2-[(1s,2s)-2-Carboxycyclopropyl]-3-(9h-Xanthen-9-Yl)-D-Alanine (BioDeep_00000173654)
human metabolite blood metabolite
代谢物信息卡片
化学式: C20H19NO5 (353.1263)
中文名称:
谱图信息:
最多检出来源 Mus musculus(blood) 92.86%
分子结构信息
SMILES: C1C(C1C(CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O
InChI: InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)
描述信息
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists
同义名列表
4 个代谢物同义名
(2S)-2-[(1S)-1-Amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]cyclopropane-1-carboxylate; 2-[1-amino-1-carboxy-2-(9H-xanthen-9-yl)ethyl]cyclopropane-1-carboxylic acid; 2-Amino-2-(2-carboxycycloprop-1-yl)-3-(xanth-9-yl)propanoic acid; 2-[(1s,2s)-2-Carboxycyclopropyl]-3-(9h-Xanthen-9-Yl)-D-Alanine
相关代谢途径
Reactome()
BioCyc()
PlantCyc()
代谢反应
个相关的代谢反应过程信息。
Reactome()
BioCyc()
WikiPathways()
Plant Reactome()
INOH()
PlantCyc()
COVID-19 Disease Map()
PathBank()
PharmGKB()
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Paula Pierozan, Marie Andersson, Ingvar Brandt, Oskar Karlsson. The environmental neurotoxin β-N-methylamino-L-alanine inhibits melatonin synthesis in primary pinealocytes and a rat model.
Journal of pineal research.
2018 Aug; 65(1):e12488. doi:
10.1111/jpi.12488. [PMID: 29528516] - Aintzane García-Bea, Isabel Bermudez, Paul J Harrison, Tracy A Lane. A group II metabotropic glutamate receptor 3 (mGlu3, GRM3) isoform implicated in schizophrenia interacts with canonical mGlu3 and reduces ligand binding.
Journal of psychopharmacology (Oxford, England).
2017 12; 31(12):1519-1526. doi:
10.1177/0269881117715597. [PMID: 28655286] - Zhong-Wei Sun, Lan Zhang, Shu-Jia Zhu, Wen-Chun Chen, Bing Mei. Excitotoxicity effects of glutamate on human neuroblastoma SH-SY5Y cells via oxidative damage.
Neuroscience bulletin.
2010 Feb; 26(1):8-16. doi:
10.1007/s12264-010-0813-7. [PMID: 20101268] - Douglas J Sheffler, P Jeffrey Conn. Allosteric potentiators of metabotropic glutamate receptor subtype 1a differentially modulate independent signaling pathways in baby hamster kidney cells.
Neuropharmacology.
2008 Sep; 55(4):419-27. doi:
10.1016/j.neuropharm.2008.06.047. [PMID: 18625258] - Mara D'Onofrio, Antonietta Arcella, Valeria Bruno, Richard T Ngomba, Giuseppe Battaglia, Vincenza Lombari, Giuseppe Ragona, Antonella Calogero, Ferdinando Nicoletti. Pharmacological blockade of mGlu2/3 metabotropic glutamate receptors reduces cell proliferation in cultured human glioma cells.
Journal of neurochemistry.
2003 Mar; 84(6):1288-95. doi:
10.1046/j.1471-4159.2003.01633.x. [PMID: 12614329] - M P Johnson, G Kelly, M Chamberlain. Changes in rat serum corticosterone after treatment with metabotropic glutamate receptor agonists or antagonists.
Journal of neuroendocrinology.
2001 Aug; 13(8):670-7. doi:
10.1046/j.1365-2826.2001.00678.x. [PMID: 11489083]
