5-Hydroperoxyeicosatetraenoic acid (BioDeep_00000174708)

   

human metabolite blood metabolite natural product


代谢物信息卡片


5-hydroperoxyicosa-2,4,6,8-tetraenoic acid

化学式: C20H32O4 (336.23)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 100%

分子结构信息

SMILES: CCCCCCCCCCCC=CC=CC(=CC=CC(=O)O)OO
InChI: InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h12-18,23H,2-11H2,1H3,(H,21,22)

描述信息

同义名列表

3 个代谢物同义名

5-hydroperoxyicosa-2,4,6,8-tetraenoic acid; 5-Hydroperoxyeicosatetraenoic acid; 5-Hydroperoxyeicosatetraenoate



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

22 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Hoffman Peter, Bezáková Lýdia. [Modulation of leukotriene pathway - potential targets]. Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti. 2012 Jun; 61(3):101-6. doi: . [PMID: 22913825]
  • E Patterson, R Wall, G F Fitzgerald, R P Ross, C Stanton. Health implications of high dietary omega-6 polyunsaturated Fatty acids. Journal of nutrition and metabolism. 2012; 2012(?):539426. doi: 10.1155/2012/539426. [PMID: 22570770]
  • Venkata R Narala, Ravi K Adapala, Madathilparambil V Suresh, Thomas G Brock, Marc Peters-Golden, Raju C Reddy. Leukotriene B4 is a physiologically relevant endogenous peroxisome proliferator-activated receptor-alpha agonist. The Journal of biological chemistry. 2010 Jul; 285(29):22067-74. doi: 10.1074/jbc.m109.085118. [PMID: 20400503]
  • Yuxiang Zheng, Alan R Brash. Formation of a cyclopropyl epoxide via a leukotriene A synthase-related pathway in an anaerobic reaction of soybean lipoxygenase-1 with 15S-hydroperoxyeicosatetraenoic acid: evidence that oxygen access is a determinant of secondary reactions with fatty acid hydroperoxides. The Journal of biological chemistry. 2010 Apr; 285(18):13427-36. doi: 10.1074/jbc.m109.084632. [PMID: 20194505]
  • Alexandra-Zoi Andreou, Ellen Hornung, Susan Kunze, Sabine Rosahl, Ivo Feussner. On the substrate binding of linoleate 9-lipoxygenases. Lipids. 2009 Mar; 44(3):207-15. doi: 10.1007/s11745-008-3264-4. [PMID: 19037675]
  • Charles G Knutson, Emily H Rubinson, Dapo Akingbade, Carolyn S Anderson, Donald F Stec, Katya V Petrova, Ivan D Kozekov, F Peter Guengerich, Carmelo J Rizzo, Lawrence J Marnett. Oxidation and glycolytic cleavage of etheno and propano DNA base adducts. Biochemistry. 2009 Feb; 48(4):800-9. doi: 10.1021/bi801654j. [PMID: 19132922]
  • Xiaohong Liu, Peimin Zhu, Bruce D Freedman. Multiple eicosanoid-activated nonselective cation channels regulate B-lymphocyte adhesion to integrin ligands. American journal of physiology. Cell physiology. 2006 Mar; 290(3):C873-82. doi: 10.1152/ajpcell.00229.2005. [PMID: 16251477]
  • Simona Zarini, Robert C Murphy. Biosynthesis of 5-oxo-6,8,11,14-eicosatetraenoic acid from 5-hydroperoxyeicosatetraenoic acid in the murine macrophage. The Journal of biological chemistry. 2003 Mar; 278(13):11190-6. doi: 10.1074/jbc.m208496200. [PMID: 12547823]
  • A Miller, C Stanton, R Devery. Modulation of arachidonic acid distribution by conjugated linoleic acid isomers and linoleic acid in MCF-7 and SW480 cancer cells. Lipids. 2001 Oct; 36(10):1161-8. doi: 10.1007/s11745-001-0827-0. [PMID: 11768161]