6-Aminonicotinamide (BioDeep_00000174902)

   

human metabolite blood metabolite


代谢物信息卡片


6-imino-1,6-dihydropyridine-3-carboximidic acid

化学式: C6H7N3O (137.0589)
中文名称: 6-氨基烟酰胺
谱图信息: 最多检出来源 Mus musculus(blood) 56.82%

分子结构信息

SMILES: C1=CC(=NC=C1C(=O)N)N
InChI: InChI=1S/C6H7N3O/c7-5-2-1-4(3-9-5)6(8)10/h1-3H,(H2,7,9)(H2,8,10)

描述信息

C274 - Antineoplastic Agent > C798 - Radiosensitizing Agent
D009676 - Noxae > D013723 - Teratogens

同义名列表

13 个代谢物同义名

6-imino-1,6-dihydropyridine-3-carboximidic acid; 6-imino-1H-pyridine-3-carboximidic acid; 6-Amino-3-pyridinecarboxamide; 2-Amino-5-carbamoylpyridine; 6-Aminonicotinic acid amide; 6-Aminonikotinsaeureamid; 6-Aminonicotinate amide; 6 Aminonicotinamide; 6-aminonicotinamide; SR 4388; 6-ANA; 6-AN; 6-Aminonicotinamide



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Ahmad Salimi, Maryam Paeezi, Bahareh Sadat Yousefsani, Shahin Shadnia, Hossein Hassanian-Moghaddam, Nasim Zamani, Jalal Pourahmad. Inhibition of glucose-6-phosphate dehydrogenase protects hepatocytes from aluminum phosphide-induced toxicity. Pesticide biochemistry and physiology. 2017 Nov; 143(?):141-146. doi: 10.1016/j.pestbp.2017.08.005. [PMID: 29183584]
  • Magali Balteau, Nicolas Tajeddine, Carole de Meester, Audrey Ginion, Christine Des Rosiers, Nathan R Brady, Caroline Sommereyns, Sandrine Horman, Jean-Louis Vanoverschelde, Philippe Gailly, Louis Hue, Luc Bertrand, Christophe Beauloye. NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1. Cardiovascular research. 2011 Nov; 92(2):237-46. doi: 10.1093/cvr/cvr230. [PMID: 21859816]
  • Richa Bhardwaj, Pradeep Kumar Sharma, Suryaprakash Singh Jadon, Rajeev Varshney. A combination of 2-deoxy-D-glucose and 6-aminonicotinamide induces oxidative stress mediated selective radiosensitization of malignant cells via mitochondrial dysfunction. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2011 Oct; 32(5):951-64. doi: 10.1007/s13277-011-0197-y. [PMID: 21660566]
  • Hirotaka Ata, Dhwajbhadur K Rawat, Thomas Lincoln, Sachin A Gupte. Mechanism of glucose-6-phosphate dehydrogenase-mediated regulation of coronary artery contractility. American journal of physiology. Heart and circulatory physiology. 2011 Jun; 300(6):H2054-63. doi: 10.1152/ajpheart.01155.2010. [PMID: 21398595]
  • Seigo Usuki, Ying-Ying Tsai, Keiko Morikawa, Shota Nonaka, Yasuhide Okuhara, Mitsuo Kise, Robert K Yu. IGF-1 induction by acylated steryl β-glucosides found in a pre-germinated brown rice diet reduces oxidative stress in streptozotocin-induced diabetes. PloS one. 2011; 6(12):e28693. doi: 10.1371/journal.pone.0028693. [PMID: 22194889]
  • Pradeep K Sharma, Richa Bhardwaj, Bilikere S Dwarakanath, Rajeev Varshney. Metabolic oxidative stress induced by a combination of 2-DG and 6-AN enhances radiation damage selectively in malignant cells via non-coordinated expression of antioxidant enzymes. Cancer letters. 2010 Sep; 295(2):154-66. doi: 10.1016/j.canlet.2010.02.021. [PMID: 20363070]
  • Laurence Lejay, Judith Wirth, Marjorie Pervent, Joanna Marie-France Cross, Pascal Tillard, Alain Gojon. Oxidative pentose phosphate pathway-dependent sugar sensing as a mechanism for regulation of root ion transporters by photosynthesis. Plant physiology. 2008 Apr; 146(4):2036-53. doi: 10.1104/pp.107.114710. [PMID: 18305209]
  • Patrick F Finn, Nicholas T Mesires, Michaela Vine, J Fred Dice. Effects of small molecules on chaperone-mediated autophagy. Autophagy. 2005 Oct; 1(3):141-5. doi: 10.4161/auto.1.3.2000. [PMID: 16874031]
  • Andrew P Garlick, Catherine Moore, Nicholas J Kruger. Monitoring flux through the oxidative pentose phosphate pathway using [1-14C]gluconate. Planta. 2002 Dec; 216(2):265-72. doi: 10.1007/s00425-002-0842-1. [PMID: 12447540]
  • Y B Lee, I K Park. Effects of neurotoxin 6-aminonicotinamide on levels of enzyme activities and metabolites in quail plasma. The international journal of biochemistry & cell biology. 2001 Jun; 33(6):613-20. doi: 10.1016/s1357-2725(01)00036-x. [PMID: 11378442]
  • M M Jørgensen, O N Jensen, H U Holst, J J Hansen, T J Corydon, P Bross, L Bolund, N Gregersen. Grp78 is involved in retention of mutant low density lipoprotein receptor protein in the endoplasmic reticulum. The Journal of biological chemistry. 2000 Oct; 275(43):33861-8. doi: 10.1074/jbc.m004663200. [PMID: 10906332]
  • Y C Yang, J Y Kim, I K Park. Neurotoxin 6-aminonicotinamide affects levels of soluble proteins and enzyme activities in various tissues of golden hamsters. The international journal of biochemistry & cell biology. 2000 May; 32(5):549-56. doi: 10.1016/s1357-2725(99)00150-8. [PMID: 10736570]
  • M Penkowa, J Hidalgo. IL-6 deficiency leads to reduced metallothionein-I+II expression and increased oxidative stress in the brain stem after 6-aminonicotinamide treatment. Experimental neurology. 2000 May; 163(1):72-84. doi: 10.1006/exnr.2000.7383. [PMID: 10785446]
  • D L Walker, J M Reid, P A Svingen, R Rios, J M Covey, M C Alley, M G Hollingshead, I I Budihardjo, S Eckdahl, S A Boerner, S H Kaufmann, M M Ames. Murine pharmacokinetics of 6-aminonicotinamide (NSC 21206), a novel biochemical modulating agent. Biochemical pharmacology. 1999 Sep; 58(6):1057-66. doi: 10.1016/s0006-2952(99)00179-3. [PMID: 10509758]
  • J Y Kim, I K Park. Effects of 6-aminonicotinamide on levels of soluble proteins and enzyme activities in various tissues of Japanese quail. The international journal of biochemistry & cell biology. 1998 Dec; 30(12):1337-44. doi: 10.1016/s1357-2725(98)00102-2. [PMID: 9924803]
  • M Penkowa, J Hidalgo, T Moos. Increased astrocytic expression of metallothioneins I + II in brainstem of adult rats treated with 6-aminonicotinamide. Brain research. 1997 Nov; 774(1-2):256-9. doi: 10.1016/s0006-8993(97)81716-7. [PMID: 9452221]
  • J M Krum. Experimental gliopathy in the adult rat CNS: effect on the blood-spinal cord barrier. Glia. 1994 Aug; 11(4):354-66. doi: 10.1002/glia.440110408. [PMID: 7960038]
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  • L H Davis, F C Kauffman. Metabolism via the pentose phosphate pathway in rat pheochromocytoma PC12 cells: effects of nerve growth factor and 6-aminonicotinamide. Neurochemical research. 1987 Jun; 12(6):521-7. doi: 10.1007/bf01000236. [PMID: 2955240]
  • H Aikawa, S Kobayashi, K Suzuki. Aqueductal lesions in 6-aminonicotinamide-treated suckling mice. Acta neuropathologica. 1986; 71(3-4):243-50. doi: 10.1007/bf00688046. [PMID: 2948367]
  • S G Rostand, J Work. Effect of 6-aminonicotinamide on renin release in isolated rat kidney: possible role for the pentose pathway. The American journal of physiology. 1985 Aug; 249(2 Pt 2):F213-9. doi: 10.1152/ajprenal.1985.249.2.f213. [PMID: 3161339]
  • J Sudo, A Ishihara, T Tanabe. Inhibitory effect of 6-aminonicotinamide on the renal transport of para-aminohippurate in the rat. Japanese journal of pharmacology. 1984 Dec; 36(4):491-8. doi: 10.1254/jjp.36.491. [PMID: 6241269]
  • A Ishihara, J Sudo, T Tanabe. Inhibition of glucose reabsorption induced by 6-aminonicotinamide in the rat kidney. The Journal of toxicological sciences. 1984 Nov; 9(4):353-62. doi: 10.2131/jts.9.353. [PMID: 6241267]
  • S Sugiyama, T Satoh, B Uzalp, K Ueno, T Igarashi, H Kitagawa. Effects of a single administration of 6-aminonicotinamide on hepatic microsomal drug metabolism in rats. Archives internationales de pharmacodynamie et de therapie. 1984 May; 269(1):20-33. doi: NULL. [PMID: 6235789]
  • G Benzi, R F Villa, M Dossena, L Vercesi, A Gorini, O Pastoris. Cerebral endogenous substrate utilization during the recovery period after profound hypoglycemia. Journal of neuroscience research. 1984; 11(4):437-50. doi: 10.1002/jnr.490110410. [PMID: 6748113]
  • C L Kaul, P K Talwalker, R S Grewal. Participation of adrenal medulla in 6-amino-nicotinamide-induced hyperglycaemia in the rat. The Journal of pharmacy and pharmacology. 1980 Oct; 32(10):701-4. doi: 10.1111/j.2042-7158.1980.tb13042.x. [PMID: 6107344]
  • L Simchowitz, J Mehta, I Spilberg. Chemotactic factor-induced generation of superoxide radicals by human neutrophils: effect of metabolic inhibitors and antiinflammatory drugs. Arthritis and rheumatism. 1979 Jul; 22(7):755-63. doi: 10.1002/art.1780220711. [PMID: 222300]
  • H Herken, K Keller, H Kolbe, K Lange. Renal gluconate excretion after 6-aminonicotinamide. Naunyn-Schmiedeberg's archives of pharmacology. 1975; 291(2):213-6. doi: 10.1007/bf00500051. [PMID: 127949]
  • H HERKEN, V NEUHOFF. [SPECTROFLUOROMETRIC DETERMINATION OF THEINCORPORATION OF 6-AMINONICOTINAMIDE INTO OXIDATED PYRIDINE NUCLEOTIDE IN THE KIDNEY]. Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie. 1964 May; 247(?):187-201. doi: 10.1007/bf00245963. [PMID: 14230230]
  • V MAGGI, A V GRECO, S SENSI, M MAGARO, G GAMBASSI. [The action of 6-aminonicotinamide on cholesterol and phosphatide synthesis from acetate-1-C14]. Bollettino della Societa italiana di biologia sperimentale. 1959 Jul; 35(?):866-8. doi: ". [PMID: 14419816]
  • V MAGGI, A V GRECO, S SENSI, M MAGARO. [Cholesterol, lipid phosphorus and glycogen of the left myocardial ventricle in rats treated with 6-aminonicotinamide]. Bollettino della Societa italiana di biologia sperimentale. 1959 May; 35(10):566-7. doi: ". [PMID: 13662472]
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