Cholest-5-ene-3,25-diol (BioDeep_00000173681)
human metabolite blood metabolite
代谢物信息卡片
化学式: C27H46O2 (402.34976159999997)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CCCC(C)(C)O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
InChI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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Plant Reactome(0)
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1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jorge A López-Velázquez, Luis D Carrillo-Córdova, Norberto C Chávez-Tapia, Misael Uribe, Nahum Méndez-Sánchez. Nuclear receptors in nonalcoholic Fatty liver disease.
Journal of lipids.
2012; 2012(?):139875. doi:
10.1155/2012/139875. [PMID: 22187655] - Thomas J Berrodin, Qi Shen, Elaine M Quinet, Matthew R Yudt, Leonard P Freedman, Sunil Nagpal. Identification of 5α, 6α-epoxycholesterol as a novel modulator of liver X receptor activity.
Molecular pharmacology.
2010 Dec; 78(6):1046-58. doi:
10.1124/mol.110.065193. [PMID: 20837678] - Makiko Fukunaga, Satoshi Nunomura, Shigeru Nishida, Kaori Endo, Yasuhiro Gon, Shu Hashimoto, Yuichi Hashimoto, Yoshimichi Okayama, Makoto Makishima, Chisei Ra. Mast cell death induced by 24(S),25-epoxycholesterol.
Experimental cell research.
2010 Nov; 316(19):3272-81. doi:
10.1016/j.yexcr.2010.09.002. [PMID: 20854813] - Hiromi Ando, Yasuhiro Horibata, Satoko Yamashita, Tetsunari Oyama, Hiroyuki Sugimoto. Low-density lipoprotein and oxysterols suppress the transcription of CTP: Phosphoethanolamine cytidylyltransferase in vitro.
Biochimica et biophysica acta.
2010 Apr; 1801(4):487-95. doi:
10.1016/j.bbalip.2009.12.014. [PMID: 20045741] - Mireille Ouimet, Ming-Dong Wang, Natalie Cadotte, Kenneth Ho, Yves L Marcel. Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux.
Arteriosclerosis, thrombosis, and vascular biology.
2008 Jun; 28(6):1144-50. doi:
10.1161/atvbaha.107.157115. [PMID: 18369155] - M B Patel, N A Oza, I S Anand, S S Deshpande, C N Patel. Liver x receptor: a novel therapeutic target.
Indian journal of pharmaceutical sciences.
2008 Mar; 70(2):135-44. doi:
10.4103/0250-474x.41445. [PMID: 20046702] - Tatiana Saldanha, Neura Bragagnolo. Cholesterol oxidation is increased and PUFA decreased by frozen storage and grilling of Atlantic hake fillets (Merluccius hubbsi).
Lipids.
2007 Jul; 42(7):671-8. doi:
10.1007/s11745-007-3062-4. [PMID: 17492472] - Murray W Huff, Dawn E Telford. Lord of the rings--the mechanism for oxidosqualene:lanosterol cyclase becomes crystal clear.
Trends in pharmacological sciences.
2005 Jul; 26(7):335-40. doi:
10.1016/j.tips.2005.05.004. [PMID: 15951028] - Nicolas Venteclef, Raphaelle Guillard, Marc Issandou. The imidazoline-like drug S23515 affects lipid metabolism in hepatocyte by inhibiting the oxidosqualene: lanosterol cyclase activity.
Biochemical pharmacology.
2005 Apr; 69(7):1041-8. doi:
10.1016/j.bcp.2005.01.005. [PMID: 15763540] - Andrea H Rowe, Carmen A Argmann, Jane Y Edwards, Cynthia G Sawyez, Olivier H Morand, Robert A Hegele, Murray W Huff. Enhanced synthesis of the oxysterol 24(S),25-epoxycholesterol in macrophages by inhibitors of 2,3-oxidosqualene:lanosterol cyclase: a novel mechanism for the attenuation of foam cell formation.
Circulation research.
2003 Oct; 93(8):717-25. doi:
10.1161/01.res.0000097606.43659.f4. [PMID: 14512442] - Emi Kaneko, Morihiro Matsuda, Yukio Yamada, Yoji Tachibana, Iichiro Shimomura, Makoto Makishima. Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist.
The Journal of biological chemistry.
2003 Sep; 278(38):36091-8. doi:
10.1074/jbc.m304153200. [PMID: 12847102] - X Fu, J G Menke, Y Chen, G Zhou, K L MacNaul, S D Wright, C P Sparrow, E G Lund. 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells.
The Journal of biological chemistry.
2001 Oct; 276(42):38378-87. doi:
10.1074/jbc.m105805200. [PMID: 11504730]