3-Hydroxy-10,13-dimethyl-17-(6-methylheptan-2-yl)-1,2,3,4,5,6,7,9,11,12,16,17-dodecahydrocyclopenta[a]phenanthren-15-one (BioDeep_00000174790)

   

human metabolite blood metabolite


代谢物信息卡片


3-Hydroxy-10,13-dimethyl-17-(6-methylheptan-2-yl)-1,2,3,4,5,6,7,9,11,12,16,17-dodecahydrocyclopenta[a]phenanthren-15-one

化学式: C27H44O2 (400.3341124)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CCCC(C)C1CC(=O)C2=C3CCC4CC(CCC4(C3CCC12C)C)O
InChI: InChI=1S/C27H44O2/c1-17(2)7-6-8-18(3)23-16-24(29)25-21-10-9-19-15-20(28)11-13-26(19,4)22(21)12-14-27(23,25)5/h17-20,22-23,28H,6-16H2,1-5H3

描述信息

同义名列表

10 个代谢物同义名

3-Hydroxy-10,13-dimethyl-17-(6-methylheptan-2-yl)-1,2,3,4,5,6,7,9,11,12,16,17-dodecahydrocyclopenta[a]phenanthren-15-one; 5-hydroxy-2,15-dimethyl-14-(6-methylheptan-2-yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-10-en-12-one; Cholest-8(14)-en-3-ol-15-one, (3alpha,5alpha)-isomer; 3-beta-Hydroxy-5-alpha-cholest-8(14)-en-15-one; 5 alpha-Cholest-8(14)-en-3 beta-ol-15-one; 3-Hydroxy-5alpha-cholest-8(14)-en-15-one; Cholest-8(14)-en-3-ol-15-one; 15-ketocholestane; 15-KC Steroid; ACEBOO



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Md Omedul Islam, Yan Ting Lim, Conrad En Zuo Chan, Amaury Cazenave-Gassiot, J Ludovic Croxford, Markus R Wenk, Paul A Macary, Brendon J Hanson. Generation and characterization of a novel recombinant antibody against 15-ketocholestane isolated by phage-display. International journal of molecular sciences. 2012; 13(4):4937-48. doi: 10.3390/ijms13044937. [PMID: 22606021]
  • I Björkhem, A Lövgren-Sandblom, F Piehl, M Khademi, H Pettersson, V Leoni, T Olsson, U Diczfalusy. High levels of 15-oxygenated steroids in circulation of patients with multiple sclerosis: fact or fiction?. Journal of lipid research. 2011 Jan; 52(1):170-4. doi: 10.1194/jlr.d011072. [PMID: 20934989]
  • Robert J Schmidt, James V Ficorilli, Youyan Zhang, Kelli S Bramlett, Thomas P Beyer, Kristen Borchert, Michele S Dowless, Keith A Houck, Thomas P Burris, Patrick I Eacho, Guosheng Liang, Li-Wei Guo, William K Wilson, Laura F Michael, Guoqing Cao. A 15-ketosterol is a liver X receptor ligand that suppresses sterol-responsive element binding protein-2 activity. Journal of lipid research. 2006 May; 47(5):1037-44. doi: 10.1194/jlr.m500526-jlr200. [PMID: 16415294]
  • S Swaminathan, A U Siddiqui, N Gerst, F D Pinkerton, A Kisic, L J Kim, W K Wilson, G J Schroepfer. Inhibitors of sterol synthesis. Metabolism-based design and construction of a new analog of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one and its effects in cultured mammalian cells and in rats. Journal of lipid research. 1995 Apr; 36(4):767-86. doi: . [PMID: 7616123]
  • N Gerst, F D Pinkerton, A Kisic, W K Wilson, S Swaminathan, G J Schroepfer. Inhibitors of sterol synthesis. Effects of a new fluorinated analog of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one in rats. Journal of lipid research. 1994 Jun; 35(6):1040-56. doi: 10.1016/s0022-2275(20)40100-2. [PMID: 8077843]
  • H S Kim, W K Wilson, N D Kirkpatrick, F D Pinkerton, S Swaminathan, M D Hylarides, G J Schroepfer. Inhibitors of sterol synthesis. Chemical synthesis of 7 alpha-ethyl and 16 alpha-ethyl derivatives of delta 8(14)-15-oxygenated sterols and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase in CHO-K1 cells. Chemistry and physics of lipids. 1992 Jul; 62(1):55-67. doi: 10.1016/0009-3084(92)90054-s. [PMID: 1423803]
  • J St Pyrek, W K Wilson, S Numazawa, G J Schoepfer. Inhibitors of sterol synthesis. Characterization of trimethylsilyl dienol ethers of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one. Applications in the analysis of mitochondrial metabolites of the 15-ketosterol by gas chromatography-mass spectrometry. Journal of lipid research. 1991 Aug; 32(8):1371-80. doi: . [PMID: 1770319]
  • W K Wilson, M E Wheeler, F D Pinkerton, J St Pyrek, G J Schroepfer. Inhibitors of sterol synthesis. Characterization of beta,gamma-unsaturated analogs of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells. Journal of lipid research. 1991 Jul; 32(7):1215-27. doi: ". [PMID: 1940644]
  • T N Pajewski, F D Pinkerton, L R Miller, G J Schroepfer. Inhibitors of sterol synthesis. Studies of the metabolism of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one in Chinese hamster ovary cells and its effects on activities of early enzymes in cholesterol biosynthesis. Chemistry and physics of lipids. 1988 Oct; 48(3-4):153-68. doi: 10.1016/0009-3084(88)90086-2. [PMID: 2907421]
  • A J Chu. Secretion of metabolites of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one by Hep G2 cells. Proceedings of the National Science Council, Republic of China. Part B, Life sciences. 1988 Oct; 12(4):209-14. doi: ". [PMID: 3244817]
  • G T Emmons, J St Pyrek, R Dam, M Martin, K Kudo, G J Schroepfer. 5 alpha-cholest-8(14)-en-3 beta-ol-15-one, a potent regulator of cholesterol metabolism: occurrence in rat skin. Journal of lipid research. 1988 Aug; 29(8):1039-54. doi: ". [PMID: 3183517]
  • A Chu, G J Schroepfer. Inhibitors of sterol synthesis. Reverse phase high performance liquid chromatography for the separation of cholesterol, 5 alpha-cholest-8(14)-en-3 beta-ol-15-one, and their fatty acid esters. Journal of lipid research. 1988 Feb; 29(2):235-9. doi: ". [PMID: 3367091]
  • J St Pyrek, W K Wilson, G J Schroepfer. Inhibitors of sterol synthesis. Spectral characterization of derivatives of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one. Journal of lipid research. 1987 Nov; 28(11):1296-307. doi: ". [PMID: 3430060]
  • J St Pyrek, G J Schroepfer. Inhibitors of sterol synthesis. Synthesis and spectral characterization of fatty acids esters of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one. Journal of lipid research. 1987 Nov; 28(11):1308-12. doi: ". [PMID: 3430061]