3-Deoxyglucosone (BioDeep_00000173893)
Secondary id: BioDeep_00000789541
human metabolite blood metabolite
代谢物信息卡片
4,5,6-trihydroxy-2-oxohexanal
化学式: C6H10O5 (162.052821)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 11.11%
分子结构信息
SMILES: C(C(=O)C=O)[C@@H]([C@@H](CO)O)O
InChI: InChI=1S/C6H10O5/c7-2-4(9)1-5(10)6(11)3-8/h2,5-6,8,10-11H,1,3H2
数据库引用编号
7 个数据库交叉引用编号
- PubChem: 15120156
- HMDB: HMDB0245856
- Wikipedia: 3-Deoxyglucosone
- chemspider: 10784988
- CAS: 4084-27-9
- KEGG: C22311
- RefMet: 3-Deoxyglucosone
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Catrin Herpich, Bastian Kochlik, Daniela Weber, Christiane Ott, Tilman Grune, Kristina Norman, Jana Raupbach. Fasting Concentrations and Postprandial Response of 1,2-Dicarbonyl Compounds 3-Deoxyglucosone, Glyoxal, and Methylglyoxal Are Not Increased in Healthy Older Adults.
The journals of gerontology. Series A, Biological sciences and medical sciences.
2022 05; 77(5):934-940. doi:
10.1093/gerona/glab331. [PMID: 34726231] - Kim Maasen, Simone J P M Eussen, Jean L J M Scheijen, Carla J H van der Kallen, Pieter C Dagnelie, Antoon Opperhuizen, Coen D A Stehouwer, Marleen M J van Greevenbroek, Casper G Schalkwijk. Higher habitual intake of dietary dicarbonyls is associated with higher corresponding plasma dicarbonyl concentrations and skin autofluorescence: the Maastricht Study.
The American journal of clinical nutrition.
2022 01; 115(1):34-44. doi:
10.1093/ajcn/nqab329. [PMID: 34625788] - M Piazza, N M J Hanssen, F Persson, J L Scheijen, M P H van de Waarenburg, M M J van Greevenbroek, P Rossing, P Hovind, C D A Stehouwer, H-H Parving, C G Schalkwijk. Irbesartan treatment does not influence plasma levels of the dicarbonyls methylglyoxal, glyoxal and 3-deoxyglucosone in participants with type 2 diabetes and microalbuminuria: An IRMA2 sub-study.
Diabetic medicine : a journal of the British Diabetic Association.
2021 09; 38(9):e14405. doi:
10.1111/dme.14405. [PMID: 32961617] - Shingo Yoshioka, Hiroko Odani, Tadaaki Furuhashi, Tsutomu Tanaka, Toyoaki Ogawa. Increase in the peripheral blood methylglyoxal levels in 10\% of hospitalized chronic schizophrenia patients.
Nagoya journal of medical science.
2021 Feb; 83(1):51-61. doi:
10.18999/nagjms.83.1.51. [PMID: 33727737] - Jin Cai, Liang Zhou, Xiudao Song, Meiqi Yin, Guoqiang Liang, Heng Xu, Lurong Zhang, Guorong Jiang, Fei Huang. Alteration of Intestinal Microbiota in 3-Deoxyglucosone-Induced Prediabetic Rats.
BioMed research international.
2020; 2020(?):8406846. doi:
10.1155/2020/8406846. [PMID: 32908918] - Xin-Jie Wang, Hong-Xia Zhang, Heng Li, Ai-Hua Zhu, Wen-Yun Gao. Measurement of α-dicarbonyl compounds in human saliva by pre-column derivatization HPLC.
Clinical chemistry and laboratory medicine.
2019 Nov; 57(12):1915-1922. doi:
10.1515/cclm-2019-0350. [PMID: 31377732] - Xiudao Song, Guoqiang Liang, Min Shi, Liang Zhou, Fei Wang, Lurong Zhang, Fei Huang, Guorong Jiang. Acute exposure to 3‑deoxyglucosone at high glucose levels impairs insulin secretion from β‑cells by downregulating the sweet taste receptor signaling pathway.
Molecular medicine reports.
2019 Jun; 19(6):5015-5022. doi:
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PloS one.
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