5-Hydroxy-1-methylhydantoin (BioDeep_00000174710)
human metabolite blood metabolite
代谢物信息卡片
化学式: C4H6N2O3 (130.03784059999998)
中文名称: 5-羟基-1-甲基咪唑啉-2,4-二酮
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
分子结构信息
SMILES: CN1C(C(=O)NC1=O)O
InChI: InChI=1S/C4H6N2O3/c1-6-3(8)2(7)5-4(6)9/h3,8H,1H3,(H,5,7,9)
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 3036247
- HMDB: HMDB0246800
- chemspider: 2300307
- CAS: 121146-02-9
- CAS: 84210-26-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lina Gao, Huiya Yuan, Enyu Xu, Junting Liu. Toxicology of paraquat and pharmacology of the protective effect of 5-hydroxy-1-methylhydantoin on lung injury caused by paraquat based on metabolomics.
Scientific reports.
2020 02; 10(1):1790. doi:
10.1038/s41598-020-58599-y. [PMID: 32019966] - Lina Gao, Huiya Yuan, Zhipengn Cao, Enyu Xu, Junting Liu. [Exploration about the protection mechanism of 5-hydroxy-1-methylhydantoin on paraquat poisoning model].
Zhonghua wei zhong bing ji jiu yi xue.
2018 Dec; 30(12):1184-1189. doi:
10.3760/cma.j.issn.2095-4352.2018.012.016. [PMID: 30592955] - Lina Gao, Shuang Yang, Junting Liu, Libo Liu. [Preventive effects of 5-hydroxy-1-methylhydantoin on paraquat-induced nephrotoxicity in rat].
Zhonghua wei zhong bing ji jiu yi xue.
2015 Apr; 27(4):246-9. doi:
10.3760/cma.j.issn.2095-4352.2015.04.004. [PMID: 25891451] - Kazuharu Ienaga, Mimi Sohn, Mitsuru Naiki, Ayad A Jaffa. Creatinine metabolite, HMH (5-hydroxy-1-methylhydantoin; NZ-419), modulates bradykinin-induced changes in vascular smooth muscle cells.
Journal of receptor and signal transduction research.
2014 Jun; 34(3):195-200. doi:
10.3109/10799893.2013.876039. [PMID: 24641698] - Kazuharu Ienaga, Chan Hum Park, Takako Yokozawa. Protective effect of an intrinsic antioxidant, HMH (5-hydroxy-1-methylhydantoin; NZ-419), against cellular damage of kidney tubules.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2013 Jul; 65(5):559-66. doi:
10.1016/j.etp.2012.05.001. [PMID: 22749566] - G Hasegawa, K Nakano, K Ienaga. Serum accumulation of a creatinine oxidative metabolite (NZ-419: 5-hydroxy-1- methylhydatoin) as an intrinsic antioxidant in diabetic patients with or without chronic kidney disease.
Clinical nephrology.
2011 Oct; 76(4):284-9. doi:
10.5414/cn107025. [PMID: 21955863] - Kazuharu Ienaga, Takako Yokozawa. Treatment with NZ-419 (5-Hydroxy-1-methylimidazoline-2,4-dione), a novel intrinsic antioxidant, against the progression of chronic kidney disease at stages 3 and 4 in rats.
Biological & pharmaceutical bulletin.
2010; 33(5):809-15. doi:
10.1248/bpb.33.809. [PMID: 20460759] - Kazuharu Ienaga, Hiroki Mikami, Takako Yokozawa. First indications demonstrating the preventive effects of NZ-419, a novel intrinsic antioxidant, on the initiation and/or progression of chronic renal failure in rats.
Biological & pharmaceutical bulletin.
2009 Jul; 32(7):1204-8. doi:
10.1248/bpb.32.1204. [PMID: 19571386] - K Nakamura, K Ienaga. Creatol (5-hydroxycreatinine), a new toxin candidate in uremic patients.
Experientia.
1990 May; 46(5):470-2. doi:
10.1007/bf01954234. [PMID: 2347396]