2-Pyrazinoylguanidine (BioDeep_00000174984)

   

human metabolite blood metabolite


代谢物信息卡片


N-(diaminomethylidene)pyrazine-2-carboxamide

化学式: C6H7N5O (165.0651)
中文名称: 2-吡嗪基胍
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CN=C(C=N1)C(=O)N=C(N)N
InChI: InChI=1S/C6H7N5O/c7-6(8)11-5(12)4-3-9-1-2-10-4/h1-3H,(H4,7,8,11,12)

描述信息

同义名列表

2 个代谢物同义名

N-(diaminomethylidene)pyrazine-2-carboxamide; 2-pyrazinoylguanidine



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • E S Vesell, K H Beyer. Studies on pyrazinoylguanidine: a novel antihypertensive, hypoglycemic and lipolytic drug intended for adjunctive use in hypertensive patients with type 2 diabetes mellitus. Toxicology. 2000 Apr; 144(1-3):5-11. doi: 10.1016/s0300-483x(99)00213-9. [PMID: 10781866]
  • E S Vesell, K H Beyer. Studies on pyrazinoylguanidine. 7. Effects of single oral doses in normal human subjects. Pharmacology. 1999 Mar; 58(3):140-6. doi: 10.1159/000028276. [PMID: 9925970]
  • N Ahsan, Z Korsunsky, K H Beyer, E S Vesell. Pyrazinoylguanidine in end-stage renal disease: a prospective, placebo-controlled pilot study. Pharmacology. 1998 Aug; 57(2):96-103. doi: 10.1159/000028230. [PMID: 9691229]
  • M H Follansbee, K H Beyer, J W Griffith, E S Vesell. Studies on pyrazinoylguanidine. 5. Temporal effects over 24 weeks demonstrating attenuation of diabetic nephropathy in STZ-diabetic rats. Pharmacology. 1997 May; 54(5):241-55. doi: 10.1159/000139492. [PMID: 9380770]
  • Y I A-Rahim, K H Beyer, E S Vesell. Studies on pyrazinoylguanidine. 1. Characterization of metabolic effects in diabetic rats. Pharmacology. 1996 Mar; 52(3):135-44. doi: 10.1159/000139377. [PMID: 8849482]
  • Y I A-Rahim, K H Beyer, E S Vesell. Studies on pyrazinoylguanidine. 2. Comparative drug and dose effects on glucose and lipid metabolism in streptozotocin-induced diabetic rats. Pharmacology. 1996 Mar; 52(3):145-52. doi: 10.1159/000139378. [PMID: 8849483]
  • E S Vesell, C E Chambers, T D Seaton, G T Passananti, L M Demers, K H Beyer. Pyrazinoylguanidine downregulates the glucose fatty-acid cycle in hypertensive, hyperinsulinemic diabetic patients. Journal of clinical pharmacology. 1994 Dec; 34(12):1234-45. doi: 10.1002/j.1552-4604.1994.tb04737.x. [PMID: 7738221]
  • K H Beyer, T D Ward, J E Vary, R T Gelarden, D W Knutson, E S Vesell. Contrasting effects of pyrazinoylguanidine and hydrochlorothiazide in patients with renal insufficiency. Journal of clinical pharmacology. 1993 Jun; 33(6):554-61. doi: 10.1002/j.1552-4604.1993.tb04703.x. [PMID: 8366180]
  • C E Chambers, E S Vesell, C Helm, G T Passananti, K H Beyer. Pyrazinoylguanidine: antihypertensive, hypocholesterolemic, and renin effects. Journal of clinical pharmacology. 1992 Dec; 32(12):1128-34. doi: NULL. [PMID: 1487552]
  • G T Passananti, E S Vesell, E V Jeszenka, R T Gelarden, K H Beyer. Pharmacokinetics of pyrazinoyl-guanidine, 3-aminopyrazinoyl-guanidine and their corresponding pyrazinoic acid metabolites in humans and dogs. Pharmacology. 1992; 45(3):129-41. doi: 10.1159/000138991. [PMID: 1438523]
  • K H Beyer, R T Gelarden, E S Vesell. Inhibition of urea transport across renal tubules by pyrazinoylguanidine and analogs. Pharmacology. 1992; 44(3):124-38. doi: 10.1159/000138905. [PMID: 1579595]
  • K H Beyer, R T Gelarden, J E Vary, L E Brown, E S Vesell. Novel multivalent effects of pyrazinoylguanidine in patients with azotemia. Clinical pharmacology and therapeutics. 1990 May; 47(5):629-38. doi: 10.1038/clpt.1990.84. [PMID: 2188773]
  • K H Beyer, R T Gelarden. Active transport of urea by mammalian kidney. Proceedings of the National Academy of Sciences of the United States of America. 1988 Jun; 85(11):4030-1. doi: 10.1073/pnas.85.11.4030. [PMID: 3131771]