5-Hydroxy-3,3',4',6,7,8-hexamethoxyflavone (BioDeep_00000017428)

 

Secondary id: BioDeep_00000270285

human metabolite PANOMIX_OTCML-2023 Endogenous PANOMIX_OTCML-2025


代谢物信息卡片


4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7,8-tetramethoxy-

  化学式: C21H22O9 (418.1264)
中文名称:
  谱图信息: 最多检出来源 Viridiplantae(otcml) 20.34%

分子结构信息

SMILES: c1(c(c(c2c(c1OC)oc(c(c2=O)OC)c1ccc(c(c1)OC)OC)O)OC)OC
InChI: InChI=1S/C21H22O9/c1-24-11-8-7-10(9-12(11)25-2)16-18(26-3)14(22)13-15(23)19(27-4)21(29-6)20(28-5)17(13)30-16/h7-9,23H,1-6H3


描述信息

5-Hydroxy-3,3,4,6,7,8-hexamethoxyflavone is a member of flavonoids and an ether.
5-Hydroxy-3,6,7,8,3,4-hexamethoxyflavone is a natural product found in Maclurodendron porteri, Polanisia trachysperma, and other organisms with data available.
See also: Tangerine peel (part of); Citrus aurantium fruit rind (part of).
5-Hydroxy-3,3,4,6,7,8-hexamethoxyflavone is found in citrus. 5-Hydroxy-3,3,4,6,7,8-hexamethoxyflavone is isolated from peel of orange (Citrus sinensis
Isolated from peel of orange (Citrus sinensis). 5-Hydroxy-3,3,4,6,7,8-hexamethoxyflavone is found in sweet orange and citrus.

同义名列表

21 个代谢物同义名

4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7,8-tetramethoxy-; 2-(3,4-Dimethoxyphenyl)-5-hydroxy-3,6,7,8-tetramethoxy-4H-1-benzopyran-4-one; 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7,8-tetramethoxy-4H-chromen-4-one; 2-(3,4-Dimethoxy-phenyl)-5-hydroxy-3,6,7,8-tetramethoxy-chromen-4-one; 2-(3,4-dimethoxyphenyl)-5-hydroxy-3,6,7,8-tetramethoxychromen-4-one; FLAVONE, 5-HYDROXY-3,3,4,6,7,8-HEXAMETHOXY-; 5-Hydroxy-3,6,7,8,3,4-hexamethoxyflavone; 5-hydroxy-3,3,4,6,7,8-hexamethoxyflavone; 5-hydroxy-3,6,7,8,3,4-hexamethoxyflavone; 5-Hydroxy-3,6,7,8,34-hexamethoxyflavone; UNII-07JTS22V9J; MEGxp0_001193; ACon1_000728; NCI60_005671; 07JTS22V9J; 5-OH-HxMF; 5-hydroxy-3,3',4',6,7,8-hexamethoxyflavone; 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone; 5-hydroxy-3,6,7,8,3'',4''-hexamethoxyflavone; 5-Hydroxy-3,6,7,8,3'4'-hexamethoxyflavone; FLAVONE, 5-HYDROXY-3,3',4',6,7,8-HEXAMETHOXY-



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Yu Wang, Pei-Sheng Lee, Yi-Fen Chen, Chi-Tang Ho, Min-Hsiung Pan. Suppression of Adipogenesis by 5-Hydroxy-3,6,7,8,3',4'-Hexamethoxyflavone from Orange Peel in 3T3-L1 Cells. Journal of medicinal food. 2016 Sep; 19(9):830-5. doi: 10.1089/jmf.2016.0060. [PMID: 27542074]
  • Mei-Chun Kou, Shih-Hang Fu, Jui-Hung Yen, Ching-Yi Weng, Shiming Li, Chi-Tang Ho, Ming-Jiuan Wu. Effects of citrus flavonoids, 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone and 3,5,6,7,8,3',4'-heptamethoxyflavone, on the activities of macrophage scavenger receptors and the hepatic LDL receptor. Food & function. 2013 Apr; 4(4):602-9. doi: 10.1039/c3fo30301b. [PMID: 23370792]
  • Min Jeong Kim, Hye Hyeon Lee, Min Jeong Seo, Byoung Won Kang, Jeong Uck Park, Kyoung-Sook Kim, Gi-Young Kim, Woo Hong Joo, Yung Hyun Choi, Young-Su Cho, Yong Kee Jeong. Identification of 5-hydroxy-3,6,7,8,3´,4´-hexamethoxyflavone from Hizikia fusiforme involved in the induction of the apoptosis mediators in human AGS carcinoma cells. Journal of microbiology and biotechnology. 2012 Dec; 22(12):1665-72. doi: 10.4014/jmb.1208.08016. [PMID: 23221529]
  • Peiju Qiu, Huashi Guan, Ping Dong, Shanshan Guo, Jinkai Zheng, Shiming Li, Yun Chen, Chi-Tang Ho, Min-Hsiung Pan, David Julian McClements, Hang Xiao. The inhibitory effects of 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone on human colon cancer cells. Molecular nutrition & food research. 2011 Oct; 55(10):1523-32. doi: 10.1002/mnfr.201100070. [PMID: 21648071]
  • Shiming Li, Yu Wang, Zhenyu Wang, Hang Xiao, Chih-Yu Lo, Nancy Rawson, Chi-Tang Ho. Quantitative analysis of hydroxylated polymethoxyflavones by high-performance liquid chromatography. Biomedical chromatography : BMC. 2010 Aug; 24(8):838-45. doi: 10.1002/bmc.1372. [PMID: 20033889]
  • Ping Dong, Peiju Qiu, Yi Zhu, Shiming Li, Chi-Tang Ho, David Julian McClements, Hang Xiao. Simultaneous determination of four 5-hydroxy polymethoxyflavones by reversed-phase high performance liquid chromatography with electrochemical detection. Journal of chromatography. A. 2010 Jan; 1217(5):642-7. doi: 10.1016/j.chroma.2009.11.097. [PMID: 20022018]
  • Shiming Li, Min-Hsiung Pan, Ching-Shu Lai, Chih-Yu Lo, Slavik Dushenkov, Chi-Tang Ho. Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines. Bioorganic & medicinal chemistry. 2007 May; 15(10):3381-9. doi: 10.1016/j.bmc.2007.03.021. [PMID: 17391969]
  • B Delaney, K Phillips, C Vasquez, A Wilson, D Cox, H-B Wang, J Manthey. Genetic toxicity of a standardized mixture of citrus polymethoxylated flavones. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2002 May; 40(5):617-24. doi: 10.1016/s0278-6915(02)00007-8. [PMID: 11955667]
  • J J Lichius, O Thoison, A Montagnac, M Païs, F Guéritte-Voegelein, T Sévenet, J P Cosson, A H Hadi. Antimitotic and cytotoxic flavonols from Zieridium pseudobtusifolium and Acronychia porteri. Journal of natural products. 1994 Jul; 57(7):1012-6. doi: 10.1021/np50109a024. [PMID: 7964782]