Alphate (BioDeep_00000173688)
human metabolite blood metabolite
代谢物信息卡片
3-[(dimethoxyphosphoryl)oxy]-N-methylbut-2-enamide
化学式: C7H14NO5P (223.06095639999998)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CNC(=O)C=C(C)OP(=O)(OC)OC
InChI: InChI=1S/C7H14NO5P/c1-6(5-7(9)8-2)13-14(10,11-3)12-4/h5H,1-4H3,(H,8,9)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
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PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Madhusudan Reddy Narra, Ghousia Begum, Kodimyala Rajender, J Venkateswara Rao. Toxic impact of two organophosphate insecticides on biochemical parameters of a food fish and assessment of recovery response.
Toxicology and industrial health.
2012 May; 28(4):343-52. doi:
10.1177/0748233711412423. [PMID: 21983276] - Kevin Chien-Chang Wu, Ying-Yeh Chen, Paul S F Yip. Suicide methods in Asia: implications in suicide prevention.
International journal of environmental research and public health.
2012 04; 9(4):1135-58. doi:
10.3390/ijerph9041135. [PMID: 22690187] - John E Casida. The greening of pesticide-environment interactions: some personal observations.
Environmental health perspectives.
2012 Apr; 120(4):487-93. doi:
10.1289/ehp.1104405. [PMID: 22472325] - Apurva Kumar Ramesh Joshi, Raju Nagaraju, Padmanabhan Sharda Rajini. Insights into the mechanisms mediating hyperglycemic and stressogenic outcomes in rats treated with monocrotophos, an organophosphorus insecticide.
Toxicology.
2012 Mar; 294(1):9-16. doi:
10.1016/j.tox.2012.01.009. [PMID: 22305719] - Amajad Iqbal Kazi, Anna Oommen. Monocrotophos induced oxidative damage associates with severe acetylcholinesterase inhibition in rat brain.
Neurotoxicology.
2012 Mar; 33(2):156-61. doi:
10.1016/j.neuro.2012.01.008. [PMID: 22285544] - Poonam Sharma, Rambir Singh. Dichlorvos and lindane induced oxidative stress in rat brain: Protective effects of ginger.
Pharmacognosy research.
2012 Jan; 4(1):27-32. doi:
10.4103/0974-8490.91031. [PMID: 22224058] - Satya Srinivas P, Kaushik Banerjee, Manjusha R Jadhav, Manoj S Ghaste, K E Lawande. Bioefficacy, dissipation kinetics and safety evaluation of selected insecticides in Allium cepa L.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.
2012; 47(7):700-9. doi:
10.1080/03601234.2012.669262. [PMID: 22560033] - Apurva Kumar R Joshi, P S Rajini. Hyperglycemic and stressogenic effects of monocrotophos in rats: evidence for the involvement of acetylcholinesterase inhibition.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2012 Jan; 64(1-2):115-20. doi:
10.1016/j.etp.2010.07.003. [PMID: 20674316] - Cátia S A Santos, Marta S Monteiro, Amadeu M V M Soares, Susana Loureiro. Characterization of cholinesterases in plasma of three Portuguese native bird species: application to biomonitoring.
PloS one.
2012; 7(3):e33975. doi:
10.1371/journal.pone.0033975. [PMID: 22470503] - Khamrunissa Begum, P S Rajini. Augmentation of hepatic and renal oxidative stress and disrupted glucose homeostasis by monocrotophos in streptozotocin-induced diabetic rats.
Chemico-biological interactions.
2011 Sep; 193(3):240-5. doi:
10.1016/j.cbi.2011.07.003. [PMID: 21821013] - Ashraf S Alias, Muna H I Al-Zubaidy, Yaareb J Mousa, Fouad K Mohammad. Plasma and whole brain cholinesterase activities in three wild bird species in Mosul, IRAQ: In vitro inhibition by insecticides.
Interdisciplinary toxicology.
2011 Sep; 4(3):144-8. doi:
10.2478/v10102-011-0022-x. [PMID: 22058655] - Madhusudan Reddy Narra, Ghousia Begum, Kodimyala Rajender, J Venkateswara Rao. In vivo impact of monocrotophos on biochemical parameters of a freshwater fish during subacute toxicity and following cessation of exposure to the insecticide.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
2011 Sep; 66(9-10):507-14. doi:
10.1515/znc-2011-9-1011. [PMID: 22191217] - Natalie A Belsey, Sarah F Cordery, Annette L Bunge, Richard H Guy. Assessment of dermal exposure to pesticide residues during re-entry.
Environmental science & technology.
2011 May; 45(10):4609-15. doi:
10.1021/es200172q. [PMID: 21510672] - HaiFeng Qian, Tao Lu, XiaoFeng Peng, Xiao Han, ZhengWei Fu, WeiPing Liu. Enantioselective phytotoxicity of the herbicide imazethapyr on the response of the antioxidant system and starch metabolism in Arabidopsis thaliana.
PloS one.
2011 May; 6(5):e19451. doi:
10.1371/journal.pone.0019451. [PMID: 21573119] - Nidhi Dwivedi, Swaran J S Flora. Concomitant exposure to arsenic and organophosphates on tissue oxidative stress in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2011 May; 49(5):1152-9. doi:
10.1016/j.fct.2011.02.007. [PMID: 21349312] - Anwar Masoud, Ravi Kiran, Rajat Sandhir. Modulation of dopaminergic system and neurobehavioral functions in delayed neuropathy induced by organophosphates.
Toxicology mechanisms and methods.
2011 Jan; 21(1):1-5. doi:
10.3109/15376516.2010.529182. [PMID: 21067471] - Vinay Pandit, Shubha Seshadri, S N Rao, Charmaine Samarasinghe, Ashwini Kumar, Rohith Valsalan. A case of organophosphate poisoning presenting with seizure and unavailable history of parenteral suicide attempt.
Journal of emergencies, trauma, and shock.
2011 Jan; 4(1):132-4. doi:
10.4103/0974-2700.76825. [PMID: 21633583] - Kaniyarikkal Divakaran Prathapan, Caroline Simmrita Chaboo. Biology of Blepharida-group flea beetles with first notes on natural history of Podontia congregata Baly, 1865 an endemic flea beetle from southern India (Coleoptera, Chrysomelidae, Galerucinae, Alticini).
ZooKeys.
2011; ?(157):95-130. doi:
10.3897/zookeys.157.1472. [PMID: 22303106] - M P Kashyap, A K Singh, M A Siddiqui, V Kumar, V K Tripathi, V K Khanna, S Yadav, S K Jain, A B Pant. Caspase cascade regulated mitochondria mediated apoptosis in monocrotophos exposed PC12 cells.
Chemical research in toxicology.
2010 Nov; 23(11):1663-72. doi:
10.1021/tx100234m. [PMID: 20957986] - Hua Tian, Shaoguo Ru, Xin Bing, Wei Wang. Effects of monocrotophos on the reproductive axis in the male goldfish (Carassius auratus): potential mechanisms underlying vitellogenin induction.
Aquatic toxicology (Amsterdam, Netherlands).
2010 Jun; 98(1):67-73. doi:
10.1016/j.aquatox.2010.01.011. [PMID: 20149464] - Hua Tian, Shaoguo Ru, Wei Wang, Xin Bing. Effects of monocrotophos on the reproductive axis in the female goldfish (Carassius auratus).
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2010 Jun; 152(1):107-13. doi:
10.1016/j.cbpc.2010.03.004. [PMID: 20298809] - Jérôme Carletto, Thibaud Martin, Flavie Vanlerberghe-Masutti, Thierry Brévault. Insecticide resistance traits differ among and within host races in Aphis gossypii.
Pest management science.
2010 Mar; 66(3):301-7. doi:
10.1002/ps.1874. [PMID: 19908228] - Nidhi Dwivedi, Yangchen D Bhutia, Vinesh Kumar, Preeti Yadav, Pramod Kushwaha, Harimohan Swarnkar, S J S Flora. Effects of combined exposure to dichlorvos and monocrotophos on blood and brain biochemical variables in rats.
Human & experimental toxicology.
2010 Feb; 29(2):121-9. doi:
10.1177/0960327109357212. [PMID: 20026515] - Ung-Kyu Choi, Ok-Hwan Lee, Joo Hyuk Yim, Chang-Won Cho, Young Kyung Rhee, Seong-Il Lim, Young-Chan Kim. Hypolipidemic and antioxidant effects of dandelion (Taraxacum officinale) root and leaf on cholesterol-fed rabbits.
International journal of molecular sciences.
2010 Jan; 11(1):67-78. doi:
10.3390/ijms11010067. [PMID: 20162002] - Anwar Masoud, Ravi Kiran, Rajat Sandhir. Impaired mitochondrial functions in organophosphate induced delayed neuropathy in rats.
Cellular and molecular neurobiology.
2009 Dec; 29(8):1245-55. doi:
10.1007/s10571-009-9420-4. [PMID: 19517227] - Hua Tian, Shaoguo Ru, Zhenyu Wang, Wenting Cai, Wei Wang. Estrogenic effects of monocrotophos evaluated by vitellogenin mRNA and protein induction in male goldfish (Carassius auratus).
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2009 Aug; 150(2):231-6. doi:
10.1016/j.cbpc.2009.04.014. [PMID: 19439194] - Y-H Yang, Y-J Yang, W-Y Gao, J-J Guo, Y-H Wu, Y-D Wu. Introgression of a disrupted cadherin gene enables susceptible Helicoverpa armigera to obtain resistance to Bacillus thuringiensis toxin Cry1Ac.
Bulletin of entomological research.
2009 Apr; 99(2):175-81. doi:
10.1017/s0007485308006226. [PMID: 18954492] - Chandrakala Patil, Ravindra Paul, Malkanna. Neuroendocrine regulation and pesticidal impact on freshwater crab, Barytelphusa guerini (H. Milne Edwards).
Journal of environmental biology.
2008 Nov; 29(6):887-92. doi:
". [PMID: 19297986] - Daoud Ali, Sudhir Kumar. Long-term genotoxic effect of monocrotophos in different tissues of freshwater fish Channa punctatus (Bloch) using alkaline single cell gel electrophoresis.
The Science of the total environment.
2008 Nov; 405(1-3):345-50. doi:
10.1016/j.scitotenv.2008.05.037. [PMID: 18649923] - S K Rastogi, Vipul K Singh, C Kesavachandran, Jyoti, M K J Siddiqui, N Mathur, R S Bharti. Monitoring of plasma butyrylcholinesterase activity and hematological parameters in pesticide sprayers.
Indian journal of occupational and environmental medicine.
2008 Apr; 12(1):29-32. doi:
10.4103/0019-5278.40813. [PMID: 20040995] - B Velmurugan, M Selvanayagam, E I Cengiz, E Unlu. The effects of monocrotophos to different tissues of freshwater fish Cirrhinus mrigala.
Bulletin of environmental contamination and toxicology.
2007 Jun; 78(6):450-4. doi:
10.1007/s00128-007-9190-y. [PMID: 17619798] - Mao-hua Chen, Zhao-jun Han, Xian-feng Qiao, Ming-jing Qu. Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and carbamate insecticides.
Genome.
2007 Feb; 50(2):172-9. doi:
10.1139/g07-021. [PMID: 17546082] - Sandra Yucra, Kyle Steenland, Arturo Chung, Fredy Choque, Gustavo F Gonzales. Dialkyl phosphate metabolites of organophosphorus in applicators of agricultural pesticides in Majes - Arequipa (Peru).
Journal of occupational medicine and toxicology (London, England).
2006 Dec; 1(?):27. doi:
10.1186/1745-6673-1-27. [PMID: 17177990] - J Venkateswara Rao. Biochemical alterations in euryhaline fish, Oreochromis mossambicus exposed to sub-lethal concentrations of an organophosphorus insecticide, monocrotophos.
Chemosphere.
2006 Dec; 65(10):1814-20. doi:
10.1016/j.chemosphere.2006.04.015. [PMID: 16730777] - M Ahmed Azmi, S N H Naqvi, M Arshad Azmi, M Aslam. Effect of pesticide residues on health and different enzyme levels in the blood of farm workers from Gadap (rural area) Karachi-Pakistan.
Chemosphere.
2006 Sep; 64(10):1739-44. doi:
10.1016/j.chemosphere.2006.01.016. [PMID: 16487989] - J Venkateswara Rao. Sublethal effects of an organophosphorus insecticide (RPR-II) on biochemical parameters of tilapia, Oreochromis mossambicus.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2006 Aug; 143(4):492-8. doi:
10.1016/j.cbpc.2006.05.001. [PMID: 16765096] - Shweta Agrahari, Krishna Gopal, K C Pandey. Biomarkers of monocrotophos in a freshwater fish Channa punctatus (Bloch).
Journal of environmental biology.
2006 May; 27(2 Suppl):453-7. doi:
. [PMID: 17436543] - S S Sarnaik, P P Kanekar, V M Raut, S P Taware, K S Chavan, B J Bhadbhade. Effect of application of different pesticides to soybean on the soil microflora.
Journal of environmental biology.
2006 May; 27(2 Suppl):423-6. doi:
". [PMID: 17436537] - Nidhi Benjamin, Ameeta Kushwah, R K Sharma, A K Katiyar. Histopathological changes in liver, kidney and muscles of pesticides exposed malnourished and diabetic rats.
Indian journal of experimental biology.
2006 Mar; 44(3):228-32. doi:
. [PMID: 16538862] - J Castillo-Cadena, L E Tenorio-Vieyra, A I Quintana-Carabia, M M García-Fabila, E Ramírez-San Juan, E Madrigal-Bujaidar. Determination of DNA damage in floriculturists exposed to mixtures of pesticides.
Journal of biomedicine & biotechnology.
2006; 2006(2):97896. doi:
10.1155/jbb/2006/97896. [PMID: 16883059] - G Mikunthan, M Manjunatha. Fusarium semitectum, a potential mycopathogen against thrips and mites in chilli, Capsicum annuum.
Communications in agricultural and applied biological sciences.
2006; 71(2 Pt B):449-63. doi:
". [PMID: 17385513] - Selvaraj Venkatesh, Anand Zachariah, Anna Oommen. Myofibril membranes in relation to the neuromuscular weakness of acute monocrotophos poisoning.
Toxicology mechanisms and methods.
2006; 16(8):419-26. doi:
10.1080/15376520600685813. [PMID: 20021016] - Cristina S Bastos, Raul P de Almeida, Fábio A Suinaga. Selectivity of pesticides used on cotton (Gossypium hirsutum) to Trichogramma pretiosum reared on two laboratory-reared hosts.
Pest management science.
2006 Jan; 62(1):91-8. doi:
10.1002/ps.1140. [PMID: 16308868] - Sukhdeep Kaur, C K Dhanju. Biochemical effects of some organophosphorus pesticides on the ovaries of albino rats.
Indian journal of physiology and pharmacology.
2005 Apr; 49(2):148-52. doi:
". [PMID: 16170982] - Biljana Antonijević, Dubravko Bokonjić, Milos P Stojiljković, Vesna Kilibarda, Zoran A Milovanović, Mirjana Nedeljković, Matej Maksimović. Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos.
Basic & clinical pharmacology & toxicology.
2005 Feb; 96(2):111-7. doi:
10.1111/j.1742-7843.2005.pto960204.x. [PMID: 15679473] - Umesh K Garg, Asim K Pal, Gautam J Jha, Sanjay B Jadhao. Haemato-biochemical and immuno-pathophysiological effects of chronic toxicity with synthetic pyrethroid, organophosphate and chlorinated pesticides in broiler chicks.
International immunopharmacology.
2004 Dec; 4(13):1709-22. doi:
10.1016/j.intimp.2004.08.002. [PMID: 15454122] - Sukhdeep Kaur, C K Dhanju. Enzymatic changes induced by some organophosphorus pesticides in female rats.
Indian journal of experimental biology.
2004 Oct; 42(10):1017-9. doi:
NULL. [PMID: 15511008] - Mohammed Mahboob, Mohammed Kaleem, Javed Siddiqui. Effects of a novel organophosphorus pesticide (RPR-V) on extra hepatic detoxifying enzymes after repeated oral doses in rats.
Toxicology.
2004 Oct; 202(3):159-64. doi:
10.1016/j.tox.2004.05.004. [PMID: 15337579] - Umesh K Garg, Asim K Pal, Gautam J Jha, Sanjay B Jadhao. Pathophysiological effects of chronic toxicity with synthetic pyrethroid, organophosphate and chlorinated pesticides on bone health of broiler chicks.
Toxicologic pathology.
2004 May; 32(3):364-9. doi:
10.1080/01926230490431745. [PMID: 15204980] - F A Tarbah, B Kardel, S Pier, O Temme, T Daldrup. Acute poisoning with phosphamidon: determination of dimethyl phosphate (DMP) as a stable metabolite in a case of organophosphate insecticide intoxication.
Journal of analytical toxicology.
2004 Apr; 28(3):198-203. doi:
10.1093/jat/28.3.198. [PMID: 15107151] - Fei Li, Zhaojun Han. Mutations in acetylcholinesterase associated with insecticide resistance in the cotton aphid, Aphis gossypii Glover.
Insect biochemistry and molecular biology.
2004 Apr; 34(4):397-405. doi:
10.1016/j.ibmb.2004.02.001. [PMID: 15041023] - Mohan Singh, Rajat Sandhir, Ravi Kiran. In vitro effects of organophosphate pesticides on rat erythrocytes.
Indian journal of experimental biology.
2004 Mar; 42(3):292-6. doi:
. [PMID: 15233300] - Mohammed F Rahman, Mohammed K J Siddiqui. Biochemical enzyme activity in different tissues of rats exposed to a novel phosphorothionate (RPR-V).
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.
2003 Jan; 38(1):59-71. doi:
10.1081/pfc-120016606. [PMID: 12602824] - Yunxiu Hou, Fenghua Fu, Shiwen Liu, Chenghua Liu, Yihua Sun, Shicui Qiu. [The profiles of free organophosphorus poisons in the bile of rabbits poisoned with different organophosphates].
Zhonghua nei ke za zhi.
2002 Dec; 41(12):795-7. doi:
NULL. [PMID: 12654229] - Yüksel Gokel. Subarachnoid hemorrhage and rhabdomyolysis induced acute renal failure complicating organophosphate intoxication.
Renal failure.
2002 Nov; 24(6):867-71. doi:
10.1081/jdi-120015689. [PMID: 12472209] - M Mahboob, M K J Siddiqui. Long-term effects of a novel phosphorothionate (RPR-II) on detoxifying enzymes in brain, lung, and kidney rats.
Ecotoxicology and environmental safety.
2002 Nov; 53(3):355-60. doi:
10.1016/s0147-6513(02)00016-7. [PMID: 12485578] - Xiaoxia Ren, Zhaojun Han, Yinchang Wang. Mechanisms of monocrotophos resistance in cotton bollworm, Helicoverpa armigera (Hübner).
Archives of insect biochemistry and physiology.
2002 Nov; 51(3):103-10. doi:
10.1002/arch.10054. [PMID: 12386838] - M J Parma De Croux, A Loteste, J Cazenave. Inhibition of plasma cholinesterase and acute toxicity of monocrotophos in a neotropical fish Prochilodus lineatus (pisces, curimatidae).
Bulletin of environmental contamination and toxicology.
2002 Sep; 69(3):356-63. doi:
10.1007/s00128-002-0070-1. [PMID: 12177756] - Alicia Loteste, Jimena Cazenave, M Julieta Parma de Croux. Recovery of plasmatic cholinesterase activity in a neotropical fish Prochilodus lineatus (Pisces, Curimatidae) exposed to organophosphorous pesticides.
Journal of environmental biology.
2002 Jul; 23(3):225-9. doi:
NULL. [PMID: 12597563] - I A Khan, B V Reddy, M Mahboob, M F Rahman, Kaiser Jamil. Acute and sub-acute effects of 2-butenoic acid-3-(diethoxy phosphinothioyl) methyl ester (RPR-II) on testis of albino rat.
Indian journal of experimental biology.
2002 Feb; 40(2):162-8. doi:
NULL. [PMID: 12622178] - A Maklakov, I Ishaaya, A Freidberg, A Yawetz, A R Horowitz, I Yarom. Toxicological studies of organophosphate and pyrethroid insecticides for controlling the fruit fly Dacus ciliatus (Diptera: Tephritidae).
Journal of economic entomology.
2001 Oct; 94(5):1059-66. doi:
10.1603/0022-0493-94.5.1059. [PMID: 11681666] - I A Khan, B V Reddy, M Mahboob, M F Rahman, K Jamil. Effects of phosphorothionate on the reproductive system of male rats.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.
2001 Jul; 36(4):445-56. doi:
10.1081/pfc-100104188. [PMID: 11495022]