1-Fluoro-2,4-dinitrobenzene (BioDeep_00000173555)

 

Secondary id: BioDeep_00001871800

human metabolite blood metabolite


代谢物信息卡片


2,4-Dinitrobenzene fluoride

化学式: C6H3FN2O4 (186.007685)
中文名称: 2,4-二硝基氟苯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])F
InChI: InChI=1S/C6H3FN2O4/c7-5-2-1-4(8(10)11)3-6(5)9(12)13/h1-3H



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(4)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Valéria Costa Da Silva, Gerlane Coelho Bernardo Guerra, Daline Fernandes De Souza Araújo, Edilane Rodrigues De Araújo, Aurigena Antunes De Araújo, Renato Dantas-Medeiros, Ana Caroline Zanatta, Isadora Luisa Gomes Da Silva, Raimundo Fernandes De Araújo Júnior, Debora Esposito, Marvin Moncada, Silvana Maria Zucolotto. Chemopreventive and immunomodulatory effects of phenolic-rich extract of Commiphora leptophloeos against inflammatory bowel disease: Preclinical evidence. Journal of ethnopharmacology. 2024 Jun; 328(?):118025. doi: 10.1016/j.jep.2024.118025. [PMID: 38458342]
  • Kun Yang, Jiang-Yan Yong, Yan He, Lu Yu, Gui-Ning Luo, Jilan Chen, Yi-Man Ge, You-Jun Yang, Wei-Jun Ding, Yi-Mei Hu. Melatonin restores DNFB-induced dysbiosis of skin microbiota in a mouse model of atopic dermatitis. Life sciences. 2024 Apr; 342(?):122513. doi: 10.1016/j.lfs.2024.122513. [PMID: 38387700]
  • Stefania Lama, Ester Pagano, Francesca Borrelli, Maria Maisto, Gian Carlo Tenore, Maria Francesca Nanì, Pilar Chacon-Millan, Ettore Novellino, Paola Stiuso. Polyphenol-Rich Extract from 'Limoncella' Apple Variety Ameliorates Dinitrobenzene Sulfonic Acid-Induced Colitis and Linked Liver Damage. International journal of molecular sciences. 2024 Mar; 25(6):. doi: 10.3390/ijms25063210. [PMID: 38542183]
  • Jian-Li Huang, Yi-Hua Xu, Xin-Wei Yang, Jie Wang, Yu Zhu, Xian-Bo Wu. Jiawei guomin decoction regulates the degranulation of mast cells in atopic dermatitis mice via the HIS/PAR-2 pathway. Journal of ethnopharmacology. 2024 Mar; 321(?):117485. doi: 10.1016/j.jep.2023.117485. [PMID: 38008276]
  • Yihan Huang, Chenrui Zhao, Guodong Zheng, Yujuan Yuan, Ling Gong, Rui Liu, Jingang An. Dictamnine Ameliorates DNFB-Induced Atopic Dermatitis Like Skin Lesions in Mice by Inhibiting M1 Macrophage Polarization and Promoting Autophagy. Biological & pharmaceutical bulletin. 2024 Jan; 47(1):175-186. doi: 10.1248/bpb.b23-00436. [PMID: 38092386]
  • Yun-Seong Lee, Byeong-Jun Ji, Hyun-Ock Pae, Mu-Weon Cheon, Guangpeng Xu, Hyun-Soo Chun, Sooah Kim. Anti-Inflammatory Effect of Fermented Cabbage Extract Containing Nitric Oxide Metabolites with Silica. International journal of molecular sciences. 2024 Jan; 25(2):. doi: 10.3390/ijms25020775. [PMID: 38255849]
  • Kukhwa Kim, Daniel Lee, Han-Young Kim, Soyeon Kim, Ji-Hyo Lyu, Sujung Park, Young-Chul Park, Hyungwoo Kim. Anti-Inflammatory Effects of Spirodela polyrhiza (L.) SCHLEID. Extract on Contact Dermatitis in Mice-Its Active Compounds and Molecular Targets. International journal of molecular sciences. 2023 Aug; 24(17):. doi: 10.3390/ijms241713271. [PMID: 37686078]
  • Niuniu Yang, Haifeng Shao, Jialin Deng, Yan Yang, Zongxiang Tang, Guanyi Wu, Yanqing Liu. Dictamnine ameliorates chronic itch in DNFB-induced atopic dermatitis mice via inhibiting MrgprA3. Biochemical pharmacology. 2023 02; 208(?):115368. doi: 10.1016/j.bcp.2022.115368. [PMID: 36493846]
  • Ciyu Yao, Wenzhen Ye, Mengxue Chen. Inhibition of Mast Cell Degranulation in Atopic Dermatitis by Celastrol through Suppressing MRGPRX2. Disease markers. 2023; 2023(?):9049256. doi: 10.1155/2023/9049256. [PMID: 36712922]
  • Yujing Wang, Liaoxi Tan, Kejun Jiao, Chu Xue, Qinglian Tang, Shan Jiang, Younan Ren, Hao Chen, Tarek Mohamed Abd El-Aziz, Khalid N M Abdelazeem, Ye Yu, Fang Zhao, Michael X Zhu, Zhengyu Cao. Scutellarein attenuates atopic dermatitis by selectively inhibiting transient receptor potential vanilloid 3 channels. British journal of pharmacology. 2022 10; 179(20):4792-4808. doi: 10.1111/bph.15913. [PMID: 35771623]
  • Yoona Oh, Hongbum Lee, Beodeul Yang, Sura Kim, Hyunwoo Jeong, Hyungwoo Kim. Anti-inflammatory Effects of Ampelopsis Japonica Root on Contact Dermatitis in Mice. Chinese journal of integrative medicine. 2022 Aug; 28(8):719-724. doi: 10.1007/s11655-022-3517-0. [PMID: 35907172]
  • José R Cruz-Muñoz, Tonatiuh Barrios-García, Eduardo E Valdez-Morales, María F Durán-Vazquez, Karen B Méndez-Rodríguez, Alma Barajas-Espinosa, Fernando Ochoa-Cortes, María C Martínez-Saldaña, Yenny A Gómez-Aguirre, Raquel Guerrero Alba. Ethanolic extract from Lepidium virginicum L. ameliorates DNBS-induced colitis in rats. Journal of ethnopharmacology. 2022 May; 289(?):115056. doi: 10.1016/j.jep.2022.115056. [PMID: 35104576]
  • Nanae Nagata, Yuta Hamasaki, Shinichiro Inagaki, Tatsuro Nakamura, Daiki Horikami, Kiwako Yamamoto-Hanada, Yusuke Inuzuka, Tatsuo Shimosawa, Koji Kobayashi, Masami Narita, Yukihiro Ohya, Takahisa Murata. Urinary lipid profile of atopic dermatitis in murine model and human patients. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021 11; 35(11):e21949. doi: 10.1096/fj.202100828r. [PMID: 34591339]
  • Younsook Kim, Yoona Oh, Hongbum Lee, Beodeul Yang, Chan-Hun Choi, Hyunwoo Jeong, Hyungwoo Kim, Wongun An. Prediction of the therapeutic mechanism responsible for the effects of Sophora japonica flower buds on contact dermatitis by network-based pharmacological analysis. Journal of ethnopharmacology. 2021 May; 271(?):113843. doi: 10.1016/j.jep.2021.113843. [PMID: 33493588]
  • Xin Xiong, Chuanqi Huang, Fuqian Wang, Junli Dong, Dan Zhang, Jie Jiang, Yan Feng, Bin Wu, Tingting Xie, Lu Cheng. Qingxue jiedu formulation ameliorated DNFB-induced atopic dermatitis by inhibiting STAT3/MAPK/NF-κB signaling pathways. Journal of ethnopharmacology. 2021 Apr; 270(?):113773. doi: 10.1016/j.jep.2020.113773. [PMID: 33388430]
  • Azusa Saika, Takahiro Nagatake, So-Ichiro Hirata, Kento Sawane, Jun Adachi, Yuichi Abe, Junko Isoyama, Sakiko Morimoto, Eri Node, Prabha Tiwari, Koji Hosomi, Ayu Matsunaga, Tetsuya Honda, Takeshi Tomonaga, Makoto Arita, Kenji Kabashima, Jun Kunisawa. ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021 04; 35(4):e21354. doi: 10.1096/fj.202001687r. [PMID: 33749892]
  • J M Viveros-Paredes, A M Puebla-Pérez, O Gutiérrez-Coronado, A M Macías-Lamas, G Hernández-Flores, P C Ortiz-Lazareno, A Bravo-Cuéllar, M M Villaseñor-García. Capsaicin attenuates immunosuppression induced by chronic stress in BALB/C mice. International immunopharmacology. 2021 Apr; 93(?):107341. doi: 10.1016/j.intimp.2020.107341. [PMID: 33486334]
  • Emiliano Manzo, Aniello Schiano Moriello, Francesco Tinto, Roberta Verde, Marco Allarà, Luciano De Petrocellis, Ester Pagano, Angelo A Izzo, Vincenzo Di Marzo, Stefania Petrosino. A Glucuronic Acid-Palmitoylethanolamide Conjugate (GLUPEA) Is an Innovative Drug Delivery System and a Potential Bioregulator. Cells. 2021 02; 10(2):. doi: 10.3390/cells10020450. [PMID: 33672574]
  • Carmen Parisio, Elena Lucarini, Laura Micheli, Alessandra Toti, Maria Bellumori, Lorenzo Cecchi, Laura Calosi, Daniele Bani, Lorenzo Di Cesare Mannelli, Nadia Mulinacci, Carla Ghelardini. Extra virgin olive oil and related by-products (Olea europaea L.) as natural sources of phenolic compounds for abdominal pain relief in gastrointestinal disorders in rats. Food & function. 2020 Dec; 11(12):10423-10435. doi: 10.1039/d0fo02293d. [PMID: 33237043]
  • Shinsuke Nakazawa, Takatoshi Shimauchi, Atsuko Funakoshi, Masahiro Aoshima, Pawit Phadungsaksawasdi, Jun-Ichi Sakabe, Sanki Asakawa, Noriyasu Hirasawa, Taisuke Ito, Yoshiki Tokura. Suprabasin-null mice retain skin barrier function and show high contact hypersensitivity to nickel upon oral nickel loading. Scientific reports. 2020 09; 10(1):14559. doi: 10.1038/s41598-020-71536-3. [PMID: 32884021]
  • Suzy Jo, Junghyun Ryu, Hanna Kim, Miyoung Kim, Mi Heon Ryu, Hyungwoo Kim, Su-In Cho. Anti-inflammatory Effects of Sanguisorbae Radix on Contact Dermatitis Induced by Dinitrofluorobenzene in Mice. Chinese journal of integrative medicine. 2020 Sep; 26(9):688-693. doi: 10.1007/s11655-015-2148-8. [PMID: 26264569]
  • Liu Tang, Xiao-Lei Li, Zi-Xin Deng, Yao Xiao, Ya-Hong Cheng, Jing Li, Hong Ding. Conjugated linoleic acid attenuates 2,4-dinitrofluorobenzene-induced atopic dermatitis in mice through dual inhibition of COX-2/5-LOX and TLR4/NF-κB signaling. The Journal of nutritional biochemistry. 2020 07; 81(?):108379. doi: 10.1016/j.jnutbio.2020.108379. [PMID: 32330842]
  • Kelvin Anderson, Nathan Ryan, Arham Siddiqui, Travis Pero, Greta Volpedo, Jessica L Cooperstone, Steve Oghumu. Black Raspberries and Protocatechuic Acid Mitigate DNFB-Induced Contact Hypersensitivity by Down-Regulating Dendritic Cell Activation and Inhibiting Mediators of Effector Responses. Nutrients. 2020 Jun; 12(6):. doi: 10.3390/nu12061701. [PMID: 32517233]
  • Aye Aye, Young-Jae Song, Yong-Deok Jeon, Jong-Sik Jin. Xanthone suppresses allergic contact dermatitis in vitro and in vivo. International immunopharmacology. 2020 Jan; 78(?):106061. doi: 10.1016/j.intimp.2019.106061. [PMID: 31821937]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Bo Hyun Kim, Wook-Joo Lee, Babina Sanjel, Kyohee Cho, Youn Kyoung Son, Hye Yoon Park, Sun Yeou Kim, Won-Sik Shim. Extracts of the leaves of Pyrus ussuriensis Maxim. Alleviate itch sensation via TSLP-dependent manner in mouse models of atopic dermatitis. Physiology & behavior. 2019 10; 210(?):112624. doi: 10.1016/j.physbeh.2019.112624. [PMID: 31325512]
  • Beebie Boo, Rohit Kamath, Erica Arriaga-Gomez, Jasmine Landry, Elizabeth Emanuel, Sookyong Joo, Marietta Saldías Montivero, Tijana Martinov, Brian T Fife, Devavani Chatterjea. Tetrahydrocannabinol Reduces Hapten-Driven Mast Cell Accumulation and Persistent Tactile Sensitivity in Mouse Model of Allergen-Provoked Localized Vulvodynia. International journal of molecular sciences. 2019 May; 20(9):. doi: 10.3390/ijms20092163. [PMID: 31052404]
  • Baknoon Ham, Myungsuk Kim, Yang-Ju Son, Sungyul Chang, Sang Hoon Jung, Chu Won Nho, Man Jae Kwon. Inhibitory Effects of Pterocarpus santalinus Extract against IgE/Antigen-Sensitized Mast Cells and Atopic Dermatitis-Like Skin Lesions. Planta medica. 2019 May; 85(7):599-607. doi: 10.1055/a-0824-1282. [PMID: 30609435]
  • Phil-Dong Moon, Na-Ra Han, Jin Soo Lee, Sungwei Hong, Min-Sun Yoo, Hyeong-Jin Kim, Ji-Hyeon Kim, Soonsik Kang, Hyun-Woo Jee, Hyung-Min Kim, Hyun-Ja Jeong. Use of Physcion to Improve Atopic Dermatitis-Like Skin Lesions through Blocking of Thymic Stromal Lymphopoietin. Molecules (Basel, Switzerland). 2019 Apr; 24(8):. doi: 10.3390/molecules24081484. [PMID: 30991764]
  • Yu Zhang, Yujie Liang, Feng Huang, Yue Zhang, Xuechen Li, Jiang Xia. Site-Selective Lysine Reactions Guided by Protein-Peptide Interaction. Biochemistry. 2019 02; 58(7):1010-1018. doi: 10.1021/acs.biochem.8b01223. [PMID: 30624906]
  • Valéria Costa da Silva, Aurigena Antunes de Araújo, Daline Fernandes de Souza Araújo, Maíra Conceição Jerônimo Souza Lima, Roseane Carvalho Vasconcelos, Raimundo Fernandes de Araújo Júnior, Silvana Maria Zucolotto Langasnner, Matheus de Freitas Fernandes Pedrosa, Caroline Addison Carvalho Xavier de Medeiros, Gerlane Coelho Bernardo Guerra. Intestinal Anti-Inflammatory Activity of the Aqueous Extract from Ipomoea asarifolia in DNBS-Induced Colitis in Rats. International journal of molecular sciences. 2018 Dec; 19(12):. doi: 10.3390/ijms19124016. [PMID: 30545135]
  • K J Ryu, M S Yoou, Y Seo, K W Yoon, H M Kim, H J Jeong. Therapeutic effects of Artemisia scoparia Waldst. et Kitaib in a murine model of atopic dermatitis. Clinical and experimental dermatology. 2018 Oct; 43(7):798-805. doi: 10.1111/ced.13565. [PMID: 29740850]
  • Na-Ra Han, Phil-Dong Moon, Hyung-Min Kim, Hyun-Ja Jeong. Cordycepin ameliorates skin inflammation in a DNFB-challenged murine model of atopic dermatitis. Immunopharmacology and immunotoxicology. 2018 Oct; 40(5):401-407. doi: 10.1080/08923973.2018.1510964. [PMID: 30183461]
  • Yan-Yan Gao, Yue Jiang, Guo-Chao Chen, Shuang-Shuang Li, Fei Yang, Qun Ma. A Sensitive and Rapid UPLC-MS/MS Method for Determination of Monosaccharides and Anti-Allergic Effect of the Polysaccharides Extracted from Saposhnikoviae Radix. Molecules (Basel, Switzerland). 2018 Aug; 23(8):. doi: 10.3390/molecules23081924. [PMID: 30071672]
  • Admire Munanairi, Xian-Yu Liu, Devin M Barry, Qianyi Yang, Jun-Bin Yin, Hua Jin, Hui Li, Qing-Tao Meng, Jia-Hang Peng, Zhen-Yu Wu, Jun Yin, Xuan-Yi Zhou, Li Wan, Ping Mo, Seungil Kim, Fu-Quan Huo, Joseph Jeffry, Yun-Qing Li, Rita Bardoni, Michael R Bruchas, Zhou-Feng Chen. Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice. Cell reports. 2018 Apr; 23(3):866-877. doi: 10.1016/j.celrep.2018.03.087. [PMID: 29669290]
  • Ayaka Kitamura, Ryohei Takata, Shin Aizawa, Hajime Watanabe, Tadashi Wada. A murine model of atopic dermatitis can be generated by painting the dorsal skin with hapten twice 14 days apart. Scientific reports. 2018 04; 8(1):5988. doi: 10.1038/s41598-018-24363-6. [PMID: 29662233]
  • Weihua Li, Fanxiu Liu, Jun Wang, Man Long, Zhigang Wang. MicroRNA-21-Mediated Inhibition of Mast Cell Degranulation Involved in the Protective Effect of Berberine on 2,4-Dinitrofluorobenzene-Induced Allergic Contact Dermatitis in Rats via p38 Pathway. Inflammation. 2018 Mar; 41(2):689-699. doi: 10.1007/s10753-017-0723-1. [PMID: 29282578]
  • Kozo Ohkusu-Tsukada, Daiki Ito, Yuki Okuno, Teruyo Tsukada, Kimimasa Takahashi. Signs of atopic dermatitis and contact dermatitis affected by distinct H2-haplotype in the NC/Nga genetic background. Scientific reports. 2018 02; 8(1):2586. doi: 10.1038/s41598-018-21049-x. [PMID: 29416104]
  • Myoung-Schook Yoou, Sun-Young Nam, Kyoung Wan Yoon, Hyun-Ja Jeong, Hyung-Min Kim. Bamboo salt suppresses skin inflammation in mice with 2, 4-dinitrofluorobenzene-induced atopic dermatitis. Chinese journal of natural medicines. 2018 Feb; 16(2):97-104. doi: 10.1016/s1875-5364(18)30035-9. [PMID: 29455734]
  • Kozo Ohkusu-Tsukada, Daiki Ito, Kimimasa Takahashi. The Role of Proteasome Inhibitor MG132 in 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis in NC/Nga Mice. International archives of allergy and immunology. 2018; 176(2):91-100. doi: 10.1159/000488155. [PMID: 29669333]
  • Zhigang Wang, Tao Yi, Man Long, Yisen Gao, Chunhao Cao, Chenwei Huang, Qian Wang, Nina Yin, Zebin Chen. Electro-Acupuncture at Zusanli Acupoint (ST36) Suppresses Inflammation in Allergic Contact Dermatitis Via Triggering Local IL-10 Production and Inhibiting p38 MAPK Activation. Inflammation. 2017 Aug; 40(4):1351-1364. doi: 10.1007/s10753-017-0578-5. [PMID: 28493082]
  • Hyeong-U Son, Seul Lee, Jin-Chul Heo, Sang-Han Lee. The solid-state fermentation of Artemisia capillaris leaves with Ganoderma lucidum enhances the anti-inflammatory effects in a model of atopic dermatitis. International journal of molecular medicine. 2017 May; 39(5):1233-1241. doi: 10.3892/ijmm.2017.2945. [PMID: 28393198]
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  • Mir Ali Farajzadeh, Mohammad Reza Afshar Mogaddam, Ali Akbar Alizadeh Nabil. A sensitive and efficient method for trace analysis of some phenolic compounds using simultaneous derivatization and air-assisted liquid-liquid microextraction from human urine and plasma samples followed by gas chromatography-nitrogen phosphorous detection. Biomedical chromatography : BMC. 2015 Dec; 29(12):1921-31. doi: 10.1002/bmc.3517. [PMID: 26014445]
  • Gun-Dong Kim, Yong Seek Park, Hyun-Jong Ahn, Jeong-Je Cho, Cheung-Seog Park. Aspartame Attenuates 2, 4-Dinitrofluorobenzene-Induced Atopic Dermatitis-Like Clinical Symptoms in NC/Nga Mice. The Journal of investigative dermatology. 2015 Nov; 135(11):2705-2713. doi: 10.1038/jid.2015.234. [PMID: 26099025]
  • Hee Jung Lee, Suzy Jo, Jeonghyun Ryu, Han-Sol Jeong, Guemsan Lee, Mi Heon Ryu, Myeong Ho Jung, Hyungwoo Kim, Byung Joo Kim. Effects of Schisandra chinensis Turcz. fruit on contact dermatitis induced by dinitrofluorobenzene in mice. Molecular medicine reports. 2015 Aug; 12(2):2135-9. doi: 10.3892/mmr.2015.3618. [PMID: 25892286]
  • Nidhi Goyal, Ajay Rana, Krishna Reddy V Bijjem, Puneet Kumar. Effect of chenodeoxycholic acid and sodium hydrogen sulfide in dinitro benzene sulfonic acid (DNBS)--Induced ulcerative colitis in rats. Pharmacological reports : PR. 2015 Jun; 67(3):616-23. doi: 10.1016/j.pharep.2014.12.018. [PMID: 25933978]
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