3-Methylsulfonyl-4-piperidin-1-ylbenzoyl guanidine (BioDeep_00000173961)

   

human metabolite blood metabolite


代谢物信息卡片


N-Carbamimidoyl-3-methanesulphonyl-4-(piperidin-1-yl)benzene-1-carboximidic acid

化学式: C14H20N4O3S (324.1256)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CS(=O)(=O)C1=C(C=CC(=C1)C(=O)N=C(N)N)N1CCCCC1
InChI: InChI=1S/C14H20N4O3S/c1-22(20,21)12-9-10(13(19)17-14(15)16)5-6-11(12)18-7-3-2-4-8-18/h5-6,9H,2-4,7-8H2,1H3,(H4,15,16,17,19)



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Gisela Di Giusto, Alejandro Pizzoni, Valeria Rivarola, Natalia Beltramone, Alan White, Paula Ford, Claudia Capurro. Aquaporin-2 and Na+ /H+ exchanger isoform 1 modulate the efficiency of renal cell migration. Journal of cellular physiology. 2020 05; 235(5):4443-4454. doi: 10.1002/jcp.29320. [PMID: 31628683]
  • D C A Leite-Dellova, M Oliveira-Souza, G Malnic, M Mello-Aires. Genomic and nongenomic dose-dependent biphasic effect of aldosterone on Na+/H+ exchanger in proximal S3 segment: role of cytosolic calcium. American journal of physiology. Renal physiology. 2008 Nov; 295(5):F1342-52. doi: 10.1152/ajprenal.00048.2008. [PMID: 18715944]
  • Liping Xu, Mehul P Dixit, Kevin D Nullmeyer, Hua Xu, Pawel R Kiela, Ronald M Lynch, Fayez K Ghishan. Regulation of Na+/H+ exchanger-NHE3 by angiotensin-II in OKP cells. Biochimica et biophysica acta. 2006 Apr; 1758(4):519-26. doi: 10.1016/j.bbamem.2006.02.023. [PMID: 16603121]
  • Ji-Hyun Shin, Wan Namkung, Chang-Hoon Kim, Jae Young Choi, Jong-Bum Yoo, Kyung-Dong Lee, Jeung-Gweon Lee, Min Goo Lee, Joo-Heon Yoon. Expression of Na+/H+ exchanger isoforms in normal human nasal epithelial cells and functional activity of Na+/H+ exchanger 1 in intracellular pH regulation. Acta oto-laryngologica. 2005 Mar; 125(3):286-92. doi: 10.1080/00016480410022976. [PMID: 15966699]
  • Matthew A Bailey, Gerhard Giebisch, Thecla Abbiati, Peter S Aronson, Lara R Gawenis, Gary E Shull, Tong Wang. NHE2-mediated bicarbonate reabsorption in the distal tubule of NHE3 null mice. The Journal of physiology. 2004 Dec; 561(Pt 3):765-75. doi: 10.1113/jphysiol.2004.074716. [PMID: 15604231]
  • Amanda Tattersall, David Meredith, Paola Furla, Meng-Ru Shen, Clive Ellory, Robert Wilkins. Molecular and functional identification of the Na(+)/H(+) exchange isoforms NHE1 and NHE3 in isolated bovine articular chondrocytes. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2003; 13(4):215-22. doi: 10.1159/000072424. [PMID: 12876379]
  • Matthias Schäfer, Claudia Schäfer, Hans Michael Piper, Klaus-Dieter Schlüter. Hypertrophic responsiveness of cardiomyocytes to alpha- or beta-adrenoceptor stimulation requires sodium-proton-exchanger-1 (NHE-1) activation but not cellular alkalization. European journal of heart failure. 2002 Jun; 4(3):249-54. doi: 10.1016/s1388-9842(02)00016-8. [PMID: 12034148]
  • T Wang, M Hropot, P S Aronson, G Giebisch. Role of NHE isoforms in mediating bicarbonate reabsorption along the nephron. American journal of physiology. Renal physiology. 2001 Dec; 281(6):F1117-22. doi: 10.1152/ajprenal.2001.281.6.f1117. [PMID: 11704563]
  • K Drumm, B Gassner, S Silbernagl, M Gekle. Inhibition of Na superset+/H superset+ exchange decreases albumin-induced NF-kappaB activation in renal proximal tubular cell lines (OK and LLC-PK1 cells). European journal of medical research. 2001 Oct; 6(10):422-32. doi: NULL. [PMID: 11698229]
  • V M Rajendran, J Geibel, H J Binder. Characterization of apical membrane Cl-dependent Na/H exchange in crypt cells of rat distal colon. American journal of physiology. Gastrointestinal and liver physiology. 2001 Mar; 280(3):G400-5. doi: 10.1152/ajpgi.2001.280.3.g400. [PMID: 11171622]
  • M Klein, P Seeger, B Schuricht, S L Alper, A Schwab. Polarization of Na(+)/H(+) and Cl(-)/HCO (3)(-) exchangers in migrating renal epithelial cells. The Journal of general physiology. 2000 May; 115(5):599-608. doi: 10.1085/jgp.115.5.599. [PMID: 10779317]
  • K L Aldred, P J Harris, E Eitle. Increased proximal tubule NHE-3 and H+-ATPase activities in spontaneously hypertensive rats. Journal of hypertension. 2000 May; 18(5):623-8. doi: 10.1097/00004872-200018050-00016. [PMID: 10826566]
  • J Y Choi, M Shah, M G Lee, P J Schultheis, G E Shull, S Muallem, M Baum. Novel amiloride-sensitive sodium-dependent proton secretion in the mouse proximal convoluted tubule. The Journal of clinical investigation. 2000 Apr; 105(8):1141-6. doi: 10.1172/jci9260. [PMID: 10772659]
  • B A Watts, D W Good. Hyposmolality stimulates apical membrane Na(+)/H(+) exchange and HCO(3)(-) absorption in renal thick ascending limb. The Journal of clinical investigation. 1999 Dec; 104(11):1593-602. doi: 10.1172/jci7332. [PMID: 10587523]
  • M Gekle, K Drumm, S Mildenberger, R Freudinger, B Gassner, S Silbernagl. Inhibition of Na+-H+ exchange impairs receptor-mediated albumin endocytosis in renal proximal tubule-derived epithelial cells from opossum. The Journal of physiology. 1999 Nov; 520 Pt 3(?):709-21. doi: 10.1111/j.1469-7793.1999.00709.x. [PMID: 10545138]
  • C W Chow. Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3. Clinical and investigative medicine. Medecine clinique et experimentale. 1999 Oct; 22(5):195-206. doi: NULL. [PMID: 10579058]
  • F Di Sole, V Casavola, L Mastroberardino, F Verrey, O W Moe, G Burckhardt, H Murer, C Helmle-Kolb. Adenosine inhibits the transfected Na+-H+ exchanger NHE3 in Xenopus laevis renal epithelial cells (A6/C1). The Journal of physiology. 1999 Mar; 515 ( Pt 3)(?):829-42. doi: 10.1111/j.1469-7793.1999.829ab.x. [PMID: 10066908]
  • J Levitsky, D Gurell, W H Frishman. Sodium ion/hydrogen ion exchange inhibition: a new pharmacologic approach to myocardial ischemia and reperfusion injury. Journal of clinical pharmacology. 1998 Oct; 38(10):887-97. doi: 10.1002/j.1552-4604.1998.tb04383.x. [PMID: 9807968]
  • M C De la Horra, M L Calonge, A A Ilundáin. Effect of dehydration on apical Na+-H+ exchange activity and Na+-dependent sugar transport in brush-border membrane vesicles isolated from chick intestine. Pflugers Archiv : European journal of physiology. 1998 Jun; 436(1):112-6. doi: 10.1007/s004240050611. [PMID: 9560454]
  • L Guerra, F Di Sole, G Valenti, P M Ronco, E Perlino, V Casavola, S J Reshkin. Polarized distribution of Na+/H+ exchanger isoforms in rabbit collecting duct cells. Kidney international. 1998 May; 53(5):1269-77. doi: 10.1046/j.1523-1755.1998.00897.x. [PMID: 9573542]
  • J H Cho, M W Musch, C M Bookstein, R L McSwine, K Rabenau, E B Chang. Aldosterone stimulates intestinal Na+ absorption in rats by increasing NHE3 expression of the proximal colon. The American journal of physiology. 1998 03; 274(3):C586-94. doi: 10.1152/ajpcell.1998.274.3.c586. [PMID: 9530089]
  • E Schlatter, I Ankorina-Stark, S Haxelmans, H Hohage. Moxonidine inhibits Na+/H+ exchange in proximal tubule cells and cortical collecting duct. Kidney international. 1997 Aug; 52(2):454-9. doi: 10.1038/ki.1997.352. [PMID: 9264001]
  • M P Kelly, P A Quinn, J E Davies, L L Ng. Activity and expression of Na(+)-H+ exchanger isoforms 1 and 3 in kidney proximal tubules of hypertensive rats. Circulation research. 1997 Jun; 80(6):853-60. doi: 10.1161/01.res.80.6.853. [PMID: 9168788]
  • D W Johnson, B K Brew, P Poronnik, D I Cook, M J Field, A Z Györy, C A Pollock. Insulin-like growth factor I stimulates apical sodium/hydrogen exchange in human proximal tubule cells. The American journal of physiology. 1997 Apr; 272(4 Pt 2):F484-90. doi: 10.1152/ajprenal.1997.272.4.f484. [PMID: 9140049]
  • X Lin, T A Voyno-Yasenetskaya, R Hooley, C Y Lin, J Orlowski, D L Barber. Galpha12 differentially regulates Na+-H+ exchanger isoforms. The Journal of biological chemistry. 1996 Sep; 271(37):22604-10. doi: 10.1074/jbc.271.37.22604. [PMID: 8798430]
  • J Orlowski, R A Kandasamy. Delineation of transmembrane domains of the Na+/H+ exchanger that confer sensitivity to pharmacological antagonists. The Journal of biological chemistry. 1996 Aug; 271(33):19922-7. doi: 10.1074/jbc.271.33.19922. [PMID: 8702706]
  • E Schlatter, S Haxelmans, I Ankorina, R Kleta. Regulation of Na+/H+ exchange by diadenosine polyphosphates, angiotensin II, and vasopressin in rat cortical collecting duct. Journal of the American Society of Nephrology : JASN. 1995 Oct; 6(4):1223-9. doi: 10.1681/asn.v641223. [PMID: 8589290]