Sulforaphane (BioDeep_00000017454)

   

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


(R)-Sulforaphane;(-)-Sulforaphane;4-Methylsulfinylbutyl isothiocyanate

化学式: C6H11NOS2 (177.0282036)
中文名称: 莱菔硫烷, 萝卜硫素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 4.38%

分子结构信息

SMILES: CS(=O)CCCCN=C=S
InChI: InChI=1S/C6H11NOS2/c1-10(8)5-3-2-4-7-6-9/h2-5H2,1H3

描述信息

Sulforaphane (SFN) is the most characterized isothiocyanate. SFN has received a great deal of attention because of its ability to simultaneously modulate multiple cellular targets involved in cancer development, including: (i) DNA protection by modulating carcinogen-metabolizing enzymes and blocking the action of mutagens; (ii) inhibition of cell proliferation and induction of apoptosis, thereby retarding or eliminating clonal expansion of initiated, transformed, and/or neoplastic cells; (iii) inhibition of neoangiogenesis, progression of benign tumors to malignant tumors, and metastasis formation. SFN is therefore able to prevent, delay, or reverse preneoplastic lesions, as well as to act on cancer cells as a therapeutic agent. Taking into account this evidence and its favorable toxicological profile, SFN can be viewed as a conceptually promising agent in cancer prevention and/or therapy. SFN is the hydrolysis product of glucoraphanin, particularly high in the young sprouts of broccoli and cauliflower. SFN can also be obtained by eating cruciferous vegetables such as brussel sprouts, broccoli, cauliflower, bok choy, kale, collards, arugula, broccoli sprouts, chinese broccoli, broccoli raab, kohlrabi, mustard, turnip, radish, watercress and cabbage (PMID:17134937).
Sulforaphane is an isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen. It has a role as an antineoplastic agent, a plant metabolite, an antioxidant and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is a sulfoxide and an isothiocyanate.
Sulforaphane is a natural product found in Brassica oleracea var. sabauda, Arabidopsis thaliana, and other organisms with data available.
Sulforaphane is a naturally-occurring phytochemical belonging to the class of isothiocyanates. As the aglycone metabolite of glucosinolate glucoraphanin (sulforaphane glucosinolate), sulforaphane acts as an antioxidant and potent stimulator of endogenous detoxifying enzymes. This agent displays anticarcinogenic properties due to its ability to induce phase II detoxification enzymes, such as glutathione S-transferase and quinone reductase, thereby providing protection against certain carcinogens and toxic, reactive oxygen species. Broccoli sprouts contain large amounts of sulforaphane, which is also found in other cruciferous vegetables including cabbage and kale. (NCI04)
Present in brassicas. Potential nutriceutical. (R)-Sulforaphane is found in brassicas.
An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
D020011 - Protective Agents > D016588 - Anticarcinogenic Agents
D000970 - Antineoplastic Agents

同义名列表

39 个代谢物同义名

(R)-Sulforaphane;(-)-Sulforaphane;4-Methylsulfinylbutyl isothiocyanate; ISOTHIOCYANIC ACID, 4-(METHYLSULFINYL)BUTYL ESTER; DL-Sulforaphane, >=90\\% (HPLC), synthetic, liquid; Butane, 1-isothiocyanato-4-[(S)-methylsulfinyl]-; (S)-1-Isothiocyanato-4-(methylsulfinyl)butane; Butane, 1-isothiocyanato-4-(methylsulfinyl)-; 1-Isothiocyanato-4-(methylsulfinyl)butane #; 1-Isothiocyanato-4-(methylsulfinyl)-butane; 1-Isothiocyanato-4-(methylsulfinyl)butane; 1-isothiocyanato-4-methanesulfinylbutane; 1-isothiocyanato-4-methylsulphinylbutane; 1-isothiocyanato-4-methylsulfinyl-butane; 1-isothiocyanato-4-methylsulfinylbutane; 4-(Methylsulfinyl)-butyl isothiocyanate; 4-isothiocyanatobutyl methyl sulfoxide; 4-(Methylsulfinyl)Butyl Isothiocyanate; 4-Methylsulfinyl butyl isothiocyanate; 4-Methylsulphinylbutyl glucosinolate; 4-Methylsulfinylbutyl isothiocyanate; 4-methylsulfoxybutylisothiocyanate; Methylsulfoxybutylisothiocyanate; SULFORAPHANE (+/-)-FORM [MI]; SULFORAPHANE, (+/-)-; sulforaphane, (R)-; (+/-)-sulforaphane; (R)-Sulphoraphane; (+-)-sulforaphane; R,S-Sulforaphane; D,L-Sulforaphane; (S)-sulforaphane; (R)-sulforaphane; DL-Sulforaphane; S)-Sulforaphane; sulphoraphane; sulforaphane; Sulforathane; Sulphorafan; sulforafan; SFN



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

29 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Martí Wilson-Verdugo, Brandon Bustos-García, Olga Adame-Guerrero, Jaqueline Hersch-González, Nallely Cano-Domínguez, Maribel Soto-Nava, Carlos A Acosta, Teresa Tusie-Luna, Santiago Avila-Rios, Lilia G Noriega, Victor J Valdes. Reversal of high-glucose-induced transcriptional and epigenetic memories through NRF2 pathway activation. Life science alliance. 2024 Aug; 7(8):. doi: 10.26508/lsa.202302382. [PMID: 38755006]
  • Yusuke Yamaguchi, Mikio Sugiki, Motomi Shimizu, Kazuki Ogawa, Hitomi Kumagai. Comparative analysis of isothiocyanates in eight cruciferous vegetables and evaluation of the hepatoprotective effects of 4-(methylsulfinyl)-3-butenyl isothiocyanate (sulforaphene) from daikon radish (Raphanus sativus L.) sprouts. Food & function. 2024 May; 15(9):4894-4904. doi: 10.1039/d4fo00133h. [PMID: 38597802]
  • Laura Yunuen Hernández-Sánchez, María Eva González-Trujano, Diego A Moreno, David Martínez-Vargas, Heike Vibrans, Alberto Hernandez-Leon, Alejandro Dorazco-González, Francisco Pellicer, Marcos Soto-Hernández. Antinociceptive effects of Raphanus sativus sprouts involve the opioid and 5-HT1A serotonin receptors, cAMP/cGMP pathways, and the central activity of sulforaphane. Food & function. 2024 May; 15(9):4773-4784. doi: 10.1039/d3fo05229j. [PMID: 38469873]
  • Saeed Ghanbari Hassan Kiadeh, Somayeh Rahaiee, Hossein Azizi, Mostafa Govahi. The synthesis of broccoli sprout extract-loaded silk fibroin nanoparticles as efficient drug delivery vehicles: development and characterization. Pharmaceutical development and technology. 2024 Apr; 29(4):359-370. doi: 10.1080/10837450.2024.2336101. [PMID: 38546461]
  • Lixia He, Hanmin Jiang, Yaotong Li, Xu Zhang, Wenting Sun, Ce Liu, Zekai Zhao, Chengrong Yun, Hui Li, Chunguo Wang. Sulforaphane-Enriched Extracts from Broccoli Exhibit Antimicrobial Activity against Plant Pathogens, Promising a Natural Antimicrobial Agent for Crop Protection. Biomolecules. 2024 Mar; 14(3):. doi: 10.3390/biom14030352. [PMID: 38540770]
  • Ao-Chun Yue, Xu-Dong Zhou, Hui-Ping Song, Xu-Han Liu, Ming-Jun Bi, Wei Han, Qin Li. Effect and molecular mechanism of Sulforaphane alleviates brain damage caused by acute carbon monoxide poisoning:Network pharmacology analysis, molecular docking, and experimental evidence. Environmental toxicology. 2024 Mar; 39(3):1140-1162. doi: 10.1002/tox.24000. [PMID: 37860845]
  • Ruqing Xu, Yue Wu, Xia Xiang, Xiaoqin Lv, Miao He, Chang Xu, Guoqi Lai, Tingxiu Xiang. Sulforaphane effectively inhibits HBV by altering Treg/Th17 immune balance and the MIF-macrophages polarizing axis in vitro and in vivo. Virus research. 2024 03; 341(?):199316. doi: 10.1016/j.virusres.2024.199316. [PMID: 38215982]
  • Antonio Costa-Pérez, Paola Sánchez-Bravo, Sonia Medina, Raúl Domínguez-Perles, Cristina García-Viguera. Bioaccessible Organosulfur Compounds in Broccoli Stalks Modulate the Inflammatory Mediators Involved in Inflammatory Bowel Disease. International journal of molecular sciences. 2024 Jan; 25(2):. doi: 10.3390/ijms25020800. [PMID: 38255874]
  • Marcia Ribeiro, Ludmila Fmf Cardozo, Bruna R Paiva, Beatriz Germer Baptista, Susane Fanton, Livia Alvarenga, Ligia Soares Lima, Isadora Britto, Lia S Nakao, Denis Fouque, Marcelo Ribeiro-Alves, Denise Mafra. Sulforaphane Supplementation Did Not Modulate NRF2 and NF-kB mRNA Expressions in Hemodialysis Patients. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 2024 Jan; 34(1):68-75. doi: 10.1053/j.jrn.2023.08.008. [PMID: 37619675]
  • John A Bouranis, Laura M Beaver, Carmen P Wong, Jaewoo Choi, Sean Hamer, Ed W Davis, Kevin S Brown, Duo Jiang, Thomas J Sharpton, Jan F Stevens, Emily Ho. Sulforaphane and Sulforaphane-Nitrile Metabolism in Humans Following Broccoli Sprout Consumption: Inter-individual Variation, Association with Gut Microbiome Composition, and Differential Bioactivity. Molecular nutrition & food research. 2023 Dec; ?(?):e2300286. doi: 10.1002/mnfr.202300286. [PMID: 38143283]
  • Nieves Baenas, Angélica Vega-García, Joaquín Manjarrez-Marmolejo, Diego A Moreno, Iris A Feria-Romero. The preventive effects of broccoli bioactives against cancer: Evidence from a validated rat glioma model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 168(?):115720. doi: 10.1016/j.biopha.2023.115720. [PMID: 37839110]
  • Shanmugam Thangapandiyan, Tamilselvan Hema, Selvaraj Miltonprabu, Manickam Paulpandi, Uma Dutta. Sulforaphane ameliorate Arsenic induced cardiotoxicity in rats: Role of PI3k/Akt mediated Nrf2 signaling pathway. Journal of biochemical and molecular toxicology. 2023 Oct; ?(?):e23576. doi: 10.1002/jbt.23576. [PMID: 37906532]
  • Ahhyeon Chun, So Jeong Paik, Jongbeom Park, Ryeongeun Kim, Sujeong Park, Sung Keun Jung, Soo Rin Kim. Physicochemical and Functional Properties of Yeast-Fermented Cabbage. Journal of microbiology and biotechnology. 2023 Oct; 33(10):1329-1336. doi: 10.4014/jmb.2302.02025. [PMID: 37463863]
  • Omar Guadarrama-Enríquez, Gabriel Fernando Moreno-Pérez, María Eva González-Trujano, Guadalupe Esther Ángeles-López, Rosa Ventura-Martínez, Irene Díaz-Reval, Agustina Cano-Martínez, Francisco Pellicer, Nieves Baenas, Diego A Moreno, Cristina García-Viguera. Antinociceptive and antiedema effects produced in rats by Brassica oleracea var. italica sprouts involving sulforaphane. Inflammopharmacology. 2023 Sep; ?(?):. doi: 10.1007/s10787-023-01326-6. [PMID: 37728726]
  • Jining Yang, Xinxin Guo, Tianyou Li, Yingquan Xie, Dawei Wang, Long Yi, Mantian Mi. Sulforaphane Inhibits Exhaustive Exercise-Induced Liver Injury and Transcriptome-Based Mechanism Analysis. Nutrients. 2023 Jul; 15(14):. doi: 10.3390/nu15143220. [PMID: 37513640]
  • Hussain Ahmed, Muhammad Umar Ijaz, Mehreen Riaz, Sarwat Jahan. Sulforaphane inclusion in a freezing medium augments post-thaw motility, functional and biochemical features, and fertility potential of buffalo (Bubalus bubalis) spermatozoa. Research in veterinary science. 2023 May; 158(?):196-202. doi: 10.1016/j.rvsc.2023.03.020. [PMID: 37030095]
  • Bo Wang, Zhizhou Xu, Yangyang Zhao, Guichun Wu, Kaihuai Li, Rongxian Hou, Baodian Guo, Bao Tang, Yancun Zhao, Fengquan Liu. SstF, a novel sulforaphane-sensing transcription factor of Xanthomonas campestris, is required for sulforaphane tolerance and virulence. Molecular plant pathology. 2023 05; 24(5):452-465. doi: 10.1111/mpp.13314. [PMID: 36829260]
  • Shiyan Liu, Yuan Zhang, Xiangyu Zheng, Ziling Wang, Pan Wang, Mengdi Zhang, Mengfan Shen, Yongping Bao, Dan Li. Sulforaphane Inhibits Foam Cell Formation and Atherosclerosis via Mechanisms Involving the Modulation of Macrophage Cholesterol Transport and the Related Phenotype. Nutrients. 2023 Apr; 15(9):. doi: 10.3390/nu15092117. [PMID: 37432260]
  • Zhiqiang Feng, Tengfei Wang, Yawen Sun, Siying Chen, Haisheng Hao, Weihua Du, Huiying Zou, Dawei Yu, Huabin Zhu, Yunwei Pang. Sulforaphane suppresses paraquat-induced oxidative damage in bovine in vitro-matured oocytes through Nrf2 transduction pathway. Ecotoxicology and environmental safety. 2023 Apr; 254(?):114747. doi: 10.1016/j.ecoenv.2023.114747. [PMID: 36907095]
  • Jiaying Wu, Weiling Guo, Shumao Cui, Xin Tang, Qiuxiang Zhang, Wenwei Lu, Yan Jin, Jianxin Zhao, Bingyong Mao, Wei Chen. Broccoli seed extract rich in polysaccharides and glucoraphanin ameliorates DSS-induced colitis via intestinal barrier protection and gut microbiota modulation in mice. Journal of the science of food and agriculture. 2023 Mar; 103(4):1749-1760. doi: 10.1002/jsfa.12382. [PMID: 36495024]
  • Zinuo Chen, Ruikun Du, Laura Cooper, Jazmin Galvan Achi, Meiyue Dong, Yan Ran, Jiwei Zhang, Peng Zhan, Lijun Rong, Qinghua Cui. Sulforaphane is a reversible covalent inhibitor of 3-chymotrypsin-like protease of SARS-CoV-2. Journal of medical virology. 2023 Feb; ?(?):. doi: 10.1002/jmv.28609. [PMID: 36840402]
  • Ghadha Ibrahim Fouad, Mostafa Mabrouk, Sara A M El-Sayed, Maha Z Rizk, Hanan H Beherei. Neurotherapeutic efficacy of loaded sulforaphane on iron oxide nanoparticles against cuprizone-induced neurotoxicity: role of MMP-9 and S100β. Toxicology mechanisms and methods. 2023 Feb; ?(?):1-17. doi: 10.1080/15376516.2023.2177219. [PMID: 36775846]
  • Tao Zhang, Johanna Holman, Delaney McKinstry, Bruno C Trindade, Kathryn A Eaton, Jonny Mendoza-Castrejon, Sharon Ho, Emily Wells, Hebao Yuan, Bo Wen, Duxin Sun, Grace Y Chen, Yanyan Li. A steamed broccoli sprout diet preparation that reduces colitis via the gut microbiota. The Journal of nutritional biochemistry. 2023 02; 112(?):109215. doi: 10.1016/j.jnutbio.2022.109215. [PMID: 36370930]
  • Lixia Hong, Yide Xu, Dongdong Wang, Qi Zhang, Xiaoting Li, Chunfeng Xie, Jieshu Wu, Caiyun Zhong, Jinyan Fu, Shanshan Geng. Sulforaphane ameliorates bisphenol A-induced hepatic lipid accumulation by inhibiting endoplasmic reticulum stress. Scientific reports. 2023 01; 13(1):1147. doi: 10.1038/s41598-023-28395-5. [PMID: 36670177]
  • Ghadha Ibrahim Fouad. Sulforaphane, an Nrf-2 Agonist, Modulates Oxidative Stress and Inflammation in a Rat Model of Cuprizone-Induced Cardiotoxicity and Hepatotoxicity. Cardiovascular toxicology. 2023 01; 23(1):46-60. doi: 10.1007/s12012-022-09776-0. [PMID: 36650404]
  • Dana J Somers, David B Kushner, Alexandria R McKinnis, Dzejlana Mehmedovic, Rachel S Flame, Thomas M Arnold. Epigenetic weapons in plant-herbivore interactions: Sulforaphane disrupts histone deacetylases, gene expression, and larval development in Spodoptera exigua while the specialist feeder Trichoplusia ni is largely resistant to these effects. PloS one. 2023; 18(10):e0293075. doi: 10.1371/journal.pone.0293075. [PMID: 37856454]
  • María Ángeles Núñez-Sánchez, María Antonia Martínez-Sánchez, Marina Verdejo-Sánchez, Paula García-Ibáñez, Alba Oliva Bolarín, Bruno Ramos-Molina, Diego A Moreno, Antonio J Ruiz-Alcaraz. Anti-Leukemic Activity of Brassica-Derived Bioactive Compounds in HL-60 Myeloid Leukemia Cells. International journal of molecular sciences. 2022 Nov; 23(21):. doi: 10.3390/ijms232113400. [PMID: 36362202]
  • Jinyu Bao, Xu Lu, Lei Ma, Xiumin Zhang, Peng Tian, Xiaoling Zhang, Sheng Li, Shaoying Ma, Jie Yang, Yaqi Lu, Yunchun Wei, Congcong Zhang, Xiaotong Shi. Transcriptome analysis of genes related to glucoraphanin and sulforaphane synthesis in methyl jasmonate treated broccoli (Brassica oleracea var. italica) hairy roots. Journal of plant research. 2022 Nov; 135(6):757-770. doi: 10.1007/s10265-022-01407-7. [PMID: 35999478]
  • Xiao Men, Xionggao Han, Se-Jeong Lee, Keun-Tae Park, Jong-Kwon Han, Sun-Il Choi, Ok-Hwan Lee. Anti-adipogenic Effects of Sulforaphane-rich Ingredient with Broccoli Sprout and Mustard Seed in 3T3-L1 Preadipocytes. Planta medica. 2022 Oct; ?(?):. doi: 10.1055/a-1853-7101. [PMID: 35577064]
  • Ghadha Ibrahim Fouad, Sara A M El-Sayed, Mostafa Mabrouk, Kawkab A Ahmed, Hanan H Beherei. Neuroprotective Potential of Intranasally Delivered Sulforaphane-Loaded Iron Oxide Nanoparticles Against Cisplatin-Induced Neurotoxicity. Neurotoxicity research. 2022 Oct; 40(5):1479-1498. doi: 10.1007/s12640-022-00555-x. [PMID: 35969308]
  • Bo Wang, Kaihuai Li, Guichun Wu, Zhizhou Xu, Rongxian Hou, Baodian Guo, Yancun Zhao, Fengquan Liu. Sulforaphane, a secondary metabolite in crucifers, inhibits the oxidative stress adaptation and virulence of Xanthomonas by directly targeting OxyR. Molecular plant pathology. 2022 10; 23(10):1508-1523. doi: 10.1111/mpp.13245. [PMID: 35942507]
  • Shumin Li, Zhongkai Xu, Majed Alrobaian, Obaid Afzal, Imran Kazmi, Waleed H Almalki, Abdulmalik Saleh Alfawaz Altamimi, Fahad A Al-Abbasi, Khalid S Alharbi, Waleed M Altowayan, Tanuja Singh, Md Habban Akhter, Manish Gupta, Mahfoozur Rahman, Sarwar Beg. EGF-functionalized lipid-polymer hybrid nanoparticles of 5-fluorouracil and sulforaphane with enhanced bioavailability and anticancer activity against colon carcinoma. Biotechnology and applied biochemistry. 2022 Oct; 69(5):2205-2221. doi: 10.1002/bab.2279. [PMID: 34775646]
  • Xiao Men, Xionggao Han, Se-Jeong Lee, Geon Oh, Keun-Tae Park, Jong-Kwon Han, Sun-Il Choi, Ok-Hwan Lee. Anti-Obesogenic Effects of Sulforaphane-Rich Broccoli (Brassica oleracea var. italica) Sprouts and Myrosinase-Rich Mustard (Sinapis alba L.) Seeds In Vitro and In Vivo. Nutrients. 2022 Sep; 14(18):. doi: 10.3390/nu14183814. [PMID: 36145190]
  • Somaya Z Mansour, Enas M Moustafa, Fatma S M Moawed. Modulation of endoplasmic reticulum stress via sulforaphane-mediated AMPK upregulation against nonalcoholic fatty liver disease in rats. Cell stress & chaperones. 2022 09; 27(5):499-511. doi: 10.1007/s12192-022-01286-w. [PMID: 35779187]
  • Shaoying Ma, Jinyu Bao, Yaqi Lu, Xu Lu, Peng Tian, Xiaoling Zhang, Jie Yang, Xiaotong Shi, Zhihui Pu, Sheng Li. Glucoraphanin and sulforaphane biosynthesis by melatonin mediating nitric oxide in hairy roots of broccoli (Brassica oleracea L. var. italica Planch): insights from transcriptome data. BMC plant biology. 2022 Aug; 22(1):403. doi: 10.1186/s12870-022-03747-x. [PMID: 35974315]
  • Masashi Masuda, Risa Yoshida-Shimizu, Yuki Mori, Kohta Ohnishi, Yuichiro Adachi, Maiko Sakai, Serina Kabutoya, Hirokazu Ohminami, Hisami Yamanaka-Okumura, Hironori Yamamoto, Makoto Miyazaki, Yutaka Taketani. Sulforaphane induces lipophagy through the activation of AMPK-mTOR-ULK1 pathway signaling in adipocytes. The Journal of nutritional biochemistry. 2022 08; 106(?):109017. doi: 10.1016/j.jnutbio.2022.109017. [PMID: 35461903]
  • Ya Zhang, Qifang Wu, Jian Liu, Zhongshan Zhang, Xiaojing Ma, Yaoyue Zhang, Jiawen Zhu, Ronald W Thring, Mingjiang Wu, Yitian Gao, Haibin Tong. Sulforaphane alleviates high fat diet-induced insulin resistance via AMPK/Nrf2/GPx4 axis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Aug; 152(?):113273. doi: 10.1016/j.biopha.2022.113273. [PMID: 35709656]
  • Ahmed I Ashmawy, Hanan S El-Abhar, Dalaal M Abdallah, Mennatallah A Ali. Chloroquine modulates the sulforaphane anti-obesity mechanisms in a high-fat diet model: Role of JAK-2/ STAT-3/ SOCS-3 pathway. European journal of pharmacology. 2022 Jul; 927(?):175066. doi: 10.1016/j.ejphar.2022.175066. [PMID: 35643302]
  • Yi-Kuan Wu, Zheng-Nan Ren, Sheng-Long Zhu, Yun-Zhou Wu, Gang Wang, Hao Zhang, Wei Chen, Zhao He, Xian-Long Ye, Qi-Xiao Zhai. Sulforaphane ameliorates non-alcoholic fatty liver disease in mice by promoting FGF21/FGFR1 signaling pathway. Acta pharmacologica Sinica. 2022 Jun; 43(6):1473-1483. doi: 10.1038/s41401-021-00786-2. [PMID: 34654875]
  • Chia Siang Kow, Dinesh Sangarran Ramachandram, Syed Shahzad Hasan. Use of sulforaphane in COVID-19: Clinical trials are needed. Molecular immunology. 2022 05; 145(?):78-79. doi: 10.1016/j.molimm.2022.03.001. [PMID: 35303531]
  • Taoqi Zhou, Minming Zhou, Chaochao Tong, Mali Zhuo. Cauliflower bioactive compound sulforaphane inhibits breast cancer development by suppressing NF-κB /MMP-9 signaling pathway expression. Cellular and molecular biology (Noisy-le-Grand, France). 2022 Apr; 68(4):134-143. doi: 10.14715/cmb/2022.68.4.17. [PMID: 35988280]
  • Rui Tang, Qian-Qian Cao, Sheng-Wei Hu, Lu-Juan He, Peng-Fei Du, Gang Chen, Rao Fu, Fei Xiao, Yi-Rong Sun, Ji-Chun Zhang, Qi Qi. Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription. Acta pharmacologica Sinica. 2022 Apr; 43(4):829-839. doi: 10.1038/s41401-021-00727-z. [PMID: 34272506]
  • Alvaro A Ordonez, C Korin Bullen, Andres F Villabona-Rueda, Elizabeth A Thompson, Mitchell L Turner, Vanessa F Merino, Yu Yan, John Kim, Stephanie L Davis, Oliver Komm, Jonathan D Powell, Franco R D'Alessio, Robert H Yolken, Sanjay K Jain, Lorraine Jones-Brando. Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice. Communications biology. 2022 03; 5(1):242. doi: 10.1038/s42003-022-03189-z. [PMID: 35304580]
  • Helena Galádová, Zoltán Polozsányi, Albert Breier, Martin Šimkovič. Sulphoraphane Affinity-Based Chromatography for the Purification of Myrosinase from Lepidium sativum Seeds. Biomolecules. 2022 03; 12(3):. doi: 10.3390/biom12030406. [PMID: 35327598]
  • Zhen Luo, Xuewu Zhang. Brassica oleracea extract, glucosinlates, and sulforaphane promote hair growth in vitro and ex vivo. Journal of cosmetic dermatology. 2022 Mar; 21(3):1178-1184. doi: 10.1111/jocd.14180. [PMID: 33901343]
  • Xiuxia Yang, Pingping Liu, Xiaojing Zhao, Chengcheng Yang, Binhui Li, Ye Liu, Yang Liu. Sulforaphane inhibits cytokine-stimulated chemokine and adhesion molecule expressions in human corneal fibroblasts: Involvement of the MAPK, STAT, and NF-κB signaling pathways. Experimental eye research. 2022 03; 216(?):108946. doi: 10.1016/j.exer.2022.108946. [PMID: 35038457]
  • Weiqiang Liang, Johannes Greven, Athanassios Fragoulis, Klemens Horst, Felix Bläsius, Christoph Wruck, Thomas Pufe, Philipp Kobbe, Frank Hildebrand, Philipp Lichte. Sulforaphane-Dependent Up-Regulation of NRF2 Activity Alleviates Both Systemic Inflammatory Response and Lung Injury After Hemorrhagic Shock/Resuscitation in Mice. Shock (Augusta, Ga.). 2022 02; 57(2):221-229. doi: 10.1097/shk.0000000000001859. [PMID: 34559743]
  • Sachithra S Ranaweera, Premkumar Natraj, Priyanka Rajan, Laksi A Dayarathne, Suyama P Mihindukulasooriya, Duong Thi Thuy Dinh, Youngheun Jee, Chang-Hoon Han. Anti-obesity effect of sulforaphane in broccoli leaf extract on 3T3-L1 adipocytes and ob/ob mice. The Journal of nutritional biochemistry. 2022 02; 100(?):108885. doi: 10.1016/j.jnutbio.2021.108885. [PMID: 34655754]
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