4-Methoxy-N-methylbenzeneethanamine (BioDeep_00000174571)
human metabolite blood metabolite natural product
代谢物信息卡片
化学式: C10H15NO (165.115358)
中文名称: N-甲基-2-(4-甲氧基苯基)乙胺
谱图信息:
最多检出来源 Homo sapiens(blood) 3.57%
分子结构信息
SMILES: CNCCC1=CC=C(C=C1)OC
InChI: InChI=1S/C10H15NO/c1-11-8-7-9-3-5-10(12-2)6-4-9/h3-6,11H,7-8H2,1-2H3
描述信息
同义名列表
18 个代谢物同义名
[2-(4-methoxyphenyl)ethyl](methyl)amine; phenethylamine, p-methoxy-n-methyl-; 4-Methoxy-N-methylbenzeneethanamine; N-(p-Methoxyphenethyl)methylamine; N-(4-Methoxyphenethyl)methylamine; p Methoxy N methylphenethylamine; N-Methyl-p-methoxyphenethylamine; p-Methoxy-N-methylphenethylamine; 4-Methoxy-N-methylphenethylamine; Preparation 48 80; Preparation 48-80; Preparation 4880; Compound 48-80; Compound 48 80; Compound 4880; Agent 48 80; Agent 48-80; Agent 4880
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:75143
- PubChem: 104735
- HMDB: HMDB0246647
- MeSH: p-Methoxy-N-methylphenethylamine
- chemspider: 94550
- CAS: 4091-50-3
- LOTUS: LTS0039603
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
33 个相关的物种来源信息
- 25641 - Aloe: LTS0039603
- 1389509 - Aloe harlana: 10.1055/S-2006-961396
- 1389509 - Aloe harlana: LTS0039603
- 117801 - Aloe inermis: 10.1055/S-2006-961396
- 117801 - Aloe inermis: LTS0039603
- 117802 - Aloe jucunda: 10.1055/S-2006-961396
- 117802 - Aloe jucunda: LTS0039603
- 1593093 - Aloe mcloughlinii: 10.1055/S-2006-961396
- 1593093 - Aloe mcloughlinii: LTS0039603
- 117807 - Aloe peckii: 10.1055/S-2006-961396
- 117807 - Aloe peckii: LTS0039603
- 2029215 - Aloe rauhii: 10.1055/S-2006-961396
- 2029215 - Aloe rauhii: LTS0039603
- 117812 - Aloe somaliensis: 10.1055/S-2006-961396
- 117812 - Aloe somaliensis: LTS0039603
- 1811903 - Aloe turkanensis: 10.1055/S-2006-961396
- 1811903 - Aloe turkanensis: LTS0039603
- 51383 - Asphodelaceae: LTS0039603
- 63080 - Eriogonum: LTS0039603
- 1214293 - Eriogonum annuum: 10.1021/NP50033A034
- 1214293 - Eriogonum annuum: LTS0039603
- 1214447 - Eriogonum brevicaule: 10.1021/NP50033A034
- 1214447 - Eriogonum brevicaule: LTS0039603
- 1214448 - Eriogonum brevicaule var. brevicaule: 10.1021/NP50033A034
- 1214448 - Eriogonum brevicaule var. brevicaule: LTS0039603
- 2759 - Eukaryota: LTS0039603
- 9606 - Homo sapiens: -
- 4447 - Liliopsida: LTS0039603
- 3398 - Magnoliopsida: LTS0039603
- 3615 - Polygonaceae: LTS0039603
- 35493 - Streptophyta: LTS0039603
- 58023 - Tracheophyta: LTS0039603
- 33090 - Viridiplantae: LTS0039603
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Amit Kaushik, Dewasya P Singh, Mridula Sahu, Ashish Kumar, Pratibha, Pallavi Pandey, Manish K Patel, Debabrata Chanda, Velusamy Sundaresan, Daya N Mani, Ashutosh K Shukla. Protective effect of Achyranthes aspera against compound 48/80, histamine and ovalbumin-induced allergic disorders in murine model.
Molecular biology reports.
2024 Jan; 51(1):202. doi:
10.1007/s11033-023-09137-2
. [PMID: 38270668] - Xiangyu Liang, Xiangsheng Li, Shusen Sun, Han Zhang, Bikun Wang, Feng Xu, Yanfen Zhang, Zhongcheng Liu. Effects and potential mechanisms of Saposhnikovia divaricata (Turcz.) Schischk. On type I allergy and pseudoallergic reactions in vitro and in vivo.
Journal of ethnopharmacology.
2023 Jul; 318(Pt A):116942. doi:
10.1016/j.jep.2023.116942
. [PMID: 37487961] - Zi-Wen Zhou, Xue-Yan Zhu, Shu-Ying Li, Si-En Lin, Yu-Han Zhu, Kunmei Ji, Jia-Jie Chen. Formononetin Inhibits Mast Cell Degranulation to Ameliorate Compound 48/80-Induced Pseudoallergic Reactions.
Molecules (Basel, Switzerland).
2023 Jul; 28(13):. doi:
10.3390/molecules28135271
. [PMID: 37446928] - Xinyu Sun, Wanlin Lv, Yalan Wang, Xiao Zhang, Zhen Ouyang, Runting Yin, Yuan Wei. Mrgprb2 gene plays a role in the anaphylactoid reactions induced by Houttuynia cordata injection.
Journal of ethnopharmacology.
2022 May; 289(?):115053. doi:
10.1016/j.jep.2022.115053
. [PMID: 35104575] - Mariano Ezequiel Vera, María Laura Mariani, Cristina Aguilera, Alicia Beatriz Penissi. Effect of a Cytoprotective Dose of Dehydroleucodine, Xanthatin, and 3-Benzyloxymethyl-5H-furan-2-one on Gastric Mucosal Lesions Induced by Mast Cell Activation.
International journal of molecular sciences.
2021 Jun; 22(11):. doi:
10.3390/ijms22115983
. [PMID: 34205991] - Bao-Jun Zhu, Ze-Quan Qian, Hui-Run Yang, Ru-Xia Li. Tripterine: A Potential Anti-Allergic Compound.
Current pharmaceutical biotechnology.
2021; 22(1):159-167. doi:
10.2174/1389201021666200327163322
. [PMID: 32216736] - Jae Yeon Lee, Eun-Kyung Ahn, Ju-Hyoung Park, Joa Sub Oh. Wheat Bran Extract Regulates Mast Cell-Mediated Allergic Responses In Vitro and In Vivo.
Molecules (Basel, Switzerland).
2020 Sep; 25(17):. doi:
10.3390/molecules25173997
. [PMID: 32887288] - Jiao Cao, Yuejin Wang, Shiling Hu, Yuanyuan Ding, Qianqian Jia, Jing Zhu, Hongli An. Kaempferol ameliorates secretagogue-induced pseudo-allergic reactions via inhibiting intracellular calcium fluctuation.
The Journal of pharmacy and pharmacology.
2020 Sep; 72(9):1221-1231. doi:
10.1111/jphp.13312
. [PMID: 32557699] - Frane Banovic, Tara Denley, Amanda Blubaugh, Ileia Scheibe, Niksa Lemo, Mark G Papich. Effect of diphenhydramine and cetirizine on immediate and late-phase cutaneous allergic reactions in healthy dogs: a randomized, double-blinded crossover study.
Veterinary dermatology.
2020 Aug; 31(4):256-e58. doi:
10.1111/vde.12840
. [PMID: 31899570] - Yan Sun, Chen-Guang Wu, Qun Han, Sheng-Yang Huang. [Real-time cell analysis combined with pattern recognition to evaluate anaphylaxis of Zushima Injection].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2020 Jun; 45(12):2865-2871. doi:
10.19540/j.cnki.cjcmm.20200328.310
. [PMID: 32627461] - Eun Kyeong Lee, Jeongah Song, Youjin Seo, Eun Mi Koh, Seon-Hee Kim, Kyung Jin Jung. Inhibitory Effects of AF-343, a Mixture of Cassia tora L., Ulmus pumila L., and Taraxacum officinale, on Compound 48/80-Mediated Allergic Responses in RBL-2H3 Cells.
Molecules (Basel, Switzerland).
2020 May; 25(10):. doi:
10.3390/molecules25102434
. [PMID: 32456051] - Aye Aye, Young-Jae Song, Yong-Deok Jeon, Jong-Sik Jin. Xanthone suppresses allergic contact dermatitis in vitro and in vivo.
International immunopharmacology.
2020 Jan; 78(?):106061. doi:
10.1016/j.intimp.2019.106061
. [PMID: 31821937] - Tetsuya Tachibana, Misaki Hirai, Asumi Tomita, Yoko Ishimaru, Md Sakirul Islam Khan, Ryosuke Makino, Mark A Cline. Physiological responses to central and peripheral injections of compound 48/80 and histamine in chicks.
Physiology & behavior.
2019 11; 211(?):112681. doi:
10.1016/j.physbeh.2019.112681
. [PMID: 31525390] - Denis Nchang Che, Byoung Ok Cho, Jae Young Shin, Hyun Ju Kang, Ji-Su Kim, Hyeonhwa Oh, Young-Soo Kim, Seon Il Jang. Apigenin Inhibits IL-31 Cytokine in Human Mast Cell and Mouse Skin Tissues.
Molecules (Basel, Switzerland).
2019 Apr; 24(7):. doi:
10.3390/molecules24071290
. [PMID: 30987029] - C S P Della Pasqua, R D Iwamoto, E Antunes, A A Borghi, A C H F Sawaya, E C T Landucci. Pharmacological study of anti-inflammatory activity of aqueous extracts of Mikania glomerata (Spreng.) and Mikania laevigata (Sch. Bip. ex Baker).
Journal of ethnopharmacology.
2019 Mar; 231(?):50-56. doi:
10.1016/j.jep.2018.11.012
. [PMID: 30415057] - Katja Zschiebsch, Caroline Fischer, Annett Wilken-Schmitz, Gerd Geisslinger, Keith Channon, Katrin Watschinger, Irmgard Tegeder. Mast cell tetrahydrobiopterin contributes to itch in mice.
Journal of cellular and molecular medicine.
2019 02; 23(2):985-1000. doi:
10.1111/jcmm.13999
. [PMID: 30450838] - Meng Fu, Shuilian Fu, Saihong Ni, Danni Wang, Tie Hong. Inhibitory effects of bisdemethoxycurcumin on mast cell-mediated allergic diseases.
International immunopharmacology.
2018 Dec; 65(?):182-189. doi:
10.1016/j.intimp.2018.10.005
. [PMID: 30316076] - Dóra Rédei, Norbert Kúsz, Nikoletta Jedlinszki, Gábor Blazsó, István Zupkó, Judit Hohmann. Bioactivity-Guided Investigation of the Anti-Inflammatory Activity of Hippophae rhamnoides Fruits.
Planta medica.
2018 Jan; 84(1):26-33. doi:
10.1055/s-0043-114424
. [PMID: 28662529] - Feng-Ming Zhou, Ruo-Xiao Cheng, Shuai Wang, Ya Huang, Yong-Jing Gao, Yan Zhou, Teng-Teng Liu, Xue-Long Wang, Li-Hua Chen, Tong Liu. Antioxidants Attenuate Acute and Chronic Itch: Peripheral and Central Mechanisms of Oxidative Stress in Pruritus.
Neuroscience bulletin.
2017 Aug; 33(4):423-435. doi:
10.1007/s12264-016-0076-z
. [PMID: 27783328] - N E Gómez González, I Cabas, J Montero, A García Alcázar, V Mulero, A García Ayala. Histamine and mast cell activator compound 48/80 are safe but inefficient systemic adjuvants for gilthead seabream vaccination.
Developmental and comparative immunology.
2017 07; 72(?):1-8. doi:
10.1016/j.dci.2017.02.002
. [PMID: 28193449] - E Kilinc, Y Dagistan, B Kotan, A Cetinkaya. Effects of Nigella sativa seeds and certain species of fungi extracts on number and activation of dural mast cells in rats.
Physiology international.
2017 Mar; 104(1):15-24. doi:
10.1556/2060.104.2017.1.8
. [PMID: 28361577] - Yuki Nakamura, Kayoko Ishimaru, Shigenobu Shibata, Atsuhito Nakao. Regulation of plasma histamine levels by the mast cell clock and its modulation by stress.
Scientific reports.
2017 01; 7(?):39934. doi:
10.1038/srep39934
. [PMID: 28074918] - Shreyasi Chakraborty, Nabanita Kar, Leena Kumari, Asit De, Tanmoy Bera. Inhibitory effect of a new orally active cedrol-loaded nanostructured lipid carrier on compound 48/80-induced mast cell degranulation and anaphylactic shock in mice.
International journal of nanomedicine.
2017; 12(?):4849-4868. doi:
10.2147/ijn.s132114
. [PMID: 28744120] - A Solís-López, U Kriebs, A Marx, S Mannebach, W B Liedtke, M J Caterina, M Freichel, V V Tsvilovskyy. Analysis of TRPV channel activation by stimulation of FCεRI and MRGPR receptors in mouse peritoneal mast cells.
PloS one.
2017; 12(2):e0171366. doi:
10.1371/journal.pone.0171366
. [PMID: 28158279] - Jong Phil Bak, Young Mi Cho, Inhye Kim, Dae Won Park, Jung Eun Kwon, Yong Joon Jeong, Jong Hwan Kwak, Se Chan Kang. Inhibitory effects of norlignans isolated from Anemarrhena asphodeloides on degranulation of rat basophilic leukemia- 2H3Cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Dec; 84(?):1061-1066. doi:
10.1016/j.biopha.2016.10.039
. [PMID: 27780134] - Na-Ra Han, Phil-Dong Moon, Sun-Young Nam, Ka-Jung Ryu, Myoung-Schook Yoou, Jung-Hye Choi, Sung-Yeoun Hwang, Hyung-Min Kim, Hyun-Ja Jeong. Inhibitory effects of atractylone on mast cell-mediated allergic reactions.
Chemico-biological interactions.
2016 Oct; 258(?):59-68. doi:
10.1016/j.cbi.2016.08.015
. [PMID: 27553716] - Chang Ho Song, Thi Tho Bui, Chun Hua Piao, Hee Soon Shin, Dong-Hwa Shon, Eui-Hyeog Han, Hyoung Tae Kim, Ok Hee Chai. Rosae Multiflorae Fructus Hot Water Extract Inhibits a Murine Allergic Asthma Via the Suppression of Th2 Cytokine Production and Histamine Release from Mast Cells.
Journal of medicinal food.
2016 Sep; 19(9):853-9. doi:
10.1089/jmf.2016.3736
. [PMID: 27574849] - Hua-Long Wang, Zhen-Hu Li, Hong-Hua Wu, Xiu-Mei Gao, Yan-Tong Xu. [A high content screening method for detection of anaphylactoid reaction of injection formulations].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2016 May; 41(10):1903-1909. doi:
10.4268/cjcmm20161024
. [PMID: 28895341] - Hye Kyung Kim, Myung-Gyou Kim, Kang-Hyun Leem. Extrusion process of Acanthopanax senticosus leaves enhances the gastroprotective effect of compound 48/80 on acute gastric mucosal lesion in rats.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2016 Apr; 36(2):187-96. doi:
10.1016/s0254-6272(16)30026-7
. [PMID: 27400473] - Fei Tong, Lei Luo, Daojun Liu. Effect of Intervention in Mast Cell Function Before Reperfusion on Renal Ischemia-Reperfusion Injury in Rats.
Kidney & blood pressure research.
2016; 41(3):335-44. doi:
10.1159/000443437
. [PMID: 27304487] - Seok Cheol Yoon, In-Gyu Je, Xun Cui, Hae Ran Park, Dongwoo Khang, Jeong-Suk Park, Sang-Hyun Kim, Tae-Yong Shin. Anti-allergic and anti-inflammatory effects of aqueous extract of Pogostemon cablin.
International journal of molecular medicine.
2016 Jan; 37(1):217-24. doi:
10.3892/ijmm.2015.2401
. [PMID: 26531835] - Yubin Xu, Na Guo, Deqiang Dou, Xiaoku Ran, Xiande Ma, Haixue Kuang. Proteomics Study on Nonallergic Hypersensitivity Induced by Compound 4880 and Ovalbumin.
PloS one.
2016; 11(2):e0148262. doi:
10.1371/journal.pone.0148262
. [PMID: 26829397] - Yaw-Syan Fu, Su-Yu Kuo, Hsuan-Yea Lin, Chun-Lin Chen, Shi-Ying Huang, Zhi-Hong Wen, Kun-Zer Lee, Hung-Tu Huang. Pretreatment with Evans blue, a stimulator of BK(Ca) channels, inhibits compound 48/80-induced shock, systemic inflammation, and mast cell degranulation in the rat.
Histochemistry and cell biology.
2015 Sep; 144(3):237-47. doi:
10.1007/s00418-015-1332-4
. [PMID: 26003544] - D Bento, H F Staats, T Gonçalves, O Borges. Development of a novel adjuvanted nasal vaccine: C48/80 associated with chitosan nanoparticles as a path to enhance mucosal immunity.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2015 Jun; 93(?):149-64. doi:
10.1016/j.ejpb.2015.03.024
. [PMID: 25818119] - Ji-Ye Kee, Akiko Inujima, Tsugunobu Andoh, Ken Tanaka, Feng Li, Yasushi Kuraishi, Hiroaki Sakurai, Naotoshi Shibahara, Ikuo Saiki, Keiichi Koizumi. Inhibitory effect of Moutan Cortex aqueous fraction on mast cell-mediated allergic inflammation.
Journal of natural medicines.
2015 Apr; 69(2):209-17. doi:
10.1007/s11418-014-0880-6
. [PMID: 25516374] - Mei Zheng, Fen Liu, Yiqing Shen, Shilei Wang, Wenting Xu, Fang Fang, Bing Sun, Zhenyuan Xie, Ze Chen. Cross-protection against influenza virus infection by intranasal administration of nucleoprotein-based vaccine with compound 48/80 adjuvant.
Human vaccines & immunotherapeutics.
2015; 11(2):397-406. doi:
10.4161/21645515.2014.995056
. [PMID: 25607884] - Hee-Yun Kim, Kyung-Ja Ko, Sun-Young Nam, Hyun-Ja Jeong, Hyung-Min Kim. The Sound of a Buk (Korean Traditional Drum) Attenuates Anaphylactic Reactions by the Activation of Estrogen Receptor-β.
International archives of allergy and immunology.
2015; 167(4):242-9. doi:
10.1159/000439567
. [PMID: 26418257] - Xiaoliang Gan, Dandan Xing, Guangjie Su, Shun Li, Chenfang Luo, Michael G Irwin, Zhengyuan Xia, Haobo Li, Ziqing Hei. Propofol Attenuates Small Intestinal Ischemia Reperfusion Injury through Inhibiting NADPH Oxidase Mediated Mast Cell Activation.
Oxidative medicine and cellular longevity.
2015; 2015(?):167014. doi:
10.1155/2015/167014
. [PMID: 26246867] - Pin-Jie Huang, Xiao-Liang Gan, Jian-Pei Liu, De-Zhao Liu, Yan-Ling Wang, Zi-Qing Hei. Effects of anti-histamine treatment on liver injury triggered by small intestinal ischemia reperfusion in rats.
The Chinese journal of physiology.
2014 Oct; 57(5):271-8. doi:
10.4077/cjp.2014.bac230
. [PMID: 25241987] - Min-Ho Kim, Hyun-Ja Jeong. Damnacanthal inhibits the NF-κB/RIP-2/caspase-1 signal pathway by inhibiting p56lck tyrosine kinase.
Immunopharmacology and immunotoxicology.
2014 Oct; 36(5):355-63. doi:
10.3109/08923973.2014.952819
. [PMID: 25139491] - Mahavir Hiralal Ghante, Kishore P Bhusari, Nandkishore J Duragkar, Nitin B Ghiware. Pharmacological evaluation for anti-asthmatic and anti-inflammatory potential of Woodfordia fruticosa flower extracts.
Pharmaceutical biology.
2014 Jul; 52(7):804-13. doi:
10.3109/13880209.2013.869232
. [PMID: 24405177] - M Yang, Y Ma, J Ding, L Rao, J Li. Preconditioning donor livers with cromolyn or compound 48/80 prolongs recipient survival in a rat orthotopic liver transplantation model.
Transplantation proceedings.
2014 Jun; 46(5):1554-9. doi:
10.1016/j.transproceed.2014.01.017
. [PMID: 24935329] - R L Shirole, N L Shirole, A A Kshatriya, R Kulkarni, M N Saraf. Investigation into the mechanism of action of essential oil of Pistacia integerrima for its antiasthmatic activity.
Journal of ethnopharmacology.
2014 May; 153(3):541-51. doi:
10.1016/j.jep.2014.02.009
. [PMID: 24556221] - Hyun-A Oh, Myong-Jo Kim, Tae-Yong Shin, Hyung-Min Kim, Hyun-Ja Jeong. The antiallergic mechanisms of Citrus sunki and bamboo salt (K-ALL) in an allergic rhinitis model.
Experimental biology and medicine (Maywood, N.J.).
2014 Jan; 239(1):83-93. doi:
10.1177/1535370213505826
. [PMID: 24131540] - Jing Wang, Sara Sjöberg, Viviane Tia, Blandine Secco, Han Chen, Min Yang, Galina K Sukhova, Guo-Ping Shi. Pharmaceutical stabilization of mast cells attenuates experimental atherogenesis in low-density lipoprotein receptor-deficient mice.
Atherosclerosis.
2013 Aug; 229(2):304-9. doi:
10.1016/j.atherosclerosis.2013.05.025
. [PMID: 23880180] - David D Obiri, Newman Osafo. Aqueous ethanol extract of the fruit of Xylopia aethiopica (Annonaceae) exhibits anti-anaphylactic and anti-inflammatory actions in mice.
Journal of ethnopharmacology.
2013 Jul; 148(3):940-5. doi:
10.1016/j.jep.2013.05.047
. [PMID: 23747538] - Jose M Cabeza, Jorge Acosta, Eva Alés. Mechanisms of granule membrane recapture following exocytosis in intact mast cells.
The Journal of biological chemistry.
2013 Jul; 288(28):20293-305. doi:
10.1074/jbc.m113.459065
. [PMID: 23709219] - Ok Hee Chai, Dong-Hwa Shon, Eui-Hyeog Han, Hyoung Tae Kim, Chang Ho Song. Effects of Anemarrhena asphodeloides on IgE-mediated passive cutaneous anaphylaxis, compound 48/80-induced systemic anaphylaxis and mast cell activation.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2013 May; 65(4):419-26. doi:
10.1016/j.etp.2011.12.006
. [PMID: 22261360] - Peng Zhao, Tetsuya Hiramoto, Yasunari Asano, Chiharu Kubo, Nobuyuki Sudo. Chronic psychological stress exaggerates the compound 48/80-induced scratching behavior of mice.
Pharmacology, biochemistry, and behavior.
2013 Apr; 105(?):173-6. doi:
10.1016/j.pbb.2013.02.014
. [PMID: 23474370] - Geetha Mathew, Anija Jacob, Ega Durgashivaprasad, N D Reddy, M K Unnikrishnan. 6b,11b-Dihydroxy-6b,11b-dihydro-7H-indeno[1,2-b]naphtho[2,1-d]furan-7-one (DHFO), a small molecule targeting NF-κB, demonstrates therapeutic potential in immunopathogenic chronic inflammatory conditions.
International immunopharmacology.
2013 Jan; 15(1):182-9. doi:
10.1016/j.intimp.2012.10.028
. [PMID: 23159605] - Yuan-Yuan Xie, Jia-Lin Qu, Qi-Long Wang, Yan Wang, Masayuki Yoshikawa, Dan Yuan. Comparative evaluation of cultivars of Chrysanthemum morifolium flowers by HPLC-DAD-ESI/MS analysis and antiallergic assay.
Journal of agricultural and food chemistry.
2012 Dec; 60(51):12574-83. doi:
10.1021/jf304080v
. [PMID: 23214422] - Yongxin Liu, Huanjiu Xi, Weiwei Xing, Jingcheng Gu. Aquaporin changes in compound 48/80 induced inflammatory sublaryngeal edema in rat.
Journal of voice : official journal of the Voice Foundation.
2012 Nov; 26(6):815.e17-23. doi:
10.1016/j.jvoice.2012.04.007
. [PMID: 22921298] - Rohan N Andhare, Mayuresh K Raut, Suresh R Naik. Evaluation of antiallergic and anti-anaphylactic activity of ethanolic extract of Sanseveiria trifasciata leaves (EEST) in rodents.
Journal of ethnopharmacology.
2012 Aug; 142(3):627-33. doi:
10.1016/j.jep.2012.05.007
. [PMID: 22683909] - Hyo Won Jung, Jin-Ki Jung, Cheong Weon Cho, Jong-Seong Kang, Yong-Ki Park. Antiallergic effect of KOB03, a polyherbal medicine, on mast cell-mediated allergic responses in ovalbumin-induced allergic rhinitis mouse and human mast cells.
Journal of ethnopharmacology.
2012 Aug; 142(3):684-93. doi:
10.1016/j.jep.2012.05.039
. [PMID: 22687252] - Sa-Rang Oh, Jae-Young Um, Hyong-Jun Choi, Chae-Kwang Im, Kwang-Joong Kim, Ji-Wook Jung, Gil-Saeng Jeong, Seung-Heon Hong, Su-Jin Kim. Betula platyphylla attenuated mast cell-mediated allergic inflammation in vivo and in vitro.
Life sciences.
2012 Jul; 91(1-2):20-8. doi:
10.1016/j.lfs.2012.05.018
. [PMID: 22683427] - Yathiraj Ashwini, Mohamed Rafiq, Gollapalle L Viswanatha, Subbanna Rajesh, Selvam Senthilraja, Mohammed Azeemuddin, Suryakanth D Anturlikar, Paramesh Rangesh, Pralhad S Patki. Polyherbal formulation Bresol® protects the mast cells against compound 48/80-induced disruption and histamine release: a non-immunological mechanism of mast cell stabilization.
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2012 Jun; 10(6):690-4. doi:
10.3736/jcim20120614
. [PMID: 22704419] - Hyuk-Sang Jung, Mi Hye Kim, Nam-Gil Gwak, Yong-Seok Im, Ka-Yeon Lee, Youngjoo Sohn, Hyeon Choi, Woong Mo Yang. Antiallergic effects of Scutellaria baicalensis on inflammation in vivo and in vitro.
Journal of ethnopharmacology.
2012 May; 141(1):345-9. doi:
10.1016/j.jep.2012.02.044
. [PMID: 22414480] - N H Kim, H J Jeong, H M Kim. Theanine is a candidate amino acid for pharmacological stabilization of mast cells.
Amino acids.
2012 May; 42(5):1609-18. doi:
10.1007/s00726-011-0847-9
. [PMID: 21344174] - Sunita Priyashree, S Jha, Shakti Prasad Pattanayak. Bronchodilatory and mast cell stabilising activity of Cressa cretica L.: evaluation through in vivo and in vitro experimental models.
Asian Pacific journal of tropical medicine.
2012 Mar; 5(3):180-6. doi:
10.1016/s1995-7645(12)60021-2
. [PMID: 22305781] - Hui-Hun Kim, Phil Hyung Choi, Jin-Su Yoo, Hoon Jeon, Byeong-Suk Chae, Jeong-Suk Park, Sang-Hyun Kim, Tae-Yong Shin. Ripe fruit of Rubus coreanus inhibits mast cell-mediated allergic inflammation.
International journal of molecular medicine.
2012 Feb; 29(2):303-10. doi:
10.3892/ijmm.2011.829
. [PMID: 22075758] - L L Silva, B S Gomes, B P Sousa-Neto, J P C Oliveira, E L F Ferreira, M H Chaves, F A Oliveira. Effects of Lecythis pisonis Camb. (Lecythidaceae) in a mouse model of pruritus.
Journal of ethnopharmacology.
2012 Jan; 139(1):90-7. doi:
10.1016/j.jep.2011.10.023
. [PMID: 22063727] - Bodi Zhang, Shahrzad Asadi, Zuyi Weng, Nikolaos Sismanopoulos, Theoharis C Theoharides. Stimulated human mast cells secrete mitochondrial components that have autocrine and paracrine inflammatory actions.
PloS one.
2012; 7(12):e49767. doi:
10.1371/journal.pone.0049767
. [PMID: 23284625] - Savita D Patil, Milap R Patel, Sachin R Patel, Sanjay J Surana. Amaranthus spinosus Linn. inhibits mast cell-mediated anaphylactic reactions.
Journal of immunotoxicology.
2012 Jan; 9(1):77-84. doi:
10.3109/1547691x.2011.631609
. [PMID: 22145857] - Xian Qiong Liu, Hao Wu, Hong Li Yu, Teng Fei Zhao, Yao Zong Pan, Run Jun Shi. Purification of a lectin from Arisaema erubescens (Wall.) Schott and its pro-inflammatory effects.
Molecules (Basel, Switzerland).
2011 Nov; 16(11):9480-94. doi:
10.3390/molecules16119480
. [PMID: 22083235] - Se-Eun Jang, Yang-Jin Hyun, Hien-Trung Trinh, Myung Joo Han, Dong-Hyun Kim. Anti-scratching behavioral effect of Lactobacillus plantarum PM008 isolated from kimchi in mice.
Immunopharmacology and immunotoxicology.
2011 Sep; 33(3):539-44. doi:
10.3109/08923973.2010.549136
. [PMID: 21275795] - V M Chandrashekhar, K S Halagali, R B Nidavani, M H Shalavadi, B S Biradar, D Biswas, I S Muchchandi. Anti-allergic activity of German chamomile (Matricaria recutita L.) in mast cell mediated allergy model.
Journal of ethnopharmacology.
2011 Sep; 137(1):336-40. doi:
10.1016/j.jep.2011.05.029
. [PMID: 21651969] - Hui-Hun Kim, Jin-Su Yoo, Hyun-Shik Lee, Taeg Kyu Kwon, Tae-Yong Shin, Sang-Hyun Kim. Elsholtzia ciliata inhibits mast cell-mediated allergic inflammation: role of calcium, p38 mitogen-activated protein kinase and nuclear factor-{kappa}B.
Experimental biology and medicine (Maywood, N.J.).
2011 Sep; 236(9):1070-7. doi:
10.1258/ebm.2011.011017
. [PMID: 21807818] - Yunju Bae, Soyoung Lee, Sang-Hyun Kim. Chrysin suppresses mast cell-mediated allergic inflammation: involvement of calcium, caspase-1 and nuclear factor-κB.
Toxicology and applied pharmacology.
2011 Jul; 254(1):56-64. doi:
10.1016/j.taap.2011.04.008
. [PMID: 21515303] - Ana Paula T Monteiro, Carla S Pinheiro, Tatiana Luna-Gomes, Liliane R Alves, Clarissa M Maya-Monteiro, Barbara N Porto, Christina Barja-Fidalgo, Claudia F Benjamim, Marc Peters-Golden, Christianne Bandeira-Melo, Marcelo T Bozza, Claudio Canetti. Leukotriene B4 mediates neutrophil migration induced by heme.
Journal of immunology (Baltimore, Md. : 1950).
2011 Jun; 186(11):6562-7. doi:
10.4049/jimmunol.1002400
. [PMID: 21536805] - Su-Jin Kim, Ji-Ye Kee, In-Young Choi, Min-Cheol Kim, Dae-Seung Kim, Yong-Deok Jeon, Se-Gun Kim, Beom-Su Kim, Hyun-Ju Jung, Hyung-Min Kim, Seung-Heon Hong, Jae-Young Um. Insamhodo-tang, a traditional Korean medicine, regulates mast cell-mediated allergic inflammation in vivo and in vitro.
Journal of ethnopharmacology.
2011 Mar; 134(2):339-47. doi:
10.1016/j.jep.2010.12.023
. [PMID: 21184820] - Miriam Lee-Rueckert, Reija Silvennoinen, Noemi Rotllan, Ilona Judström, Francisco Blanco-Vaca, Jari Metso, Matti Jauhiainen, Petri T Kovanen, Joan Carles Escola-Gil. Mast cell activation in vivo impairs the macrophage reverse cholesterol transport pathway in the mouse.
Arteriosclerosis, thrombosis, and vascular biology.
2011 Mar; 31(3):520-7. doi:
10.1161/atvbaha.110.221069
. [PMID: 21212401] - Ik-Hyun Cho, Min Jung Lee, Jong-Hyun Kim, Na Young Han, Kyu Won Shin, Youngjoo Sohn, Hyuk-Sang Jung. Fritillaria ussuriensis extract inhibits the production of inflammatory cytokine and MAPKs in mast cells.
Bioscience, biotechnology, and biochemistry.
2011; 75(8):1440-5. doi:
10.1271/bbb.110076
. [PMID: 21821956] - Sahar Da'as, Evelyn M Teh, J Tristan Dobson, Gheyath K Nasrallah, Eileen R McBride, Hao Wang, Donna S Neuberg, Jean S Marshall, Tong-Jun Lin, Jason N Berman. Zebrafish mast cells possess an FcɛRI-like receptor and participate in innate and adaptive immune responses.
Developmental and comparative immunology.
2011 Jan; 35(1):125-34. doi:
10.1016/j.dci.2010.09.001
. [PMID: 20849876] - Massimo Zerani, Francesco Parillo, Gabriele Brecchia, Gabriella Guelfi, Cecilia Dall'Aglio, Lorena Lilli, Margherita Maranesi, Anna Gobbetti, Cristiano Boiti. Expression of type I GNRH receptor and in vivo and in vitro GNRH-I effects in corpora lutea of pseudopregnant rabbits.
The Journal of endocrinology.
2010 Dec; 207(3):289-300. doi:
10.1677/joe-10-0109
. [PMID: 20880984] - Yun Ho Choi, Ok Hee Chai, Eui-Hyeog Han, Su-Young Choi, Hyoung Tae Kim, Chang Ho Song. Lipoic acid suppresses compound 48/80-induced anaphylaxis-like reaction.
Anatomy & cell biology.
2010 Dec; 43(4):317-24. doi:
10.5115/acb.2010.43.4.317
. [PMID: 21267406] - P Venkatesh, Pulok K Mukherjee, Debajyoti Mukherjee, A Bandyopadhyay, Hiroyuki Fukui, Hiroyuki Mizuguchi. Potential of Baliospermum montanum against compound 48/80-induced systemic anaphylaxis.
Pharmaceutical biology.
2010 Nov; 48(11):1213-7. doi:
10.3109/13880201003677827
. [PMID: 20818926] - Tae-Yong Shin, Seung-Bin Park, Jin-Su Yoo, In Kyeom Kim, Hyun-Shik Lee, Taeg Kyu Kwon, Moon Kyu Kim, Jung Chul Kim, Sang-Hyun Kim. Anti-allergic inflammatory activity of the fruit of Prunus persica: role of calcium and NF-kappaB.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2010 Oct; 48(10):2797-802. doi:
10.1016/j.fct.2010.07.009
. [PMID: 20633593] - Naoki Iwata, Susumu Kitanaka. Tetracyclic chromane derivatives from Rhododendron anthopogonoides.
Journal of natural products.
2010 Jul; 73(7):1203-6. doi:
10.1021/np900543r
. [PMID: 20586436] - Seung-Bin Park, Sang-Hyun Kim, Kyoungho Suk, Hyun-Shik Lee, Taeg Kyu Kwon, Min-Gyu Ju, Hoon Jeon, Dae-Keun Kim, Jong-Pil Lim, Tae-Yong Shin. Clinopodium gracile inhibits mast cell-mediated allergic inflammation: involvement of calcium and nuclear factor-kappaB.
Experimental biology and medicine (Maywood, N.J.).
2010 May; 235(5):606-13. doi:
10.1258/ebm.2010.009292
. [PMID: 20463301] - Jin Lee, Kye-Taek Lim. Inhibitory effect of phytoglycoprotein (24kDa) on allergy-related factors in compound 48/80-induced mast cells in vivo and in vitro.
International immunopharmacology.
2010 May; 10(5):591-9. doi:
10.1016/j.intimp.2010.02.009
. [PMID: 20188214] - Shingo Kaida, Yoshiji Ohta, Yoichiro Imai, Koji Ohashi, Minoru Kawanishi. Compound 48/80 causes oxidative stress in the adrenal gland of rats through mast cell degranulation.
Free radical research.
2010 Feb; 44(2):171-80. doi:
10.3109/10715760903380466
. [PMID: 19886753] - Kye-Taek Lim. Inhibitory effect of glycoprotein isolated from Opuntia ficus-indica var. saboten MAKINO on activities of allergy-mediators in compound 48/80-stimulated mast cells.
Cellular immunology.
2010; 264(1):78-85. doi:
10.1016/j.cellimm.2010.05.001
. [PMID: 20510397] - Tae-Hee Kang, In-Young Choi, Su-Jin Kim, Phil-Dong Moon, Jae-Uk Seo, Jae-Joong Kim, Nyeon-Hyung An, Sung-Hoon Kim, Min-Ho Kim, Jae-Young Um, Seung-Heon Hong, Hyung-Min Kim, Hyun-Ja Jeong. Ailanthus altissima swingle has anti-anaphylactic effect and inhibits inflammatory cytokine expression via suppression of nuclear factor-kappaB activation.
In vitro cellular & developmental biology. Animal.
2010 Jan; 46(1):72-81. doi:
10.1007/s11626-009-9237-y
. [PMID: 19789931] - H R Chitme, Mallikarjun Malipatil, V M Chandrashekhar, P M Prashant. Antiallergic activity of Aristolochia bracteolata Lank in animal model.
Indian journal of experimental biology.
2010 Jan; 48(1):46-52. doi:
NULL
. [PMID: 20358866] - P Venkatesh, Pulok K Mukherjee, Satheesh N Kumar, Neelesh K Nema, A Bandyopadhyay, Hiroyuki Fukui, Hiroyuki Mizuguchi. Mast cell stabilization and antihistaminic potentials of Curculigo orchioides rhizomes.
Journal of ethnopharmacology.
2009 Dec; 126(3):434-6. doi:
10.1016/j.jep.2009.09.019
. [PMID: 19781614] - Hien-Trung Trinh, Eun-Ah Bae, Jung Joon Lee, Dong-Hyun Kim. Inhibitory effects of curcuminoids on passive cutaneous anaphylaxis reaction and scratching behavior in mice.
Archives of pharmacal research.
2009 Dec; 32(12):1783-7. doi:
10.1007/s12272-009-2217-7
. [PMID: 20162408] - Y Ohta, T Kobayashi, K Inui, J Yoshino, S Nakazawa. Repeated recurrence of gastric mucosal lesions in rats after a single treatment with compound 48/80, a mast cell degranulator.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2009 Dec; 60 Suppl 7(?):139-48. doi:
NULL
. [PMID: 20388957] - Bomi Lee, Hien Trung Trinh, Eun-Ah Bae, Kangshik Jung, Dong-Hyun Kim. Mangiferin inhibits passive cutaneous anaphylaxis reaction and pruritus in mice.
Planta medica.
2009 Oct; 75(13):1415-7. doi:
10.1055/s-0029-1185773
. [PMID: 19533581] - Mathew George, Lincy Joseph, Ramaswamy. Anti-allergic, anti-pruritic, and anti-inflammatory activities of Centella asiatica extracts.
African journal of traditional, complementary, and alternative medicines : AJTCAM.
2009 Jul; 6(4):554-9. doi:
10.4314/ajtcam.v6i4.57206
. [PMID: 20606777] - Afton L McGowen, Laura P Hale, Christopher P Shelburne, Soman N Abraham, Herman F Staats. The mast cell activator compound 48/80 is safe and effective when used as an adjuvant for intradermal immunization with Bacillus anthracis protective antigen.
Vaccine.
2009 Jun; 27(27):3544-52. doi:
10.1016/j.vaccine.2009.03.069
. [PMID: 19464533] - Sang-Hyun Kim, Young-Ee Kwon, Won-Hwan Park, Hoon Jeon, Tae-Yong Shin. Effect of leaves of Eriobotrya japonica on anaphylactic allergic reaction and production of tumor necrosis factor-alpha.
Immunopharmacology and immunotoxicology.
2009 Jun; 31(2):314-9. doi:
10.1080/08923970802714775
. [PMID: 19514997] - Jeong Hee Jeon, Sang-Chul Kwon, Dongsun Park, Sunhee Shin, Jae-Hyun Jeong, So-Young Park, Seock-Yeon Hwang, Yun-Bae Kim, Seong Soo Joo. Anti-allergic effects of white rose petal extract and anti-atopic properties of its hexane fraction.
Archives of pharmacal research.
2009 Jun; 32(6):823-30. doi:
10.1007/s12272-009-1602-6
. [PMID: 19557358] - Jessy E Mathew, K K Srinivasan, Vachala Dinakaran, Alex Joseph. Mast cell stabilizing effects of Sphaeranthus indicus.
Journal of ethnopharmacology.
2009 Mar; 122(2):394-6. doi:
10.1016/j.jep.2009.01.015
. [PMID: 19330926] - Myung Hee Hong, Ji Young Lee, Hee Jung, Dong-Hoon Jin, Ho Yeon Go, Ji Hye Kim, Bo-Hyoung Jang, Yong-Cheol Shin, Seong-Gyu Ko. Sophora flavescens Aiton inhibits the production of pro-inflammatory cytokines through inhibition of the NF kappaB/IkappaB signal pathway in human mast cell line (HMC-1).
Toxicology in vitro : an international journal published in association with BIBRA.
2009 Mar; 23(2):251-8. doi:
10.1016/j.tiv.2008.12.002
. [PMID: 19118619] - Ya-ling Tang, Yong-zong Yang, Shuang Wang, Tao Huang, Chao-ke Tang, Zeng-xiang Xu, Yu-hui Sun. Mast cell degranulator compound 48-80 promotes atherosclerotic plaque in apolipoprotein E knockout mice with perivascular common carotid collar placement.
Chinese medical journal.
2009 Feb; 122(3):319-25. doi:
NULL
. [PMID: 19236812] - Sang-Hyun Kim, Seung-Bin Park, Sin-Myoung Kang, Hoon Jeon, Jong-Pil Lim, Taeg Kyu Kwon, Won-Hwan Park, Hyung-Min Kim, Tae-Yong Shin. Anti-allergic effects of Teucrium japonicum on mast cell-mediated allergy model.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2009 Feb; 47(2):398-403. doi:
10.1016/j.fct.2008.11.030
. [PMID: 19070642] - Noriko Hirata, Shunsuke Naruto, Kazunori Inaba, Kimihisa Itoh, Masashi Tokunaga, Munekazu Iinuma, Hideaki Matsuda. Histamine release inhibitory activity of Piper nigrum leaf.
Biological & pharmaceutical bulletin.
2008 Oct; 31(10):1973-6. doi:
10.1248/bpb.31.1973
. [PMID: 18827366] - Zi-qing Hei, Xiao-liang Gan, Pin-jie Huang, Jing Wei, Ning Shen, Wan-ling Gao. Influence of Ketotifen, Cromolyn Sodium, and Compound 48/80 on the survival rates after intestinal ischemia reperfusion injury in rats.
BMC gastroenterology.
2008 Sep; 8(?):42. doi:
10.1186/1471-230x-8-42
. [PMID: 18808687] - R Costa, D M Marotta, M N Manjavachi, E S Fernandes, J F Lima-Garcia, A F Paszcuk, N L M Quintão, L Juliano, S D Brain, J B Calixto. Evidence for the role of neurogenic inflammation components in trypsin-elicited scratching behaviour in mice.
British journal of pharmacology.
2008 Jul; 154(5):1094-103. doi:
10.1038/bjp.2008.172
. [PMID: 18454165]