20-Hydroxyeicosatetraenic acid (BioDeep_00000175060)
human metabolite blood metabolite
代谢物信息卡片
20-hydroxyicosa-2,4,6,8-tetraenoic acid
化学式: C20H32O3 (320.2351)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: OCCCCCCCCCCCC=CC=CC=CC=CC(O)=O
InChI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h4,6,8,10,12,14,16,18,21H,1-3,5,7,9,11,13,15,17,19H2,(H,22,23)
描述信息
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Guangrui Lai, Jingjing Wu, Xiaoliang Liu, Yanyan Zhao. 20-HETE induces hyperglycemia through the cAMP/PKA-PhK-GP pathway.
Molecular endocrinology (Baltimore, Md.).
2012 Nov; 26(11):1907-16. doi:
10.1210/me.2012-1139. [PMID: 22918876] - Xiaoliang Liu, Jingjing Wu, Hong Liu, Guangrui Lai, Yanyan Zhao. Disturbed ratio of renal 20-HETE/EETs is involved in androgen-induced hypertension in cytochrome P450 4F2 transgenic mice.
Gene.
2012 Sep; 505(2):352-9. doi:
10.1016/j.gene.2012.02.029. [PMID: 22387726] - Emmanuelle Plée-Gautier, Joseph Antoun, Sophie Goulitquer, Catherine Le Jossic-Corcos, Brigitte Simon, Yolande Amet, Jean-Pierre Salaün, Laurent Corcos. Statins increase cytochrome P450 4F3-mediated eicosanoids production in human liver cells: a PXR dependent mechanism.
Biochemical pharmacology.
2012 Aug; 84(4):571-9. doi:
10.1016/j.bcp.2012.05.012. [PMID: 22634049] - Cristiano Fava, Marco Ricci, Olle Melander, Pietro Minuz. Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation?.
Prostaglandins & other lipid mediators.
2012 Aug; 98(3-4):75-85. doi:
10.1016/j.prostaglandins.2011.11.007. [PMID: 22173545] - Maria M Federik Fernandez, Daniel Gonzalez, Jan M Williams, Richard J Roman, Susana Nowicki. Inhibitors of 20-hydroxyeicosatetraenoic acid (20-HETE) formation attenuate the natriuretic effect of dopamine.
European journal of pharmacology.
2012 Jul; 686(1-3):97-103. doi:
10.1016/j.ejphar.2012.04.039. [PMID: 22575524] - Katherine N Theken, Robert N Schuck, Matthew L Edin, Bryant Tran, Kyle Ellis, Almasa Bass, Fred B Lih, Kenneth B Tomer, Samuel M Poloyac, Michael C Wu, Alan L Hinderliter, Darryl C Zeldin, George A Stouffer, Craig R Lee. Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease.
Atherosclerosis.
2012 Jun; 222(2):530-6. doi:
10.1016/j.atherosclerosis.2012.03.022. [PMID: 22503544] - Mayuko Morita, Noriko Ishida, Kazuhiko Uchiyama, Kanji Yamaguchi, Yoshito Itoh, Mototada Shichiri, Yasukazu Yoshida, Yoshihisa Hagihara, Yuji Naito, Toshikazu Yoshikawa, Etsuo Niki. Fatty liver induced by free radicals and lipid peroxidation.
Free radical research.
2012 Jun; 46(6):758-65. doi:
10.3109/10715762.2012.677840. [PMID: 22468959] - Ting Tian, Jin Li, Meng-Ying Wang, Xian-Fei Xie, Qi-Xiong Li. Protective effect of 20-hydroxyeicosatetraenoic acid (20-HETE) on adriamycin-induced toxicity of human renal tubular epithelial cell (HK-2).
European journal of pharmacology.
2012 May; 683(1-3):246-51. doi:
10.1016/j.ejphar.2012.03.001. [PMID: 22421401] - Katherine N Theken, Yangmei Deng, Robert N Schuck, Akinyemi Oni-Orisan, Tricia M Miller, M Alison Kannon, Samuel M Poloyac, Craig R Lee. Enalapril reverses high-fat diet-induced alterations in cytochrome P450-mediated eicosanoid metabolism.
American journal of physiology. Endocrinology and metabolism.
2012 Mar; 302(5):E500-9. doi:
10.1152/ajpendo.00370.2011. [PMID: 22185841] - Yutaka Hirashima, Masaru Doshi, Nakamasa Hayashi, Shunro Endo, Yoko Akazawa, Mototada Shichiri, Yasukazu Yoshida. Plasma platelet-activating factor-acetyl hydrolase activity and the levels of free forms of biomarker of lipid peroxidation in cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage.
Neurosurgery.
2012 Mar; 70(3):602-9. doi:
10.1227/neu.0b013e3182333c69. [PMID: 21866060] - Christian Lacks Lino Cardenas, Aurore Devos, Aminata Toure, Jaime Cardenas Garcia, Abderraouf Kenani, Florence Migot-Nabias, Franck Broly, Dany Chevalier. Arachidonic acid ω-hydroxylase CYP4A11: inter-ethnic variations in the 8590T>C loss-of-function variant.
Molecular biology reports.
2012 Feb; 39(2):1503-8. doi:
10.1007/s11033-011-0888-x. [PMID: 21617944] - Bahar Tunctan, Belma Korkmaz, Ayse Nihal Sari, Meltem Kacan, Demet Unsal, Mehmet Sami Serin, C Kemal Buharalioglu, Seyhan Sahan-Firat, Wolf-Hagen Schunck, John R Falck, Kafait U Malik. A novel treatment strategy for sepsis and septic shock based on the interactions between prostanoids, nitric oxide, and 20-hydroxyeicosatetraenoic acid.
Anti-inflammatory & anti-allergy agents in medicinal chemistry.
2012; 11(2):121-50. doi:
10.2174/187152312803305759. [PMID: 23013331] - Sung Young Kim, Sang Chul Park. Physiological antioxidative network of the bilirubin system in aging and age-related diseases.
Frontiers in pharmacology.
2012; 3(?):45. doi:
10.3389/fphar.2012.00045. [PMID: 22457648] - Guangrui Lai, Xiaoliang Liu, Jingjing Wu, Hong Liu, Yanyan Zhao. Evaluation of CMV and KAP promoters for driving the expression of human CYP4F2 in transgenic mice.
International journal of molecular medicine.
2012 Jan; 29(1):107-12. doi:
10.3892/ijmm.2011.787. [PMID: 21887457] - Yasunori Sato, Xiang Shan Ren, Yasuni Nakanuma. Caroli's Disease: Current Knowledge of Its Biliary Pathogenesis Obtained from an Orthologous Rat Model.
International journal of hepatology.
2012; 2012(?):107945. doi:
10.1155/2012/107945. [PMID: 22007315] - Ramón Rodrigo. Prevention of postoperative atrial fibrillation: novel and safe strategy based on the modulation of the antioxidant system.
Frontiers in physiology.
2012; 3(?):93. doi:
10.3389/fphys.2012.00093. [PMID: 22518106] - Dirk Schäfer, Steffen Maune. Pathogenic Mechanisms and In Vitro Diagnosis of AERD.
Journal of allergy.
2012; 2012(?):789232. doi:
10.1155/2012/789232. [PMID: 22654920] - Giuseppe Vezzoli, Annalisa Terranegra, Francesco Rainone, Teresa Arcidiacono, Mario Cozzolino, Andrea Aloia, Elena Dogliotti, Daniele Cusi, Laura Soldati. Calcium-sensing receptor and calcium kidney stones.
Journal of translational medicine.
2011 Nov; 9(?):201. doi:
10.1186/1479-5876-9-201. [PMID: 22107799] - Cheng-Chia Wu, Michal Laniado Schwartzman. The role of 20-HETE in androgen-mediated hypertension.
Prostaglandins & other lipid mediators.
2011 Nov; 96(1-4):45-53. doi:
10.1016/j.prostaglandins.2011.06.006. [PMID: 21722750] - Raymond C S Seet, Chung-Yung J Lee, Erle C H Lim, Amy M L Quek, Huiwen Huang, Shan Hong Huang, Woan Foon Looi, Lee Hua Long, Barry Halliwell. Oral zinc supplementation does not improve oxidative stress or vascular function in patients with type 2 diabetes with normal zinc levels.
Atherosclerosis.
2011 Nov; 219(1):231-9. doi:
10.1016/j.atherosclerosis.2011.07.097. [PMID: 21840002] - Chenghui Xie, Jie Kang, Jin-Ran Chen, Oxana P Lazarenko, Matthew E Ferguson, Thomas M Badger, Shanmugam Nagarajan, Xianli Wu. Lowbush blueberries inhibit scavenger receptors CD36 and SR-A expression and attenuate foam cell formation in ApoE-deficient mice.
Food & function.
2011 Oct; 2(10):588-94. doi:
10.1039/c1fo10136f. [PMID: 21952555] - Jatuporn Wichitsranoi, Natthida Weerapreeyakul, Patcharee Boonsiri, Chatri Settasatian, Nongnuch Settasatian, Nantarat Komanasin, Suchart Sirijaichingkul, Yaovalak Teerajetgul, Nuchanart Rangkadilok, Naruemon Leelayuwat. Antihypertensive and antioxidant effects of dietary black sesame meal in pre-hypertensive humans.
Nutrition journal.
2011 Aug; 10(?):82. doi:
10.1186/1475-2891-10-82. [PMID: 21827664] - Raymond C S Seet, Chung-Yung J Lee, Bernard P L Chan, Vijay K Sharma, Hock-Luen Teoh, Narayanaswamy Venketasubramanian, Erle C H Lim, Wan-Ling Chong, Woan-Foon Looi, Shan-Hong Huang, Benjamin K C Ong, Barry Halliwell. Oxidative damage in ischemic stroke revealed using multiple biomarkers.
Stroke.
2011 Aug; 42(8):2326-9. doi:
10.1161/strokeaha.111.618835. [PMID: 21700941] - Beshay N M Zordoky, Anwar Anwar-Mohamed, Mona E Aboutabl, Ayman O S El-Kadi. Acute doxorubicin toxicity differentially alters cytochrome P450 expression and arachidonic acid metabolism in rat kidney and liver.
Drug metabolism and disposition: the biological fate of chemicals.
2011 Aug; 39(8):1440-50. doi:
10.1124/dmd.111.039123. [PMID: 21571947] - Sungjin Chung, Cheol Whee Park. Role of Peroxisome Proliferator-Activated Receptor α in Diabetic Nephropathy.
Diabetes & metabolism journal.
2011 Aug; 35(4):327-36. doi:
10.4093/dmj.2011.35.4.327. [PMID: 21977451] - Janny C de Grauw, Chris H A van de Lest, Paul René van Weeren. A targeted lipidomics approach to the study of eicosanoid release in synovial joints.
Arthritis research & therapy.
2011 Jul; 13(4):R123. doi:
10.1186/ar3427. [PMID: 21794148] - Gabrielle Fredman, Charles N Serhan. Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution.
The Biochemical journal.
2011 Jul; 437(2):185-97. doi:
10.1042/bj20110327. [PMID: 21711247] - Raymond C S Seet, Chung-Yung J Lee, Wai Mun Loke, Shan Hong Huang, Huiwen Huang, Woan Foon Looi, Eng Soh Chew, Amy M L Quek, Erle C H Lim, Barry Halliwell. Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress?.
Free radical biology & medicine.
2011 Jun; 50(12):1787-93. doi:
10.1016/j.freeradbiomed.2011.03.019. [PMID: 21420490] - I J Tsai, K D Croft, I B Puddey, L J Beilin, A Barden. 20-Hydroxyeicosatetraenoic acid synthesis is increased in human neutrophils and platelets by angiotensin II and endothelin-1.
American journal of physiology. Heart and circulatory physiology.
2011 Apr; 300(4):H1194-200. doi:
10.1152/ajpheart.00733.2010. [PMID: 21239640] - William B Rizzo. The role of fatty aldehyde dehydrogenase in epidermal structure and function.
Dermato-endocrinology.
2011 Apr; 3(2):91-9. doi:
10.4161/derm.3.2.14619. [PMID: 21695018] - Grant R J Gordon, Clare Howarth, Brian A MacVicar. Bidirectional control of arteriole diameter by astrocytes.
Experimental physiology.
2011 Apr; 96(4):393-9. doi:
10.1113/expphysiol.2010.053132. [PMID: 21257665] - Bang-Chuan Hu, Yan Li, Fa-Hong Li, Yi Zhang, Chang-Sheng Sheng, Hong-Qi Fan, Ji-Guang Wang. Peripheral and central augmentation indexes in relation to the CYP4F2 polymorphisms in Chinese.
Journal of hypertension.
2011 Mar; 29(3):501-8. doi:
10.1097/hjh.0b013e328342673c. [PMID: 21150635] - Dexter L Lee, Justin L Wilson, Rong Duan, Tamaro Hudson, Ahmed El-Marakby. Peroxisome Proliferator-Activated Receptor-α Activation Decreases Mean Arterial Pressure, Plasma Interleukin-6, and COX-2 While Increasing Renal CYP4A Expression in an Acute Model of DOCA-Salt Hypertension.
PPAR research.
2011; 2011(?):502631. doi:
10.1155/2011/502631. [PMID: 22190908] - Yoshitaro Torii, Toshiki Shimizu, Takashi Yokoi, Hiroyuki Sugimoto, Yuichi Katashiba, Ryotaro Ozasa, Shinya Fujita, Yasushi Adachi, Masahiko Maki, Shosaku Nomura. Antiplatelet antibody may cause delayed transfusion-related acute lung injury.
International journal of general medicine.
2011; 4(?):677-80. doi:
10.2147/ijgm.s23220. [PMID: 21941454] - Katherine N Theken, Yangmei Deng, M Alison Kannon, Tricia M Miller, Samuel M Poloyac, Craig R Lee. Activation of the acute inflammatory response alters cytochrome P450 expression and eicosanoid metabolism.
Drug metabolism and disposition: the biological fate of chemicals.
2011 Jan; 39(1):22-9. doi:
10.1124/dmd.110.035287. [PMID: 20947618] - Joshua S Speed, Eric M George, Marietta Arany, Kathy Cockrell, Joey P Granger. Role of 20-hydroxyeicosatetraenoic acid in mediating hypertension in response to chronic renal medullary endothelin type B receptor blockade.
PloS one.
2011; 6(10):e26063. doi:
10.1371/journal.pone.0026063. [PMID: 22016812] - Carlos Eduardo Paiva, Andréia Fernanda Carvalho Leone Aguiar, Fernando Nobre, Eduardo Barbosa Coelho. A comparison between sphygmomanometer-based and ambulatory blood pressure monitoring in acute salt loading and depletion protocol.
Clinics (Sao Paulo, Brazil).
2011; 66(5):767-72. doi:
10.1590/s1807-59322011000500010. [PMID: 21789378] - Marion Girod, Yunzhou Shi, Ji-Xin Cheng, R Graham Cooks. Mapping lipid alterations in traumatically injured rat spinal cord by desorption electrospray ionization imaging mass spectrometry.
Analytical chemistry.
2011 Jan; 83(1):207-15. doi:
10.1021/ac102264z. [PMID: 21142140] - Rémi Fiancette, Christelle Vincent-Fabert, Estelle Guerin, Franck Trimoreau, Yves Denizot. Lipid mediators and human leukemic blasts.
Journal of oncology.
2011; 2011(?):. doi:
10.1155/2011/389021. [PMID: 20953410] - D Somjen, S Katzburg, M Grafi-Cohen, E Knoll, O Sharon, G H Posner. Vitamin D metabolites and analogs induce lipoxygenase mRNA expression and activity as well as reactive oxygen species (ROS) production in human bone cell line.
The Journal of steroid biochemistry and molecular biology.
2011 Jan; 123(1-2):85-9. doi:
10.1016/j.jsbmb.2010.11.010. [PMID: 21111046] - Etsuo Niki. Do free radicals play causal role in atherosclerosis? Low density lipoprotein oxidation and vitamin E revisited.
Journal of clinical biochemistry and nutrition.
2011 Jan; 48(1):3-7. doi:
10.3164/jcbn.11-007fr. [PMID: 21297905] - Claire M Payne, Cheray Crowley-Skillicorn, Carol Bernstein, Hana Holubec, Harris Bernstein. Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis.
Clinical and experimental gastroenterology.
2011; 4(?):75-119. doi:
10.2147/ceg.s17114. [PMID: 21753893] - Dipak Panigrahy, Arja Kaipainen, Emily R Greene, Sui Huang. Cytochrome P450-derived eicosanoids: the neglected pathway in cancer.
Cancer metastasis reviews.
2010 Dec; 29(4):723-35. doi:
10.1007/s10555-010-9264-x. [PMID: 20941528] - Yoshiro Saito, Keiko Nishio, Yoko Ogawa Akazawa, Kazunori Yamanaka, Akiko Miyama, Yasukazu Yoshida, Noriko Noguchi, Etsuo Niki. Cytoprotective effects of vitamin E homologues against glutamate-induced cell death in immature primary cortical neuron cultures: Tocopherols and tocotrienols exert similar effects by antioxidant function.
Free radical biology & medicine.
2010 Nov; 49(10):1542-9. doi:
10.1016/j.freeradbiomed.2010.08.016. [PMID: 20736061] - Xingbin Yang, Kevin D Croft, Ya P Lee, Trevor A Mori, Ian B Puddey, Sofia Sipsas, Anne Barden, Ewald Swinny, Jonathan M Hodgson. The effects of a lupin-enriched diet on oxidative stress and factors influencing vascular function in overweight subjects.
Antioxidants & redox signaling.
2010 Nov; 13(10):1517-24. doi:
10.1089/ars.2010.3133. [PMID: 20214496] - Bahar Tunctan, Belma Korkmaz, Tuba Cuez, C Kemal Buharalioglu, Seyhan Sahan-Firat, John Falck, Kafait U Malik. Contribution of vasoactive eicosanoids and nitric oxide production to the effect of selective cyclooxygenase-2 inhibitor, NS-398, on endotoxin-induced hypotension in rats.
Basic & clinical pharmacology & toxicology.
2010 Nov; 107(5):877-82. doi:
10.1111/j.1742-7843.2010.00589.x. [PMID: 22545970] - Paul Fidelis, Leticia Wilson, Kayama Thomas, Mayra Villalobos, Adebayo O Oyekan. Renal function and vasomotor activity in mice lacking the Cyp4a14 gene.
Experimental biology and medicine (Maywood, N.J.).
2010 Nov; 235(11):1365-74. doi:
10.1258/ebm.2010.009233. [PMID: 20943934] - Komal Sodhi, Cheng-Chia Wu, Jennifer Cheng, Katherine Gotlinger, Kazuyoshi Inoue, Mohan Goli, John R Falck, Nader G Abraham, Michal L Schwartzman. CYP4A2-induced hypertension is 20-hydroxyeicosatetraenoic acid- and angiotensin II-dependent.
Hypertension (Dallas, Tex. : 1979).
2010 Nov; 56(5):871-8. doi:
10.1161/hypertensionaha.110.154559. [PMID: 20837888] - Jitka Fricova, Martin Vejražka, Pavel Stopka, Jana Krizova, Jaromír Běláček, Richard Rokyta. The influence of pre-emptive analgesia on postoperative analgesia and its objective evaluation.
Archives of medical science : AMS.
2010 Oct; 6(5):764-71. doi:
10.5114/aoms.2010.17093. [PMID: 22419937] - Pauli V Luoma. Gene activation regresses atherosclerosis, promotes health, and enhances longevity.
Lipids in health and disease.
2010 Jul; 9(?):67. doi:
10.1186/1476-511x-9-67. [PMID: 20604930] - D Somjen, S Katzburg, E Knoll, O Sharon, G H Posner, N Stern. Vitamin D analogs induce lipoxygenase mRNA expression and activity as well as reactive oxygen species (ROS) production in human bone cells.
The Journal of steroid biochemistry and molecular biology.
2010 Jul; 121(1-2):265-7. doi:
10.1016/j.jsbmb.2010.03.047. [PMID: 20307663] - Tuba Cuez, Belma Korkmaz, C Kemal Buharalioglu, Seyhan Sahan-Firat, John Falck, Kafait U Malik, Bahar Tunctan. A synthetic analogue of 20-HETE, 5,14-HEDGE, reverses endotoxin-induced hypotension via increased 20-HETE levels associated with decreased iNOS protein expression and vasodilator prostanoid production in rats.
Basic & clinical pharmacology & toxicology.
2010 May; 106(5):378-88. doi:
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Diabetes care.
2010 May; 33(5):1140-2. doi:
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PloS one.
2010 Apr; 5(4):e10235. doi:
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Nuclear receptor signaling.
2010 Apr; 8(?):e002. doi:
10.1621/nrs.08002. [PMID: 20414453] - Agnieszka Walkowska, Petra Skaroupková, Zuzana Husková, Zdenka Vanourková, Vera Certíková Chábová, Vladimír Tesar, Herbert J Kramer, John R Falck, John D Imig, Elzbieta Kompanowska-Jezierska, Janusz Sadowski, Ludek Cervenka. Intrarenal cytochrome P-450 metabolites of arachidonic acid in the regulation of the nonclipped kidney function in two-kidney, one-clip Goldblatt hypertensive rats.
Journal of hypertension.
2010 Mar; 28(3):582-93. doi:
10.1097/hjh.0b013e328334dfd4. [PMID: 19940786] - Philip C Calder. Omega-3 fatty acids and inflammatory processes.
Nutrients.
2010 Mar; 2(3):355-374. doi:
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BMC medical genomics.
2010 Feb; 3(?):5. doi:
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Free radical biology & medicine.
2010 Feb; 48(4):560-6. doi:
10.1016/j.freeradbiomed.2009.11.026. [PMID: 19969070] - Lynette K Rogers, Trent E Tipple, Rodney D Britt, Stephen E Welty. Hyperoxia exposure alters hepatic eicosanoid metabolism in newborn mice.
Pediatric research.
2010 Feb; 67(2):144-9. doi:
10.1203/pdr.0b013e3181c2df4f. [PMID: 19809377] - Sally Mustafa, Harish Vasudevan, Violet G Yuen, John H McNeill. Renal expression of arachidonic acid metabolizing enzymes and RhoA/Rho kinases in fructose insulin resistant hypertensive rats.
Molecular and cellular biochemistry.
2010 Jan; 333(1-2):203-9. doi:
10.1007/s11010-009-0220-4. [PMID: 19633817] - Huiyong Yin, Todd Davis, Ned A Porter. Simultaneous analysis of multiple lipid oxidation products in vivo by liquid chromatographic-mass spectrometry (LC-MS).
Methods in molecular biology (Clifton, N.J.).
2010; 610(?):375-86. doi:
10.1007/978-1-60327-029-8_22. [PMID: 20013190] - Jason H Y Wu, Jonathan M Hodgson, Michael W Clarke, Adeline P Indrawan, Anne E Barden, Ian B Puddey, Kevin D Croft. Inhibition of 20-hydroxyeicosatetraenoic acid synthesis using specific plant lignans: in vitro and human studies.
Hypertension (Dallas, Tex. : 1979).
2009 Nov; 54(5):1151-8. doi:
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Pediatric nephrology (Berlin, Germany).
2009 Nov; 24(11):2097-108. doi:
10.1007/s00467-009-1137-6. [PMID: 19247694] - Rui-Min Gu, Lei Yang, Yunhong Zhang, Lijun Wang, Shumin Kong, Chengbiao Zhang, Yuanyuan Zhai, Mingxiao Wang, Peng Wu, Liping Liu, Feng Gu, Jiye Zhang, Wen-Hui Wang. CYP-omega-hydroxylation-dependent metabolites of arachidonic acid inhibit the basolateral 10 pS chloride channel in the rat thick ascending limb.
Kidney international.
2009 Oct; 76(8):849-56. doi:
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American journal of physiology. Renal physiology.
2009 Oct; 297(4):F875-84. doi:
10.1152/ajprenal.00364.2009. [PMID: 19675180] - Cristiano Fava, Martina Montagnana, Olle Melander. Overexpression of cytochrome P450 4F2 in mice increases 20-hydroxyeicosatetraenoic acid production and arterial blood pressure.
Kidney international.
2009 Oct; 76(8):913; author reply 913-4. doi:
10.1038/ki.2009.281. [PMID: 19789547] - Raymond C S Seet, Chung-Yung J Lee, Erle C H Lim, Amy M L Quek, Leonard L L Yeo, Shan-Hong Huang, Barry Halliwell. Oxidative damage in dengue fever.
Free radical biology & medicine.
2009 Aug; 47(4):375-80. doi:
10.1016/j.freeradbiomed.2009.04.035. [PMID: 19427377] - Alwena H Morgan, Vincent Dioszeghy, Benjamin H Maskrey, Christopher P Thomas, Stephen R Clark, Sara A Mathie, Clare M Lloyd, Hartmut Kühn, Nicholas Topley, Barbara C Coles, Philip R Taylor, Simon A Jones, Valerie B O'Donnell. Phosphatidylethanolamine-esterified eicosanoids in the mouse: tissue localization and inflammation-dependent formation in Th-2 disease.
The Journal of biological chemistry.
2009 Aug; 284(32):21185-91. doi:
10.1074/jbc.m109.021634. [PMID: 19531470] - Yi Zhang, Jason H Y Wu, Janine J Vickers, Sharon L H Ong, Suzanna E L Temple, Trevor A Mori, Kevin D Croft, Judith A Whitworth. The role of 20-hydroxyeicosatetraenoic acid in adrenocorticotrophic hormone and dexamethasone-induced hypertension.
Journal of hypertension.
2009 Aug; 27(8):1609-16. doi:
10.1097/hjh.0b013e32832cc56c. [PMID: 19458537] - Yiqiang Cai. Arachidonic acid cytochrome P450 4F2 in hypertension: what can we learn from a transgenic mouse model??.
Kidney international.
2009 Jun; 75(12):1253-1254. doi:
10.1038/ki.2009.82. [PMID: 19483747] - Xiaoliang Liu, Yanyan Zhao, Luzeng Wang, Xianghong Yang, Zhihong Zheng, Yuanyuan Zhang, Fangjie Chen, Hong Liu. Overexpression of cytochrome P450 4F2 in mice increases 20-hydroxyeicosatetraenoic acid production and arterial blood pressure.
Kidney international.
2009 Jun; 75(12):1288-1296. doi:
10.1038/ki.2009.67. [PMID: 19279555] - Chung-Yung Jetty Lee, Helen B Isaac, Shan Hong Huang, Lee Hua Long, Huansong Wang, Jan Gruber, Choon Nam Ong, Ronan P Kelly, Barry Halliwell. Limited antioxidant effect after consumption of a single dose of tomato sauce by young males, despite a rise in plasma lycopene.
Free radical research.
2009 Jun; 43(6):622-8. doi:
10.1080/10715760902942816. [PMID: 19437211] - Sandra J Hamilton, Gerard T Chew, Gerald F Watts. Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients.
Diabetes care.
2009 May; 32(5):810-2. doi:
10.2337/dc08-1736. [PMID: 19228872] - O Tornavaca, G Pascual, M L Barreiro, M T Grande, A Carretero, M Riera, E Garcia-Arumi, B Bardaji, M González-Núñez, M A Montero, J M López-Novoa, A Meseguer. Kidney androgen-regulated protein transgenic mice show hypertension and renal alterations mediated by oxidative stress.
Circulation.
2009 Apr; 119(14):1908-17. doi:
10.1161/circulationaha.108.808543. [PMID: 19332469] - Chung-Yung J Lee, Raymond C S Seet, Shan Hong Huang, Lee Hua Long, Barry Halliwell. Different patterns of oxidized lipid products in plasma and urine of dengue fever, stroke, and Parkinson's disease patients: cautions in the use of biomarkers of oxidative stress.
Antioxidants & redox signaling.
2009 Mar; 11(3):407-20. doi:
10.1089/ars.2008.2179. [PMID: 18785817] - Kevin R Regner, Anna Zuk, Scott K Van Why, Brian D Shames, Robert P Ryan, John R Falck, Vijay L Manthati, Meghan E McMullen, Steven R Ledbetter, Richard J Roman. Protective effect of 20-HETE analogues in experimental renal ischemia reperfusion injury.
Kidney international.
2009 Mar; 75(5):511-7. doi:
10.1038/ki.2008.600. [PMID: 19052533] - Xiaofang Wang, Peter C Harris, Stefan Somlo, Daniel Batlle, Vicente E Torres. Effect of calcium-sensing receptor activation in models of autosomal recessive or dominant polycystic kidney disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2009 Feb; 24(2):526-34. doi:
10.1093/ndt/gfn527. [PMID: 18826972] - Su Wang, Fei Meng, Jingyuan Xu, Yuchun Gu. Effects of lipids on ENaC activity in cultured mouse cortical collecting duct cells.
The Journal of membrane biology.
2009 Jan; 227(2):77-85. doi:
10.1007/s00232-008-9145-1. [PMID: 19122972] - M H M Yousif, I F Benter, K M J Dunn, A J Dahly-Vernon, S Akhtar, R J Roman. Role of 20-hydroxyeicosatetraenoic acid in altering vascular reactivity in diabetes.
Autonomic & autacoid pharmacology.
2009 Jan; 29(1-2):1-12. doi:
10.1111/j.1474-8673.2009.00426.x. [PMID: 19302551] - Graziano Riccioni, Alessandra Zanasi, Nicola Vitulano, Barbara Mancini, Nicolantonio D'Orazio. Leukotrienes in atherosclerosis: new target insights and future therapy perspectives.
Mediators of inflammation.
2009; 2009(?):737282. doi:
10.1155/2009/737282. [PMID: 20150962] - Jan Michael Williams, Albert Sarkis, Kimberly M Hoagland, Katherine Fredrich, Robert P Ryan, Carol Moreno, Bernardo Lopez, Jozef Lazar, Francisco J Fenoy, Mukut Sharma, Michael R Garrett, Howard J Jacob, Richard J Roman. Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury.
American journal of physiology. Renal physiology.
2008 Dec; 295(6):F1764-77. doi:
10.1152/ajprenal.90525.2008. [PMID: 18842817] - Beshay N M Zordoky, Mona E Aboutabl, Ayman O S El-Kadi. Modulation of cytochrome P450 gene expression and arachidonic acid metabolism during isoproterenol-induced cardiac hypertrophy in rats.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Nov; 36(11):2277-86. doi:
10.1124/dmd.108.023077. [PMID: 18725507] - Maude Fer, Laurent Corcos, Yvonne Dréano, Emmanuelle Plée-Gautier, Jean-Pierre Salaün, François Berthou, Yolande Amet. Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.
Journal of lipid research.
2008 Nov; 49(11):2379-89. doi:
10.1194/jlr.m800199-jlr200. [PMID: 18577768] - Yiqiang Zhou, Pengcheng Luo, Hsin-Hsin Chang, Hui Huang, Tianxin Yang, Zheng Dong, Cong-Yi Wang, Mong-Heng Wang. Colfibrate attenuates blood pressure and sodium retention in DOCA-salt hypertension.
Kidney international.
2008 Oct; 74(8):1040-8. doi:
10.1038/ki.2008.300. [PMID: 18596730] - Frank Park, William E Sweeney, Guangfu Jia, Richard J Roman, Ellis D Avner. 20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease.
Journal of the American Society of Nephrology : JASN.
2008 Oct; 19(10):1929-39. doi:
10.1681/asn.2007070771. [PMID: 18596124] - Bahar Tunctan, Belma Korkmaz, C Kemal Buharalioglu, Seyhan Sahan Firat, Siddam Anjaiah, John Falck, Richard J Roman, Kafait U Malik. A 20-hydroxyeicosatetraenoic acid agonist, N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats.
Shock (Augusta, Ga.).
2008 Sep; 30(3):329-35. doi:
10.1097/shk.0b013e31816471c6. [PMID: 18323740] - Yasukazu Yoshida, Shintaro Kodai, Shigekazu Takemura, Yukiko Minamiyama, Etsuo Niki. Simultaneous measurement of F2-isoprostane, hydroxyoctadecadienoic acid, hydroxyeicosatetraenoic acid, and hydroxycholesterols from physiological samples.
Analytical biochemistry.
2008 Aug; 379(1):105-15. doi:
10.1016/j.ab.2008.04.028. [PMID: 18482573] - Syed J Khundmiri, Mohammed Ameen, Nicholas A Delamere, Eleanor D Lederer. PTH-mediated regulation of Na+-K+-ATPase requires Src kinase-dependent ERK phosphorylation.
American journal of physiology. Renal physiology.
2008 Aug; 295(2):F426-37. doi:
10.1152/ajprenal.00516.2007. [PMID: 18550646] - James V Gainer, Michael S Lipkowitz, Chang Yu, Michael R Waterman, Elliott P Dawson, Jorge H Capdevila, Nancy J Brown. Association of a CYP4A11 variant and blood pressure in black men.
Journal of the American Society of Nephrology : JASN.
2008 Aug; 19(8):1606-12. doi:
10.1681/asn.2008010063. [PMID: 18385420] - Zhigang Wang, Xiaobo Tang, Yumei Li, Changlian Leu, Lei Guo, Xiaodong Zheng, Daling Zhu. 20-Hydroxyeicosatetraenoic acid inhibits the apoptotic responses in pulmonary artery smooth muscle cells.
European journal of pharmacology.
2008 Jun; 588(1):9-17. doi:
10.1016/j.ejphar.2008.03.045. [PMID: 18455723] - Munish Ahuja, Avinash S Dhake, Surendra K Sharma, Dipak K Majumdar. Topical ocular delivery of NSAIDs.
The AAPS journal.
2008 Jun; 10(2):229-41. doi:
10.1208/s12248-008-9024-9. [PMID: 18437583] - Zhaohui Gao, Satoshi Koba, Lawrence Sinoway, Jianhua Li. 20-HETE increases renal sympathetic nerve activity via activation of chemically and mechanically sensitive muscle afferents.
The Journal of physiology.
2008 May; 586(10):2581-91. doi:
10.1113/jphysiol.2008.150730. [PMID: 18372304] - Yu-Jung Chen, Jing Li, John Quilley. Deficient renal 20-HETE release in the diabetic rat is not the result of oxidative stress.
American journal of physiology. Heart and circulatory physiology.
2008 May; 294(5):H2305-12. doi:
10.1152/ajpheart.00868.2007. [PMID: 18326808] - Natalie C Ward, I-Jung Tsai, Anne Barden, Frank M van Bockxmeer, Ian B Puddey, Jonathan M Hodgson, Kevin D Croft. A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure.
Hypertension (Dallas, Tex. : 1979).
2008 May; 51(5):1393-8. doi:
10.1161/hypertensionaha.107.104463. [PMID: 18391101] - Yi Zhang, Lexian Hu, Trevor A Mori, Anne Barden, Kevin D Croft, Judith A Whitworth. Arachidonic acid metabolism in glucocorticoid-induced hypertension.
Clinical and experimental pharmacology & physiology.
2008 May; 35(5-6):557-62. doi:
10.1111/j.1440-1681.2007.04839.x. [PMID: 18067589] - Chung-Yung J Lee, Shan Hong Huang, Andrew M Jenner, Barry Halliwell. Measurement of F2-isoprostanes, hydroxyeicosatetraenoic products, and oxysterols from a single plasma sample.
Free radical biology & medicine.
2008 Apr; 44(7):1314-22. doi:
10.1016/j.freeradbiomed.2007.12.026. [PMID: 18226605] - Hong Liu, Yanyan Zhao, Dong Nie, Jingpu Shi, Lingyu Fu, Yan Li, Dahai Yu, Jingyu Lu. Association of a functional cytochrome P450 4F2 haplotype with urinary 20-HETE and hypertension.
Journal of the American Society of Nephrology : JASN.
2008 Apr; 19(4):714-21. doi:
10.1681/asn.2007060713. [PMID: 18235092] - Cheryl L Laffer, James V Gainer, Michael R Waterman, Jorge H Capdevila, Michal Laniado-Schwartzman, Alberto Nasjletti, Nancy J Brown, Fernando Elijovich. The T8590C polymorphism of CYP4A11 and 20-hydroxyeicosatetraenoic acid in essential hypertension.
Hypertension (Dallas, Tex. : 1979).
2008 Mar; 51(3):767-72. doi:
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