5-(N-Methyl-N-isobutyl)amiloride (BioDeep_00000174651)
human metabolite blood metabolite
代谢物信息卡片
化学式: C11H18ClN7O (299.1261288)
中文名称: 5-(N-甲基-N-异戊基)阿米洛利
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CN(C)C1=NC(=C(N=C1Cl)C(=O)N=C(N)N)N
InChI: InChI=1S/C11H18ClN7O/c1-5(2)4-19(3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 73314
- HMDB: HMDB0246735
- ChEMBL: CHEMBL1256180
- chemspider: 66046
- CAS: 96861-65-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Edmund C Jenkins, Shawon Debnath, Stephen Gundry, Sajini Gundry, Umit Uyar, Jimmie E Fata. Intracellular pH regulation by Na⁺/H⁺ exchanger-1 (NHE1) is required for growth factor-induced mammary branching morphogenesis.
Developmental biology.
2012 May; 365(1):71-81. doi:
10.1016/j.ydbio.2012.02.010. [PMID: 22366186] - Hans R Pedersen, Helmer Ring-Larsen, Niels Vidiendal Olsen, Fin Stolze Larsen. Hyperammonemia acts synergistically with lipopolysaccharide in inducing changes in cerebral hemodynamics in rats anaesthetised with pentobarbital.
Journal of hepatology.
2007 Aug; 47(2):245-52. doi:
10.1016/j.jhep.2007.03.026. [PMID: 17532089] - Novikova IYu, O V Muravyeva, E J Cragoe, L B Margolis. Study of fibroblast spreading: pH dependence, involvement of the Na+/H(+)-antiporter and PKC.
Biochimica et biophysica acta.
1993 Sep; 1178(3):267-72. doi:
10.1016/0167-4889(93)90203-2. [PMID: 8395891] - V Torres-Zamorano, V Ganapathy, P Reinach. Characterization and subtype identification of the Na(+)-H+ exchanger in bovine corneal epithelium.
Current eye research.
1993 Jan; 12(1):69-76. doi:
10.3109/02713689308999498. [PMID: 8382145] - M Mackovic-Basic, L G Fine, J T Norman, E J Cragoe, I Kurtz. Stimulation of Na+/H+ exchange is not required for induction of hypertrophy of renal cells in vitro.
Journal of the American Society of Nephrology : JASN.
1992 Nov; 3(5):1124-30. doi:
10.1681/asn.v351124. [PMID: 1336406] - R D Bloch, D Zikos, K A Fisher, L Schleicher, M Oyama, J C Cheng, H A Skopicki, E J Sukowski, E J Cragoe, D R Peterson. Activation of proximal tubular Na(+)-H+ exchange by angiotensin II.
The American journal of physiology.
1992 Jul; 263(1 Pt 2):F135-43. doi:
10.1152/ajprenal.1992.263.1.f135. [PMID: 1322054] - G V Desir, E J Cragoe, P S Aronson. High affinity binding of amiloride analogs at an internal site in renal microvillus membrane vesicles.
The Journal of biological chemistry.
1991 Feb; 266(4):2267-71. doi:
10.1016/s0021-9258(18)52238-9. [PMID: 1846621] - N Cook, T M Dexter, B I Lord, E J Cragoe, A D Whetton. Identification of a common signal associated with cellular proliferation stimulated by four haemopoietic growth factors in a highly enriched population of granulocyte/macrophage colony-forming cells.
The EMBO journal.
1989 Oct; 8(10):2967-74. doi:
10.1002/j.1460-2075.1989.tb08446.x. [PMID: 2555152] - J S Wu, J E Lever. Photoaffinity labeling by [3H]-N5-methyl-N5-isobutylamiloride of proteins which cofractionate with Na+/H+ antiport activity.
Biochemistry.
1989 Apr; 28(7):2980-4. doi:
10.1021/bi00433a036. [PMID: 2545241] - Z Talor, S C Ng, E J Cragoe, J A Arruda. Methyl isobutyl amiloride: a new probe to assess the number of Na-H antiporters.
Life sciences.
1989; 45(6):517-23. doi:
10.1016/0024-3205(89)90102-1. [PMID: 2549314]
