4-(Diethylamino)benzaldehyde (BioDeep_00000174279)

   

human metabolite blood metabolite


代谢物信息卡片


4-(N,N-Diethylamino)benzaldehyde

化学式: C11H15NO (177.115358)
中文名称: 4-二乙氨基苯甲醛
谱图信息: 最多检出来源 Mus musculus(blood) 73.91%

分子结构信息

SMILES: CCN(CC)C1=CC=C(C=C1)C=O
InChI: InChI=1S/C11H15NO/c1-3-12(4-2)11-7-5-10(9-13)6-8-11/h5-9H,3-4H2,1-2H3

描述信息

4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenases (ALDHs) inhibitor, with a Ki of 4 nM for ALDH1. 4-Diethylaminobenzaldehyde displays potent anti-androgenic effect (IC50= 1.71μM)[1][2].

同义名列表

6 个代谢物同义名

4-(N,N-Diethylamino)benzaldehyde; 4-(Diethylamino)benzaldehyde; p-(Diethylamino)benzaldehyde; p-Formyl-N,N-diethylaniline; 4-Diethylaminobenzaldehyde; DEABZ



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Shuming Yang, Panayiotis Savvides, Lili Liu, Stanton L Gerson, Yan Xu. Development and validation of an LC-MS/MS method for pharmacokinetic study of methoxyamine in phase I clinical trial. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Jul; 901(?):25-33. doi: 10.1016/j.jchromb.2012.05.036. [PMID: 22743337]
  • Rebecca A Wingert, Rori Selleck, Jing Yu, Huai-Dong Song, Zhu Chen, Anhua Song, Yi Zhou, Bernard Thisse, Christine Thisse, Andrew P McMahon, Alan J Davidson. The cdx genes and retinoic acid control the positioning and segmentation of the zebrafish pronephros. PLoS genetics. 2007 Oct; 3(10):1922-38. doi: 10.1371/journal.pgen.0030189. [PMID: 17953490]
  • Jianbo Song, Hyon J Kim, Zhiyuan Gong, Ning-Ai Liu, Shuo Lin. Vhnf1 acts downstream of Bmp, Fgf, and RA signals to regulate endocrine beta cell development in zebrafish. Developmental biology. 2007 Mar; 303(2):561-75. doi: 10.1016/j.ydbio.2006.11.040. [PMID: 17217944]
  • Shuming Yang, Lili Liu, Stanton L Gerson, Yan Xu. Measurement of anti-cancer agent methoxyamine in plasma by tandem mass spectrometry with on-line sample extraction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Oct; 795(2):295-307. doi: 10.1016/s1570-0232(03)00594-4. [PMID: 14522034]
  • M I Mahmoud, J J Potter, O M Colvin, J Hilton, E Mezey. Effect of 4-(diethylamino)benzaldehyde on ethanol metabolism in mice. Alcoholism, clinical and experimental research. 1993 Dec; 17(6):1223-7. doi: 10.1111/j.1530-0277.1993.tb05233.x. [PMID: 8116835]
  • P Szylman, O S Better, C Chaimowitz, A Rosler. Role of hyperkalemia in the metabolic acidosis of isolated hypoaldosteronism. The New England journal of medicine. 1976 Feb; 294(7):361-5. doi: 10.1056/nejm197602122940703. [PMID: 1674]