N(4)-Methylcytosine (BioDeep_00000175000)
human metabolite blood metabolite Volatile Flavor Compounds
代谢物信息卡片
2(1H)-Pyrimidinone, 4-(methylamino)- (9CI)
化学式: C5H7N3O (125.0589092)
中文名称: 6-(甲基氨基)-2(1h)-嘧啶酮, N（4）-甲基胞嘧啶
谱图信息:
最多检出来源 Mus musculus(blood) 80%
分子结构信息
SMILES: CNC1=CC=NC(=O)N1
InChI: InChI=1S/C5H7N3O/c1-6-4-2-3-7-5(9)8-4/h2-3H,1H3,(H2,6,7,8,9)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Andrzej T Wierzbicki, Ross Cocklin, Anoop Mayampurath, Ryan Lister, M Jordan Rowley, Brian D Gregory, Joseph R Ecker, Haixu Tang, Craig S Pikaard. Spatial and functional relationships among Pol V-associated loci, Pol IV-dependent siRNAs, and cytosine methylation in the Arabidopsis epigenome.
Genes & development.
2012 Aug; 26(16):1825-36. doi:
10.1101/gad.197772.112. [PMID: 22855789] - Li-Chun Huang, Lin-June Hsiao, Szu-Yuan Pu, Ching-I Kuo, Bau-Lian Huang, Tsung-Che Tseng, Hao-Jen Huang, Yu-Ting Chen. DNA methylation and genome rearrangement characteristics of phase change in cultured shoots of Sequoia sempervirens.
Physiologia plantarum.
2012 Jun; 145(2):360-8. doi:
10.1111/j.1399-3054.2012.01606.x. [PMID: 22380594] - Robert L Byers, David B Harker, Scott M Yourstone, Peter J Maughan, Joshua A Udall. Development and mapping of SNP assays in allotetraploid cotton.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik.
2012 May; 124(7):1201-14. doi:
10.1007/s00122-011-1780-8. [PMID: 22252442] - Sachiko Arase, Megumi Kasai, Akira Kanazawa. In planta assays involving epigenetically silenced genes reveal inhibition of cytosine methylation by genistein.
Plant methods.
2012 Mar; 8(?):10. doi:
10.1186/1746-4811-8-10. [PMID: 22424588] - Kaori Sako, Yuko Maki, Tomoyuki Kanai, Eriko Kato, Shugo Maekawa, Shigetaka Yasuda, Takeo Sato, Masaaki K Watahiki, Junji Yamaguchi. Arabidopsis RPT2a, 19S proteasome subunit, regulates gene silencing via DNA methylation.
PloS one.
2012; 7(5):e37086. doi:
10.1371/journal.pone.0037086. [PMID: 22615900] - Natalia Borowska, Dominika Idziak, Robert Hasterok. DNA methylation patterns of Brachypodium distachyon chromosomes and their alteration by 5-azacytidine treatment.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology.
2011 Nov; 19(8):955-67. doi:
10.1007/s10577-011-9243-2. [PMID: 22076608] - Adolfo Lopez Torres, Eunice Yanez Barrientos, Katarzyna Wrobel, Kazimierz Wrobel. Selective derivatization of cytosine and methylcytosine moieties with 2-bromoacetophenone for submicrogram DNA methylation analysis by reversed phase HPLC with spectrofluorimetric detection.
Analytical chemistry.
2011 Oct; 83(20):7999-8005. doi:
10.1021/ac2020799. [PMID: 21905673] - Guro E Lind, Stine A Danielsen, Terje Ahlquist, Marianne A Merok, Kim Andresen, Rolf I Skotheim, Merete Hektoen, Torleiv O Rognum, Gunn I Meling, Geir Hoff, Michael Bretthauer, Espen Thiis-Evensen, Arild Nesbakken, Ragnhild A Lothe. Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas.
Molecular cancer.
2011 Jul; 10(?):85. doi:
10.1186/1476-4598-10-85. [PMID: 21777459] - Adriana Telias, Kui Lin-Wang, David E Stevenson, Janine M Cooney, Roger P Hellens, Andrew C Allan, Emily E Hoover, James M Bradeen. Apple skin patterning is associated with differential expression of MYB10.
BMC plant biology.
2011 May; 11(?):93. doi:
10.1186/1471-2229-11-93. [PMID: 21599973] - Taiko Kim To, Jong-Myong Kim, Akihiro Matsui, Yukio Kurihara, Taeko Morosawa, Junko Ishida, Maho Tanaka, Takaho Endo, Tetsuji Kakutani, Tetsuro Toyoda, Hiroshi Kimura, Shigeyuki Yokoyama, Kazuo Shinozaki, Motoaki Seki. Arabidopsis HDA6 regulates locus-directed heterochromatin silencing in cooperation with MET1.
PLoS genetics.
2011 Apr; 7(4):e1002055. doi:
10.1371/journal.pgen.1002055. [PMID: 21552333] - Asmita Kulkarni, Kamini Dangat, Anvita Kale, Pratiksha Sable, Preeti Chavan-Gautam, Sadhana Joshi. Effects of altered maternal folic acid, vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats.
PloS one.
2011 Mar; 6(3):e17706. doi:
10.1371/journal.pone.0017706. [PMID: 21423696] - Wen-Sheng Wang, Ya-Jiao Pan, Xiu-Qin Zhao, D Dwivedi, Ling-Hua Zhu, J Ali, Bin-Ying Fu, Zhi-Kang Li. Drought-induced site-specific DNA methylation and its association with drought tolerance in rice (Oryza sativa L.).
Journal of experimental botany.
2011 Mar; 62(6):1951-60. doi:
10.1093/jxb/erq391. [PMID: 21193578] - Yun Zhang, Wen-kai Jiang, Li-zhi Gao. Evolution of microRNA genes in Oryza sativa and Arabidopsis thaliana: an update of the inverted duplication model.
PloS one.
2011; 6(12):e28073. doi:
10.1371/journal.pone.0028073. [PMID: 22194805] - Katie L Robinson, Donya Tohidi-Esfahani, Nathan Lo, Stephen J Simpson, Gregory A Sword. Evidence for widespread genomic methylation in the migratory locust, Locusta migratoria (Orthoptera: Acrididae).
PloS one.
2011; 6(12):e28167. doi:
10.1371/journal.pone.0028167. [PMID: 22163001] - Mary Gehring, Victor Missirian, Steven Henikoff. Genomic analysis of parent-of-origin allelic expression in Arabidopsis thaliana seeds.
PloS one.
2011; 6(8):e23687. doi:
10.1371/journal.pone.0023687. [PMID: 21858209] - Frédéric Pontvianne, Mohamed Abou-Ellail, Julien Douet, Pascale Comella, Isabel Matia, Chinmayi Chandrasekhara, Anne Debures, Todd Blevins, Richard Cooke, Francisco J Medina, Sylvette Tourmente, Craig S Pikaard, Julio Sáez-Vásquez. Nucleolin is required for DNA methylation state and the expression of rRNA gene variants in Arabidopsis thaliana.
PLoS genetics.
2010 Nov; 6(11):e1001225. doi:
10.1371/journal.pgen.1001225. [PMID: 21124873] - Carlos Guerrero-Bosagna, Matthew Settles, Ben Lucker, Michael K Skinner. Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome.
PloS one.
2010 Sep; 5(9):. doi:
10.1371/journal.pone.0013100. [PMID: 20927350] - Dario Cantu, Leonardo S Vanzetti, Adam Sumner, Martin Dubcovsky, Marta Matvienko, Assaf Distelfeld, Richard W Michelmore, Jorge Dubcovsky. Small RNAs, DNA methylation and transposable elements in wheat.
BMC genomics.
2010 Jun; 11(?):408. doi:
10.1186/1471-2164-11-408. [PMID: 20584339] - Fabio Coppedè. One-carbon metabolism and Alzheimer's disease: focus on epigenetics.
Current genomics.
2010 Jun; 11(4):246-60. doi:
10.2174/138920210791233090. [PMID: 21119889] - Pedro Costa-Nunes, Olga Pontes, Sasha B Preuss, Craig S Pikaard. Extra views on RNA-dependent DNA methylation and MBD6-dependent heterochromatin formation in nucleolar dominance.
Nucleus (Austin, Tex.).
2010 May; 1(3):254-9. doi:
10.4161/nucl.1.3.11741. [PMID: 21327072] - Keiichi Mochida, Kazuo Shinozaki. Genomics and bioinformatics resources for crop improvement.
Plant & cell physiology.
2010 Apr; 51(4):497-523. doi:
10.1093/pcp/pcq027. [PMID: 20208064] - Haining Lin, Gaurav Moghe, Shu Ouyang, Amy Iezzoni, Shin-Han Shiu, Xun Gu, C Robin Buell. Comparative analyses reveal distinct sets of lineage-specific genes within Arabidopsis thaliana.
BMC evolutionary biology.
2010 Feb; 10(?):41. doi:
10.1186/1471-2148-10-41. [PMID: 20152032] - Ming Zhao, Jinling Tang, Fei Gao, Xiaoyan Wu, Yunsheng Liang, Heng Yin, Qianjin Lu. Hypomethylation of IL10 and IL13 promoters in CD4+ T cells of patients with systemic lupus erythematosus.
Journal of biomedicine & biotechnology.
2010; 2010(?):931018. doi:
10.1155/2010/931018. [PMID: 20589076] - Todd Blevins, Olga Pontes, Craig S Pikaard, Frederick Meins. Heterochromatic siRNAs and DDM1 independently silence aberrant 5S rDNA transcripts in Arabidopsis.
PloS one.
2009 Jun; 4(6):e5932. doi:
10.1371/journal.pone.0005932. [PMID: 19529764] - Ryan Lister, Joseph R Ecker. Finding the fifth base: genome-wide sequencing of cytosine methylation.
Genome research.
2009 Jun; 19(6):959-66. doi:
10.1101/gr.083451.108. [PMID: 19273618] - Asuka Miura, Miyuki Nakamura, Soichi Inagaki, Akie Kobayashi, Hidetoshi Saze, Tetsuji Kakutani. An Arabidopsis jmjC domain protein protects transcribed genes from DNA methylation at CHG sites.
The EMBO journal.
2009 Apr; 28(8):1078-86. doi:
10.1038/emboj.2009.59. [PMID: 19262562] - Felipe Karam Teixeira, Vincent Colot. Gene body DNA methylation in plants: a means to an end or an end to a means?.
The EMBO journal.
2009 Apr; 28(8):997-8. doi:
10.1038/emboj.2009.87. [PMID: 19384348] - Nicolas Widman, Steve E Jacobsen, Matteo Pellegrini. Determining the conservation of DNA methylation in Arabidopsis.
Epigenetics.
2009 Feb; 4(2):119-24. doi:
10.4161/epi.4.2.8214. [PMID: 19384058] - Yu-I Weng, Tim H-M Huang, Pearlly S Yan. Methylated DNA immunoprecipitation and microarray-based analysis: detection of DNA methylation in breast cancer cell lines.
Methods in molecular biology (Clifton, N.J.).
2009; 590(?):165-76. doi:
10.1007/978-1-60327-378-7_10. [PMID: 19763503] - Sasha B Preuss, Pedro Costa-Nunes, Sarah Tucker, Olga Pontes, Richard J Lawrence, Rebecca Mosher, Kristin D Kasschau, James C Carrington, David C Baulcombe, Wanda Viegas, Craig S Pikaard. Multimegabase silencing in nucleolar dominance involves siRNA-directed DNA methylation and specific methylcytosine-binding proteins.
Molecular cell.
2008 Dec; 32(5):673-84. doi:
10.1016/j.molcel.2008.11.009. [PMID: 19061642] - Jennifer A Rusiecki, Andrea Baccarelli, Valentina Bollati, Letizia Tarantini, Lee E Moore, Eva C Bonefeld-Jorgensen. Global DNA hypomethylation is associated with high serum-persistent organic pollutants in Greenlandic Inuit.
Environmental health perspectives.
2008 Nov; 116(11):1547-52. doi:
10.1289/ehp.11338. [PMID: 19057709] - E Jean Finnegan, Emma Whitelaw. Leaving the past behind.
PLoS genetics.
2008 Oct; 4(10):e1000248. doi:
10.1371/journal.pgen.1000248. [PMID: 18974866] - Benjamin Jaffé, Katalin Kovács, Calin Andras, Zsuzsanna Bódi, Zheng Liu, Rupert G Fray. Methylation of chloroplast DNA does not affect viability and maternal inheritance in tobacco and may provide a strategy towards transgene containment.
Plant cell reports.
2008 Aug; 27(8):1377-84. doi:
10.1007/s00299-008-0567-0. [PMID: 18536921] - Kazi Mirajul Hoque, Linxi Chen, George P H Leung, Chung-Ming Tse. A purine-selective nucleobase/nucleoside transporter in PK15NTD cells.
American journal of physiology. Regulatory, integrative and comparative physiology.
2008 Jun; 294(6):R1988-95. doi:
10.1152/ajpregu.00016.2008. [PMID: 18417653] - Xu Zhang, Shin-Han Shiu, Shinhan Shiu, Andrew Cal, Justin O Borevitz. Global analysis of genetic, epigenetic and transcriptional polymorphisms in Arabidopsis thaliana using whole genome tiling arrays.
PLoS genetics.
2008 Mar; 4(3):e1000032. doi:
10.1371/journal.pgen.1000032. [PMID: 18369451] - Salvatore Sotgia, Ciriaco Carru, Flavia Franconi, Paolo Battista Fiori, Salvatorica Manca, Silvestro Pettinato, Stefania Magliona, Renzo Ginanneschi, Luca Deiana, Angelo Zinellu. Rapid quantification of total genomic DNA methylation degree by short-end injection capillary zone electrophoresis.
Journal of chromatography. A.
2008 Mar; 1185(1):145-50. doi:
10.1016/j.chroma.2008.01.032. [PMID: 18255082] - Percy Ho, K F Kong, Y H Chan, Jimmy S H Tsang, Joseph T Y Wong. An unusual S-adenosylmethionine synthetase gene from dinoflagellate is methylated.
BMC molecular biology.
2007 Oct; 8(?):87. doi:
10.1186/1471-2199-8-87. [PMID: 17915037] - Mario A Moscarello, Fabrizio G Mastronardi, D Denise Wood. The role of citrullinated proteins suggests a novel mechanism in the pathogenesis of multiple sclerosis.
Neurochemical research.
2007 Feb; 32(2):251-6. doi:
10.1007/s11064-006-9144-5. [PMID: 17031564] - Adisa Causevic, Marie-Véronique Gentil, Alain Delaunay, Walid Abu El-Soud, Zacarias Garcia, Christophe Pannetier, Franck Brignolas, Daniel Hagège, Stéphane Maury. Relationship between DNA methylation and histone acetylation levels, cell redox and cell differentiation states in sugarbeet lines.
Planta.
2006 Sep; 224(4):812-27. doi:
10.1007/s00425-006-0267-3. [PMID: 16607556] - Simon W-L Chan, Ian R Henderson, Xiaoyu Zhang, Govind Shah, Jason S-C Chien, Steven E Jacobsen. RNAi, DRD1, and histone methylation actively target developmentally important non-CG DNA methylation in arabidopsis.
PLoS genetics.
2006 Jun; 2(6):e83. doi:
10.1371/journal.pgen.0020083. [PMID: 16741558] - David Ratel, Jean-Luc Ravanat, François Berger, Didier Wion. N6-methyladenine: the other methylated base of DNA.
BioEssays : news and reviews in molecular, cellular and developmental biology.
2006 Mar; 28(3):309-15. doi:
10.1002/bies.20342. [PMID: 16479578] - Adisa Causevic, Alain Delaunay, Saïda Ounnar, Michel Righezza, Francis Delmotte, Franck Brignolas, Daniel Hagège, Stéphane Maury. DNA methylating and demethylating treatments modify phenotype and cell wall differentiation state in sugarbeet cell lines.
Plant physiology and biochemistry : PPB.
2005 Jul; 43(7):681-91. doi:
10.1016/j.plaphy.2005.05.011. [PMID: 16046142] - Motoyuki Kunii, Masanori Kanda, Hironori Nagano, Ichiro Uyeda, Yuji Kishima, Yoshio Sano. Reconstruction of putative DNA virus from endogenous rice tungro bacilliform virus-like sequences in the rice genome: implications for integration and evolution.
BMC genomics.
2004 Oct; 5(?):80. doi:
10.1186/1471-2164-5-80. [PMID: 15488154] - Massimiliano Lauria, Mary Rupe, Mei Guo, Erhard Kranz, Raul Pirona, Angelo Viotti, Gertrud Lund. Extensive maternal DNA hypomethylation in the endosperm of Zea mays.
The Plant cell.
2004 Feb; 16(2):510-22. doi:
10.1105/tpc.017780. [PMID: 14729913] - Radosław Januchowski, Janusz Prokop, Paweł P Jagodziński. Role of epigenetic DNA alterations in the pathogenesis of systemic lupus erythematosus.
Journal of applied genetics.
2004; 45(2):237-48. doi:
NULL. [PMID: 15131354] - Miloslava Fojtova, Helena Van Houdt, Anna Depicker, Ales Kovarik. Epigenetic switch from posttranscriptional to transcriptional silencing is correlated with promoter hypermethylation.
Plant physiology.
2003 Nov; 133(3):1240-50. doi:
10.1104/pp.103.023796. [PMID: 14551338] - Pablo D Rabinowicz. Constructing gene-enriched plant genomic libraries using methylation filtration technology.
Methods in molecular biology (Clifton, N.J.).
2003; 236(?):21-36. doi:
10.1385/1-59259-413-1:21. [PMID: 14501056] - N Kishimoto, H Sakai, J Jackson, S E Jacobsen, E M Meyerowitz, E S Dennis, E J Finnegan. Site specificity of the Arabidopsis METI DNA methyltransferase demonstrated through hypermethylation of the superman locus.
Plant molecular biology.
2001 May; 46(2):171-83. doi:
10.1023/a:1010636222327. [PMID: 11442057]