2,4,5-Trimethyl-4,5-dihydrothiazole (BioDeep_00000174577)
human metabolite blood metabolite
代谢物信息卡片
2,4,5-trimethyl-4,5-dihydro-1,3-thiazole
化学式: C6H11NS (129.0612)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES: CC1C(SC(=N1)C)C
InChI: InChI=1S/C6H11NS/c1-4-5(2)8-6(3)7-4/h4-5H,1-3H3
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Emmanuel Galliot, Lucie Laurent, Romain Hacquemand, Gregory Pourié, Jean-Louis Millot. Fear-like behavioral responses in mice in different odorant environments: Trigeminal versus olfactory mediation under low doses.
Behavioural processes.
2012 Jun; 90(2):161-6. doi:
10.1016/j.beproc.2012.01.002. [PMID: 22248569] - Melanie S Kessler, Sébastien Debilly, Stephanie Schöppenthau, Thomas Bielser, Andreas Bruns, Basil Künnecke, Markus von Kienlin, Joseph G Wettstein, Jean-Luc Moreau, Céline Risterucci. fMRI fingerprint of unconditioned fear-like behavior in rats exposed to trimethylthiazoline.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2012 Mar; 22(3):222-30. doi:
10.1016/j.euroneuro.2011.07.011. [PMID: 21856130] - Christopher J Fitzpatrick, Dayan Knox, Israel Liberzon. Inactivation of the prelimbic cortex enhances freezing induced by trimethylthiazoline, a component of fox feces.
Behavioural brain research.
2011 Aug; 221(1):320-3. doi:
10.1016/j.bbr.2011.03.024. [PMID: 21420435] - Marcelo Febo, Ashley S Pira. Increased BOLD activation to predator stressor in subiculum and midbrain of amphetamine-sensitized maternal rats.
Brain research.
2011 Mar; 1382(?):118-27. doi:
10.1016/j.brainres.2010.11.092. [PMID: 21134359] - Kelly S Sink, David L Walker, Yong Yang, Michael Davis. Calcitonin gene-related peptide in the bed nucleus of the stria terminalis produces an anxiety-like pattern of behavior and increases neural activation in anxiety-related structures.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2011 Feb; 31(5):1802-10. doi:
10.1523/jneurosci.5274-10.2011. [PMID: 21289190] - Harry Pantazopoulos, Hamid Dolatshad, Fred C Davis. A fear-inducing odor alters PER2 and c-Fos expression in brain regions involved in fear memory.
PloS one.
2011; 6(5):e20658. doi:
10.1371/journal.pone.0020658. [PMID: 21655193] - Christine H Kapelewski, Jeanette M Bennett, Sonia A Cavigelli, Laura C Klein. Application of a naturalistic psychogenic stressor in periadolescent mice: effect on serum corticosterone levels differs by strain but not sex.
BMC research notes.
2010 Jun; 3(?):170. doi:
10.1186/1756-0500-3-170. [PMID: 20565762] - Loïc Dayon, Carla Pasquarello, Christine Hoogland, Jean-Charles Sanchez, Alexander Scherl. Combining low- and high-energy tandem mass spectra for optimized peptide quantification with isobaric tags.
Journal of proteomics.
2010 Feb; 73(4):769-77. doi:
10.1016/j.jprot.2009.10.015. [PMID: 19903544] - Romain Hacquemand, Laurence Jacquot, Gérard Brand. Comparative Fear-Related Behaviors to Predator Odors (TMT and Natural Fox Feces) before and after Intranasal ZnSO(4) Treatment in Mice.
Frontiers in behavioral neuroscience.
2010; 4(?):188. doi:
10.3389/fnbeh.2010.00188. [PMID: 21206761] - Jerome H Pagani, Jeffrey B Rosen. The medial hypothalamic defensive circuit and 2,5-dihydro-2,4,5-trimethylthiazoline (TMT) induced fear: comparison of electrolytic and neurotoxic lesions.
Brain research.
2009 Aug; 1286(?):133-46. doi:
10.1016/j.brainres.2009.06.062. [PMID: 19559688] - Thomas Endres, Markus Fendt. Aversion- vs fear-inducing properties of 2,4,5-trimethyl-3-thiazoline, a component of fox odor, in comparison with those of butyric acid.
The Journal of experimental biology.
2009 Aug; 212(Pt 15):2324-7. doi:
10.1242/jeb.028498. [PMID: 19617424] - Y Nikaido, T Nakashima. Effects of environmental novelty on fear-related behavior and stress responses of rats to emotionally relevant odors.
Behavioural brain research.
2009 May; 199(2):241-6. doi:
10.1016/j.bbr.2008.11.043. [PMID: 19103229] - Jeffrey B Rosen, Jerome H Pagani, Katherine L G Rolla, Cameron Davis. Analysis of behavioral constraints and the neuroanatomy of fear to the predator odor trimethylthiazoline: a model for animal phobias.
Neuroscience and biobehavioral reviews.
2008 Sep; 32(7):1267-76. doi:
10.1016/j.neubiorev.2008.05.006. [PMID: 18619675] - Gaelle Buron, Romain Hacquemand, Gregory Pourie, Annie Lucarz, Laurence Jacquot, Gerard Brand. Comparative behavioral effects between synthetic 2,4,5-trimethylthiazoline (TMT) and the odor of natural fox (Vulpes vulpes) feces in mice.
Behavioral neuroscience.
2007 Oct; 121(5):1063-72. doi:
10.1037/0735-7044.121.5.1063. [PMID: 17907837] - Leandro Franco Vendruscolo, Janaína Carrinho Muniz Vendruscolo, Elena Terenina-Rigaldie, Frantz Raba, André Ramos, Reinaldo Naoto Takahashi, Pierre Mormède. Genetic influences on behavioral and neuroendocrine responses to predator-odor stress in rats.
Neuroscience letters.
2006 Dec; 409(2):89-94. doi:
10.1016/j.neulet.2006.07.026. [PMID: 17052845] - Martin Müller, Markus Fendt. Temporary inactivation of the medial and basolateral amygdala differentially affects TMT-induced fear behavior in rats.
Behavioural brain research.
2006 Feb; 167(1):57-62. doi:
10.1016/j.bbr.2005.08.016. [PMID: 16213603] - Elizabeth A Myers, Linda Rinaman. Trimethylthiazoline supports conditioned flavor avoidance and activates viscerosensory, hypothalamic, and limbic circuits in rats.
American journal of physiology. Regulatory, integrative and comparative physiology.
2005 Jun; 288(6):R1716-26. doi:
10.1152/ajpregu.00479.2004. [PMID: 15661969] - D Caroline Blanchard, Chris Markham, Mu Yang, David Hubbard, Eric Madarang, Robert J Blanchard. Failure to produce conditioning with low-dose trimethylthiazoline or cat feces as unconditioned stimuli.
Behavioral neuroscience.
2003 Apr; 117(2):360-8. doi:
10.1037/0735-7044.117.2.360. [PMID: 12708532] - Markus Fendt, Thomas Endres, Raimund Apfelbach. Temporary inactivation of the bed nucleus of the stria terminalis but not of the amygdala blocks freezing induced by trimethylthiazoline, a component of fox feces.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2003 Jan; 23(1):23-8. doi:
10.1523/jneurosci.23-01-00023.2003. [PMID: 12514197] - Bret A Morrow, John D Elsworth, Robert H Roth. Fear-like biochemical and behavioral responses in rats to the predator odor, TMT, are dependent on the exposure environment.
Synapse (New York, N.Y.).
2002 Oct; 46(1):11-8. doi:
10.1002/syn.10109. [PMID: 12211094]
