20-Hydroxyarachlidonic acid (BioDeep_00000174776)
human metabolite blood metabolite
代谢物信息卡片
20-hydroxyicosa-5,8,11,14-tetraenoic acid
化学式: C20H32O3 (320.2351)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: OCCCCCC=CCC=CCC=CCC=CCCCC(O)=O
InChI: InChI=1S/C20H32O3/c21-19-17-15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18-20(22)23/h1,3-4,6-7,9-10,12,21H,2,5,8,11,13-19H2,(H,22,23)
数据库引用编号
4 个数据库交叉引用编号
- PubChem: 123803
- HMDB: HMDB0246872
- Wikipedia: 20-Hydroxyeicosatetraenoic acid
- chemspider: 21230772
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Guangrui Lai, Jingjing Wu, Xiaoliang Liu, Yanyan Zhao. 20-HETE induces hyperglycemia through the cAMP/PKA-PhK-GP pathway.
Molecular endocrinology (Baltimore, Md.).
2012 Nov; 26(11):1907-16. doi:
10.1210/me.2012-1139. [PMID: 22918876] - Xiaoliang Liu, Jingjing Wu, Hong Liu, Guangrui Lai, Yanyan Zhao. Disturbed ratio of renal 20-HETE/EETs is involved in androgen-induced hypertension in cytochrome P450 4F2 transgenic mice.
Gene.
2012 Sep; 505(2):352-9. doi:
10.1016/j.gene.2012.02.029. [PMID: 22387726] - Emmanuelle Plée-Gautier, Joseph Antoun, Sophie Goulitquer, Catherine Le Jossic-Corcos, Brigitte Simon, Yolande Amet, Jean-Pierre Salaün, Laurent Corcos. Statins increase cytochrome P450 4F3-mediated eicosanoids production in human liver cells: a PXR dependent mechanism.
Biochemical pharmacology.
2012 Aug; 84(4):571-9. doi:
10.1016/j.bcp.2012.05.012. [PMID: 22634049] - Cristiano Fava, Marco Ricci, Olle Melander, Pietro Minuz. Hypertension, cardiovascular risk and polymorphisms in genes controlling the cytochrome P450 pathway of arachidonic acid: A sex-specific relation?.
Prostaglandins & other lipid mediators.
2012 Aug; 98(3-4):75-85. doi:
10.1016/j.prostaglandins.2011.11.007. [PMID: 22173545] - Li Chen, Rachel Ackerman, Austin M Guo. 20-HETE in neovascularization.
Prostaglandins & other lipid mediators.
2012 Aug; 98(3-4):63-8. doi:
10.1016/j.prostaglandins.2011.12.005. [PMID: 22227460] - Haixia Zhao, Ying Li, Yuzhong Wang, Jing Zhang, Xiaoming Ouyang, Renxiu Peng, Jing Yang. Antitumor and immunostimulatory activity of a polysaccharide-protein complex from Scolopendra subspinipes mutilans L. Koch in tumor-bearing mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2012 Aug; 50(8):2648-55. doi:
10.1016/j.fct.2012.05.018. [PMID: 22613217] - Maria M Federik Fernandez, Daniel Gonzalez, Jan M Williams, Richard J Roman, Susana Nowicki. Inhibitors of 20-hydroxyeicosatetraenoic acid (20-HETE) formation attenuate the natriuretic effect of dopamine.
European journal of pharmacology.
2012 Jul; 686(1-3):97-103. doi:
10.1016/j.ejphar.2012.04.039. [PMID: 22575524] - Jun Yang, Jason P Eiserich, Carroll E Cross, Brian M Morrissey, Bruce D Hammock. Metabolomic profiling of regulatory lipid mediators in sputum from adult cystic fibrosis patients.
Free radical biology & medicine.
2012 Jul; 53(1):160-71. doi:
10.1016/j.freeradbiomed.2012.05.001. [PMID: 22580336] - Anna Alexanian, Bradley Miller, Richard J Roman, Andrey Sorokin. 20-HETE-producing enzymes are up-regulated in human cancers.
Cancer genomics & proteomics.
2012 Jul; 9(4):163-9. doi:
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Atherosclerosis.
2012 Jun; 222(2):530-6. doi:
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Journal of the American Society of Nephrology : JASN.
2012 Jun; 23(6):1019-26. doi:
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American journal of physiology. Regulatory, integrative and comparative physiology.
2012 May; 302(10):R1209-18. doi:
10.1152/ajpregu.00604.2011. [PMID: 22442195] - Ting Tian, Jin Li, Meng-Ying Wang, Xian-Fei Xie, Qi-Xiong Li. Protective effect of 20-hydroxyeicosatetraenoic acid (20-HETE) on adriamycin-induced toxicity of human renal tubular epithelial cell (HK-2).
European journal of pharmacology.
2012 May; 683(1-3):246-51. doi:
10.1016/j.ejphar.2012.03.001. [PMID: 22421401] - A Paliege, T Roeschel, H Neymeyer, S Seidel, T Kahl, A L Daigeler, K Mutig, R Mrowka, N R Ferreri, B S Wilson, N Himmerkus, M Bleich, S Bachmann. Group VIA phospholipase A2 is a target for vasopressin signaling in the thick ascending limb.
American journal of physiology. Renal physiology.
2012 Apr; 302(7):F865-74. doi:
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Journal of lipid research.
2012 Mar; 53(3):437-445. doi:
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American journal of physiology. Endocrinology and metabolism.
2012 Mar; 302(5):E500-9. doi:
10.1152/ajpendo.00370.2011. [PMID: 22185841] - Kevin R Regner, Richard J Roman. Role of medullary blood flow in the pathogenesis of renal ischemia-reperfusion injury.
Current opinion in nephrology and hypertension.
2012 Jan; 21(1):33-8. doi:
10.1097/mnh.0b013e32834d085a. [PMID: 22080855] - Bahar Tunctan, Belma Korkmaz, Ayse Nihal Sari, Meltem Kacan, Demet Unsal, Mehmet Sami Serin, C Kemal Buharalioglu, Seyhan Sahan-Firat, Wolf-Hagen Schunck, John R Falck, Kafait U Malik. A novel treatment strategy for sepsis and septic shock based on the interactions between prostanoids, nitric oxide, and 20-hydroxyeicosatetraenoic acid.
Anti-inflammatory & anti-allergy agents in medicinal chemistry.
2012; 11(2):121-50. doi:
10.2174/187152312803305759. [PMID: 23013331] - Yasunori Sato, Xiang Shan Ren, Yasuni Nakanuma. Caroli's Disease: Current Knowledge of Its Biliary Pathogenesis Obtained from an Orthologous Rat Model.
International journal of hepatology.
2012; 2012(?):107945. doi:
10.1155/2012/107945. [PMID: 22007315] - Guangrui Lai, Xiaoliang Liu, Jingjing Wu, Hong Liu, Yanyan Zhao. Evaluation of CMV and KAP promoters for driving the expression of human CYP4F2 in transgenic mice.
International journal of molecular medicine.
2012 Jan; 29(1):107-12. doi:
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International journal of hypertension.
2012; 2012(?):189512. doi:
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Frontiers in physiology.
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PloS one.
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10.1371/journal.pone.0029779. [PMID: 22279544] - Raquel Martín-Venegas, Rosario Casillas, Olga Jáuregui, Juan José Moreno. Rapid simultaneous analysis of cyclooxygenase, lipoxygenase and cytochrome P-450 metabolites of arachidonic and linoleic acids using high performance liquid chromatography/mass spectrometry in tandem mode.
Journal of pharmaceutical and biomedical analysis.
2011 Dec; 56(5):976-82. doi:
10.1016/j.jpba.2011.06.018. [PMID: 21880455] - Natalie C Ward, Kevin D Croft, David Blacker, Graeme J Hankey, Anne Barden, Trevor A Mori, Ian B Puddey, Christopher D Beer. Cytochrome P450 metabolites of arachidonic acid are elevated in stroke patients compared with healthy controls.
Clinical science (London, England : 1979).
2011 Dec; 121(11):501-7. doi:
10.1042/cs20110215. [PMID: 21689071] - Giuseppe Vezzoli, Annalisa Terranegra, Francesco Rainone, Teresa Arcidiacono, Mario Cozzolino, Andrea Aloia, Elena Dogliotti, Daniele Cusi, Laura Soldati. Calcium-sensing receptor and calcium kidney stones.
Journal of translational medicine.
2011 Nov; 9(?):201. doi:
10.1186/1479-5876-9-201. [PMID: 22107799] - David Sacerdoti, Houli Jiang, Silvia Gaiani, John C McGiff, Angelo Gatta, Massimo Bolognesi. 11,12-EET increases porto-sinusoidal resistance and may play a role in endothelial dysfunction of portal hypertension.
Prostaglandins & other lipid mediators.
2011 Nov; 96(1-4):72-5. doi:
10.1016/j.prostaglandins.2011.08.002. [PMID: 21856435] - Fumihiko Yoshino, Ayaka Yoshida, Naofumi Umigai, Koya Kubo, Masaichi-Chang-Il Lee. Crocetin reduces the oxidative stress induced reactive oxygen species in the stroke-prone spontaneously hypertensive rats (SHRSPs) brain.
Journal of clinical biochemistry and nutrition.
2011 Nov; 49(3):182-7. doi:
10.3164/jcbn.11-01. [PMID: 22128217] - Cheng-Chia Wu, Michal Laniado Schwartzman. The role of 20-HETE in androgen-mediated hypertension.
Prostaglandins & other lipid mediators.
2011 Nov; 96(1-4):45-53. doi:
10.1016/j.prostaglandins.2011.06.006. [PMID: 21722750] - Tengis S Pavlov, Daria V Ilatovskaya, Vladislav Levchenko, David L Mattson, Richard J Roman, Alexander Staruschenko. Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC).
American journal of physiology. Renal physiology.
2011 Sep; 301(3):F672-81. doi:
10.1152/ajprenal.00597.2010. [PMID: 21697242] - Jatuporn Wichitsranoi, Natthida Weerapreeyakul, Patcharee Boonsiri, Chatri Settasatian, Nongnuch Settasatian, Nantarat Komanasin, Suchart Sirijaichingkul, Yaovalak Teerajetgul, Nuchanart Rangkadilok, Naruemon Leelayuwat. Antihypertensive and antioxidant effects of dietary black sesame meal in pre-hypertensive humans.
Nutrition journal.
2011 Aug; 10(?):82. doi:
10.1186/1475-2891-10-82. [PMID: 21827664] - Howard Trachtman, Fernando C Fervenza, Debbie S Gipson, Peter Heering, David R W Jayne, Harm Peters, Stefano Rota, Giuseppe Remuzzi, L Christian Rump, Lorenz K Sellin, Jeremy P W Heaton, James B Streisand, Marjie L Hard, Steven R Ledbetter, Flavio Vincenti. A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis.
Kidney international.
2011 Jun; 79(11):1236-43. doi:
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American journal of physiology. Regulatory, integrative and comparative physiology.
2011 Jun; 300(6):R1543-8. doi:
10.1152/ajpregu.00387.2010. [PMID: 21474427] - Alexandra Sporková, Libor Kopkan, Sárka Varcabová, Zuzana Husková, Sung Hee Hwang, Bruce D Hammock, John D Imig, Herbert J Kramer, Ludek Cervenka. Role of cytochrome P-450 metabolites in the regulation of renal function and blood pressure in 2-kidney 1-clip hypertensive rats.
American journal of physiology. Regulatory, integrative and comparative physiology.
2011 Jun; 300(6):R1468-75. doi:
10.1152/ajpregu.00215.2010. [PMID: 21411763] - Kanyarat Boonprasert, Ronnatrai Ruengweerayut, Soisungwan Satarug, Kesara Na-Bangchang. Study on the association between environmental cadmium exposure, cytochrome P450-mediated 20-HETE, heme-oxygenase-1 polymorphism and hypertension in Thai population residing in a malaria endemic areas with cadmium pollution.
Environmental toxicology and pharmacology.
2011 May; 31(3):416-26. doi:
10.1016/j.etap.2011.02.003. [PMID: 21787712] - I J Tsai, K D Croft, I B Puddey, L J Beilin, A Barden. 20-Hydroxyeicosatetraenoic acid synthesis is increased in human neutrophils and platelets by angiotensin II and endothelin-1.
American journal of physiology. Heart and circulatory physiology.
2011 Apr; 300(4):H1194-200. doi:
10.1152/ajpheart.00733.2010. [PMID: 21239640] - M Kuczeriszka, K H Olszyński, A Gąsiorowska, J Sadowski, E Kompanowska-Jezierska. Interaction of nitric oxide and the cytochrome P-450 system on blood pressure and renal function in the rat: dependence on sodium intake.
Acta physiologica (Oxford, England).
2011 Apr; 201(4):493-502. doi:
10.1111/j.1748-1716.2010.02222.x. [PMID: 21073660] - Bang-Chuan Hu, Yan Li, Fa-Hong Li, Yi Zhang, Chang-Sheng Sheng, Hong-Qi Fan, Ji-Guang Wang. Peripheral and central augmentation indexes in relation to the CYP4F2 polymorphisms in Chinese.
Journal of hypertension.
2011 Mar; 29(3):501-8. doi:
10.1097/hjh.0b013e328342673c. [PMID: 21150635] - Joshua S Speed, Eric M George, Marietta Arany, Kathy Cockrell, Joey P Granger. Role of 20-hydroxyeicosatetraenoic acid in mediating hypertension in response to chronic renal medullary endothelin type B receptor blockade.
PloS one.
2011; 6(10):e26063. doi:
10.1371/journal.pone.0026063. [PMID: 22016812] - Katherine N Theken, Yangmei Deng, M Alison Kannon, Tricia M Miller, Samuel M Poloyac, Craig R Lee. Activation of the acute inflammatory response alters cytochrome P450 expression and eicosanoid metabolism.
Drug metabolism and disposition: the biological fate of chemicals.
2011 Jan; 39(1):22-9. doi:
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Journal of biomedicine & biotechnology.
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PPAR research.
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Kidney international.
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Kidney international.
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2010 Dec; 25(12):4061-7. doi:
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American journal of physiology. Heart and circulatory physiology.
2010 Dec; 299(6):H1891-901. doi:
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Cancer metastasis reviews.
2010 Dec; 29(4):723-35. doi:
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Antioxidants & redox signaling.
2010 Nov; 13(10):1517-24. doi:
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PloS one.
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Basic & clinical pharmacology & toxicology.
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Hypertension (Dallas, Tex. : 1979).
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Drug metabolism letters.
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Basic & clinical pharmacology & toxicology.
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PloS one.
2010 Apr; 5(4):e10235. doi:
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Nuclear receptor signaling.
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Journal of hypertension.
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BMC medical genomics.
2010 Feb; 3(?):5. doi:
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Physiological genomics.
2010 Feb; 40(3):158-66. doi:
10.1152/physiolgenomics.00088.2009. [PMID: 19920212] - Tengis S Pavlov, John D Imig, Alexander Staruschenko. Regulation of ENaC-Mediated Sodium Reabsorption by Peroxisome Proliferator-Activated Receptors.
PPAR research.
2010; 2010(?):703735. doi:
10.1155/2010/703735. [PMID: 20613963] - Haroon-Ur Rashid. Renoprotection, renin inhibition, and blood pressure control: the impact of aliskiren on integrated blood pressure control.
Integrated blood pressure control.
2010; 3(?):133-44. doi:
10.2147/ibpc.s12407. [PMID: 21949629] - Elvira L Liclican, Anabel B Doumad, Jianjin Wang, Jing Li, John R Falck, Charles T Stier, Mairéad A Carroll. Inhibition of the adenosine2A receptor-epoxyeicosatrienoic acid pathway renders Dahl salt-resistant rats hypertensive.
Hypertension (Dallas, Tex. : 1979).
2009 Dec; 54(6):1284-90. doi:
10.1161/hypertensionaha.108.123570. [PMID: 19822802] - Mary Pat Kunert, Jill Friesma, John R Falck, Julian H Lombard. CYP450 4A inhibition attenuates O2 induced arteriolar constriction in chronic but not acute Goldblatt hypertension.
Microvascular research.
2009 Dec; 78(3):442-6. doi:
10.1016/j.mvr.2009.09.002. [PMID: 19761780] - Jason H Y Wu, Jonathan M Hodgson, Michael W Clarke, Adeline P Indrawan, Anne E Barden, Ian B Puddey, Kevin D Croft. Inhibition of 20-hydroxyeicosatetraenoic acid synthesis using specific plant lignans: in vitro and human studies.
Hypertension (Dallas, Tex. : 1979).
2009 Nov; 54(5):1151-8. doi:
10.1161/hypertensionaha.109.139352. [PMID: 19786646] - Anna Alexanian, Victoriya A Rufanova, Bradley Miller, Averia Flasch, Richard J Roman, Andrey Sorokin. Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth.
Anticancer research.
2009 Oct; 29(10):3819-24. doi:
NULL. [PMID: 19846914] - Kazuyoshi Inoue, Komal Sodhi, Nitin Puri, Katherine H Gotlinger, Jiang Cao, Rita Rezzani, John R Falck, Nader G Abraham, Michal Laniado-Schwartzman. Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE.
American journal of physiology. Renal physiology.
2009 Oct; 297(4):F875-84. doi:
10.1152/ajprenal.00364.2009. [PMID: 19675180] - Cristiano Fava, Martina Montagnana, Olle Melander. Overexpression of cytochrome P450 4F2 in mice increases 20-hydroxyeicosatetraenoic acid production and arterial blood pressure.
Kidney international.
2009 Oct; 76(8):913; author reply 913-4. doi:
10.1038/ki.2009.281. [PMID: 19789547] - Timothy Pearson, Averil Y Warren, David A Barrett, Raheela N Khan. Detection of EETs and HETE-generating cytochrome P-450 enzymes and the effects of their metabolites on myometrial and vascular function.
American journal of physiology. Endocrinology and metabolism.
2009 Sep; 297(3):E647-56. doi:
10.1152/ajpendo.00227.2009. [PMID: 19549792] - Talha Akbulut, Kevin R Regner, Richard J Roman, Ellis D Avner, John R Falck, Frank Park. 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
American journal of physiology. Renal physiology.
2009 Sep; 297(3):F662-70. doi:
10.1152/ajprenal.00146.2009. [PMID: 19570883] - Yi Zhang, Jason H Y Wu, Janine J Vickers, Sharon L H Ong, Suzanna E L Temple, Trevor A Mori, Kevin D Croft, Judith A Whitworth. The role of 20-hydroxyeicosatetraenoic acid in adrenocorticotrophic hormone and dexamethasone-induced hypertension.
Journal of hypertension.
2009 Aug; 27(8):1609-16. doi:
10.1097/hjh.0b013e32832cc56c. [PMID: 19458537] - Yiqiang Cai. Arachidonic acid cytochrome P450 4F2 in hypertension: what can we learn from a transgenic mouse model??.
Kidney international.
2009 Jun; 75(12):1253-1254. doi:
10.1038/ki.2009.82. [PMID: 19483747] - Xiaoliang Liu, Yanyan Zhao, Luzeng Wang, Xianghong Yang, Zhihong Zheng, Yuanyuan Zhang, Fangjie Chen, Hong Liu. Overexpression of cytochrome P450 4F2 in mice increases 20-hydroxyeicosatetraenoic acid production and arterial blood pressure.
Kidney international.
2009 Jun; 75(12):1288-1296. doi:
10.1038/ki.2009.67. [PMID: 19279555] - Suyi Cao, Liang-Chao Wang, Herman Kwansa, Richard J Roman, David R Harder, Raymond C Koehler. Endothelin rather than 20-HETE contributes to loss of pial arteriolar dilation during focal cerebral ischemia with and without polymeric hemoglobin transfusion.
American journal of physiology. Regulatory, integrative and comparative physiology.
2009 May; 296(5):R1412-8. doi:
10.1152/ajpregu.00003.2009. [PMID: 19261918] - Sandra J Hamilton, Gerard T Chew, Gerald F Watts. Coenzyme Q10 improves endothelial dysfunction in statin-treated type 2 diabetic patients.
Diabetes care.
2009 May; 32(5):810-2. doi:
10.2337/dc08-1736. [PMID: 19228872] - Barbara Dołegowska, Wojciech Błogowski, Leszek Domański. Is it possible to predict the early post-transplant allograft function using 20-HETE measurements? A preliminary report.
Transplant international : official journal of the European Society for Organ Transplantation.
2009 May; 22(5):546-53. doi:
10.1111/j.1432-2277.2008.00829.x. [PMID: 19175563] - Pengcheng Luo, Yiqiang Zhou, Hsin-Hsin Chang, Jie Zhang, Tsugio Seki, Cong-Yi Wang, Edward W Inscho, Mong-Heng Wang. Glomerular 20-HETE, EETs, and TGF-beta1 in diabetic nephropathy.
American journal of physiology. Renal physiology.
2009 Mar; 296(3):F556-63. doi:
10.1152/ajprenal.90613.2008. [PMID: 19129258] - Kevin R Regner, Anna Zuk, Scott K Van Why, Brian D Shames, Robert P Ryan, John R Falck, Vijay L Manthati, Meghan E McMullen, Steven R Ledbetter, Richard J Roman. Protective effect of 20-HETE analogues in experimental renal ischemia reperfusion injury.
Kidney international.
2009 Mar; 75(5):511-7. doi:
10.1038/ki.2008.600. [PMID: 19052533] - Mohammed A Nayeem, Dovenia S Ponnoth, Matthew A Boegehold, Darryl C Zeldin, John R Falck, S Jamal Mustafa. High-salt diet enhances mouse aortic relaxation through adenosine A2A receptor via CYP epoxygenases.
American journal of physiology. Regulatory, integrative and comparative physiology.
2009 Mar; 296(3):R567-74. doi:
10.1152/ajpregu.90798.2008. [PMID: 19109366] - Frank Park, William E Sweeney, Guangfu Jia, Talha Akbulut, Benjamin Mueller, J Russell Falck, Saritha Birudaraju, Richard J Roman, Ellis D Avner. Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD.
American journal of physiology. Renal physiology.
2009 Mar; 296(3):F575-82. doi:
10.1152/ajprenal.90705.2008. [PMID: 19129252] - Noriko Sakano, Da-Hong Wang, Noriko Takahashi, Bingling Wang, Rani Sauriasari, Sakiko Kanbara, Yoshie Sato, Tomoko Takigawa, Jiro Takaki, Keiki Ogino. Oxidative stress biomarkers and lifestyles in Japanese healthy people.
Journal of clinical biochemistry and nutrition.
2009 Mar; 44(2):185-95. doi:
10.3164/jcbn.08-252. [PMID: 19308273] - I-Jung Tsai, Kevin D Croft, Trevor A Mori, John R Falck, Lawrence J Beilin, Ian B Puddey, Anne E Barden. 20-HETE and F2-isoprostanes in the metabolic syndrome: the effect of weight reduction.
Free radical biology & medicine.
2009 Jan; 46(2):263-70. doi:
10.1016/j.freeradbiomed.2008.10.028. [PMID: 19013235] - Su Wang, Fei Meng, Jingyuan Xu, Yuchun Gu. Effects of lipids on ENaC activity in cultured mouse cortical collecting duct cells.
The Journal of membrane biology.
2009 Jan; 227(2):77-85. doi:
10.1007/s00232-008-9145-1. [PMID: 19122972] - M H M Yousif, I F Benter, K M J Dunn, A J Dahly-Vernon, S Akhtar, R J Roman. Role of 20-hydroxyeicosatetraenoic acid in altering vascular reactivity in diabetes.
Autonomic & autacoid pharmacology.
2009 Jan; 29(1-2):1-12. doi:
10.1111/j.1474-8673.2009.00426.x. [PMID: 19302551] - James P Hardwick, Douglas Osei-Hyiaman, Homer Wiland, Mohamed A Abdelmegeed, Byoung-Joon Song. PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease.
PPAR research.
2009; 2009(?):952734. doi:
10.1155/2009/952734. [PMID: 20300478] - Jan Michael Williams, Albert Sarkis, Kimberly M Hoagland, Katherine Fredrich, Robert P Ryan, Carol Moreno, Bernardo Lopez, Jozef Lazar, Francisco J Fenoy, Mukut Sharma, Michael R Garrett, Howard J Jacob, Richard J Roman. Transfer of the CYP4A region of chromosome 5 from Lewis to Dahl S rats attenuates renal injury.
American journal of physiology. Renal physiology.
2008 Dec; 295(6):F1764-77. doi:
10.1152/ajprenal.90525.2008. [PMID: 18842817] - E Kompanowska-Jezierska, M Kuczeriszka. Cytochrome P-450 metabolites in renal circulation and excretion--interaction with the nitric oxide (NO) system.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2008 Dec; 59 Suppl 9(?):137-49. doi:
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Journal of lipid research.
2008 Nov; 49(11):2379-89. doi:
10.1194/jlr.m800199-jlr200. [PMID: 18577768] - Vandana Hirani, Anton Yarovoy, Anita Kozeska, Ronald P Magnusson, Jerome M Lasker. Expression of CYP4F2 in human liver and kidney: assessment using targeted peptide antibodies.
Archives of biochemistry and biophysics.
2008 Oct; 478(1):59-68. doi:
10.1016/j.abb.2008.06.025. [PMID: 18662666] - Raymond C Koehler, Clara Fronticelli, Enrico Bucci. Insensitivity of cerebral oxygen transport to oxygen affinity of hemoglobin-based oxygen carriers.
Biochimica et biophysica acta.
2008 Oct; 1784(10):1387-94. doi:
10.1016/j.bbapap.2008.01.001. [PMID: 18230370] - Frank Park, William E Sweeney, Guangfu Jia, Richard J Roman, Ellis D Avner. 20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease.
Journal of the American Society of Nephrology : JASN.
2008 Oct; 19(10):1929-39. doi:
10.1681/asn.2007070771. [PMID: 18596124] - Yiqiang Zhou, Pengcheng Luo, Hsin-Hsin Chang, Hui Huang, Tianxin Yang, Zheng Dong, Cong-Yi Wang, Mong-Heng Wang. Colfibrate attenuates blood pressure and sodium retention in DOCA-salt hypertension.
Kidney international.
2008 Oct; 74(8):1040-8. doi:
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Journal of lipid research.
2008 Oct; 49(10):2135-41. doi:
10.1194/jlr.m800043-jlr200. [PMID: 18566475] - Bahar Tunctan, Belma Korkmaz, C Kemal Buharalioglu, Seyhan Sahan Firat, Siddam Anjaiah, John Falck, Richard J Roman, Kafait U Malik. A 20-hydroxyeicosatetraenoic acid agonist, N-[20-hydroxyeicosa-5(Z),14(Z)-dienoyl]glycine, opposes the fall in blood pressure and vascular reactivity in endotoxin-treated rats.
Shock (Augusta, Ga.).
2008 Sep; 30(3):329-35. doi:
10.1097/shk.0b013e31816471c6. [PMID: 18323740] - Hsin-Yi Yang, Jiun-Rong Chen. Renoprotective effects of soy protein hydrolysates in N(omega)-nitro-L-arginine methyl ester hydrochloride-induced hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2008 Jul; 31(7):1477-83. doi:
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European journal of pharmacology.
2008 Jun; 588(1):9-17. doi:
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