoate; FDCR 1 Protein; FDCR-1 Protein; OCIF protein
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:196519
- PubChem: 4378574
- HMDB: HMDB0247278
- ChEMBL: CHEMBL2397332
- MeSH: Osteoprotegerin
- chemspider: 3580682
- CAS: 19220-35-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Ting Wang, Zhao-Bo Wang, Chun-Miao Jiang, Yang Zhao, Li Tang, Xi-Mei Xiao, Jing Fu. Oroxylin A inhibits inflammatory cytokines in periodontitis via HO‑1.
Molecular medicine reports.
2024 Jul; 30(1):. doi:
10.3892/mmr.2024.13249. [PMID: 38785151] - Shiwei Yao, Hongling Lu, Tianhuan Zhou, Qihong Jiang, Chenkai Jiang, Wenjun Hu, Mingqian Li, Chin Ping Tan, Yongcai Feng, Qun Du, Guoxin Shen, Xingwei Xiang, Lin Chen. Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice.
Food & function.
2024 Apr; 15(8):4490-4502. doi:
10.1039/d3fo04527g. [PMID: 38566566] - Xuefei Li, Wenhua Chen, Dan Liu, Pinghua Chen, Shiyun Wang, Fangfang Li, Qian Chen, Shunyi Lv, Fangyu Li, Chen Chen, Suxia Guo, Weina Yuan, Pan Li, Zhijun Hu. Pathological progression of osteoarthritis: a perspective on subchondral bone.
Frontiers of medicine.
2024 Apr; 18(2):237-257. doi:
10.1007/s11684-024-1061-y. [PMID: 38619691] - Linbi Xie, Xu Song, Ling Lei, Chu Chen, Huan Zhao, Jingyi Hu, Yue Yu, Xiaolu Bai, Xia Wu, Xiangfeng Li, Xiao Yang, Bo Yuan, Dongxiao Li, Xiangdong Zhu, Xingdong Zhang. Exploring the potential mechanism of Heng-Gu-Gu-Shang-Yu-He-Ji therapy for osteoporosis based on network pharmacology and transcriptomics.
Journal of ethnopharmacology.
2024 Mar; 321(?):117480. doi:
10.1016/j.jep.2023.117480. [PMID: 37995823] - A Naga Sailaja, Nivedita Nanda, B S Suryanarayana, G K Pal. Association of rs2073618 polymorphism and osteoprotegerin levels with hypertension and cardiovascular risks in patients with type 2 diabetes mellitus.
Scientific reports.
2023 10; 13(1):17451. doi:
10.1038/s41598-023-44554-0. [PMID: 37838749] - Ye Cheng, Jianwei Chen, Shujuan Zou, Li Huang, Guifeng Li. The mechanism underlying the remodeling effect of lactoferrin on midpalatal sutures during maxillary expansion and relapse in rats.
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics.
2023 Jun; 163(6):e137-e151. doi:
10.1016/j.ajodo.2023.03.006. [PMID: 37012109] - Shaobo Wu, Yao Wu, Lan Lin, Changshun Ruan, Fang Li, Rong Chen, Hongxin Du, Xianxiang Zhang, Xiaohe Luo. Osteoprotegerin deficiency aggravates methionine-choline-deficient diet-induced nonalcoholic steatohepatitis in mice.
Scientific reports.
2023 Feb; 13(1):3194. doi:
10.1038/s41598-023-30001-7. [PMID: 36823220] - Yangxin Li, Chuan Liu, Jie Luo, Yong Zeng, Xianli Meng, Shaohui Wang, Yi Zhang. Ershiwuwei Lvxue Pill alleviates rheumatoid arthritis by different pathways and produces changes in the gut microbiota.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Dec; 107(?):154462. doi:
10.1016/j.phymed.2022.154462. [PMID: 36162242] - Yinghui Ma, Jinbei Zhang, Huan Yu, Yanfei Zhang, Huifeng Zhang, Chengyi Hao, Lili Zuo, Nianqiu Shi, Wenliang Li. Traditional Chinese Medicine Rhodiola Sachalinensis Borissova from Baekdu Mountain (RsBBM) for Rheumatoid Arthritis: Therapeutic Effect and Underlying Molecular Mechanisms.
Molecules (Basel, Switzerland).
2022 Sep; 27(18):. doi:
10.3390/molecules27186058. [PMID: 36144788] - A Naga Sailaja, Nivedita Nanda, B S Suryanarayana, G K Pal. Hypertension attenuates the link of osteoprotegerin to reduced baroreflex sensitivity in type 2 diabetes mellitus patients on oral antidiabetic and antihypertensive therapy - a cross sectional study.
BMC endocrine disorders.
2022 Sep; 22(1):226. doi:
10.1186/s12902-022-01137-w. [PMID: 36085061] - Yating Yang, Ruining Cheng, Jingyun Liu, Jing Fang, Xiaojing Wang, Yingxue Cui, Pan Zhang, Bin Du. Linarin Protects against Cadmium-Induced Osteoporosis Via Reducing Oxidative Stress and Inflammation and Altering RANK/RANKL/OPG Pathway.
Biological trace element research.
2022 Aug; 200(8):3688-3700. doi:
10.1007/s12011-021-02967-w. [PMID: 34674107] - Karolina Czerwińska, Małgorzata Poręba, Adam Prokopowicz, Lidia Januszewska, Aleksandra Jaremków, Iwona Markiewicz-Górka, Helena Martynowicz, Grzegorz Mazur, Rafał Poręba, Krystyna Pawlas, Paweł Gać. Association Between Serum Selenium Concentration and OPG/RANKL/RANK Axis in Patients with Arterial Hypertension.
Cardiovascular toxicology.
2022 07; 22(7):620-630. doi:
10.1007/s12012-022-09741-x. [PMID: 35412194] - Mieczysław Dutka, Rafał Bobiński, Wojciech Wojakowski, Tomasz Francuz, Celina Pająk, Karolina Zimmer. Osteoprotegerin and RANKL-RANK-OPG-TRAIL signalling axis in heart failure and other cardiovascular diseases.
Heart failure reviews.
2022 07; 27(4):1395-1411. doi:
10.1007/s10741-021-10153-2. [PMID: 34313900] - Fang Wang, Gaohong Yang, Yu Li, Zhijuan Tang, Jiayi Du, Haizhao Song, Ling Xiong, Luanfeng Wang, Zebin Weng, Xinchun Shen. A peptide from wheat germ abolishes the senile osteoporosis by regulating OPG/RANKL/RANK/TRAF6 signaling pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jun; 104(?):154304. doi:
10.1016/j.phymed.2022.154304. [PMID: 35793596] - Qin Luxue, Guo Changqing, Zhao Ruili, Wang Tong, Wang Junmei, Guo Yan, Zhang Wei, H U Tingyao, Chen Xilin, Zhang Qian, Zhang Dian, X U Yue. Acupotomy inhibits aberrant formation of subchondral bone through regulating osteoprotegerin/receptor activator of nuclear factor-κB ligand pathway in rabbits with knee osteoarthritis induced by modified Videman method.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2022 06; 42(3):389-399. doi:
10.19852/j.cnki.jtcm.2022.03.006. [PMID: 35610008] - Michał Kosowski, Marcin Basiak, Marcin Hachuła, Bogusław Okopień. Plasma Concentrations of New Biochemical Markers of Atherosclerosis in Patients with Dyslipidemia-A Pilot Study.
Medicina (Kaunas, Lithuania).
2022 May; 58(6):. doi:
10.3390/medicina58060717. [PMID: 35743980] - Xing Shui, Ruimin Dong, Zhen Wu, Zefeng Chen, Zheqi Wen, Leile Tang, Xujing Xie, Lin Chen. Association of serum sclerostin and osteoprotegerin levels with the presence, severity and prognosis in patients with acute myocardial infarction.
BMC cardiovascular disorders.
2022 05; 22(1):213. doi:
10.1186/s12872-022-02654-1. [PMID: 35546224] - Rehab H Werida, Sohaila Abou-Madawy, Mohamed Abdelsalam, Maged W Helmy. Omega 3 fatty acids effect on the vascular calcification biomarkers fetuin A and osteoprotegerin in hemodialysis patients.
Clinical and experimental medicine.
2022 May; 22(2):301-310. doi:
10.1007/s10238-021-00740-w. [PMID: 34286397] - Diana Moldovan, Crina Rusu, Alina Potra, Cosmina Bondor, Maria Ticala, Dacian Tirinescu, Anca Coman, Olga Orasan, Ioan Moldovan, Remus Orasan, Ina Kacso. Arterial calcifications and osteoprotegerin in chronic hemodialysis patients: impact on 6-year survival.
International urology and nephrology.
2022 May; 54(5):1135-1143. doi:
10.1007/s11255-021-02988-3. [PMID: 34505226] - Rachel Mintz, Mei Wang, Shuai Xu, Graham A Colditz, Chris Markovic, Adetunji T Toriola. Hormone and receptor activator of NF-κB (RANK) pathway gene expression in plasma and mammographic breast density in postmenopausal women.
Breast cancer research : BCR.
2022 04; 24(1):28. doi:
10.1186/s13058-022-01522-2. [PMID: 35422057] - María I García-Parra, Matilde Jiménez-Coello, Bertha A Carrillo-Ávila, Ivonne Hernández-Cortázar, Georgina Chávez-Cortez, Victor M Martínez-Aguilar. Quantification of Osteoprotegerin Plasma Levels in Patients with Periodontitis.
Puerto Rico health sciences journal.
2022 03; 41(1):5-8. doi:
. [PMID: 35438888] - Nikolett Wohner, Silvie Sebastian, Vincent Muczynski, Dana Huskens, Bas de Laat, Philip G de Groot, Peter J Lenting. Osteoprotegerin modulates platelet adhesion to von Willebrand factor during release from endothelial cells.
Journal of thrombosis and haemostasis : JTH.
2022 03; 20(3):755-766. doi:
10.1111/jth.15598. [PMID: 34816579] - Benedikt Eggers, Anna-Maria Wagenheim, Susanne Jung, Johannes Kleinheinz, Marjan Nokhbehsaim, Franz-Josef Kramer, Sonja Sielker. Effect of Cold Atmospheric Plasma (CAP) on Osteogenic Differentiation Potential of Human Osteoblasts.
International journal of molecular sciences.
2022 Feb; 23(5):. doi:
10.3390/ijms23052503. [PMID: 35269642] - Marta Dobrzycka, Adrian Kołakowski, Magdalena Stefanowicz, Natalia Matulewicz, Agnieszka Nikołajuk, Monika Karczewska-Kupczewska. Inverse Regulation of Serum Osteoprotegerin and B-Type Natriuretic Peptide Concentrations by Free Fatty Acids Elevation in Young Healthy Humans.
Nutrients.
2022 Feb; 14(4):. doi:
10.3390/nu14040837. [PMID: 35215487] - Gizem Celebi, Merve Anapali, Fatma Kaya Dagistanli, Ayse Seda Akdemir, Duygu Aydemir, Nuriye Nuray Ulusu, Turgut Ulutin, Evrim Komurcu-Bayrak. Effect of vitamin D supplementation on OPG/RANKL signalling activities in endothelial tissue damage in diet-induced diabetic rat model.
Pharmacological reports : PR.
2022 Feb; 74(1):124-134. doi:
10.1007/s43440-021-00332-1. [PMID: 34657267] - Hailun Jiang, Fang Xu, Li Zeng, Chenyang Li, Yan Chen, Linlin Wang, Zhuorong Li, Rui Liu. Saponins from Nigella glandulifera seeds attenuate collagen-induced rheumatoid arthritis in rats via the OPG/RANKL/NF-κB and Ang/Tie-2 pathways.
Journal of ethnopharmacology.
2022 Jan; 283(?):114714. doi:
10.1016/j.jep.2021.114714. [PMID: 34624452] - Kelli S George, Joseph Munoz, Lauren T Ormsbee, Neda S Akhavan, Elizabeth M Foley, Shalom C Siebert, Jeong-Su Kim, Robert C Hickner, Bahram H Arjmandi. The Short-Term Effect of Prunes in Improving Bone in Men.
Nutrients.
2022 Jan; 14(2):. doi:
10.3390/nu14020276. [PMID: 35057457] - Wenxin Ma, Weidong Jin, Xijing He, Yuhang Sun, Huquan Yin, Zili Wang, Shiyuan Shi. Mycobacterium tuberculosis Induced Osteoblast Dysregulation Involved in Bone Destruction in Spinal Tuberculosis.
Frontiers in cellular and infection microbiology.
2022; 12(?):780272. doi:
10.3389/fcimb.2022.780272. [PMID: 35463641] - Zhao Ruilian, Gao Ying, Shen Hongmei, Guo Lihua. Exploration of the Effect of Icariin on Nude Mice with Lung Cancer Bone Metastasis via the OPG/RANKL/RANK System.
Computational and mathematical methods in medicine.
2022; 2022(?):2011625. doi:
10.1155/2022/2011625. [PMID: 35669373] - Ilham Youssry, Nahla Saad, Mohamed Madboly, Rania M Samy, Soha T Hamed, Hanaa Tawfik, Salwa R Elbatrawy, Normeen Kaddah, Dalia Abd Elaziz. Bone health in pediatric transfusion-dependent beta-thalassemia: Circulating osteoprotegerin and RANKL system.
Pediatric blood & cancer.
2022 01; 69(1):e29377. doi:
10.1002/pbc.29377. [PMID: 34699125] - Aleksandra Jawiarczyk-Przybyłowska, Jowita Halupczok-Żyła, Joanna Syrycka, Agnieszka Zembska, Justyna Kuliczkowska-Płaksej, Marek Bolanowski. Trabecular Bone Score and Osteoprotegerin as Useful Tools in the Assessment of Bone Deterioration in Acromegaly.
Frontiers in endocrinology.
2022; 13(?):862845. doi:
10.3389/fendo.2022.862845. [PMID: 35528019] - Saraa L Angel, Vilas D Samrit, Om Prakash Kharbanda, Ritu Duggal, Vikas Kumar, Shyam S Chauhan, Poonam Coshic. Effects of submucosally administered platelet-rich plasma on the rate of tooth movement.
The Angle orthodontist.
2022 Jan; 92(1):73-79. doi:
10.2319/011221-40.1. [PMID: 34491291] - Ryerson Fonseca Mota, Paulo Henrique Cavalcanti de Araújo, Maria Eduarda Ramos Cezine, Flávia Sayuri Matsuo, Rodrigo Jair Morandi Metzner, Carlos Alberto Oliveira de Biagi Junior, Kamila Chagas Peronni, Hiroki Hayashi, Munehisa Shimamura, Hironori Nakagami, Mariana Kiomy Osako. RANKL Impairs the TLR4 Pathway by Increasing TRAF6 and RANK Interaction in Macrophages.
BioMed research international.
2022; 2022(?):7740079. doi:
10.1155/2022/7740079. [PMID: 35463988] - Junjie Lu, Desheng Hu, Chen Ma, Xiaojuan Xu, Lin Shen, Jianhui Rong, Jia Zhao, Bo Shuai. Modified Qing' e Pills exerts anti-osteoporosis effects and prevents bone loss by enhancing type H blood vessel formation.
Frontiers in endocrinology.
2022; 13(?):998971. doi:
10.3389/fendo.2022.998971. [PMID: 36147560] - Zofia Ostrowska, Małgorzata Morawiecka-Pietrzak, Wojciech Pluskiewicz, Elżbieta Świętochowska, Joanna Strzelczyk, Karolina Gołąbek, Jadwiga Gaździcka, Katarzyna Ziora. [The relationship between chemerin, bone metabolism, the RANKL/RANK/OPG system, and bone mineral density in girls with anorexia nervosa].
Endokrynologia Polska.
2022; 73(1):26-34. doi:
10.5603/ep.a2021.0103. [PMID: 35119086] - Shan Wang, Wenjing Feng, Jianya Liu, Xufu Wang, Lina Zhong, Chengxiu Lv, Meiping Feng, Nina An, Yongjun Mao. Alginate oligosaccharide alleviates senile osteoporosis via the RANKL-RANK pathway in D-galactose-induced C57BL/6J mice.
Chemical biology & drug design.
2022 01; 99(1):46-55. doi:
10.1111/cbdd.13904. [PMID: 34145772] - Ana Rita Prata, Jorge Saraiva, Manuel Salgado, Paula Estanqueiro. Juvenile Paget's Disease: Report of a successful treatment throughout the complete growth of a patient with a missense TNFRSF11B mutation.
Joint bone spine.
2021 12; 88(6):105243. doi:
10.1016/j.jbspin.2021.105243. [PMID: 34166796] - Fang Wang, Sang Long, Jie Zhang. Moringa oleifera Lam. leaf extract safely inhibits periodontitis by regulating the expression of p38α/MAPK14-OPG/RANKL.
Archives of oral biology.
2021 Dec; 132(?):105280. doi:
10.1016/j.archoralbio.2021.105280. [PMID: 34678605] - Can Sevinc, Gulay Yilmaz, Sedat Ustundag. The relationship between calcification inhibitor levels in chronic kidney disease and the development of atherosclerosis.
Renal failure.
2021 Dec; 43(1):1349-1358. doi:
10.1080/0886022x.2021.1969248. [PMID: 34583616] - Beata Sieklucka, Dariusz Pawlak, Tomasz Domaniewski, Justyna Hermanowicz, Paweł Lipowicz, Michał Doroszko, Krystyna Pawlak. Serum PTH, PTH1R/ATF4 pathway, and the sRANKL/OPG system in bone as a new link between bone growth, cross-sectional geometry, and strength in young rats with experimental chronic kidney disease.
Cytokine.
2021 12; 148(?):155685. doi:
10.1016/j.cyto.2021.155685. [PMID: 34411988] - Mohsen Nikseresht, Nahid Azarmehr, Arash Arya, Behnam Alipoor, Reza Fadaei, Bahman Khalvati, Hassan Abidi, Amir Hossein Doustimotlagh. Circulating mRNA and plasma levels of osteoprotegerin and receptor activator of NF-κB ligand in nonalcoholic fatty liver disease.
Biotechnology and applied biochemistry.
2021 Dec; 68(6):1243-1249. doi:
10.1002/bab.2047. [PMID: 33010062] - Mutlu Gunes, Sule Temizkan, Tugce Apaydin, Can Ilgin, Goncagul Haklar, Dilek Gogas Yavuz. Serum osteoprotegerin levels, endothelial function and carotid intima-media thickness in type 2 diabetic patients.
Journal of diabetes and its complications.
2021 12; 35(12):108073. doi:
10.1016/j.jdiacomp.2021.108073. [PMID: 34635402] - Leonie Neirich, Maryam Yahiaoui-Doktor, Jacqueline Lammert, Maryam Basrai, Benjamin Seethaler, Anika Berling-Ernst, Juliane Ramser, Anne S Quante, Thorsten Schmidt, Uwe Niederberger, Kerstin Rhiem, Rita Schmutzler, Christoph Engel, Stephan C Bischoff, Martin Halle, Marion Kiechle, Sabine Grill. Physical activity and Mediterranean diet as potential modulators of osteoprotegerin and soluble RANKL in gBRCA1/2 mutation carriers: results of the lifestyle intervention pilot study LIBRE-1.
Breast cancer research and treatment.
2021 Dec; 190(3):463-475. doi:
10.1007/s10549-021-06400-7. [PMID: 34570303] - Eunhee Jang, Jeonghoon Ha, Ki-Hyun Baek, Moo Il Kang. Changes in Serum Dickkopf-1, RANK Ligand, Osteoprotegerin, and Bone Mineral Density after Allogeneic Hematopoietic Stem Cell Transplantation Treatment.
Endocrinology and metabolism (Seoul, Korea).
2021 12; 36(6):1211-1218. doi:
10.3803/enm.2021.1248. [PMID: 34875817] - Antonio Casado-Díaz, Ángel Rodríguez-Ramos, Bárbara Torrecillas-Baena, Gabriel Dorado, José Manuel Quesada-Gómez, María Ángeles Gálvez-Moreno. Flavonoid Phloretin Inhibits Adipogenesis and Increases OPG Expression in Adipocytes Derived from Human Bone-Marrow Mesenchymal Stromal-Cells.
Nutrients.
2021 Nov; 13(11):. doi:
10.3390/nu13114185. [PMID: 34836440] - Woojin Na, Min-Kyung Kang, Sin-Hye Park, Dong Yeon Kim, Su Yeon Oh, Moon-Sik Oh, Sohyun Park, Ii-Jun Kang, Young-Hee Kang. Aesculetin Accelerates Osteoblast Differentiation and Matrix-Vesicle-Mediated Mineralization.
International journal of molecular sciences.
2021 Nov; 22(22):. doi:
10.3390/ijms222212391. [PMID: 34830274] - Hussam Murad, Misbahuddin Rafeeq, Mahmoud Mosli, Mamdouh Gari, Mohammed Basheikh. Effect of sequential eradication therapy on serum osteoprotegerin levels in patients with Helicobacter pylori infection and co-existing inflammatory bowel disease.
The Journal of international medical research.
2021 Nov; 49(11):3000605211060648. doi:
10.1177/03000605211060648. [PMID: 34851775] - Moo-Seok Park, Yoonkyung Chang, Kwang-Hyun Kim, Jin Hee Park, Tae-Jin Song. Plasma osteoprotegerin levels are associated with the presence and burden of cerebral small vessel disease in patients with acute ischemic stroke.
Clinical neurology and neurosurgery.
2021 11; 210(?):107010. doi:
10.1016/j.clineuro.2021.107010. [PMID: 34752988] - Mitsuhiro Isaka, Ryuji Araki, Hiroshi Ueno, Minoru Okamoto. Intestinal fatty acid-binding protein and osteoprotegerin in anthracycline-induced rabbit models of dilated cardiomyopathy.
Research in veterinary science.
2021 Nov; 140(?):185-189. doi:
10.1016/j.rvsc.2021.09.007. [PMID: 34517162] - Nearmeen M Rashad, Amal S El-Shal, Sally M Shalaby, Hanim M Abdel-Nour, Walaa M Sarhan. Osteoprotegerin expression and serum values in obese women with type 2 diabetes mellitus.
Molecular biology reports.
2021 Nov; 48(11):7095-7104. doi:
10.1007/s11033-021-06699-x. [PMID: 34487291] - Feifei Ni, Yanchao Zhang, Yi Peng, Xiaoxiao Peng, Jianjun Li. Serum RANKL levels in Chinese patients with ankylosing spondylitis: a meta-analysis.
Journal of orthopaedic surgery and research.
2021 Oct; 16(1):615. doi:
10.1186/s13018-021-02721-x. [PMID: 34663371] - Aleksandra Rymarz, Katarzyna Romejko, Anna Matyjek, Zbigniew Bartoszewicz, Stanisław Niemczyk. Serum Osteoprotegerin Is an Independent Marker of Metabolic Complications in Non-DialysisDependent Chronic Kidney Disease Patients.
Nutrients.
2021 Oct; 13(10):. doi:
10.3390/nu13103609. [PMID: 34684610] - Kamarulzaman Karim, Nelli Giribabu, Naguib Salleh. Marantodes pumilum Var Alata (Kacip Fatimah) ameliorates derangement in RANK/RANKL/OPG pathway and reduces inflammation and oxidative stress in the bone of estrogen-deficient female rats with type-2 diabetes.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Oct; 91(?):153677. doi:
10.1016/j.phymed.2021.153677. [PMID: 34333329] - Takashi Sakai, Nadine Herrmann, Laura Maintz, Tim Joachim Nümm, Thomas Welchowski, Thomas Bieber. Serum receptor activator of nuclear factor kappa-Β ligand/osteoprotegerin ratio correlates with severity and suggests fracture's risk in older women with atopic dermatitis.
Allergy.
2021 10; 76(10):3220-3223. doi:
10.1111/all.14971. [PMID: 34080196] - Mirthe Dekker, Farahnaz Waissi, Max J M Silvis, Joelle V Bennekom, Arjan H Schoneveld, Robbert J de Winter, Ivana Isgum, Nikolas Lessmann, Birgitta K Velthuis, Gerard Pasterkamp, Arend Mosterd, Leo Timmers, Dominique P V de Kleijn. High levels of osteoprotegerin are associated with coronary artery calcification in patients suspected of a chronic coronary syndrome.
Scientific reports.
2021 09; 11(1):18946. doi:
10.1038/s41598-021-98177-4. [PMID: 34556709] - Tomoyuki Hioki, Haruhiko Tokuda, Kumiko Tanabe, Woo Kim, Junko Tachi, Shinobu Yamaguchi, Rie Matsushima-Nishiwaki, Osamu Kozawa, Hiroki Iida. Amplification by tramadol of PGD2-induced osteoprotegerin synthesis in osteoblasts: Involvement of μ-opioid receptor and 5-HT transporter.
Prostaglandins, leukotrienes, and essential fatty acids.
2021 09; 172(?):102323. doi:
10.1016/j.plefa.2021.102323. [PMID: 34392133] - Shufei Zeng, Ahmed A Hasan, Chang Chu, Yingquan Xiong, Johann-Georg Hocher, Saban Elitok, Bernhard K Krämer, Berthold Hocher. Osteoprotegerin is an independent risk factor predicting death in stable renal transplant recipients.
Clinical nephrology.
2021 Sep; 96(3):129-137. doi:
10.5414/cn110470. [PMID: 34042584] - Maliha Afroj Zinnia, Abul Bashar Mir Md Khademul Islam. Fenugreek steroidal saponins hinder osteoclastogenic bone resorption by targeting CSF-1R which diminishes the RANKL/OPG ratio.
International journal of biological macromolecules.
2021 Sep; 186(?):351-364. doi:
10.1016/j.ijbiomac.2021.06.197. [PMID: 34217743] - Anna Straburzyńska-Lupa, Tomasz Cisoń, Marta Gomarasca, Anna Babińska, Giuseppe Banfi, Giovanni Lombardi, Ewa Śliwicka. Sclerostin and bone remodeling biomarkers responses to whole-body cryotherapy (- 110 °C) in healthy young men with different physical fitness levels.
Scientific reports.
2021 08; 11(1):16156. doi:
10.1038/s41598-021-95492-8. [PMID: 34373519] - Alireza Farrokhian, Mahtab Miraftab, Minoo Chenari, Hossein Akbari, Hassan Nikoueinejad, Effat Naimi. The Relationship between Serum and Gene Expression Levels of RANK, RANKL and Osteoprotegerin Inflammatory Pathway with Unstable Angina: A Case-control Study.
Iranian journal of allergy, asthma, and immunology.
2021 Aug; 20(4):473-483. doi:
NULL. [PMID: 34418901] - Rossella Del Toro, Ilaria Cavallari, Flavia Tramontana, Kyoungmin Park, Rocky Strollo, Luciana Valente, Mariangela De Pascalis, Francesco Grigioni, Paolo Pozzilli, Raffaella Buzzetti, Nicola Napoli, Ernesto Maddaloni. Association of bone biomarkers with advanced atherosclerotic disease in people with overweight/obesity.
Endocrine.
2021 08; 73(2):339-346. doi:
10.1007/s12020-021-02736-8. [PMID: 33948786] - Tung Do Van, Tuan Nguyen Minh, Quyen Dao Bui Quy, Toan Pham Quoc, Toan Nguyen Duy, Kien Nguyen Trung, Hoang Nguyen Cong, Lan Le Thi Huong, Huong Bui Thi Thu, Tien Tran Viet, Quyet Do, Mao Can Van, Thang Le Viet. Serum osteoprotegerin level in hemodialysis patients using low-flux reused dialyzer in relation to atherosclerosis.
Journal of clinical laboratory analysis.
2021 Aug; 35(8):e23886. doi:
10.1002/jcla.23886. [PMID: 34173983] - Chia-Wen Lu, Chih-Hsien Wang, Bang-Gee Hsu, Jen-Pi Tsai. Serum Osteoprotegerin Level Is Negatively Associated with Bone Mineral Density in Patients Undergoing Maintenance Hemodialysis.
Medicina (Kaunas, Lithuania).
2021 Jul; 57(8):. doi:
10.3390/medicina57080762. [PMID: 34440966] - Alice Wang, Nishi Karunasinghe, Lindsay D Plank, Shuotun Zhu, Sue Osborne, Charis Brown, Karen Bishop, Tiffany Schwass, Sofian Tijono, Michael Holmes, Jonathan Masters, Roger Huang, Christine Keven, Lynnette R Ferguson, Ross Lawrenson. Effect of androgen deprivation therapy on serum levels of sclerostin, Dickkopf-1, and osteoprotegerin: a cross-sectional and longitudinal analysis.
Scientific reports.
2021 07; 11(1):14905. doi:
10.1038/s41598-021-94090-y. [PMID: 34290287] - Fan Xue, Zhenlei Zhao, Yanpei Gu, Jianxin Han, Keqiang Ye, Ying Zhang. 7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis.
eLife.
2021 07; 10(?):. doi:
10.7554/elife.64872. [PMID: 34227467] - Rakchna M, Nivedita Nanda, Haritha Sagili, Jasmine Manna Rani, Sailaja A Naga. Association of osteoprotegerin gene T950C polymorphism with cardiometabolic risk factors in gestational diabetes mellitus in South Indian Tamilian women.
Diabetes & metabolic syndrome.
2021 Jul; 15(4):102157. doi:
10.1016/j.dsx.2021.05.030. [PMID: 34186363] - Menghu Sun, Yuju Cao, Xiaolong Yang, Feimeng An, Huiqiang Wu, Jianzhong Wang. DNA methylation in the OPG/RANK/RANKL pathway is associated with steroid-induced osteonecrosis of the femoral head.
BMC musculoskeletal disorders.
2021 Jun; 22(1):599. doi:
10.1186/s12891-021-04472-6. [PMID: 34187427] - Aditi Sharma, Lalit Sharma, Reena V Saini, Ashwani Kumar, Rohit Goyal. Pinus roxburghii alleviates bone porosity and loss in postmenopausal osteoporosis by regulating estrogen, calcium homeostasis and receptor activator of nuclear factor-κB, osteoprotegerin, cathepsin bone markers.
The Journal of pharmacy and pharmacology.
2021 Jun; 73(7):901-915. doi:
10.1093/jpp/rgaa014. [PMID: 33769535] - Ezgi Kalaycıoğlu, Mustafa Çetin, Göksel Çinier, Tuncay Kırış, Tayyar Gökdeniz, Ali Gökhan Özyıldız, İsmet Durmuş. Serum osteoprotegerin level is independently related to subclinical left atrial mechanical function in patients with hypertension and diabetes.
Herz.
2021 Jun; 46(3):277-284. doi:
10.1007/s00059-020-04939-7. [PMID: 32462219] - Li Zhang, Yu-Song Liu, Yun-Fei Wu, Qi-Ya Fu. [Effects of chitosan oligosaccharide on alveolar bone resorption, Th17/Treg balance and OPG/RANKL/RANK pathway in periodontitis rats].
Shanghai kou qiang yi xue = Shanghai journal of stomatology.
2021 Jun; 30(3):237-242. doi:
. [PMID: 34476437] - Federico Biscetti, Giovanni Tinelli, Maria Margherita Rando, Elisabetta Nardella, Andrea Leonardo Cecchini, Flavia Angelini, Giuseppe Straface, Marco Filipponi, Vincenzo Arena, Dario Pitocco, Antonio Gasbarrini, Massimo Massetti, Andrea Flex. Association between carotid plaque vulnerability and high mobility group box-1 serum levels in a diabetic population.
Cardiovascular diabetology.
2021 05; 20(1):114. doi:
10.1186/s12933-021-01304-8. [PMID: 34044825] - Fujiang Wang, Pengfei Tu, Kewu Zeng, Yong Jiang. Total glycosides and polysaccharides of Cistanche deserticola prevent osteoporosis by activating Wnt/β-catenin signaling pathway in SAMP6 mice.
Journal of ethnopharmacology.
2021 May; 271(?):113899. doi:
10.1016/j.jep.2021.113899. [PMID: 33549763] - Vardaan Gupta, Oladapo Ekundayo, Zsofia K Nemeth, Yifan Yang, Adrian Covic, Zoltan Mathe, Csaba P Kovesdy, Miklos Z Molnar, Istvan Mucsi. Association between serum osteoprotegerin level and mortality in kidney transplant recipients - a prospective observational cohort study.
Transplant international : official journal of the European Society for Organ Transplantation.
2021 05; 34(5):844-854. doi:
10.1111/tri.13847. [PMID: 33606319] - Wenxue Lv, Mingxiu Yu, Qingyi Yang, Peng Kong, Bing Yan. Total flavonoids of Rhizoma drynariae ameliorate steroid‑induced avascular necrosis of the femoral head via the PI3K/AKT pathway.
Molecular medicine reports.
2021 05; 23(5):. doi:
10.3892/mmr.2021.11984. [PMID: 33760114] - Ismail Solmaz, Mehmet Akif Ozdemir, Ekrem Unal, Ummuhan Abdurrezzak, Sebahattin Muhtaroglu, Musa Karakukcu. Effect of vitamin K2 and vitamin D3 on bone mineral density in children with acute lymphoblastic leukemia: a prospective cohort study.
Journal of pediatric endocrinology & metabolism : JPEM.
2021 Apr; 34(4):441-447. doi:
10.1515/jpem-2020-0637. [PMID: 33639045] - Martin Blomberg Jensen, Christine Hjorth Andreassen, Anne Jørgensen, John Erik Nielsen, Li Juel Mortensen, Ida Marie Boisen, Peter Schwarz, Jorma Toppari, Roland Baron, Beate Lanske, Anders Juul. RANKL regulates male reproductive function.
Nature communications.
2021 04; 12(1):2450. doi:
10.1038/s41467-021-22734-8. [PMID: 33893301] - Daiyun Zhu, Abdur Rahman Ansari, Ke Xiao, Wei Wang, Lei Wang, Weiwei Qiu, Xinting Zheng, Hui Song, Huazhen Liu, Juming Zhong, Kemei Peng. Boron Supplementation Promotes Osteogenesis of Tibia by Regulating the Bone Morphogenetic Protein-2 Expression in African Ostrich Chicks.
Biological trace element research.
2021 Apr; 199(4):1544-1555. doi:
10.1007/s12011-020-02258-w. [PMID: 32676937] - Fawzeyah A Alnajjar, Archana Sharma-Oates, Susanne N Wijesinghe, Hussein Farah, Dominika E Nanus, Tom Nicholson, Edward T Davis, Simon W Jones. The Expression and Function of Metastases Associated Lung Adenocarcinoma Transcript-1 Long Non-Coding RNA in Subchondral Bone and Osteoblasts from Patients with Osteoarthritis.
Cells.
2021 04; 10(4):. doi:
10.3390/cells10040786. [PMID: 33916321] - Renata Ochoa-Précoma, Blanca T Pacheco-Soto, Leonardo M Porchia, Enrique Torres-Rasgado, Ricardo Pérez-Fuentes, M Elba Gonzalez-Mejia. Association between Osteoprotegerin and Charcot Neuroarthropathy: a systematic review.
Acta diabetologica.
2021 Apr; 58(4):475-484. doi:
10.1007/s00592-020-01638-x. [PMID: 33394132] - Natalia Carrillo-López, Laura Martínez-Arias, Sara Fernández-Villabrille, María Piedad Ruiz-Torres, Adriana Dusso, Jorge B Cannata-Andía, Manuel Naves-Díaz, Sara Panizo. Role of the RANK/RANKL/OPG and Wnt/β-Catenin Systems in CKD Bone and Cardiovascular Disorders.
Calcified tissue international.
2021 04; 108(4):439-451. doi:
10.1007/s00223-020-00803-2. [PMID: 33586001] - Natalia Carrillo-López, Laura Martínez-Arias, Cristina Alonso-Montes, Beatriz Martín-Carro, Julia Martín-Vírgala, Marta Ruiz-Ortega, José Luis Fernández-Martín, Adriana S Dusso, Minerva Rodriguez-García, Manuel Naves-Díaz, Jorge B Cannata-Andía, Sara Panizo. The receptor activator of nuclear factor κΒ ligand receptor leucine-rich repeat-containing G-protein-coupled receptor 4 contributes to parathyroid hormone-induced vascular calcification.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2021 03; 36(4):618-631. doi:
10.1093/ndt/gfaa290. [PMID: 33367746] - Tiantian Wang, Fei Wang, Tingting Liu, Menghu Sun, Feimeng An, Chang Liu, Ye Tian, Yuju Cao, Jianzhong Wang. OPG/RANKL/RANK gene methylation among alcohol-induced femoral head necrosis in northern Chinese men.
Journal of orthopaedic surgery and research.
2021 Mar; 16(1):223. doi:
10.1186/s13018-021-02356-y. [PMID: 33773583] - Ying-Jian Lv, Jia Song, Li-Li Xiong, Rui Huang, Pan Zhu, Ping Wang, Xu-Xia Liang, Jian-Bin Tan, Jing Wang, Shi-Xuan Wu, Qin-Zhi Wei, Xing-Fen Yang. Association of environmental cadmium exposure and bone remodeling in women over 50 years of age.
Ecotoxicology and environmental safety.
2021 Mar; 211(?):111897. doi:
10.1016/j.ecoenv.2021.111897. [PMID: 33493719] - Sanjukta Naik, Suchanda Sahu, Debapriya Bandyopadhyay, Sujit Tripathy. Serum levels of osteoprotegerin, RANK-L & vitamin D in different stages of osteoarthritis of the knee.
The Indian journal of medical research.
2021 Mar; 154(3):491-496. doi:
10.4103/ijmr.ijmr_873_19. [PMID: 35345075] - Hailong Liu, Gang Wang, Jia Wang, Tao Wang, Jiexiang Tian, Liqin Wang, Fang Yang. [Bushentongluo recipe (BSTL) attenuates bone destruction by inhibiting NF-κB/RANK/RANKL pathway in collagen-induced arthritis (CIA) rats].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2021 Mar; 37(3):205-211. doi:
NULL. [PMID: 33766227] - Zhen-Xiong Jin, Xin-Yuan Liao, Wei-Wei Da, Yong-Jian Zhao, Xiao-Feng Li, De-Zhi Tang. Osthole enhances the bone mass of senile osteoporosis and stimulates the expression of osteoprotegerin by activating β-catenin signaling.
Stem cell research & therapy.
2021 02; 12(1):154. doi:
10.1186/s13287-021-02228-6. [PMID: 33640026] - Xiaohui Zhao, Sirong Jiang, Qi Dong, Jun Dang, Zenggeng Liu, Hongping Han, Yanduo Tao, Huilan Yue. Anti-rheumatoid arthritis effects of iridoid glucosides from Lamiophlomis rotata (Benth.) kudo on adjuvant-induced arthritis in rats by OPG/RANKL/NF-κB signaling pathways.
Journal of ethnopharmacology.
2021 Feb; 266(?):113402. doi:
10.1016/j.jep.2020.113402. [PMID: 32980481] - Katharina Kerschan-Schindl, Wolfgang Gruther, Ursula Föger-Samwald, Christine Bangert, Stefan Kudlacek, Peter Pietschmann. Myostatin and markers of bone metabolism in dermatomyositis.
BMC musculoskeletal disorders.
2021 Feb; 22(1):150. doi:
10.1186/s12891-021-04030-0. [PMID: 33546660] - Mohammed Al-Bogami, Jonas Bystrom, Felix Clanchy, Taher E Taher, Pamela Mangat, Richard O Williams, Ali S Jawad, Rizgar A Mageed. TNFα inhibitors reduce bone loss in rheumatoid arthritis independent of clinical response by reducing osteoclast precursors and IL-20.
Rheumatology (Oxford, England).
2021 02; 60(2):947-957. doi:
10.1093/rheumatology/keaa551. [PMID: 32984900] - Chun-Cui Duan, Chengcheng Ma, Hai-Qin Tang. Increased Circulating Osteoprotegerin Levels in Type 1 Diabetes Mellitus: A Systematic Review and Meta-analysis Based on Observational Studies.
Immunological investigations.
2021 Feb; 50(2-3):101-112. doi:
10.1080/08820139.2019.1710531. [PMID: 31920120] - ChangSheng Yang, ZhengTao Gu, Rui Ding, CaiQiang Huang, QingChu Li, DengHui Xie, RongKai Zhang, YiYan Qiu. Long non-coding RNA MEG3 silencing and microRNA-214 restoration elevate osteoprotegerin expression to ameliorate osteoporosis by limiting TXNIP.
Journal of cellular and molecular medicine.
2021 02; 25(4):2025-2039. doi:
10.1111/jcmm.16096. [PMID: 33393160] - Gustavo Lenci Marques, Shirley Hayashi, Anna Bjällmark, Matilda Larsson, Miguel Riella, Marcia Olandoski, Bengt Lindholm, Marcelo Mazza Nascimento. Osteoprotegerin is a marker of cardiovascular mortality in patients with chronic kidney disease stages 3-5.
Scientific reports.
2021 01; 11(1):2473. doi:
10.1038/s41598-021-82072-z. [PMID: 33510348] - Peiyi Zhang, Shufen Zhou, Zhe Chen, Ye Tian, Qianqian Wang, Hui Li, Tiantian Zhang, Qin Guo, Meiying Wang, Chengshan Guo. TNF Receptor: Fc Fusion Protein Downregulates RANKL/OPG Ratio by Inhibiting CXCL16/CXCR6 in Active Ankylosing Spondylitis.
Current pharmaceutical biotechnology.
2021; 22(2):305-316. doi:
10.2174/1389201021666200302104418. [PMID: 32116188] - Maha Sabry, Seham Mostafa, Samaa Kamar, Laila Rashed, Suzanne Estaphan. The cross-talk between matrix metalloproteinase-9, RANKL/OPG system and cardiovascular risk factors in ovariectomized rat model of postmenopausal osteoporosis.
PloS one.
2021; 16(10):e0258254. doi:
10.1371/journal.pone.0258254. [PMID: 34610044] - Preethi Cherian, Irina Al-Khairi, Mohammad Jamal, Suleiman Al-Sabah, Hamad Ali, Carol Dsouza, Eman Alshawaf, Waleed Al-Ali, Ghanim Al-Khaledi, Fahd Al-Mulla, Mohamed Abu-Farha, Jehad Abubaker. Association Between Factors Involved in Bone Remodeling (Osteoactivin and OPG) With Plasma Levels of Irisin and Meteorin-Like Protein in People With T2D and Obesity.
Frontiers in endocrinology.
2021; 12(?):752892. doi:
10.3389/fendo.2021.752892. [PMID: 34777249] - Nur-Vaizura Mohamad, Soelaiman Ima-Nirwana, Kok-Yong Chin. Self-emulsified annatto tocotrienol improves bone histomorphometric parameters in a rat model of oestrogen deficiency through suppression of skeletal sclerostin level and RANKL/OPG ratio.
International journal of medical sciences.
2021; 18(16):3665-3673. doi:
10.7150/ijms.64045. [PMID: 34790038] - C A Nava-Valdivia, J M Ponce-Guarneros, A M Saldaña-Cruz, E G Corona-Sanchez, M Ramirez-Villafaña, E E Perez-Guerrero, J D Murillo-Saich, B Contreras-Haro, M L Vazquez-Villegas, F Gonzalez-Ponce, D Bonilla-Lara, H Jacobo-Cuevas, J D Centeno-Valadez, G Echeverria-Gonzalez, S Cerpa-Cruz, M F Alcaraz-Lopez, E G Cardona-Muñoz, M Salazar-Paramo, L Gonzalez-Lopez, J I Gamez-Nava. Assessment of Serum sRANKL, sRANKL/OPG Ratio, and Other Bone Turnover Markers with the Estimated 10-Year Risk of Major and Hip Osteoporotic Fractures in Rheumatoid Arthritis: A Cross-Sectional Study.
BioMed research international.
2021; 2021(?):5567666. doi:
10.1155/2021/5567666. [PMID: 34497849] - Xin Li, Lijie Zhang, Yongsong Xu, Dong Zhao, Lin Mu, Baoyu Zhang, Jing Ke. Therapeutic Effect of Matrine on Collagen-Induced Arthritis Rats and Its Regulatory Effect on RANKL and OPG Expression.
Journal of immunology research.
2021; 2021(?):4186102. doi:
10.1155/2021/4186102. [PMID: 34423052] - Tania Velletri, Yin Huang, Yu Wang, Qing Li, Mingyuan Hu, Ningxia Xie, Qian Yang, Xiaodong Chen, Qing Chen, Peishun Shou, Yurun Gan, Eleonora Candi, Margherita Annicchiarico-Petruzzelli, Massimiliano Agostini, Huilin Yang, Gerry Melino, Yufang Shi, Ying Wang. Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin.
Cell death and differentiation.
2021 01; 28(1):156-169. doi:
10.1038/s41418-020-0590-4. [PMID: 32694652]
